Prediction of Time Histories of Seismic Ground Motion Using Genetic Programming

I.Yoshihara,M. Numata,Tomoo Aoyama,Takanori Harada 제어로봇시스템학회 1999 제어로봇시스템학회 국내학술대회 논문집 Vol.5 No.10

A Magnetic Amplifier using Nanocrystalline Soft Magnetic Material

Y. Shindo,T. Yoshihara,M. Otsubo,M. Sawada 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5

A Magnetic Amplifier using saturable reactor with nanocrystalline soft magnetic material is presented. A method of obtaining the frequency response is presented. Experimental results show that the method is adequate and practical. Moreover it is shown that the efficiency of the Magnetic Amplifier is comparable to the switching power supply with primary control, despite the existence of additional saturable reactors.

The electronic behaviors of TiO2/MnO2/carbon clusters composite materials obtained by the calcination of a TiO(acac)2/Mn(acac)3/epoxy resin complex

H. Matsui,Y. Saito,S. Karuppuchamy,M. Yoshihara 한국물리학회 2009 Current Applied Physics Vol.9 No.6

The calcination of a TiO(acac)2/Mn(acac)3/epoxy resin complex under an oxygen atmosphere successfully produced nano-sized TiO2/MnO2/carbon clusters composite material. The surface characterizations of the resulting composites indicate that they are composed of nano-sized particles of TiO2, MnO2 and carbon clusters. ESR spectral examination suggests the possibility of an electron transfer in the process of MnO2→carbon clusters→TiO2. The visible light-responsive oxidation–reduction function of the composite materials has also been confirmed. The calcination of a TiO(acac)2/Mn(acac)3/epoxy resin complex under an oxygen atmosphere successfully produced nano-sized TiO2/MnO2/carbon clusters composite material. The surface characterizations of the resulting composites indicate that they are composed of nano-sized particles of TiO2, MnO2 and carbon clusters. ESR spectral examination suggests the possibility of an electron transfer in the process of MnO2→carbon clusters→TiO2. The visible light-responsive oxidation–reduction function of the composite materials has also been confirmed.

The electronic behaviors of visible light sensitive Nb2O5/Cr2O3/carbon clusters composite materials

H. Matsui,K. Kira,S. Karuppuchamy,M. Yoshihara 한국물리학회 2009 Current Applied Physics Vol.9 No.3

Nano-sized Nb2O5/Cr2O3/carbon clusters composite material has been successfully obtained by the calcination of a Nb(HC2O4)5/CrCl3/starch complex under an argon atmosphere. The compositions of the resulting composite materials were determined using ICP, elemental analysis and surface characterization by XRD and TEM. The UV–VIS and XPS spectra of the composites were also obtained. ESR spectral examinations suggest the possibility of an electron transfer in the process of Nb2O5→carbon clusters→Cr2O3. The reduction reaction of methylene blue with the resulting composite material has also been examined. Nano-sized Nb2O5/Cr2O3/carbon clusters composite material has been successfully obtained by the calcination of a Nb(HC2O4)5/CrCl3/starch complex under an argon atmosphere. The compositions of the resulting composite materials were determined using ICP, elemental analysis and surface characterization by XRD and TEM. The UV–VIS and XPS spectra of the composites were also obtained. ESR spectral examinations suggest the possibility of an electron transfer in the process of Nb2O5→carbon clusters→Cr2O3. The reduction reaction of methylene blue with the resulting composite material has also been examined.

Phase II study of niraparib in recurrent or persistent rare fraction of gynecologic malignancies with homologous recombination deficiency (JGOG2052)

Hiroshi Asano,Katsutoshi Oda,Kosuke Yoshihara,Yoichi M Ito,Noriomi Matsumura,Muneaki Shimada,Hidemichi Watari,Takayuki Enomoto 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.4

Background: Poly (adenosine diphosphate)-ribose polymerase (PARP) inhibitors for tumors with homologous recombination deficiency (HRD), including pathogenic mutationsin , have been developed. Genomic analysis revealed that about 20% of uterine leiomyosarcoma (uLMS) have HRD, including 7.5%–10% of alterations and 4%–6% of carcinomas of the uterine corpus, and 2.5%–4% of the uterine cervix have alterations of. Preclinical and clinical case reports suggest that PARP inhibitors may be effective against those targets. The Japanese Gynecologic Oncology Group (JGOG) is now planning to conduct a new investigator-initiated clinical trial, JGOG2052. Methods: JGOG2052 is a single-arm, open-label, multi-center, phase 2 clinical trial to evaluate the efficacy and safety of niraparib monotherapy for a recurrent or persistent rare fraction of gynecologic malignancies with mutations except for ovarian cancers. We will independently consider the effect of niraparib for uLMS or other gynecologic malignancies with mutations (cohort A, C) and HRD positive uLMS without mutations (cohort B). Participants must have 1–3 lines of previous chemotherapy and at least one measurable lesion according to RECIST (v.1.1). Niraparib will be orally administered once a day until lesion exacerbation or unacceptable adverse events occur. Efficacy will be evaluated by imaging through an additional computed tomography scan every 8 weeks. Safety will be measured weekly in cycle 1 and every 4 weeks after cycle 2 by blood tests and physical examinations. The sample size is 16–20 in each of cohort A and B, and 31 in cohort C. Primary endpoint is the objective response rate.

Microbial Transglutaminase Improves the Property of Meat Protein and Sausage Texture Manufactured with Low-quality Pork Loins

Katayama, K.,Chin, K.B.,Yoshihara, S.,Muguruma, M. Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.1

Microbial transglutaminase (MTGase) was investigated to determine whether it was an effective binding agent for the processing of low-quality pork loins. MTGase especially promoted the coagulation of myosin heavy chain (MHC). However, the effect of MTGase on MHC from low-quality meat was less than that from the normal meat when the reaction time was not enough. The breaking strength of the heat-induced gel made of myosin B from low-quality meat with MTGase was lower than that of normal meat. Sausage made with low-quality meat with MTGase did not exhibit improved hardness, as compared to that made with normal meat. Results of this study indicated that use of low-quality meat in the manufacture of sausage was feasible to get textural property equal to that of normal meat sausage, when a half or more of the raw material was normal meat and MTGase was used in the sausage.

Synthesis and characterization of TiO2/MoO3/carbon clusters composite material

H. Matsui,S. Nagano,S. Karuppuchamy,M. Yoshihara 한국물리학회 2009 Current Applied Physics Vol.9 No.3

Nano-sized TiO2/MoO3/carbon clusters composite material has been successfully obtained by the calcinations of a TiO(acac)2/MoO2(acac)2/epoxy resin complex under an oxygen atmosphere. The compositions of the resulting composite materials were determined using inductively coupled plasma (ICP) spectroscopy, elemental analysis and surface characterization by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The ultraviolet–visible (UV–Vis), X-ray photoelectron spectra (XPS) and electron spin resonance (ESR) spectra of the composites were also measured. ESR spectra of the composite materials suggest that they have visible light-responsive catalytic ability with an electron transfer process of carbon clusters → MoO3 → carbon clusters → TiO2. Nano-sized TiO2/MoO3/carbon clusters composite material has been successfully obtained by the calcinations of a TiO(acac)2/MoO2(acac)2/epoxy resin complex under an oxygen atmosphere. The compositions of the resulting composite materials were determined using inductively coupled plasma (ICP) spectroscopy, elemental analysis and surface characterization by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The ultraviolet–visible (UV–Vis), X-ray photoelectron spectra (XPS) and electron spin resonance (ESR) spectra of the composites were also measured. ESR spectra of the composite materials suggest that they have visible light-responsive catalytic ability with an electron transfer process of carbon clusters → MoO3 → carbon clusters → TiO2.

Electronic behavior of visible light sensitive ZrO2/Cr2O3/carbon clusters composite materials

H. Miyazaki,H. Matsui,Y. Kita,S. Karuppuchamy,S. Ito,M. Yoshihara 한국물리학회 2009 Current Applied Physics Vol.9 No.1

Nano-sized ZrO2/Cr2O3/carbon clusters composite materials were successfully obtained by the microwave-irradiated calcinations of a Zr(acac)4/Cr(acac)3/epoxy resin complex. The compositions of the resulting composite materials were determined using ICP, elemental analysis and surface characterization by XRD, SEM and TEM. The UV–Vis spectra of the composites were also obtained. ESR spectral examinations of the composites indicate that an electron transfer takes place in the process Cr2O3 → carbon clusters → ZrO2. The composite materials have been found to show visible light-responsive catalytic activities. Nano-sized ZrO2/Cr2O3/carbon clusters composite materials were successfully obtained by the microwave-irradiated calcinations of a Zr(acac)4/Cr(acac)3/epoxy resin complex. The compositions of the resulting composite materials were determined using ICP, elemental analysis and surface characterization by XRD, SEM and TEM. The UV–Vis spectra of the composites were also obtained. ESR spectral examinations of the composites indicate that an electron transfer takes place in the process Cr2O3 → carbon clusters → ZrO2. The composite materials have been found to show visible light-responsive catalytic activities.

Electronic behavior of carbon clusters/hafnium oxide composite material

H. Matsui,T. Kuroda,T. Kawahara,S. Karuppuchamy,R. Kudoh,M. Yoshihara 한국물리학회 2009 Current Applied Physics Vol.9 No.1

An alternating hafnium-O-phenylene hybrid copolymer was calcined under the reduced pressure at 400–700 ℃ to obtain black-colored materials. XRD and TEM analyses showed that the calcined materials were composed of carbon clusters with the diameters of 20 nm and hafnium oxide particles with the diameters of a few nm. ESR spectral examinations revealed that the calcined materials formed a stable cation radical on the carbon clusters and exhibited an oxidation–reduction function. When Au particles were supported on the material, an efficient oxidation–reduction function was found to appear. An alternating hafnium-O-phenylene hybrid copolymer was calcined under the reduced pressure at 400–700 ℃ to obtain black-colored materials. XRD and TEM analyses showed that the calcined materials were composed of carbon clusters with the diameters of 20 nm and hafnium oxide particles with the diameters of a few nm. ESR spectral examinations revealed that the calcined materials formed a stable cation radical on the carbon clusters and exhibited an oxidation–reduction function. When Au particles were supported on the material, an efficient oxidation–reduction function was found to appear.