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Perinatal/Postnatal Study of D-003, a Mixture of Long-Chain Fatty Acids, in Rats
M.D. Rodriguez,J.E. Gonzalez,E.F. Leon,A. Gutierrez,G. Marrero,R. Gamez,H Garcia,,E Goicochea,Y. Rodriguez,A. Gomez 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.2
D-003 is a mixture of long-chain fatty acids isolated and purified from sugar cane wax with cholesterol-low-ering and antiplatelet effects. In order to further characterize the developmental toxicity during the treatment period from lategestation up to weaning of the offspring, pregnant females received 0 (control), 500, and 1,000 mg/kg/day D-003 daily byoral gavage beginning at day 15 of pregnancy and through gestation until day 21 postpartum. Maternal clinical signs, bodyweight, and food intake were measured at regular intervals during gestation and lactation. Live pups were weighed, sexed,and examined for developmental signs. One female and male of each litter were randomly selected to evaluate the reproduc-tive potential. There were no spontaneous or dose-related maternal deaths during the course of this study. The general healthand behavioral condition of offspring was good in all groups. No significant differences among groups were found in com-parisons of litter size, survival through the weaning period, sex ratio, and male and female weights. This peri- and postnatalstudy conducted with D-003 in rats indicated that treatment of the dam during late gestation and lactation did not show ad-versely effects on reproductive performance or fetal development over two generations.
European 1: A globally important clonal complex of Mycobacterium bovis
Smith, N.H.,Berg, S.,Dale, J.,Allen, A.,Rodriguez, S.,Romero, B.,Matos, F.,Ghebremichael, S.,Karoui, C.,Donati, C.,Machado, A.d.C.,Mucavele, C.,Kazwala, R.R.,Hilty, M.,Cadmus, S.,Ngandolo, B.N.R.,Habt Elsevier Science 2011 Infection, genetics and evolution Vol.11 No.6
We have identified a globally important clonal complex of Mycobacterium bovis by deletion analysis of over one thousand strains from over 30 countries. We initially show that over 99% of the strains of M. bovis, the cause of bovine tuberculosis, isolated from cattle in the Republic of Ireland and the UK are closely related and are members of a single clonal complex marked by the deletion of chromosomal region RDEu1 and we named this clonal complex European 1 (Eu1). Eu1 strains were present at less than 14% of French, Portuguese and Spanish isolates of M. bovis but are rare in other mainland European countries and Iran. However, strains of the Eu1 clonal complex were found at high frequency in former trading partners of the UK (USA, South Africa, New Zealand, Australia and Canada). The Americas, with the exception of Brazil, are dominated by the Eu1 clonal complex which was at high frequency in Argentina, Chile, Ecuador and Mexico as well as North America. Eu1 was rare or absent in the African countries surveyed except South Africa. A small sample of strains from Taiwan were non-Eu1 but, surprisingly, isolates from Korea and Kazakhstan were members of the Eu1 clonal complex. The simplest explanation for much of the current distribution of the Eu1 clonal complex is that it was spread in infected cattle, such as Herefords, from the UK to former trading partners, although there is evidence of secondary dispersion since. This is the first identification of a globally dispersed clonal complex M. bovis and indicates that much of the current global distribution of this important veterinary pathogen has resulted from relatively recent International trade in cattle.
A. Rivera-Villegas,A. Estrada-Angulo,B.I. Castro-Perez,J.D. Urias-Estrada,F.G. Rios-Rincon,D. Rodriguez-Cordero,A. Barreras,A. Plascencia,V.M.Gonzalez-Vizcarra,J.F. Sosa-Gordillo,R.A. Zinn 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.2
Objective: We compare the effects of three different approved sources of supplemental zilpaterol on growth-performance responses and carcass characteristics of finishing lambs. Methods: Twenty four Pelibuey×Katahdin lambs (46.75±2.43 kg) were used in a 33-day feeding trial. Lambs were fed a dry rolled corn-based finishing diet. Treatments consisted of the non-supplemental basal diet (Control) versus the basal diet supplemented with 125 mg zilpaterol/kg of diet (as fed basis) from three commercial sources marketed in Mexico: Zilmax (ZIL), Grofactor, and Zipamix. Results: Compared to controls, zilpaterol (ZH) supplementation did not affect dry matter intake (DMI), but increased carcass adjusted daily weight gain (ADG, 36.7%), gain efficiency (34.2%), and dietary net energy (26.0%), and decreased (23.4%) the ratio of observed:expected DMI. Compared to controls, supplemental ZH increased hot carcass weight (6.4%), dressing percentage (3.2%), m. longissimus thoracis (LM) area (15.6%), and shoulder muscle:fat ratio (28.7%), but decreased kidney-pelvic-heart fat, and fat thickness. Supplemental ZH increased 10.9% and 14.3% whole cut weight of loin and leg, respectively, and the proportion (as percentage of cold carcass weight) of leg (4.3%). These increases were reflected in greater forequarter and hindquarter weights. Lambs fed ZH increased (4.6%) empty body weight (EBW) and reduced (14.7%) liver/spleen weight (as g/kg EBW). Likewise, ZH supplementation tended (p = 0.08) to lower (8.9%) visceral fat. Growth performance, energetic efficiency, hot carcass weight, dressing percentage, LM area and whole cuts were not different across supplemental ZH sources. However, compared with non-supplemented controls, only ZIL appreciably decreased carcass fat distribution, including fat thickness, percentage kidney pelvic and heart fat, shoulder fat, and visceral fat. Conclusion: Supplemental ZH increases ADG, gain efficiency, carcass dressing percentage, and LM area. The magnitude of these responses was similar among ZH sources. Nevertheless, compared with non-supplemented controls, only ZIL appreciably decreases carcass fat. The basis for this is uncertain, but indicative that some practical differences in zilpaterol bio-equivalency may exist across commercial sources tested.
Magnetoresistance (MR) of twisted bilayer graphene on electron transparent substrate
Hong, S.J.,Rodriguez-Manzo, J.A.,Kim, K.H.,Park, M.,Baek, S.J.,Kholin, D.I.,Lee, M.,Choi, E.S.,Jeong, D.H.,Bonnell, D.A.,Mele, E.J.,Drndic, M.,Johnson, A.,Park, Y.W. Elsevier Sequoia] 2016 Synthetic metals Vol.216 No.-
We studied the magnetoresistance (MR) of twisted bilayer graphene (tBLG) on electron transparent substrate. Samples of tBLG were assembled on free-standing silicon nitride (SiN<SUB>x</SUB>) membranes (<100nm thick) by transferring chemical vapor deposition (CVD)-grown single layer graphene (SLG) twice; this allowed the measurement of the angle of rotation between the two layers, the twist angle, by electron diffraction using a transmission electron microscope (TEM). To compare with the previous reports on tBLG, we performed Raman spectroscopy on our samples. We measured the MR of tBLG for two different twist angles: 2<SUP>o</SUP> (small) and 18<SUP>o</SUP> (large). The MR showed superposition of two Shubnikov de Haas (SdH) oscillations for both angles. An analysis of the oscillation peaks by Landau fan diagrams showed difference as twist angle. While the large twist angle (18<SUP>o</SUP>) sample had two anomalous π Berry's phases, the small twist angle (2<SUP>o</SUP>) sample had conventional 2π and anomalous π Berry's phase depending on carrier density.
Internal modifications to reduce pollutant emissions from marine engines. A numerical approach
Lamas, M.I.,Rodriguez, C.G.,Rodriguez, J.D.,Telmo, J. The Society of Naval Architects of Korea 2013 International Journal of Naval Architecture and Oc Vol.5 No.4
Taking into account the increasingly stringent legislation on emissions from marine engines, this work aims to analyze several internal engine modifications to reduce $NO_x$ (nitrogen oxides) and other pollutants. To this end, a numerical model was employed to simulate the operation cycle and characterize the exhaust gas composition. After a preliminary validation process was carried out using experimental data from a four-stroke, medium-speed marine engine, the numerical model was employed to study the influence of several internal modifications, such as water addition from 0 to 100% water to fuel ratios, exhaust gas recirculation from 0 to 100% EGR rates, modification of the overlap timing from 60 to $120^{\circ}$, modification of the intake valve closing from 510 to $570^{\circ}$, and modification of the cooling water temperature from 70 to $90^{\circ}C$. $NO_x$ was reduced by nearly 100%. As expected, it was found that, by lowering the combustion temperature, there is a notable reduction in $NO_x$, but an increase in CO (carbon monoxide), HC (hydrocarbons) and consumption.
Choi, M.,Kadara, H.,Zhang, J.,Parra, E.R.,Rodriguez-Canales, J.,Gaffney, S.G.,Zhao, Z.,Behrens, C.,Fujimoto, J.,Chow, C.,Kim, K.,Kalhor, N.,Moran, C.,Rimm, D.,Swisher, S.,Gibbons, D.L.,Heymach, J.,Kaf Elsevier 2017 Annals of oncology Vol.28 No.1
<P>Conclusion(s): Our findings pinpoint mutated genes that may impact clinical outcome as well as personalized strategies for targeted immunotherapies in early-stage LUSC.</P>
The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts
Malone, A. M. D.,Batra, N. N.,Shivaram, G.,Kwon, R. Y.,You, L.,Kim, C. H.,Rodriguez, J.,Jair, K.,Jacobs, C. R. AMERICAN PHYSIOLOGICAL SOCIETY 2007 American journal of physiology. Cell physiology Vol.292 No.5
Corté,s, M.L.,Rodriguez, W.,Doornenbal, P.,Obertelli, A.,Holt, J.D.,Lenzi, S.M.,Mené,ndez, J.,Nowacki, F.,Ogata, K.,Poves, A.,Rodrí,guez, T.R.,Schwenk, A.,Simonis, J.,Stroberg, S.R. North-Holland Pub. Co 2020 Physics letters. Section B Vol.800 No.-
<P><B>Abstract</B></P> <P>Excited states in the N = 40 isotone <SUP>62</SUP>Ti were populated via the <SUP>63</SUP>V ( p , 2 p ) <SUP>62</SUP>Ti reaction at ∼200 MeV/nucleon at the Radioactive Isotope Beam Factory and studied using <I>γ</I>-ray spectroscopy. The energies of the 2 1 + → 0 gs + and 4 1 + → 2 1 + transitions, observed here for the first time, indicate a deformed <SUP>62</SUP>Ti ground state. These energies are increased compared to the neighboring <SUP>64</SUP>Cr and <SUP>66</SUP>Fe isotones, suggesting a small decrease of quadrupole collectivity. The present measurement is well reproduced by large-scale shell-model calculations based on effective interactions, while ab initio and beyond mean-field calculations do not yet reproduce our findings. The shell-model calculations for <SUP>62</SUP>Ti show a dominant configuration with four neutrons excited across the N = 40 gap. Likewise, they indicate that the N = 40 island of inversion extends down to Z = 20 , disfavoring a possible doubly magic character of the elusive <SUP>60</SUP>Ca.</P>
Comparison of physicochemical properties of bio and commercial hydroxyapatite
A.L. Giraldo-Betancur,D.G. Espinosa-Arbelaez,A. del Real-López,B.M. Millan-Malo,E.M. Rivera-Muñoz,E. Gutierrez-Cortez,P. Pineda-Gomez,S. Jimenez-Sandoval,M.E. Rodriguez-García 한국물리학회 2013 Current Applied Physics Vol.13 No.7
This article reports a physicochemical comparison of synthetic and biological Hydroxyapatite (HAp). Eight samples were separated into two groups: bio and commercial hydroxyapatite (bio-HAp and commercial-HAp). The bio-HAp group containing defat, alkaline, and calcined samples taken from bovine bone were obtained by using three different treatments, in order to establish their effect on the final product quality. The commercial-HAp group, from different sources: NIST, sigma, apafill G, coralina, and biograft, were analyzed and compared with the bio-HAp results. Thermogravimetric analysis (TG) was used in order to establish thermal degradation of the samples; structural behavior was then analyzed by X-Ray Diffraction (XRD) to found the crystalline phases, as well as the crystalline quality. Fourier Transform Infrared Spectroscopy (FTIR) was performed in order to identify the corresponding HAp functional groups within the samples. The surface morphology was analyzed by Scanning Electron Microscopy (SEM) and the elemental composition was established by using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). It was found that the calcination process obtains HAp with comparable quality to the commercial samples. A crystallinity greater than 62% after the alkaline process was found. Additionally, the surface of the alkaline sample presents a transition behavior between dense and porous morphology.