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RISS 인기검색어
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- 저자 : Kyong Ku You (검색결과 5 건)
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Cho, Sangwoo,Ku, Jeonghun,Park, Jinsick,Han, Kiwan,Lee, Hyeongrae,Choi, You Kyong,Jung, Young-Chul,Namkoong, Kee,Kim, Jae-Jin,Kim, In Young,Kim, Sun I.,Shen, Dong Fan Mary Ann Liebert 2008 Cyber Psychology & Behavior Vol.11 No.3
<P>Alcoholism is a disease that affects parts of the brain that control emotion, decisions, and behavior. Therapy for people with alcoholism must address coping skills for facing high-risk situations. Therefore, it is important to develop tools to mimic such conditions. Cue exposure therapy (CET) provides high-risk situations during treatment, which raises the individual's ability to recognize that alcohol craving is being induced. Using CET, it is hard to simulate situations that induce alcohol craving. By contrast, virtual reality (VR) approaches can present realistic situations that cannot be experienced directly in CET. Therefore, we hypothesized that is possible to model social pressure situations using VR. We developed a VR system for inducing alcohol craving under social pressure situations and measured both the induced alcohol craving and head gaze of participants. A 2 x 2 experimental model (alcohol-related locality vs. social pressure) was designed. In situations without an avatar (no social pressure), more alcohol craving was induced if alcohol was present than if it was not. And more alcohol craving was induced in situations with an avatar (social pressure) than in situations without an avatar (no social pressure). The difference of angle between the direction of head gazing and the direction of alcohol or avatar was smaller in situations with an avatar alone (social pressure) than in situations with alcohol alone. In situations with both alcohol and an avatar, the angle between the direction of head gaze and the direction of the avatar was smaller than between the direction of head gaze and the direction of the alcohol. Considering the results, this VR system induces alcohol craving using an avatar that can express various social pressure situations.</P>
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김남욱,구정훈,이은,최유경,정영철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5
Objectives : The relationship between substance dependence and poor decision making has received much attention inrecent years. This study aimed to test the hypothesis that alcohol dependent subjects would demonstrate a more perseverative decision-making pattem, during ambiguous situations. Methods : 15 alcohol dependent patients and 15 healthy normal controls performed a novel computerized decision-making task, which presented figures of coins. The subjects were instructed to guess whether the total number of coins was 'odd' or' even'. Besides these two response, one could select a third altemative - 'pass' - in case the chances were assumed to be low. Results : There was significant difference in performance between the two groups (F=4.339, P=0.008). The control groupgained 15.4±14.4 points, whereas the alcohol dependent group lost 0.6±5.3 points. The normal control group demonstrated a tendency to make more pass responses as the trials were repeated. In contrast, the alcohol dependent group didn't make use of the altemative, but kept challenging between 'odd' and 'even', although they sensed that the chances were low. Conclusion : The alcohol dependent patients demonstrated a more rigid and perseverative response pattem and showed deficits in making use of compromise altematives.
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Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice
Choung, Sorim,Joung, Kyong Hye,You, Bo Ram,Park, Sang Ki,Kim, Hyun Jin,Ku, Bon Jeong Hindawi 2018 PPAR research Vol.2018 No.-
<P>Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance. The peroxisome proliferator-activated receptor (PPAR) activators, thiazolidinediones, (TZDs), are insulin sensitizers used as a treatment for NAFLD. However, TZDs are a controversial treatment for NAFLD because of conflicting results regarding hepatic steatosis and fibrosis. To evaluate a possible effective drug for treatment of NAFLD, we investigated the effects of a newly developed TZD, lobeglitazone, with an emphasis on hepatic lipid metabolism. Lobeglitazone treatment for 4 weeks in high fat diet- (HFD-) induced obese mice (HL group) improved insulin resistance and glucose intolerance compared to HFD-induced obese mice (HU group). The gene levels related to hepatic gluconeogenesis also decreased after treatment by lobeglitazone. The livers of mice in the HL group showed histologically reduced lipid accumulation, with lowered total plasma cholesterol and triglyceride levels. In addition, the HL group significantly decreased the hepatic expression of genes associated with lipid synthesis, cholesterol biosynthesis, and lipid droplet development and increased the hepatic expression of genes associated with fatty acid <I>β</I>-oxidation, thus suggesting that lobeglitazone decreased hepatic steatosis and reversed hepatic lipid dysregulation. Livers with steatohepatitis contained increased levels of PPAR<I>γ</I> and phosphorylated PPAR<I>γ</I> at serine 273, leading to downregulation of expression of genes associated with insulin sensitivity. Notably, the treatment of lobeglitazone increased the protein levels of PPAR<I>α</I> and diminished levels of PPAR<I>γ</I> phosphorylated at serine 273, which were increased by a HFD, suggesting that induction of PPAR<I>α</I> and posttranslational modification of PPAR<I>γ</I> in livers by lobeglitazone might be an underlying mechanism of the improvement seen in NAFLD. Taken together, our data showed that lobeglitazone might be an effective treatment for NAFLD.</P>
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