Callus distraction method를 이용한 하악골 신장술 : 계단골절단술식의 적용

김명진,윤필영,신동준,김수경,김종원,김규식 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.2

Since callus distraction technique was applied clinically for the correction of dentofacial deformity to the patients with hemifacial dysplasia by McCarthy in 1992, many surgeons have tried to apply this method to the maxillofacial region. But this technique has some drawbacks. One of the disadvantages of this technique is extensive scar formation in the facial area, which is a sequelae of extraoral approach for supraperiosteal dissection of the periosteum overlying the mandible. Recently, we have made an effort to perform this technique through intraoral approaches to prevent scar formation on the submandibular area and modified the design of the osteotomy, that is step osteotomy technique, to increase the raw bone surface on both osteotomized segments. The rationale for the application of this step osteotomy technique is to increase the amount of regeneracted bone and the length of distraction, to avoid damage of inferior alveolar neurovascular bundle, and to increase initial stability of the splitted segments. Step osteotomy procedure can be done with fine micro-osteotomy saw through subperiosteal tunneling. Extraoral pins should be inserted before making the osteotomy. Since 1974 we have applied this technique at 8 sites In 5 patients with mandibular deficiencies: 2 cases of hemifacial microsomia, 1 case of developmental facial asymmetry and 2 cases of mandibular bony defect. Mandibular elongation have been achieved from 12 to 20mm in length. 1 out of 8 site, we experienced non-union in the case of mandibular body defect. Some skeletal relapse and growth retardation phenomenon have been observed in some cases with the longest follow-up of 48 months.

口腔領域에 發生한 囊腫에 關한 臨床 및 統計學的 硏究

李春根,金圭植,南日祐,申相澈 醫藥係社 1954 綜合 醫學 Vol.11 No.12

Gastroprotective effects of Leejung-tang, an oriental traditional herbal formula, on ethanol-induced acute gastric injury in rats.

Shin, In-Sik,Lee, Mee-Young,Lim, Hye-Sun,Seo, Chang-Seob,Ha, Hye-Kyung,Shin, Hyeun-Kyoo African Networks on Ethnomedicines] 2013 African journal of traditional, complementary, and Vol.10 No.2

<P>Leejung-tang (LJT, Rechu-to in Japanese and Lizhong-tang in Chinese) is an oriental traditional traditional herbal formula. LJT has been used for treatment of gastrointestinal disorders in Korea, Japan, and China for a long time. In present study, we investigated the protective effects of LJT against absolute ethanol induced gastric injuries. Rats in the control group were given PBS orally (5 mL/kg body weight) as the vehicle, and the absolute-ethanol group (EtOH group) received absolute ethanol (5 mL/kg body weight) by oral gavage. Rats in the positive control group were given omeprazole orally (50 mg/kg body weight) 2 h prior to the administration of absolute ethanol. The treatment groups received LJT (400 mg/kg body weight) 2 h prior to absolute ethanol administration. All rats were sacrificed 1 h after receiving the ethanol treatment. The stomach was excised for macroscopic examination and biochemical analysis. The administration of LJT protected gastric mucosa against ethanol-induced acute gastric injury, including hemorrhage and hyperemia. LJT reduced the increase in lipid peroxidation in ethanol-induced acute gastric lesions. LJT increased GSH content and activities of the antioxidant enzymes, catalase, glutathione-S-transferase, glutathione reductase, glutathione peroxidase, and superoxide dismutase. These results indicate that LJT protects gastric mucosa against ethanol-induced acute gastric injury by increasing their antioxidant content. We suggest that LJT can be developed as an effective drug for the treatment of acute gastric injury.</P>

Jaeumganghwa-tang, a Traditional Herbal Formula Inhibits the Development of Benign Prostatic Hyperplasia in Rats

Shin, In-Sik,Lee, Mee-Young,Lim, Hye-Sun,Seo, Chang-Seob,Ha, Hye-Kyung,Shin, Hyeun-Kyoo The Korean Society for Applied Biological Chemisty 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.2

Benign prostate hyperplasia (BPH) is the most common proliferative disorder affecting older men and results in prostate enlargement and lowered urinary tract symptoms. Jaeumganghwa-tang (JGT), an oriental traditional herbal formula, has been used in China (Zi-yin-jiang-huo-tang in Chinese), Japan (Jiin-koka-to in Japanese), and Korea for many years. Effects of JGT on prostate dihydrotestosterone (DHT) level and prostatic hyperplasia were investigated using a rat model, in which BPH was induced using testosterone propionate (TP). Rats were divided into five groups. One group was used as a normal, and four groups received subcutaneous injections of TP for 4 weeks to induce BPH. JGT (200 or 400 mg/kg) was administered daily for 4 weeks by oral gavage concurrently with TP injections, and rats were sacrificed at scheduled times. Prostates were weighed, and histopathologic examination was conducted. DHT levels in serum and the prostate were measured, and the expression of proliferating cell nuclear antigen (PCNA) protein was investigated using Western blotting. BPH animals showed increases in absolute and relative weights of the prostate, levels of DHT in serum and the prostate, and expression of PCNA in the prostate, whereas JGT-treated animals showed significant reductions in these indices compared with the BPH animals. Administration of JGT attenuated TP-induced epithelial hyperplasia. These findings indicate that JGT inhibits the development of BPH, an effect closely associated with a reduction in DHT level.

Yijin-tang, an Oriental Herbal Formula Reduces Ethanol-induced Acute Gastric Injury in Rats

Shin, In-Sik,Lee, Mee-Young,Seo, Chang-Seob,Lim, Hye-Sun,Ha, Hye-Kyung,Shin, Hyeun-Kyoo The Korean Society for Applied Biological Chemisty 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.2

Protective effects of Yijin-tang extract (YTE) were investigated on ethanol-induced acute gastric injury. Simultaneous determination of six components, homogentisic aicd, liquiritin, hesperidin, neohesperidin, poncirin, and glycyrrhizin was performed in YTE by high performance liquid chromatography-photodiode. Acute gastric lesion was induced by oral administration of absolute ethanol (5 mL/kg). The positive control (omeprazole, 50 mg/kg) and YTE groups (200 and 400 mg/kg) were administered by oral gavage 2 h prior to ethanol treatment. The animals were sacrificed 1 h after receiving ethanol treatment. Acute toxicity study was performed to evaluate the safety of YTE. YTE protected gastric mucosa against ethanol-induced acute gastric injury including hemorrhage and hyperemia. YTE reduced the elevated lipid peroxidation of stomach and increased the activities of antioxidant enzyme. In the acute toxicity study, YTE did not cause any toxic effect at the dose level of 2000 mg/kg in rats. These results showed that YTE protects gastric mucosa from ethanol-induced acute gastric injury via increasing the antioxidant status. We suggest that YTE has a potential as a therapeutic agent for acute gastric injury.

Palmul-tang, a Traditional Herbal Formula, Protects against Ethanol-induced Acute Gastric Injury in Rats

Shin, In-Sik,Lee, Mee-Young,Seo, Chang-Seob,Lim, Hye-Sun,Kim, Jung-Hoon,Jeon, Woo-Young,Shin, Hyeun-Kyoo The Society of Korean Medicine 2011 대한한의학회지 Vol.32 No.6

Objectives: Palmul-tang (hachimotsu-to in Japanese and bawu-tang in Chinese) is a mixture of eight herbs. It is traditionally used for the treatment of anemia, anorexia, general weakness, and female infertility in China, Japan, and Korea. In this study, we investigated the protective effects of Palmul-tang water extract (PTE) against ethanol-induced acute gastric injury in rats. Material and Methods: Acute gastric lesions were induced by intragastric administration of 5mL/kg body weight of absolute ethanol to each rat. Control group rats were given PBS orally and the ethanol group (EtOH group) received absolute ethanol (5mL/kg) by oral gavage. The positive control group and the PTE group were given oral doses of omeprazole (50mg/kg) or PTE (400mg/kg), respectively, 2 h prior to the administration of absolute ethanol. The stomach of each animal was excised and examined for gastric mucosal lesions. To confirm the protective effects of PTE, we evaluated the degree of lipid peroxidation, the level of reduced glutathione (GSH), and the activities of the antioxidant enzymes catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase in the stomach. Results: PTE reduced ethanol-induced hemorrhage and hyperemia in the gastric mucosa. PTE reduced the increase in lipid peroxidation associated with ethanol-induced acute gastric lesions and increased mucosal GSH content and the activities of antioxidant enzymes. Conclusion: These results indicate that PTE protects gastric mucosa against ethanol-induced acute gastric injury by increasing antioxidant status. We suggest that PTE could be developed as an effective drug for the treatment of acute gastric injury.

신재생에너지 동향 파악을 위한 토픽 모형 분석

신규식(Shin, Kyoo-Sik),최회련(Choi, Hoe-Ryeon),이홍철(Lee, Hong-Chul) 한국산학기술학회 2015 한국산학기술학회논문지 Vol.16 No.9

기후변화 및 환경오염에 대응하기 위해 신재생에너지 정책 연구가 증가하고 있다. 신재생에너지는 녹색산업과 녹색 기술로 대표되는 새로운 성장 동력 기술이다. 현재 우리나라는 태양광, 풍력, 수소연료전지 등 3대 전략부분에 신재생에너지 보급 및 기술개발사업에 대한 투자가 이루어지고 있지만 아직은 초기 단계로, 연구 방향 및 투자 분야에 대한 불확실성을 줄이는 것이 무엇보다도 시급한 실정이다. 따라서 본 연구는 빅데이터(big data) 분석방법 중 텍스트 마이닝(Text mining method)과 토픽 모델링 기법(multinominal topic model)을 신재생에너지와 관련된 최근 10년간의 우리나라 언론기사에 적용 하여 국가 정책의 핵심이슈 및 세계적인 연구 트렌드를 분석하고, 성장 가능성이 있는 신재생에너지 분야를 예측하였다. 정보 통신기술을 바탕으로 한 연구결과는 신재생에너지 분야에 활발히 적용될 것으로 예측된다. To respond the climate change and environmental pollution, the studies on renewable energy policies are increasing. The renewable energy is a new growth engine technology represented by the green industry and green technology. At present, the investments for the renewable energy supply and technology development projects of three main strategy sectors such as sunlight, wind power and hydrogen fuel cell are implemented in our country, while they are still in the early stage, accordingly reducing those uncertainty for the research direction and investment fields is the most urgent issue among others. Thus, this study applied text mining method and multinominal topic model among the big data analysis methods on our country's newspaper articles concerning the renewable energy over the last 10 years, and then analyzed the core issues and global research trend, forecasting the renewable energy fields with the growth potential. It is predicted that these results of the study based on information and communication technology will be actively applied on the renewable energy fields.

Palmul-tang, a Traditional Herbal Formula, Protects against Ethanol-induced Acute Gastric Injury in Rats

In-Sik Shin,Mee-Young Lee,Chang-Seob Seo,Hye-Sun Lim,Jung-Hoon Kim,Woo-Young Jeon,Hyeun-Kyoo Shin 대한한의학회 2011 대한한의학회지 Vol.32 No.6

Yijin-tang, an Oriental Herbal Formula Reduces Ethanol-induced Acute Gastric Injury in Rats

In Sik Shin,이미영,서창섭,임혜선,HyeKyung Ha,,Hyeun Kyoo Shin 한국응용생명화학회 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.2

Protective effects of Yijin-tang extract (YTE) were investigated on ethanol-induced acute gastric injury. Simultaneous determination of six components, homogentisic aicd, liquiritin,hesperidin, neohesperidin, poncirin, and glycyrrhizin was performed in YTE by high performance liquid chromatography-photodiode. Acute gastric lesion was induced by oral administration of absolute ethanol (5 mL/kg). The positive control (omeprazole, 50mg/kg) and YTE groups (200 and 400 mg/kg) were administered by oral gavage 2 h prior to ethanol treatment. The animals were sacrificed 1 h after receiving ethanol treatment. Acute toxicity study was performed to evaluate the safety of YTE. YTE protected gastric mucosa against ethanol-induced acute gastric injury including hemorrhage and hyperemia. YTE reduced the elevated lipid peroxidation of stomach and increased the activities of antioxidant enzyme. In the acute toxicity study, YTE did not cause any toxic effect at the dose level of 2000 mg/kg in rats. These results showed that YTE protects gastric mucosa from ethanolinduced acute gastric injury via increasing the antioxidant status. We suggest that YTE has a potential as a therapeutic agent for acute gastric injury.

Spargue-Dawley 랫드를 이용한 평위산의 안전성 연구

신인식(In Sik Shin),김정훈(Jung Hoon Kim),하혜경(Hye Kyung Ha),황대선(Dae Sun Huang),허정임(Jung Im Huh),신현규(Hyeun Kyoo Shin) 한의병리학회 2010 동의생리병리학회지 Vol.24 No.3