Growth Inhibition of Colon Cancer through Inactivation of STAT3 Pathway by IL-10 and IL-1ra Released from Murine Macrophage

Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4

The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway

Improvement and Application for Environmental Conservation Value Assessment Map(ECVAM) of Nationwide Land in Korea

Lee, Moung-Jin,Jeon, Seong-Woo,Jo, Min-Jeong,Song, Won-Kyong,Kang, Byung-Jin The Korean Society of Remote Sensing 2007 大韓遠隔探査學會誌 Vol.23 No.5

This study is aiming at improving the Environmental Conservation Value Assessment Map(ECVAM) of National Land in Korea. The ECVAM items are composed of legal and environmental/ecological assessments. A popular method applied to ECVAM is an overlay environmental/ecological assessment items. The purpose of this study is to offer complementary items of the ECVAM by examining assessment items. In this study we assessed the ECVAM by five methods. Method 1 is Grade 1 areas of each administrative district; Method 2 is comparing overlapped areas of each assessment items Grade 1, 2 and permission of each assessment items duplication; Method 3 is Grade 1, 2 areas by only singular assessment items; Method 4 is Grade 1 areas only of Method 2; and Method 5 is Grade 2 areas only of Method 2. Method 1 showed Seoul and other metropolitan cities revealed a large proportion of Grade I regions by the legal assessment items. Gang won-Do, showed a large proportion of Grade I regions by the environmental/ecological assessment item. Method 2 showed 93.4% of diameter Grade II(standard for stability); forest diameter item accounted for 99.9% by Method 3, Method 4 showed 95.7% of forest diameter, and forest density accounted for 66.4% by Method 5. This study contributes to reduce the complexity in the process of manufacturing ECVAM of National Land, and to raise the flexibility in the process of managing and updating this map.

국내 정형외과 의료소송 현황 파악

이원(Won Lee),이미진(Mi Jin Lee),김용민(Yong Min Kim),우찬명(Chan Myung Woo),김소윤(So Yoon Kim),김양수(Yang-Soo Kim) 대한정형외과학회 2016 대한정형외과학회지 Vol.51 No.3

목적: 국내 정형외과 관련 의료소송 판결문의 분석을 통하여 정형외과 의료소송의 현황과 원인이 된 과정을 파악하고자 함이다. 대상 및 방법: 소송시작이 2005년부터 2010년인 정형외과 의료소송 판결문 341건을 대상으로 하여 빈도분석을 실시하였다. 결과: 사건 발생 시점에서 소송 종결 시점까지의 평균 소요기간은 4.22년이었다. 의료소송의 원인이 된 과정은 수술이 46.3%였고, 수술의 종류는 척추 수술이 가장 많았다. 사고의 결과는 장애가 가장 많았고, 최종심 결과는 원고일부승이 40.5%, 원고패(기각)가 34.3%였다. 감염은 전체 중 26.1%에서 발생하였고, 손해배상 청구금액은 평균 181,998,036원이었으며 인용금액은 평균 58,897,161원이었다. 결론: 정형외과 의료소송으로 이어진 의료사고의 주요 원인 과정은 수술이 가장 많았고, 그 중에서도 척추 수술이 가장 많았다. 추후 의료사고의 근본 원인분석을 통해 의료사고를 줄이고 재발을 방지하기 위한 후속 연구가 이루어져야 할 것이다. Purpose: Through the analysis of orthopedics lawsuit rulings, the purpose of this study is to understand the current trends of medical lawsuits in orthopedics in Korea. Materials and Methods: An analysis of medical lawsuits in orthopedics was conducted. As the study method, a quantitative analysis was performed on 341 cases. Results: The average period of lawsuits, from the occurrence of the medical accident to end of the ruling, took an average of 4.22 years. The most frequent procedure that was the main cause of the medical accidents was surgery, at 46.3%. When surgery is the main procedure that caused the medical accidents, the result of examining the types of surgeries showed that spine surgery had the highest percentage. For the outcome of the accident, the highest number of cases resulted in disability and for the final court outcome, 40.5% ruled partially in favor of the plaintiff (the patient) with acknowledgement of only the damage incurred due to medical error of the total sum claimed, and dismissal of the claim made by the plaintiff (patient) accounted for 34.3%; 26.1% of cases develop infection. For the amount of claim for damage, the average amount of claim was 181,998,036 won; in the judgement amount, the average amount of judgement was 58,897,161 won. Conclusion: The most frequent procedure in orthopedics was surgery and spine surgery comprised a large proportion of these surgeries. Future studies to determine root causes of medical accidents should be conducted to reduce medical lawsuits and to plan against the repeating of medical accidents.

성과측정시스템의 상호작용적 이용, 심리적 임파워먼트, 창의성 및 경영성과간의 관계

이성진(Lee, Sung-Jin),박경원(Park, Kyong-Won) 한국경영교육학회 2020 경영교육연구 Vol.35 No.4

[연구목적] 창의성은 조직의 역량을 혁신하는데 있어 필수적인 요소이며, 조직에서 관리통제시스템은 창의성을 향상시키거나 제약하는데 이용될 수 있다. 본 연구의 목적은 성과측정시스템(PMS)의 상호작용적 이용이 창의성 창출에 어떻게 연관되어 있는지를 검증하고자 한다. 또한 심리적 임파워먼트와 창의성간의 연관성을 확인하고, 경영성과의 개선에 미치는 영향도 확인하고자 한다. [연구방법] 본 연구는 KOSPI에 상장되어 있는 제조기업의 중간관리자로부터 수집한 설문자료를 이용하여 PMS 상호작용적 이용에 대한 인식을 확인하고 그에 따른 심리적 임파워먼트와 창의성에 미치는 영향을 지지하는 실증적인 증거를 제공한다. 연구가설은 PLS 구조방정식 모형을 이용하여 검증하였다. [연구결과] 분석결과, PMS의 상호작용적 이용은 심리적 임파워먼트뿐만 아니라 창의성의 창출에도 영향을 미치는 것으로 나타나서, MCS의 상호작용적 이용은 창의성을 관리하는데 도움을 준다는 이론을 지지하는 것으로 나타났다. 또한 심리적 임파워먼트와 창의성은 연관성이 높은 것으로 나타났다. 심리적 임파워먼트와 창의성은 경영성과를 개선하는 것으로 나타났다. [연구의 시사점] 본 연구는 심리적 임파워먼트가 창의성과 어떻게 연관되어 있는지에 대한 이해를 제공하고, PMS의 상호작용적 이용이 창의성 창출로 이어질 수 있는 방법에 대한 증거를 제시함으로써 관리회계연구에 기여한다. [Purpose] Creativity as a success factor is greatly importance to secure competitive advantage and improve business performance. Depending on how senior manager uses PMS, there will be a distinction in the feeling of psychological empowerment by the organization members, which will affect the creation of creativity, and result in a difference in business performance. [Methodology] Questionnaires were distributed to the manufacturing firms listed on KOSPI, of which 85 of the survey data available were utilized for the analysis. This study use PLS(partial least squares) structural equation modeling to analyze empirically hypotheses. [Findings] The interactive use of PMS has been shown to have a positive effect on psychological empowerment and creativity. It was also shown that psychological empowerment had a significant influence on creativity, and that two concepts had a significant influence on business performance. [Implications] This study has empirically verified that psychological empowerment and creativity have a positive effect on business performance. The interactive use of PMS by senior manager enhances the psychological empowerment of the members and may improve business performance by forming conditions in which creativity can be created.

Improvement and Application for Environmental Conservation Value Assessment Map (ECVAM) of Nationwide Land in Korea

Moung Jin Lee,Seong Woo Jeon,Min Jeong Jo,Won Kyong Song,Byung Jin Kang 大韓遠隔探査學會 2007 大韓遠隔探査學會誌 Vol.23 No.5

This study is aiming at improving the Environmental Conservation Value Assessment Map (ECVAM) of National Land in Korea. The ECVAM items are composed of legal and environmental/ecological assessments. A popular method applied to ECVAM is an overlay environmental/ecological assessment items. The purpose of this study is to offer complementary items of the ECVAM by examining assessment items. In this study we assessed the ECVAM by five methods. Method 1 is Grade 1 areas of each administrative district; Method 2 is comparing overlapped areas of each assessment items Grade 1, 2 and permission of each assessment items duplication; Method 3 is Grade 1, 2 areas by only singular assessment items; Method 4 is Grade 1 areas only of Method 2; and Method 5 is Grade 2 areas only of Method 2. Method 1 showed Seoul and other metropolitan cities revealed a large proportion of Grade I regions by the legal assessment items. Gang won-Do, showed a large proportion of Grade I regions by the environmental/ecological assessment item. Method 2 showed 93.4 % of diameter Grade II (standard for stability); forest diameter item accounted for 99.9 % by Method 3, Method 4 showed 95.7 % of forest diameter, and forest density accounted for 66.4 % by Method 5. This study contributes to reduce the complexity in the process of manufacturing ECVAM of National Land, and to raise the flexibility in the process of managing and updating this map.

Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

국내·외 누설률에 관한 기준 분석을 통한 국내 연기제어 기준 개선에 관한 연구

김혜원 ( Kim Hye-won ),한지우 ( Han Ji-woo ),이병흔 ( Lee Byeong-heun ),진승현 ( Jin Seung-hyeon ),권영진 ( Kwon Young-jin ) 한국건축시공학회 2018 한국건축시공학회 학술발표대회 논문집 Vol.18 No.2

On this Study, it conducts the Standards investigation about air leakage of Buildings for performance improvement of Smoke control in Fire. In domestic standards, it is incomplete the Criteria standards of air leakage. Therefore it is considered that won’t limit the smoke spread due to stack effect. But in the case of the United States, it conducts the Hot smoke air-Leakage test and it consider that can prevent the Smoke Spread in Compartment.

2010 파주, 안산지역 갈대, 억새 등 야초류의 이용실태와 사료가치 평가

서성(Sung Seo),김원호(Won Ho Kim),정민웅(Min Woong Jung),박형수(Hyung Soo Park),심재진(Jae Jin Shim),박진길(Jin Gil Park),성하균(Ha Guyn Sung),김종덕(Jong Duk Kim),이종경(Joung Kyong Lee) 한국초지조사료학회 2011 한국초지조사료학회지 Vol.31 No.2

본 연구는 부존 조사료자원의 이용을 활성화하여 수입사료를 줄이고 가축 사료비를 절감하고자 2010년도에 경기 파주 (민통선 지역)와 경기 안산 (시화지구)에서 갈대와 억새 등 야초자생지를 탐색하고, 수확?이용실태 조사와 함께 사료가치를 분석하였다. 파주 민통선 내억새 (Miscanthus sinensis)와 갈대 (Phragmites communis) 혼합 자생지는 90~100 ㏊ 규모로, 1차 곤포작업으로 사일리지 520톤 (㏊당 6톤), 2차로 380톤 (㏊당 4톤)을 조제하여, 연 사일리지 900톤 (㏊당 10톤)을 생산하였다. 곤포의 유통가격은 롤당 52~55천 원으로 ㎏당 130~137.5원이었다. 곤포는 자가소비 50~70%, 판매유통 30~50%로, 수익성은 인건비 정도로 추정되었다. 초장 70 ㎝의 재생 억새는 조단백질 9.6%, 상대사료가치 82.4 (건초 4등급), 건물 소화율 67.7%, 초장 70 ㎝의 재생 갈대는 각각 13.8%, 84.3 (4등급), 67.9%로 사료가치는 높았으며, 수확이 늦어짐에 따라 사료가치는 크게 낮아졌다. 안산 시화지구 (3공구)의 갈대 등 야초류자생지는 100 ㏊ 정도로 2009년도에는 50 ㏊에서 사일리지 550톤 (㏊당 11톤)을 생산하여 롤당 50천 원에 유통하였으며, 2010년도는 잦은 강우와 장마로 부분 이용에 그쳤다. 고초기의 갈대는 건물률 89.8%, 조단백질 2.2%, NDF 80.6%, ADF 55.4%, 상대사료가치 52.9 (5등급), 건물 소화율 36.4%로 볏짚에 비해서도 사료가치는 크게 낮았다. 초장 80 ㎝의 재생 갈대는 조단백질 12.9%, 상대사료가치 99.8 (3등급), 건물 소화율 66.6%로 사료가치는 양호하였으며, 개화기의 초장 150 ㎝ 갈대는 조단백질 4.5%, 상대사료가치 59.9 (5등급), 건물 소화율 42.2%로 볏짚의 사료가치와 비슷하였다. 이상의 결과를 종합하여볼 때, 갈대, 억새 등 야초류는 현 상태에서 최대한 수거?이용하되, 사료가치를 유지하고 가축 기호성을 고려한 시기에 수확하는 것이 중요하며, 최소한 볏짚과 비슷하거나 그 이상의 사료가치를 기대하기 위해서는 7월 중순 이전 (늦어도 7월까지)에 수확?이용하는 것이 권장된다. 본 연구에서 조사된 대부분의 야초류는 상대사료가치가 75 이하인 건초 5등급으로 사료가치는 매우 낮았으며, 키가 작은 영양생장기에 수확한 경우에만 4등급으로 나타났다. 부존 조사료자원의 이용은 양질의 사료작물 생산과 병행하여 추진하는 것이 바람직하였다. This study was carried out in 2010 to investigate the utilization and nutritive value of native grasses, such as Phragmites communis and Miscanthus sinensis which might reduce the cost of feeding domestic cattle. The regions within the Civilian Control Line in Paju and Sihwa region in Ansan were surveyed. In Paju, the yearly silage production was 900 MT harvested from 90 ha (10 MT/㏊). About 30~50% of these were sold out at the marketing price of 52,000~55,000 Won per roll (130~137.5 Won/㎏). Regrown Miscanthus sinensis of 70 ㎝ in length contained 9.6% of crude protein (CP), 82.4 of relative feed value (RFV), and 67.7% of in vitro dry matter digestibility (IVDMD). Regrown Phragmites communis of 70 ㎝ in length contained 13.8% of CP, 84.3 of RFV, and 67.9% of IVDMD. As harvesting was delayed, the quality was decreased dramatically. In Ansan region, Phragmites communis plantation covers 100 ha. The silage production was 550 MT from the area of 50 ha (11 MT/㏊) in 2009. And the marketing price was 50,000 Won per roll. But in 2010 only a small amount of grasses could have been baled due to frequent and much rainfall from spring to summer season. However, the good forage quality was observed from regrown Phragmites communis of 80 ㎝ in length, 12.9% CP, 99.8 RFV and 66.6% IVDMD, while that of late matured grasses was very low, 2.2% CP, 52.9 RFV and 36.4% IVDMD, greatly lower than forage quality of rice straw. The quality of grasses at bloom stage of 150 ㎝ in length was similar to that of rice straw, showing 4.5% CP, 59.9 RFV and 42.2% IVDMD. In conclusion, the overall quality of most native grasses in this survey were very poor. Therefore, we recommend that Phragmites communis and Miscanthus sinensis should be harvested during June or July to obtain better forage quality which is richer in forage values than rice straw. Production of high quality forage crops was also desirable for self sufficiency of forage.

사상체질에 따른 신체화 기제의 차이에 대한 연구

이고은 ( Go Eun Lee ),박장호 ( Jang Ho Park ),유윤선 ( Yun Sun Lyu ),노동진 ( Dong Jin No ),박인숙 ( In Sook Park ),강형원 ( Hyung Won Kang ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.3

Objectives: The purpose of this study was to investigate the difference of somatization psychological mechanism among Sasang constitution. Methods: Subjects were seventy four students of Won-Kwang university responded the questionnaire. We evaulated teh subjects using Minnesota Questionnaire for the Sasang Constitution Classification Ⅱ(QSCC Ⅱ), Multiphasic Personality Inventory-2(MMPI-2), 20-item Toronto Alexithymia Scale (TAS-20), Somato-Sensory Amplification Scale(SSAS), Symptom Interpretation Questionnaire(SIQ) and The Ways of Stress Coping Questionnaire(SCQ). Results: From the results of Clinical scale of MMPI-2, the scores of 2nd, 9th, 10th scales was significantly difference. In Lesser Yin group 10th score was the significantly highest of the others, 1st, 3rd, 6th, 7th, 8th score were the highest but not significant. and From the results of PSY-5 scale(The Personality Psychopathology Five scale) of MMPI-2, In Lesser Yin goup, INTR(Introversion/Low Positive Emotion) score was significantly highest, PSYC(psychoticism), NEGE (Negative Emotionality/Neuroticism) was higher than the others. In TAS-20K, SSAS, SIQ and SCQ Lesser Yin group was not significantly difference. but Lesser Yin group had the tendency of difficulty describing feelings and externally oriented thinking and higher score in physical and psychological interpretation. We observed generally lower levels of stress coping strategy scores than the others. Conclusions: These results showed that Lesser Yin group tend to somatization compared other constitution.

인공지능 모델에 따른 한국 프로야구의 승패 예측 분석에 관한 연구

김태훈 ( Tae-hun Kim ),임성원 ( Seong-won Lim ),고진광 ( Jin-gwang Koh ),이재학 ( Jae-hak Lee ) (사)한국빅데이터학회 2020 한국빅데이터학회 학회지 Vol.5 No.2

본 연구에서는 인공지능 모델에 따른 한국 프로야구의 승패 예측 분석에 관한 연구를 했다. 승리할 팀과 해당 팀의 최종 리그 순위를 예측했고, 사용자의 편의를 위해 웹사이트도 구축했다. 각 1·3·5이닝 별로 가장 정확도가 높으면서도 오차가 적은 모델을 최적 모델로 선정해 승·패 결과를 예측했고, 이를 토대로 순위표를 작성했다. 결과표는 2020년 개막인 5월 5일부터 8월 30일까지의 예측 결과를 바탕으로 작성했다. 기아타이거즈가 아닌 다른 구단끼리의 경기는 실제 결과를 사용했다. 머신러닝 모델은 KNN과 AdaBoost가 최적 모델로 선정되었으며, 실제 순위와 비교해 본 결과, 경기가 진행될수록, 예측 결과의 순위 오차가 점점 작아지는 것을 확인했다. 딥러닝 모델은 89%의 정확도를 기록했고, 머신러닝 모델과 마찬가지로 경기를 진행할수록 예측 결과 순위 오차가 작아지는 것을 확인했다. 실험 결과는 한국 프로야구 승·패 결과 예측뿐 아니라 다양한 분야에서 사용할 수 있을 것으로 사료된다. 방송국에서 야구 경기를 중계하는 중 이닝별로 인공지능 알고리즘이 예상한 승·패 여부를 중계화면에 띄울 수 있다. 시청자들에게 새로운 흥미를 일으킬 수 있을 것이고, 나아가 구단의 감독들이 이닝마다 데이터를 분석해 경기 중 유동적으로 승리하기 위한 전략을 세울 수 있을 것으로 기대된다. In this study, we conducted a study on the win-loss predicton analysis of korean professional baseball by artificial intelligence models. Based on the model, we predicted the winner as well as each team’s final rank in the league. Additionally, we developed a website for viewers’ understanding. In each game’s first, third, and fifth inning, we analyze to select the best model that performs the highest accuracy and minimizes errors. Based on the result, we generate the rankings. We used the predicted data started from May 5, the season’s opening day, to August 30, 2020 to generate the rankings. In the games which Kia Tigers did not play, however, we used actual games’ results in the data. KNN and AdaBoost selected the most optimized machine learning model. As a result, we observe a decreasing trend of the predicted results’ ranking error as the season progresses. The deep learning model recorded 89% of the model accuracy. It provides the same result of decreasing ranking error trends of the predicted results that we observe in the machine learning model. We estimate that this study’s result applies to future KBO predictions as well as other fields. We expect broadcasting enhancements by posting the predicted winning percentage per inning which is generated by AI algorism. We expect this will bring new interest to the KBO fans. Furthermore, the prediction generated at each inning would provide insights to teams so that they can analyze data and come up with successful strategies.