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Chitosan Oligomer as a Hopeful Adjuvant for H5n1 Influenza Vaccine
( Le Van Hiep ),( Mai Thi Thanh ),( Dang Thi Hong Van ),( Vo Thi Phuong Khanh ),( Nguyen Anh Dzung ) 한국키틴키토산학회 2008 한국키틴키토산학회지 Vol.13 No.1
Effect of Chitosan oligomer (dp = 8-16) and other adjuvant such as: Aluminum phosphate (AlPO4) and Freund on immune response of H5N1 influenza vaccine in Swiss mice has been investigated. The Swiss mice were twice vaccinated alternative 20 days with dose 0.1 ml/mouse. After 10, 20 and 30 days, the immune response of Swiss mice with H5N1 vaccine was detected. The result showed that after 20 days of the first vaccination, immune response of chitosan oligomer test and Freund was 100%, but Freund test reduced 80% after 30days of vaccination. Meanwhile, immune response of the control and AlPO4 test was very low, only 40%. The Effect of chitosan oligomer and the others on antibody titer has been also investigated. The result showed that the antibody titer of chitosan oligomer test was 60 HIU (Hemagglutination units), 70 HIUs after 10 and 20 days of the first vaccination, and increased up to 112 HIUs after 10 days of the second vaccination and the antibody titer of the chitosan oligomer test was higher than the others. Therefore, chitosan oligomer is a hopeful adjuvant for H5N1 influenza vaccine.
Van Nguyen Tuan,Do Ha Huu,Tekalgne Mahider,Van Le Quyet,Nguyen Thang Phan,Hong Sung Hyun,Cho Jin Hyuk,Van Dao Dung,Ahn Sang Hyun,Kim Soo Young 나노기술연구협의회 2021 Nano Convergence Vol.8 No.33
Following publication of the original article [1], the affiliation of the authors was incorrectly published in the article. The affiliation which was shown in supplementary information is correct. This has been corrected with this erratum.
Processed Vietnamese ginseng: Preliminary results in chemistry and biological activity
Le, Thi Hong Van,Lee, Seo Young,Kim, Tae Ryong,Kim, Jae Young,Kwon, Sung Won,Nguyen, Ngoc Khoi,Park, Jeong Hill,Nguyen, Minh Duc The Korean Society of Ginseng 2014 Journal of Ginseng Research Vol.38 No.2
Background: This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. Methods: Samples of powdered Vietnamese ginseng were steamed at $120^{\circ}C$ for various times and thei extracts were subjected to chemical and biological studies. Results: Upon steaming, contents of polar ginsenosides, such as Rb1, Rc, Rd, Re, and Rg1, were rapidly decreased, whereas less polar ginsenosides such as Rg3, Rg5, Rk1, Rk3, and Rh4 were increased as reported previously. However, ocotillol type saponins, which have no glycosyl moiety at the C-20 position, were relatively stable on steaming. The radical scavenging activity was increased continuously up to 20 h of steaming. Similarly, the antiproliferative activity against A549 lung cancer cells was also increased. Conclusion: It seems that the antiproliferative activity is closely related to the contents of ginsenoside Rg3, Rg5, and Rk1.
Effects of steaming on saponin compositions and antiproliferative activity of Vietnamese ginseng
Le, Thi Hong Van,Lee, Seo Young,Lee, Gwang Jin,Nguyen, Ngoc Khoi,Park, Jeong Hill,Nguyen, Minh Duc The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.3
Background: Steaming of ginseng is known to change its chemical composition and biological activity. This study was carried out to investigate the effect of different steaming time-scales on chemical constituents and antiproliferative activity of Vietnamese ginseng (VG). Methods: VG was steamed at $105^{\circ}C$ for 2-20 h. Its saponin constituents and antiproliferative activity were studied. The similarity of chemical compositions between steamed samples at $105^{\circ}C$ and $120^{\circ}C$ were compared. Results: Most protopanaxadiol and protopanaxatriol ginsenosides lost the sugar moiety at the C-20 position with 10-14 h steaming at $105^{\circ}C$ and changed to their less polar analogues. However, ocotillol (OCT) ginsenosides were reasonably stable to steaming process. Antiproliferative activity against A549 lung cancer cells was increased on steaming and reached its plateau after 12 h steaming. Conclusion: Steaming VG at $105^{\circ}C$ showed a similar tendency of chemical degradation to the steaming VG at $120^{\circ}C$ except the slower rate of reaction. Its rate was about one-third of the steaming at $120^{\circ}C$.
Switching and Electrical Memory Effect in the Colossal Permittivity Material La2NiO4+δ
Le Van Hong,Tran Dang Thanh,Dao Nguyen Hoai Nam,,Nguyen Xuan Phuc 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5
La2NiO4+δ ceramic samples were manufactured by using a solid state reaction method. The crystalline structural, magnetic and dielectric properties of the material were recorded and analyzed. A dielectric resonance, which is thought to be associated with the multiferroic behavior of the material, was observed at frequencies below 1 MHz. The I/V characteristics were easured on a capacitor-like structure, which exhibited resistance and capacitance switching when opposite voltage pulses of about 2.5 volts with a duration time of 500 ms were applied. The maximum ratios of the changes in the resistance and the capacitance were estimated to be of about 50 % and 35 % at room temperature, respectively. The electrical switching was reversible, with resistive states remaining for a rather long time. The observed capacitance switching and memory effects provide evidence for the presence of charge transfer and accumulation in the material.
WS2–WC–WO3 nano-hollow spheres as an efficient and durable catalyst for hydrogen evolution reaction
Van Nguyen Tuan,Do Ha Huu,Tekalgne Mahider,Van Le Quyet,Nguyen Thang Phan,Hong Sung Hyun,Cho Jin Hyuk,Van Dao Dung,Ahn Sang Hyun,Kim Soo Young 나노기술연구협의회 2021 Nano Convergence Vol.8 No.28
Transition metal dichalcogenides (TMDs), transition metal carbides (TMCs), and transition metal oxides (TMOs) have been widely investigated for electrocatalytic applications owing to their abundant active sites, high stability, good conductivity, and various other fascinating properties. Therefore, the synthesis of composites of TMDs, TMCs, and TMOs is a new avenue for the preparation of efficient electrocatalysts. Herein, we propose a novel low-cost and facile method to prepare TMD–TMC–TMO nano-hollow spheres (WS 2 –WC–WO 3 NH) as an efficient catalyst for the hydrogen evolution reaction (HER). The crystallinity, morphology, chemical bonding, and composition of the composite material were comprehensively investigated using X-ray diffraction, Raman spectroscopy, field emission scanning electron microscopy, and X-ray photoelectron spectroscopy. The results confirmed the successful synthesis of the WS 2 –WC–WO 3 NH spheres. Interestingly, the presence of nitrogen significantly enhanced the electrical conductivity of the hybrid material, facilitating electron transfer during the catalytic process. As a result, the WS 2 –WC–WO 3 NH hybrid exhibited better HER performance than the pure WS 2 nanoflowers, which can be attributed to the synergistic effect of the W–S, W–C, and W–O bonding in the composite. Remarkably, the Tafel slope of the WS 2 –WC–WO 3 NH spheres was 59 mV dec −1 , which is significantly lower than that of the pure WS 2 NFs (82 mV dec −1 ). The results also confirmed the unprecedented stability and superior electrocatalytic performance of the WS 2 –WC–WO 3 NH spheres toward the HER, which opens new avenues for the preparation of low-cost and highly effective materials for energy conversion and storage applications.
Interacting Superparamagnetism in La0.7Sr0.3MnO3 Nanoparticles
Le Van Hong,D. H. Manh,Ha M. Nguyen,N. X. Phuc,Y. D. Yao 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5
ThemagneticorderofLa0:7Sr0:3MnO3nanoparticles(NPs)fabricatedinaSPEXD800milwas systematicalystudied. TheLa0:7Sr0:3MnO3 nanocrystalsgrowfromthemiledconstituentoxides during the miling proceses. The magnetization data obtained by using a SQUID magnetometer show the NPs as a superparamagnet in terms of anhysteretic curves near rom temperature. Un- overlaping of the scaled M(Hext;T)=Ms vs. Hext=T plots and the dc susceptibility obeying the Curie-Weis behavior rather than the Curie law at high temperatures provide evidence that the NPs are interacting superparamagnetic ensembles. A mean-eld corection to the Langevin func- tion L([Hext+M]=kBT) worked wel for the magnetic ordering of the NPs. By means of the Langevinting,thediameteroftheNPwasestimatedtobelowerthan15nm,dependingonthe miling time. The saturation magnetization of NPs varied from 48.5 em/g to 19 emu/g, with the highervaluecorespondingtoalargerparticlesize. Acore-shelstructureoftheNPwasadopted, with the NP having the core-shel magneticaly-eective mas density.
Chaotic Mixing in Two-Dimensional Square Cavity Flow Using Finite Volume Method (FVM)
Thuy Hong Van-Le,Yong Kweon Suh,Sang Mo Kang 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.11
Chaotic mixing inside two-dimensional square cavity was examined numerically. Finite volume method is employed to obtain accurate descriptions of the velocities field which form the basis of mixing analysis. The primary form of chaotic mixing of this case is caused by imposing the non-uniform boundary conditions which is periodically applied to bottom wall at a first half of the period and to the top wall at a second half of the period, respectively. There are several parameters in this flow model; these are the Peclet number and modulation period. We will investigate numerically how these parameters affect the flow patterns within the cavity. There is also an important value, mixing index which descript the quality of mixing is obtained in this case. Furthermore, we will get the mixing efficiency using Poincare section and Lyapunov exponent. The numerical results to be obtained in this study can be used as bench-mark solutions in developing FVM codes.