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Jung, Mankil,Park, Won-Hwan,Jung, Jae-Chul,Lim, Eunyoung,Lee, Yongnam,Oh, Seikwan,Moon, Hyung-In Blackwell Publishing Ltd 2009 Chemical biology & drug design Vol.73 No.3
<P>A series of benzamide-containing stilbene derivatives was synthesized through the incorporation of short basic side-chains in the B-ring hydroxy position of resveratrol. Their antiplasmodial activity was evaluated <I>in vitro</I> against the chloroquine resistant <I>Plasmodium falciparum</I> D10 strain, showing IC<SUB>50</SUB> values between 1.5 and 80 <I>&mgr;</I><SMALL>M</SMALL>, while their cytotoxicity was assessed using an human myeloid leukemia (U-937) cell line. With a selectivity ratio of >51.02, the most selective of these derivatives, 29, also had the most lowest cytotoxic activity of the series.</P>
Antidiabetic agents from medicinal plants.
Jung, Mankil,Park, Moonsoo,Lee, Hyun Chul,Kang, Yoon-Ho,Kang, Eun Seok,Kim, Sang Ki Bentham Science Publishers 2006 Current medicinal chemistry Vol.13 No.10
<P>Currently available therapeutic options for non-insulin-dependent diabetes mellitus, such as dietary modification, oral hypoglycemics, and insulin, have limitations of their own. Many natural products and herbal medicines have been recommended for the treatment of diabetes. The present paper reviews medicinal plants that have shown experimental or clinical antidiabetic activity and that have been used in traditional systems of medicine; the review also covers natural products (active natural components and crude extracts) isolated from the medicinal plants and reported during 2001 to 2005. Many kinds of natural products, such as terpenoids, alkaloids, flavonoids, phenolics, and some others, have shown antidiabetic potential. Particularly, schulzeines A, B, and C, radicamines A and B, 2,5-imino-1,2,5-trideoxy-L-glucitol, beta-homofuconojirimycin, myrciacitrin IV, dehydrotrametenolic acid, corosolic acid (Glucosol), 4-(alpha-rhamnopyranosyl)ellagic acid, and 1,2,3,4,6-pentagalloylglucose have shown significant antidiabetic activities. Among active medicinal herbs, Momordica charantia L. (Cucurbitaceae), Pterocarpus marsupium Roxb. (Leguminoceae), and Trigonella foenum graecum L. (Leguminosae) have been reported as beneficial for treatment of type 2 diabetes.</P>
광학활성 착물의 원편광이색성 스펙트라 I. 광학활성 tris(diamine)cobalt(III)착물의 원편광이색성 스펙트라에 관한 이온혼합의 효과
이만길,김양 高神大學校 1989 論文集 Vol.17 No.-
The circular dichroism(CD) spectra of opically active [Co(diamine)₃]³+ complexes were measured in the presence of several electrolytes, where diamine is ethylenediamine or trimethylenediamine. The CD spectra of these complexes were sensitive to the types of electrolytes. And it has been concluded that the ∧(δδδ)(lel₃) isomer is stabilized by ion-pair formation with electrolytes.
광학활성 착물의 원편광이색성 스펙트라 .II. ?? 착물의 용매 의존성 원편광이색성 스펙트라
김양,이만길 高神大學校 1989 論文集 Vol.17 No.-
The circular dichroism (CD) spectra of △-[Co(R,R-ptn)₃]³+ complex have been measured in several solvents. It was observed that the degree of the change of CD spectra in the first absorption band region depends on the polarity of the solvents. It has been deduced that the conformation of (R,R)-2,4-pentanediamine ligands in the complex is stabilized as the polarity of slovent decreases, and that the CD spectra of the complex in the solvents with low polarity have a resemblance to the in the solid state.
Chemical structure and biological activity of the Caenorhabditis elegans dauer-inducing pheromone
Jeong, Pan-Young,Jung, Mankil,Yim, Yong-Hyeon,Kim, Heekyeong,Park, Moonsoo,Hong, Eunmi,Lee, Weontae,Kim, Young Hwan,Kim, Kun,Paik, Young-Ki Macmillan Journals ltd., etc.] 2005 Nature Vol.433 No.7025
Pheromones are cell type-specific signals used for communication between individuals of the same species. When faced with overcrowding or starvation, Caenorhabditis elegans secrete the pheromone daumone, which facilitates communication between individuals for adaptation to adverse environmental stimuli. Daumone signals C. elegans to enter the dauer stage, an enduring and non-ageing stage of the nematode life cycle with distinctive adaptive features and extended life. Because daumone is a key regulator of chemosensory processes in development and ageing, the chemical identification of daumone is important for elucidating features of the daumone-mediated signalling pathway. Here we report the isolation of natural daumone from C. elegans by large-scale purification, as well as the total chemical synthesis of daumone. We present the stereospecific chemical structure of purified daumone, a fatty acid derivative. We demonstrate that both natural and chemically synthesized daumones equally induce dauer larva formation in C. elegans (N2 strain) and certain dauer mutants, and also result in competition between food and daumone. These results should help to elucidate the daumone-mediated signalling pathway, which might in turn influence ageing and obesity research and the development of antinematodal drugs.
Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice
Park, Jong Hee,Chung, Hae Young,Kim, Minkyu,Lee, Jung Hwa,Jung, Mankil,Ha, Hunjoo BLACKWELL PUBLISHING 2014 AGING CELL Vol.13 No.4
<P>The liver is one of the most susceptible organs to aging, and hepatic inflammation and fibrosis increase with age. Chronic inflammation has been proposed as the major molecular mechanism underlying aging and age-related diseases, whereas calorie restriction has been shown to be the most effective in extending mammalian lifespan and to have anti-aging effects through its anti-inflammatory action. Thus, it is necessary to develop effective calorie restriction mimetics. Daumone [(2)-(6R)-(3,5-dihydroxy-6-methyltetrahydropyran-2-yloxy)heptanoic acid], a pheromone secreted by <I>Caenorhabditis elegans</I>, forces them to enter the dauer stage when facing inadequate conditions. Because <I>Caenorhabditis elegans</I> live longer during the dauer stage under energy deprivation, it was hypothesized that daumone may improve survival in mammals by mimicking calorie restriction. Daumone (2 mg kg<SUP>−1</SUP> day<SUP>−1</SUP>) was administered orally for 5 months to 24-month-old male C57BL/6J mice. Daumone was found to reduce the risk of death by 48% compared with age-matched control mice, and the increased plasma insulin normally presented in old mice was significantly reduced by daumone. The increased hepatic hypertrophy, senescence-associated β-galactosidase activity, insulin resistance, lipid accumulation, inflammation, oxidative stress, and fibrosis in old mice were significantly attenuated by daumone. From a mechanistic view, daumone reduced the phosphorylation of the IκBα and upregulation of <I>Rela</I> and <I>Nfkbia</I> mRNA in the livers of old mice. The anti-inflammatory effect of daumone was confirmed in lipopolysaccharide-induced liver injury model. Oral administration of daumone improves survival in mice and delivers anti-aging effects to the aged liver by modulating chronic inflammation, indicating that daumone could be developed as an anti-aging compound.</P>
Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells
Nam, Woong,Tak, Jungae,Ryu, Ju-Kyoung,Jung, Mankil,Yook, Jong-In,Kim, Hyung-Jun,Cha, In-Ho Wiley Subscription Services, Inc., A Wiley Company 2007 Head & neck Vol.29 No.4
<B>Background.</B><P>Artemisinin is of special biological interest because of its outstanding antimalarial activity. Recently, it was reported that artemisinin has antitumor activity. Its derivatives, artesunate, arteether, and artemeter, also have antitumor activity against melanoma, breast, ovarian, prostate, CNS, and renal cancer cell lines. Recently, monomer, dimer, and trimer derivatives were synthesized from deoxoartemisinin, and the dimers and the trimers were found to have much more potent antitumor activity than the monomers.</P><B>Methods.</B><P>We evaluated the antitumor activity of artemisinin and its various derivatives (dihydroartemisinin, dihydroartemisinin 12-benzoate, 12-(2′-hydroxyethyl) deoxoartemisinin, 12-(2′-ethylthio) deoxoartemisinin dimer, deoxoartemisinin trimer) in comparison with paclitaxel (Taxol), 5-fluorouracil (5-FU), cisplatin in vitro.</P><B>Results.</B><P>In this study, the deoxoartemisinin trimer had the most potent antitumor effect (IC<SUB>50</SUB> = 6.0 μM), even better than paclitaxel (IC<SUB>50</SUB> = 13.1 μM), on oral cancer cell line (YD-10B). In addition, it induced apoptosis through a caspase-3-dependent mechanism.</P><B>Conclusion.</B><P>The deoxoartemisinin trimer was found to have greater antitumor effect on tumor cells than other commonly used chemotherapeutic drugs, such as 5-FU, cisplatin, and paclitaxel. Furthermore, the ability of artemisinin and its derivatives to induce apoptosis highlights their potential as chemotherapeutic agents, for many anticancer drugs achieve their antitumor effects by inducing apoptosis in tumor cells. © 2006 Wiley Periodicals, Inc. Head Neck, 2007.</P>