An Attempt to Demonstrate Business Domain Extension through Extension of Technology Usage

Kyudong Cho 한국무역연구원 2013 The International Academy of Global Business and T Vol.9 No.1

Firms try to acquire new sources of revenue to operate sustainable management of the company. On occasion, there is a proposal that is not consistent with the existing business domain. This makes it possible to match it to the business by making a company decision to extend the business domain. This is obtained by searching for factors for configuring hypotheses on the basis of this consideration and then demonstrated.

Factor Analysis for RPA Market Growth in Japan

Kyudong Cho 아시아무역학회 2019 Journal of Asia Trade and Business Vol.6 No.2

The purpose of this study is to analyze the factors of market growth by analyzing the changes in the RPA market in recent industrial changes called the 4th industrial revolution. In particular, the growth of the japan RPA market can be attributed to the special characteristics of the Japanese labor market and the policy support from the Japanese government, which is a countermeasure against the declining birthrate and aging population. A decline in productivity is expected, and the work style reform policy issued by the Japanese government is thought to be strongly attributable to RPA market growth. And we will see how this RPA can continue to grow in Japan. In this study, to analyze based on information obtained from literature surveys and interviews. In addition, since RPA was directly developed, it can be recognized that the RPA software has been verified. This study confirmed the reason for the growth of the RPA market in Japan. This discovery can also identify similar markets where RPA market growth is expected. It was also possible to confirm to what level RPA has developed in terms of technology. Factors to consider in order to establish a new market in society have been derived. Until now, the factors of market growth in the RPA market have not been analyzed. It is also possible to identify growth forecasts and growth factors for similar markets, including South Korea.

Structural Variation of Alu Element and Human Disease

Kim, Songmi,Cho, Chun-Sung,Han, Kyudong,Lee, Jungnam Korea Genome Organization 2016 Genomics & informatics Vol.14 No.3

Transposable elements are one of major sources to cause genomic instability through various mechanisms including de novo insertion, insertion-mediated genomic deletion, and recombination-associated genomic deletion. Among them is Alu element which is the most abundant element, composing ~10% of the human genome. The element emerged in the primate genome 65 million years ago and has since propagated successfully in the human and non-human primate genomes. Alu element is a non-autonomous retrotransposon and therefore retrotransposed using L1-enzyme machinery. The 'master gene' model has been generally accepted to explain Alu element amplification in primate genomes. According to the model, different subfamilies of Alu elements are created by mutations on the master gene and most Alu elements are amplified from the hyperactive master genes. Alu element is frequently involved in genomic rearrangements in the human genome due to its abundance and sequence identity between them. The genomic rearrangements caused by Alu elements could lead to genetic disorders such as hereditary disease, blood disorder, and neurological disorder. In fact, Alu elements are associated with approximately 0.1% of human genetic disorders. The first part of this review discusses mechanisms of Alu amplification and diversity among different Alu subfamilies. The second part discusses the particular role of Alu elements in generating genomic rearrangements as well as human genetic disorders.

추천 시스템의 편향 및 사용자 만족도 탐구: 체계적 문헌고찰 방법을 중심으로

이지윤(Jiyoon Lee),박규동(Kyudong Park),조민수(Minsu Cho) 한국디지털콘텐츠학회 2022 한국디지털콘텐츠학회논문지 Vol.23 No.9

A recommendation system aims to provide personalized services or content by learning a huge amount of user behaviors with artificial intelligence. It enables a user-centric personalization in a heterogeneous setting, while the recommendation system can also be biased by focusing on only a limited viewpoint. A filter bubble, i.e., a typical bias of a recommendation system, signifies the system utilizes filtered data according to the user; thus, it causes a side effect of confirmation bias and selective recognition, which in turn leads to a decrease in user satisfaction. In this study, we employed a systematic literature review method to specify the relationship between the bias of the recommendation system and user satisfaction. Based on a series of literature review protocols, we analyzed the articles from three angles: (i) the relationship between the bias of the recommendation system and user satisfaction and (ii) how to mitigate bias and improve user satisfaction. This research contributes to investigating a new angle, i.e., the relationship between bias and user satisfaction, rather than a new technical algorithm of the recommendation system.

Targeted next-generation sequencing for identifying genes related to horse temperament

Song, Soyoung,Oh, Dong-Yep,Cho, Gil-Jae,Kim, Dong Hee,Park, Yong-Soo,Han, Kyudong Korean Society of Genetics 2017 Genes & Genomics Vol.39 No.12

<P> It is a fundamental challenge to discover the association of genetic traits with phenotypic traits. In this study, we aimed to identify possible genetic traits related to horse temperament. Based on previous findings, we selected 71 candidate genes related to temperamental trait and examined them in the human and horse reference genomes (hg38 and equCab2, respectively). We found 16 orthologous genes and, by comparing with the human reference genome, 17 homologous genes in the horse reference genome. We designed probes specific for the 33 horse genes. Using the probes, we built sequencing libraries of the genomic DNA samples from eight aggressive and eight docile horses, and sequenced the constructed libraries using the Illumina Hiseq2500 platform. Through the analysis of the targeted exome sequences, we identified single nucleotide polymorphisms (SNPs) in the genes. SNPs could be served as genetic markers to evaluate aggressive or docile levels of horses. To examine whether any genetic variants are associated with horse temperament, we performed genome-wide association study (GWAS) using the SNP data. GWAS analysis identified ten variants (p-value <0.05) which could be related to horse temperament. We validated the variants using Sanger sequencing. The most significant variants were found in MAOA (c.1164+41T>C) and AR (c.1047+27G>T) genes with 8.09 × 10<SUP>-4</SUP> p-value. We suggest that the variants might be used to assess horse temperament and to determine superior horses for riding or racing. </P>

High-accuracy quantitative principle of a new compact digital PCR equipment: Lab On An Array

Lee, Haeun,Lee, Cherl-Joon,Kim, Dong Hee,Cho, Chun-Sung,Shin, Wonseok,Han, Kyudong Korea Genome Organization 2021 Genomics & informatics Vol.19 No.3

Digital PCR (dPCR) is the third-generation PCR that enables real-time absolute quantification without reference materials. Recently, global diagnosis companies have developed new dPCR equipment. In line with the development, the Lab On An Array (LOAA) dPCR analyzer (Optolane) was launched last year. The LOAA dPCR is a semiconductor chip-based separation PCR type equipment. The LOAA dPCR includes Micro Electro Mechanical System that can be injected by partitioning the target gene into 56 to 20,000 wells. The amount of target gene per wells is digitized to 0 or 1 as the number of well gradually increases to 20,000 wells because its principle follows Poisson distribution, which allows the LOAA dPCR to perform precise absolute quantification. LOAA determined region of interest first prior to dPCR operation. To exclude invalid wells for the quantification, the LOAA dPCR has applied various filtering methods using brightness, slope, baseline, and noise filters. As the coronavirus disease 2019 has now spread around the world, needs for diagnostic equipment of point of care testing (POCT) are increasing. The LOAA dPCR is expected to be suitable for POCT diagnosis due to its compact size and high accuracy. Here, we describe the quantitative principle of the LOAA dPCR and suggest that it can be applied to various fields.

Genomic Structure and Expression Analyses of the PYGM Gene in the Thoroughbred Horse.

Nam, Gyu-Hwi,Ahn, Kung,Bae, Jin-Han,Han, Kyudong,Lee, Chong-Eon,Park, Kyung-Do,Lee, Sang-Hak,Cho, Byung-Wook,Kim, Heui-Soo Zoological Society of Japan 2011 Zoological science Vol.28 No.4

<P>Muscle glycogen Phosphorylase (PYGM) has been shown to catalyze the degradation of glycogen to glucose-1-phosphate. The PYGM gene can contribute to providing energy to the body by disassembling the glycogen in muscle. Here, we analyzed the genomic structure and expression of the PYGM gene in the thoroughbred horse. The PYGM gene, containing several transposable elements (MIRs, LINEs, and MERs), was highly conserved in mammalian genomes. In order to understand the expression of the horse PYGM gene, we performed quantitative RT-PCR using 11 thoroughbred horse tissue samples. The horse PYGM gene was broadly expressed in all tissues tested. In particular, the highest expression of the horse PYGM gene was observed in skeletal muscle tissue relative to the other tissues. Interestingly, the horse PYGM gene contains fewer mobile elements than its human ortholog, resulting in an increase in the structural stability of the PYGM gene sequence. This study provides insights into the genomic structure of the horse PYGM gene that may be useful in future studies of its association with exercise capability.</P>

Mutational Analysis of Extranodal NK/T-Cell Lymphoma Using Targeted Sequencing with a Comprehensive Cancer Panel

Choi, Seungkyu,Go, Jai Hyang,Kim, Eun Kyung,Lee, Hojung,Lee, Won Mi,Cho, Chun-Sung,Han, Kyudong Korea Genome Organization 2016 Genomics & informatics Vol.14 No.3

Extranodal natural killer (NK)/T-cell lymphoma, nasal type (NKTCL), is a malignant disorder of cytotoxic lymphocytes of NK or T cells. It is an aggressive neoplasm with a very poor prognosis. Although extranodal NKTCL reportedly has a strong association with Epstein-Barr virus, the molecular pathogenesis of NKTCL has been unexplored. The recent technological advancements in next-generation sequencing (NGS) have made DNA sequencing cost- and time-effective, with more reliable results. Using the Ion Proton Comprehensive Cancer Panel, we sequenced 409 cancer-related genes to identify somatic mutations in five NKTCL tissue samples. The sequencing analysis detected 25 mutations in 21 genes. Among them, KMT2D, a histone modification-related gene, was the most frequently mutated gene (four of the five cases). This result was consistent with recent NGS studies that have suggested KMT2D as a novel driver gene in NKTCL. Mutations were also found in ARID1A, a chromatin remodeling gene, and TP53, which also recurred in recent NGS studies. We also found mutations in 18 novel candidate genes, with molecular functions that were potentially implicated in cancer development. We suggest that these genes may result in multiple oncogenic events and may be used as potential bio-markers of NKTCL in the future.

자연어처리 기술을 활용한 유튜브 악성 댓글 자동 블라인드 시스템

이재은(Jae Eun Lee),이지은(Ji Eun Lee),임예희(Ye Hee Lim),박규동(Kyudong Park),조민수(Minsu Cho) 한국HCI학회 2022 한국HCI학회 학술대회 Vol.2022 No.2

인터넷 상의 댓글이 늘어나면서 악성 댓글의 심각성 또한 점점 커지는 가운데, 특히 최근 사용량이 급증한 유튜브에서 많은 양의 악성 댓글로 인해 피해가 속출하고 있다. 이를 줄이고자, 본 연구에서는 자동으로 유튜브의 악성 댓글을 검출하여 이를 노출시키지 않도록 블라인드 처리하는 크롬 확장 프로그램을 개발하였다. 먼저, 유튜브 댓글을 수집한 후 일반 댓글과 악성 댓글로 라벨링하여 학습 데이터셋을 구축하였다. 이를 바탕으로 지도학습 기반의 악성 댓글 분류기를 구축하여 서버에 내장하였다. 그리고 유튜브 웹사이트에서 댓글의 위치를 읽어서 자동으로 서버로 송신하고 악성 댓글 여부를 수신하는 크롬 확장 프로그램을 개발하였다. 실행 결과, 악성 댓글로 예측된 댓글이 자동으로 블라인드 처리됨을 확인하였다. 추후 사용성 평가를 거쳐 개선 사항을 발굴할 예정이며, 악성 댓글에 노출되지 않는 것이 유튜브의 사용 경험에 어떤 영향을 미치는지 연구하고자 한다.