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RISS 인기검색어
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- 저자 : Al-Olayan, Ebtesam Salah (검색결과 4 건)
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( Prof Dr Ebtesam Al Olayan ),( Badriah Alkathiri ),( Manal El Khadragy ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Cutaneous leishmaniasis a zoonotic disease caused by Leishmania parasites. (CL)is endemic in 88 different developing countries. There are an estimated 1.5 million new cases each year.The purpose of this study was to evaluate the effect of Ginseng in inhibiting a potent oxidative stress which induces cellular damage. Materials and Methods: In this study, BALB/c mice infected with (CL) were treated with the most effective dose of Ginseng in vitro and in vivo against (CL) of L. major and it was demonstrated effi cacy in the mouse model via the subcutenous route. Results: Ginseng has a better effect on reduction of size of lesion compared to control. In this study, the possible protective role of Ginseng ( 800 ug /ml ) on the free radical damage in serum of the liver and kidney caused by (CL) which produced severe injury, as demonstrated by dramatic elevation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and typical histopathological changes including necrosis and apoptosis. In addition, (CL) caused oxidative stress in Mice, as evidenced by a remarkable reduction in catalase (CAT) and superoxide dismutase (SOD). However, simultaneous subcutenous treatment with Ginseng signifi cantly attenuated (CL) -induced hepatotoxicity and nephrotoxicity. It ameliorated most biochemical markers tested as well as histopathological, apoptosis and necrosis features. It is therefore suggested that Ginseng can provide a defi nite protective effect against chronic injury caused by (CL) in BALB/c mice, which may mainly be associated with its antioxidative effect. Conclusions: We suggested that Ginseng was able to elevate the antioxidant defense system, clean up free radicals, lessen oxidative damages and protect the liver and the kidney against (CL),thus having a potential protective effect. The results suggest that Ginseng might be a promising approach for developing new anti-Leishmanial drugs.
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Curcumin Reorganizes miRNA Expression in a Mouse Model of Liver Fibrosis
Hassan, Zeinab Korany,Al-Olayan, Ebtisam M. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
Curcumin (CM), a biphenyl compound, possesses anti-inflammatory, antioxidant and antimicrobial activity. MicroRNAs (miRNAs) are small noncoding RNAs which regulate gene expression and the molecular mechanisms of several biological processes. Liver fibrosis is a major cause of hepatic dysfunction and cancer and there are few effective therapies emphasizing the need for new approaches to control. The present study was conducted to investigate the effect of curcumin (CM) on liver fibrosis through modulating the expression level of miRNAs (199 and 200), the main miRNAs associated with liver fibrosis. Induction of liver fibrosis by carbon tetrachloride ($CCL_4$) was confirmed by histopathological examination. Mice were divided into 3 groups: group 1 were i.p injected with 10% $CCL_4$ twice weekly for 4 weeks and then once a week for the next 4 weeks followed by 4 weeks with olive oil only. Group 2 were i.p injected with 10% $CCL_4$ twice weekly for 4 weeks and then once a week for the next 4 weeks followed by curcumin (5 mg/mouse/day) once daily for the next 4 weeks. The third group was injected with olive oil. The expression level of miR-199 and miR-200 and some of their targeted genes were measured by real time PCR. miRNA (199 and 200) levels were significantly elevated in liver fibrotic tissues compared to control groups. Curcumin was significantly returned the expression levels of mir-199 and -200 with their associated target gene nearly to their normal levels. This is the first study that highlighted the effect of curcumin on liver fibrosis through regulation of miRNAs.
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Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells
Hassan, Zeinab Korany,Elamin, Maha Hussein,Omer, Sawsan Ali,Daghestani, Maha Hassan,Al-Olayan, Ebtesam Salah,Elobeid, Mai AbdelRahman,Virk, Promy Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: Breast cancer is a major health problem worldwide. Olive oil induces apoptosis in some cancer cells due to phenolic compounds like oleuropein. Although oleuropein has anticancer activity, the underlying mechanisms of action remain unknown. The study aimed to assess the mechanism of oleuropin-induced breast cancer cell apoptosis. Materials and Methods: p53, Bcl-2 and Bax gene expression was evaluated by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in luminal MCF-7 cells. Results: Oleuropein-induced apoptosis was accompanied by up-regulation of both p53 and Bax gene expression levels and down-regulation in Bcl2. Conclusions: Oleuropein induces apoptosis in breast tumour cells via a p53-dependent pathway mediated by Bax and Bcl2 genes. Therefore, oleuropein may have therapeutic potential in breast cancer patients by inducing apoptosis via activation of the p53 pathway.
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Oleuropein Induces Anti-metastatic Effects in Breast Cancer
Hassan, Zeinab K.,Elamin, Maha H.,Daghestani, Maha H.,Omer, Sawsan A.,Al-Olayan, Ebtesam M.,Elobeid, Mai A.,Virk, Promy,Mohammed, Osama B. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Breast cancer causes death due to distant metastases in which tumor cells produce matrix metalloproteinase (MMP) enzymes which facilitate invasion. Oleuropein, the main olive oil polyphenol, has anti-proliferative effects. This study aimed to investigate the effect of oleuropein on the metastatic and anti-metastatic gene expression in the MDA human breast cancer cell line. We evaluated the MMPs and TIMPs gene expression by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in treated and untreated cells. This study demonstrated that OL may induce anti-metastatic effects on human breast cancer cells. We found that TIMP1,-3, and -4 were over-expressed after all periods of incubation in treated cancer cells compared to untreated cells, while MMP2 and MMP9 genes were down-regulated, at least initially. Treatment of breast cancer cells with oleuropein could help in prevention of cancer metastasis by increasing the TIMPs and suppressing the MMPs gene expressions.
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