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Bernard M.Y. Cheung,Benjamin Or,Yue Fei,Man-Fung Tsoi 대한심장학회 2020 Korean Circulation Journal Vol.50 No.6
Hypertension is a common chronic disease affecting a large section of the general population. Hypertension is highly prevalent in the elderly because blood pressure (BP) rises with age. The risk of developing hypertension increases with predisposing genes, intrauterine growth retardation, prematurity and childhood obesity. BP is easier to control in the young. Non-pharmacological treatment through lifestyle changes, such as weight control and leisure-time physical activity, is more likely to be successful in young people. Hypertension in older adults is more difficult to control, requiring the use of more than one antihypertensive drug. Adverse effects and compliance become problematic. Much research is now directed at novel ways of controlling BP such as denervation. The change in definition of hypertension in the American guideline highlights the need to identify and manage hypertension early, at a stage when it is potentially reversible.
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Self‐Assembled, Molecularly Aligned Conjugated Polymer Nanowires via Dewetting
Chang, Shion Seng,Tsoi, Wing C.,Higgins, Anthony M.,Kim, Ji‐,Seon,Winfield, Jessica M.,James, David T. WILEY‐VCH Verlag 2010 Advanced Functional Materials Vol.20 No.18
<P><B>Abstract</B></P><P>High aspect‐ratio poly(9,9′‐dioctylfluorene) (F8) nanowires are fabricated on top of silicon/amorphous Teflon substrates, by dewetting of F8 thin‐films. The conjugated nature of the polymers enables the self‐assembly of continuous molecularly‐aligned nanowires of several micrometers in length and tens of nanometers width, without using a template. The sizescale of the dewetted morphology can be controlled by varying the thickness of the F8 and amorphous Teflon layers. As predicted by van der Waals theory the characteristic sizescale of the dewetted morphology increases with F8 film thickness. However, the dependence of the characteristic sizescale on amorphous Teflon thickness is not accounted for, even qualitatively, by standard spinodal theory with van der Waals forces as the de‐stabilizing force across the F8 film. The Rayleigh instability is strongly suppressed in the F8 nanowires in the late stages of dewetting, compared to isotropic, amorphous polymers. Polarized Raman measurements show a systematic increase in molecular alignment along the axis of the nanowires as their width is reduced below the typical liquid‐crystalline domain size in polyfluorene films. Thus the dewetting process aligns the polymers, and the aligned polymers suppress the Rayleigh instability and enable the formation of high aspect‐ratio continuous nanowires.</P>
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Studies of Effects of Current on Exchange-Bias: A Brief Review
J. Bass,A. Sharma,Z. Wei,M. Tsoi 한국자기학회 2008 Journal of Magnetics Vol.13 No.1
MacDonald and co-workers recently predicted that high current densities could affect the magnetic order of antiferromagnetic (AFM) multilayers, in ways similar to those that occur in ferromagnetic (F) multilayers, and that changes in AFM magnetic order can produce an antiferromagnetic Giant Magnetoresistance (AGMR). Four groups have now studied current-driven effects on exchange bias at F/AFM interfaces. In this paper, we first briefly review the main predictions by MacDonald and co-workers, and then the results of experiments on exchange bias that these predictions stimulated.
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Sul, Woo Jun,Park, Joonhong,Quensen III, John F.,Rodrigues, Jorge L. M.,Seliger, Laurie,Tsoi, Tamara V.,Zylstra, Gerben J.,Tiedje, James M. American Society for Microbiology 2009 Applied and environmental microbiology Vol.75 No.17
<B>ABSTRACT</B><P>Stable isotope probing with [<SUP>13</SUP>C]biphenyl was used to explore the genetic properties of indigenous bacteria able to grow on biphenyl in PCB-contaminated River Raisin sediment. A bacterial 16S rRNA gene clone library generated from [<SUP>13</SUP>C]DNA after a 14-day incubation with [<SUP>13</SUP>C]biphenyl revealed the dominant organisms to be members of the genera <I>Achromobacter</I> and <I>Pseudomonas</I>. A library built from PCR amplification of genes for aromatic-ring-hydroxylating dioxygenases from the [<SUP>13</SUP>C]DNA fraction revealed two sequence groups similar to <I>bphA</I> (encoding biphenyl dioxygenase) of <I>Comamonas testosteroni</I> strain B-356 and of <I>Rhodococcus</I> sp. RHA1. A library of 1,568 cosmid clones was produced from the [<SUP>13</SUP>C]DNA fraction. A 31.8-kb cosmid clone, detected by aromatic dioxygenase primers, contained genes of biphenyl dioxygenase subunits <I>bphAE</I>, while the rest of the clone's sequence was similar to that of an unknown member of the <I>Gammaproteobacteria</I>. A discrepancy in G+C content near the <I>bphAE</I> genes implies their recent acquisition, possibly by horizontal transfer. The biphenyl dioxygenase from the cosmid clone oxidized biphenyl and unsubstituted and <I>para</I>-only-substituted rings of polychlorinated biphenyl (PCB) congeners. A DNA-stable isotope probing-based cosmid library enabled the retrieval of functional genes from an uncultivated organism capable of PCB metabolism and suggest dispersed dioxygenase gene organization in nature.</P>
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