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Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.
Effect of Microstructure on Thermal Conductivity of Polymer Composites
Yue Yang,Junjie Shu,Peng Chen,Ru Xia,Jiasheng Qian,Bin Yang,JIBIN MIAO,LIFEN SU,Zhengzhi Zheng,Ming Cao 한국고분자학회 2017 Macromolecular Research Vol.25 No.4
Thermal conductivity (TC) of polymer composites is strongly depended on thermal conductive fillers as well as heat conduction pathways formed by these fillers. In this work, we examined effects of morphology, size and arrangement of fillers on TC of polymer composites by using energy-conserving dissipative particle dynamic (e-DPD) simulation. Theoretically, we explored effects of ideal and “pseudo” thermal conductive pathways on composites’ TC and investigated heat conduction of filler particles with cubic-center and lamellar morphology. To confirm orientation and size effects of lamellar filler particles on composites’ TC, we prepared a series of Boron Nitride/Silicon rubber composites (BN/SiR). Being same with those observed in e-DPD simulation, orientation could efficiently improve TC of BN/SiR composites. The TC of composites with filled diameters about 10 micrometer of BN flats is 11 times higher than that of SiR matrix. Our researching results show that heat conduction pathways are essential to transportation of heat flux in polymer composites and even “pseudo” pathways by disconnected filler particles along temperature gradient can accelerate heat conduction.
A Theoretical Method to Predict Crack Initiation in Stabilizing Piles
Yang Yu,Yue-quan Shang,Hong-yue Sun 대한토목학회 2014 KSCE JOURNAL OF CIVIL ENGINEERING Vol.18 No.5
Stabilizing pile is a kind of underground structure, in which the crack initiation on the pile shaft is more dangerous than the crackon the interior concrete structure. A crack discriminant in displacement form was deduced by introducing the subgrade reactionmethod and reinforced concrete theory, in which the head displacement of stabilizing pile was the main parameter. Therefore, thehead displacement of stabilizing pile in critical state of cracking (critical head displacement) can be obtained according to the crackdiscriminant. Subsequently, the predicting crack initiation in stabilizing pile could be achieved by comparing measured headdisplacement with critical head displacement of the stabilizing pile. The crack discriminant was tested and verified in Hongyanlandslide project, Zhejiang province, China. Based on the field measurements at Hongyan landslide project, some stabilizing pileswere critically stressed to initiate the crack.
Critical effects of long non-coding RNA on fibrosis diseases
Yue Zhang,Gang Luo,Yi Zhang,Mengjie Zhang,Jian Zhou,Weiwu Gao,Xiuyun Xuan,Xia Yang,Di Yang,Zhiqiang Tian,Bing Ni,Jun Tang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
The expression or dysfunction of long non-coding RNAs (lncRNAs) is closely related to various hereditary diseases, autoimmune diseases, metabolic diseases and tumors. LncRNAs were also recently recognized as functional regulators of fibrosis, which is a secondary process in many of these diseases and a primary pathology in fibrosis diseases. We review the latest findings on lncRNAs in fibrosis diseases of the liver, myocardium, kidney, lung and peritoneum. We also discuss the potential of diseaserelated lncRNAs as therapeutic targets for the clinical treatment of human fibrosis diseases.
중국 중학생이 지각한 부모 및 교사의 자율성지지, 기본심리욕구, 사회정서역량 간의 관계 연구
( Yang Yue ),신태섭 ( Tae Seob Shin ) 인하대학교 교육연구소 2021 교육문화연구 Vol.27 No.1
본 연구의 목적은 자기결정성이론에 기반하여 부모 및 교사의 자율성 지지가 기본심리욕구를 매개로 중국 청소년의 사회정서역량에 미치는 영향을 살펴보는 데 있다. 이를 위해 중국 산동성 쯔보시 중학교 3학년 434명의 데이터를 사용하여 부모 및 교사의 자율성 지지와 중학생의 사회정서역량 간의 관계에서 중학생의 기본심리욕구의 매개효과를 확인하였다. 본 연구의 주요 결과는 다음과 같다. 첫째, 부모의 자율성 지지가 교사의 자율성 지지보다 중학생의 기본심리욕구 및 사회정서역량에 더 큰 영향을 미치는 것으로 나타났다. 둘째, 중학생의 기본심리욕구가 충족될수록 중학생의 사회정서역량 수준이 높아지는 것으로 나타났다. 셋째, 중학생이 지각한 부모 및 교사의 자율성 지지가 많을수록 중학생의 사회정서역량 수준이 높아졌다. 특히 중학생이 지각한 부모의 자율성 지지는 교사의 자율성 지지보다 중학생의 사회정서역량에 더 직접적인 영향을 주었다. 넷째, 부모와 교사의 자율성 지지는 중학생의 기본심리욕구를 충족시켜 사회정서역량에 긍정적 영향을 미쳤다. 이때 역시 부모의 자율성 지지는 교사의 자율성 지지보다 중학생의 기본심리욕구를 더 충족시키고 사회정서역량에 보다 큰 영향을 주는 것으로 나타났다. 연구 결과는 중학생의 사회·정서적 역량을 개발하기 위해 교사뿐만 아니라 부모의 역할이 필수적이고, 특히 중국에서 부모의 사회정서학습에 대한 인식 개선과 부모 교육 확대의 필요를 시사한다. Purpose of this study was intended to examine the effect of parent and teacher's autonomy support on adolescent's social and emotional competencies, focusing on the mediating effect of basic psychological needs based on self-determination theory. Data of 434 students in Zibo city in Shandong Province were used in the analysis of a structural equation modeling. The main results of this study are as follows. First, the more basic psychological needs of middle school students they were met, the higher level of social and emotional competencies of middle school students have. Second, the more parents and teachers' autonomy supported middle school students perceived, the higher level of social and emotional competencies of middle school students they had. In particular, parental autonomy support perceived by students had a more direct impact on the social and emotional competencies. Lastly, parents' autonomy support stimulated middle school students' basic psychological needs more than teachers' autonomy support, and has a greater influence on social and emotional competencies of middle school students. In conclusion, in order to develop the social and emotional competencies of middle school students, the role of parents as well as teachers is essential, suggesting the need to raise awareness of parent education in China and to expand and implement parent education at national level.
Calcium Sensitization Induced by Sodium Fluoride in Permeabilized Rat Mesenteric Arteries
Yang, En-Yue,Cho, Joon-Yong,Sohn, Uy-Dong,Kim, In-Kyeom The Korean Society of Pharmacology 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.1
It was hypothesized that NaF induces calcium sensitization in $Ca^{2+}$-controlled solution in permeabilized rat mesenteric arteries. Rat mesenteric arteries were permeabilized with $\beta$-escin and subjected to tension measurement. NaF potentiated the concentration-response curves to $Ca^{2+}$ (decreased $EC_{50}$ and increased $E_{max}$). Cumulative addition of NaF (4.0, 8.0 and 16 mM) also increased vascular tension in $Ca^{2+}$-controlled solution at pCa 7.0 or pCa 6.5, but not at pCa 8.0. NaF-induced vasocontraction and $GTP{\gamma}S$-induced vasocontraction were not additive. NaF-induced vasocontraction at pCa 7.0 was inhibited by pretreatment with Rho kinase inhibitors H1152 or Y27632 but not with a MLCK inhibitor ML-7 or a PKC inhibitor Ro31-8220. NaF induces calcium sensitization in a $Ca^{2+}$ dependent manner in $\beta$-escin-permeabilized rat mesenteric arteries. These results suggest that NaF is an activator of the Rho kinase signaling pathway during vascular contraction.
Sliding Mode Control of Three-Phase Four-Leg Inverters via State Feedback
Yang, Long-Yue,Liu, Jian-Hua,Wang, Chong-Lin,Du, Gui-Fu The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.5
To optimize controller design and improve static and dynamic performances of three-phase four-leg inverter systems, a compound control method that combines state feedback and quasi-sliding mode variable structure control is proposed. The linear coordinate change matrix and the state variable feedback equations are derived based on the mathematical model of three-phase four-leg inverters. Based on system relative degrees, sliding surfaces and quasi-sliding mode controllers are designed for converted linear systems. This control method exhibits the advantages of both state feedback and sliding mode control. The proposed controllers provide flexible dynamic control response and excellent stable control performance with chattering suppression. The feasibility of the proposed strategy is verified by conducting simulations and experiments.
Yang Zhen,Xie Jiqin,Yang Yu,Sun Xiaohong,Jing Jie,Shen Yongmei,Yue Bisong,Zhang Xiuyue 한국곤충학회 2021 Entomological Research Vol.51 No.12
Thymosin is a physiologically active polypeptide hormone which has many functions involved in promoting wound healing, promoting hair growth, and accelerating tissue and organ regeneration. American cockroach (Periplaneta americana) has three subtypes thymosin (THY1, THY2, THY3) which are different splices from the same thymosin gene. Real-time PCR was used to detect and analyze the expression differences of THY1 and THY2 in different stages, sexes, tissues and after stimulation by bacteria. Thymosins were expressed in adult, eclosion, and ootheca, and their expression levels were significantly up-regulated during the eclosion period, showing the thymosin might be involved in the eclosion process. The expression levels of thymosins in females were higher than males, and the differences in eclosion stages were more significant (P < 0.01), indicating that they were closely related to development and female reproduction. The expressions of THY1 and THY2 in hemolymph were significantly higher (P < 0.01) than that in other tissues. The up-regulated expression of thymosin in two immune-related tissues (Hemolymph and adipose) after Escherichia coli stimulation further confirmed its involvement in the immune response. Our research would provide a basis for screening of novel pesticides target genes.
Yang Wang,Li M,Yi Sun,Liman Yang,Hao Yue,Shuying Liu 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
The hot syndrome refers to any feverish conditionsduring a pathological development, a sub-healthphenomenon, and is a potential risk for human health. Themetabonomics study on the hot syndrome may provideinsight into understanding of its pathology and play a rolein the prevention and treatment of its related diseases. Inthis paper, the rats were dosed with the hot syndromeprescription, ginseng and water. The corresponding urinesamples were identified by rapid resolution liquid chromatographycombined with quadrupole time-of-flight tandemmass spectrometry. More than 1,000 metaboliccompounds from different urine samples could be furtherdifferentiated by principal component analysis. As a result,the rat body temperature and weight were recognized as thehot syndrome related factors. Some specific metaboliteshave been discovered as a pattern of the potential biomarkers for the hot syndrome. The results showed thatginseng cannot cause the hot syndrome in a reasonabledose, but the hot syndrome prescription can. It is suggestedthat ginseng cannot be used only as a tradition Chinesemedicine but also as a nutrient. The work showed metabonomicsmethod is a valuable tool in studying mechanismof the hot syndrome.
Yang, Peige,Hao, Yue,Feng, Jinghai,Lin, Hai,Feng, Yuejin,Wu, Xin,Yang, Xin,Gu, Xianhong Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.12
The objective of this study was to assess the effects of constant high ambient temperatures on meat quality, antioxidant capacity, and carnosine expression in longissimus dorsi muscle of finishing pigs. Castrated 24 male DLY (crossbreeds between Landrace${\times}$Yorkshire sows and Duroc boars) pigs were allocated to one of three treatments: constant ambient temperature at $22^{\circ}C$ and ad libitum feeding (CON, n = 8); constant high ambient temperature at $30^{\circ}C$ and ad libitum feeding (H30, n = 8); and constant ambient temperature at $22^{\circ}C$ and pair-fed with H30 (PF, n = 8). Meat quality, malondialdehyde (MDA) content, antioxidant capacity, carnosine content, and carnosine synthetase (CARNS1) mRNA expression in longissimus dorsi muscle were measured after three weeks. The results revealed that H30 had lower $pH_{24h}$, redness at 45 min, and yellowness at 24 h post-mortem (p<0.05), and higher drip loss at 48 h and lightness at 24 h post-mortem (p<0.01). Constant heat stress disrupted the pro-oxidant/antioxidant balance in longissimus dorsi muscle with higher MDA content (p<0.01) and lower antioxidant capacity (p<0.01). Carnosine content and CARNS1 mRNA expression in longissimus dorsi muscle of H30 pigs were significantly decreased (p<0.01) after three weeks at $30^{\circ}C$. In conclusion, constant high ambient temperatures affect meat quality and antioxidant capacity negatively, and the reduction of muscle carnosine content is one of the probable reasons.