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Belen Lopez-Millan,Rafael Diaz de la Guardia,Heleia Roca-Ho,Carmen M García-Herrero,Jessie R Lavoie,Michael Rosu-Myles,Elena Gonzalez-Rey,Francisco O’Valle,Gabriel Criado,Mario Delgado,Pablo Menendez 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Thalidomide is an immunomodulatory drug (IMiD) with proven therapeutic action in several autoimmune/inflammatory diseases; however, its inherent high toxicity has led to the development of more powerful and safer thalidomide analogs, including lenalidomide and pomalidomide. These are new generation IMiDs that exhibit direct antitumor activity as well as anti-inflammatory/immunomodulatory properties, and are FDA-approved for the treatment of several hematological malignances. Here we investigated the potential therapeutic effects of lenalidomide and pomalidomide in several experimental murine models of autoimmune/inflammatory diseases: 2,4,6-trinitrobenzene sulfonic acid- and dextran sulfate sodium-induced inflammatory bowel disease and type II collagen-induced arthritis. Lenalidomide displayed a strong therapeutic effect in all these models of autoimmune/inflammatory diseases, while the effect of pomalidomide was less pronounced. In vitro experiments confirmed the immunosuppressive effect of both IMiDs on the proliferative response of stimulated human lymphocytes and on the balance of secreted cytokines toward an anti-inflammatory profile. We conclude that lenalidomide may offer a therapeutic opportunity against autoimmune/inflammatory diseases.
Effect of Storage at 10OC on Aroma of Tomato (Lycopersicon esculentum) Saladet Grown in Mexico
Fernando Diaz de Leon-Sanchez,Lucia Lopez,Fernando Rivera-Cabrera,Clara Pelayo-Zaldivar,Hector B. Escalona,Beatriz Buentello,Francisco J. Fernandez,Adolfo Garcia,Laura J. Perez-Flores 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-
F.J. Alguacil,F.A. Lopez,I. Garcia-Diaz 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.1
Results on Cu(II) extraction from acidic media through pseudo-emulsion based membrane strip dispersion (PEMSD) containing Acorga M5640/Iberfluid as organic phase in the form of a pseudoemulsion with H2SO4 were presented. The transport of Cu(II) is investigated as a function of several experimental variables: hydrodynamic conditions, feed solution pH, Acorga M5640 (salicylaldoxime derivative) concentration in the organic solution, and initial metal concentration in feed phase. In this membrane technology, pseudo-emulsion is an emulsion that is formed temporarily between organic and stripping solutions, both solutions are completely separated when mixing is stopped. The value of the overall mass transfer coefficient obtained under standard experimental conditions was 5.5 103 cm/s,being the recovery of copper in the stripping solution around 80–85%. The influence of the membrane support, the selectivity of Acorga M5640/Inerfluid based PEMSD towards different metals (Fe(III), Ni(II),Co(II), Zn(II), Cr(III)) an the performance of the system Cu/Acorga M5640/Ibefluid against other commercially available salicylaldoximes (LIX 860, Acorga PT5050) were also examined.
Ernesto Barzola Navarro,Emilio Vicente Lopez,Yolanda Quijano,Riccardo Caruso,Valentina Ferri,Hipolito Durand,Isabel Fabra Cabrera,Eduardo Diaz Reques,Benedetto Ielpo,Anastasiia Yuriyivna Glagoliev,Car 한국간담췌외과학회 2019 Annals of hepato-biliary-pancreatic surgery Vol.23 No.2
BRCA gene mutations are found in up to 10% of pancreatic adenocarcinoma cases. We present a description of 4 cases along with a review of the current literature regarding pathogenesis, target treatment, response and survival rates in these types of malignancies. We describe four cases of pancreatic adenocarcinoma, in three of which the BRCA2 mutation was identified, in one - BRCA1 gene alteration. Two patients underwent surgery following the neoadjuvant treatment with Folfirinox and radiotherapy; in the first case, a distal pancreatectomy with splenectomy was performed and in the second one - the Whipple’s procedure. In both cases, a complete pathological response was reported. Other 2 patients were treated with Folfirinox after BRCA mutation identification and acceptable life expectancy was obtained. The association of pathologic complete response (PCR) with lower rates of local recurrence and better survival in patients with various types of adenocarcinomas is well known. Identification of such patients carrying BRCA mutations could provide an application of better personalized treatment. In some patients with pancreatic cancer, especially when there is clinical or demographic reason to suspect a genetic predisposition, a confirmation of the presence of BRCA mutations could provide an opportunity to use target treatment with beneficial outcomes regarding survival.
F.J. Alguacil,I. Garcia-Diaz,F.A. Lopez 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.4
The permeation of chromium (III) using PEHFSD technology and the ionic liquid (RNH3+HSO4), formed by reaction of the primary amine PRIMENE JMT and sulphuric acid, dissolved in n-decane as mobile carrier has been investigated. The alkaline feed solution containing Cr(III) was passed through the tube side, and pseudo-emulsions of the ionic liquid + n-decane + n-decanol and sulphuric acid were passed through the shell side in counter-current mode and using a single hollow fiber module for extraction and stripping. In this advanced membrane technology, the aqueous acidic strip solution is dispersed in the organic membrane solution in a tank with an impeller stirrer to form a strip dispersion. The pseudoemulsion phase is circulated from the tank to the membrane module to provide a constant supply of the organic solution to the membrane micropores. Factors affecting chromium permeability, such as hydrodynamic conditions, carrier concentration in the organic phase, metal and NaOH concentrations in the feed phase, have been analyzed. A model is reported describing the transport mechanism, whereas the experimental data are quantitatively explained by mathematical equations describing the rate of transport. Different rate-controlling processes take place as long as the metal transport occurs.
Donor Islet Endothelial Cells in Pancreatic Islet Revascularization
Nyqvist, Daniel,Speier, Stephan,Rodriguez-Diaz, Rayner,Molano, R. Damaris,Lipovsek, Saš,a,Rupnik, Marjan,Dicker, Andrea,Ilegems, Erwin,Zahr-Akrawi, Elsie,Molina, Judith,Lopez-Cabeza, Maite,Villat American Diabetes Association 2011 Diabetes Vol.60 No.10
<P><B>OBJECTIVE</B></P><P>Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet endothelial cells (ECs), which can contribute to the formation of functional blood vessels after transplantation. We have characterized how donor islet endothelial cells (DIECs) may contribute to the revascularization rate, vascular density, and endocrine graft function after transplantation of freshly isolated and cultured islets.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>Freshly isolated and cultured islets were transplanted under the kidney capsule and into the anterior chamber of the eye. Intravital laser scanning microscopy was used to monitor the revascularization process and DIECs in intact grafts. The grafts’ metabolic function was examined by reversal of diabetes, and the ultrastructural morphology by transmission electron microscopy.</P><P><B>RESULTS</B></P><P>DIECs significantly contributed to the vasculature of fresh islet grafts, assessed up to 5 months after transplantation, but were hardly detected in cultured islet grafts. Early participation of DIECs in the revascularization process correlated with a higher revascularization rate of freshly isolated islets compared with cultured islets. However, after complete revascularization, the vascular density was similar in the two groups, and host ECs gained morphological features resembling the endogenous islet vasculature. Surprisingly, grafts originating from cultured islets reversed diabetes more rapidly than those originating from fresh islets.</P><P><B>CONCLUSIONS</B></P><P>In summary, DIECs contributed to the revascularization of fresh, but not cultured, islets by participating in early processes of vessel formation and persisting in the vasculature over long periods of time. However, the DIECs did not increase the vascular density or improve the endocrine function of the grafts.</P>
Chaotic Synchronization of Regular and Irregular Complex Networks with Fractional Order Oscillators
Cornelio Posadas-Castillo,Sara Angulo-Guzman,Miguel Angel Platas-Garza,David Alejandro Diaz-Romero,Didier Lopez-Mancilla 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.4
Synchronization of N-coupled fractional-order (FO) chaotic oscillators arranged in regular and irregulartopologies is numerically studied. Synchronization is achieved based on the coupling matrix from the complexsystems theory. In particular, we consider complex dynamical networks composed by Lorenz, Volta, Duffing andFinancial FO chaotic oscillators, where the interaction of the nodes is defined by coupling only one state of eachFO oscillator.