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Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells
Hassan, Zeinab Korany,Elamin, Maha Hussein,Omer, Sawsan Ali,Daghestani, Maha Hassan,Al-Olayan, Ebtesam Salah,Elobeid, Mai AbdelRahman,Virk, Promy Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: Breast cancer is a major health problem worldwide. Olive oil induces apoptosis in some cancer cells due to phenolic compounds like oleuropein. Although oleuropein has anticancer activity, the underlying mechanisms of action remain unknown. The study aimed to assess the mechanism of oleuropin-induced breast cancer cell apoptosis. Materials and Methods: p53, Bcl-2 and Bax gene expression was evaluated by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in luminal MCF-7 cells. Results: Oleuropein-induced apoptosis was accompanied by up-regulation of both p53 and Bax gene expression levels and down-regulation in Bcl2. Conclusions: Oleuropein induces apoptosis in breast tumour cells via a p53-dependent pathway mediated by Bax and Bcl2 genes. Therefore, oleuropein may have therapeutic potential in breast cancer patients by inducing apoptosis via activation of the p53 pathway.
Oleuropein Induces Anti-metastatic Effects in Breast Cancer
Hassan, Zeinab K.,Elamin, Maha H.,Daghestani, Maha H.,Omer, Sawsan A.,Al-Olayan, Ebtesam M.,Elobeid, Mai A.,Virk, Promy,Mohammed, Osama B. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Breast cancer causes death due to distant metastases in which tumor cells produce matrix metalloproteinase (MMP) enzymes which facilitate invasion. Oleuropein, the main olive oil polyphenol, has anti-proliferative effects. This study aimed to investigate the effect of oleuropein on the metastatic and anti-metastatic gene expression in the MDA human breast cancer cell line. We evaluated the MMPs and TIMPs gene expression by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in treated and untreated cells. This study demonstrated that OL may induce anti-metastatic effects on human breast cancer cells. We found that TIMP1,-3, and -4 were over-expressed after all periods of incubation in treated cancer cells compared to untreated cells, while MMP2 and MMP9 genes were down-regulated, at least initially. Treatment of breast cancer cells with oleuropein could help in prevention of cancer metastasis by increasing the TIMPs and suppressing the MMPs gene expressions.
Mais M. Sadek,Noha E. Sabet,Islam T. Hassan 대한치과교정학회 2019 대한치과교정학회지 Vol.49 No.6
Objective: The objective of this two-arm parallel trial was to compare the type of tooth movement during en masse retraction of the maxillary anterior teeth using labial versus lingual biocreative therapy. Methods: Twenty-eight subjects were randomized in a 1 : 1 ratio to either the labial or lingual group. En masse anterior retraction was performed using labial biocreative therapy in group A and lingual biocreative therapy in group B. Cone beam computed tomography scans were taken before and after retraction and the primary outcome was the type of tooth movement during anterior retraction. Data were analyzed using paired t -tests for comparisons within each group and independent-sample t-test for comparison of the mean treatment changes between the two groups. Results: Significant differences were found between the two groups in relation to the type of tooth movement (labiolingual inclination of the central incisor; mean difference, 5.85 ± 1.85o). The canine showed significant distal tipping in the lingual group (mean difference, 6.98 ± 1.25o). The canine was significantly more intruded in the lingual group (mean difference, 1.67 ± 0.49 mm). Good anchorage control and significant soft tissue changes occurred in both groups. No serious adverse effects were detected. Conclusions: With a 10-mm retraction hook, the labial biocreative technique with the reverse curve overlay provided anterior retraction with good torque control, while in the lingual group, anterior retraction occurred with controlled tipping movement with significant distal tipping and intrusion of the canine (trial registration: The trial was registered at ClinicalTrials.gov [NCT03239275]).
A Novel Front-hauling Architecture under Centralized Radio Access Network (C-RAN)
Haoran Mei,Mai Hassan,Limei Peng,Pin Han Ho 한국통신학회 2022 Journal of communications and networks Vol.24 No.3
Residential power line is considered a cost-effectivecommunication media for building a digital indoor distributednetwork thanks to its ubiquity in the indoor environment. This paper investigates a front-hauling system under the splitcentralized radio access network (C-RAN) architecture, aimingto examine the feasibility of implementing common public radiointerface (CPRI) over power line communication (PLC) channels. Particularly, we introduce a novel device called CPRI-PLCgateway (CPG) that provides a virtual CPRI link over the PLCchannel to ensure high reliability and efficiency in delivering theCPRI hyper-frames (HFs) between the data unit (DU) and radiounit (RU). We examine the proposed CPRI over PLC system viaextensive simulations in terms of the achievable throughput andreliability.