근위 대퇴정을 이용한 대퇴 전자부 골절의 치료

문영완,서동현,강신택,권덕주,지용남,이기병 대한골절학회 2003 대한골절학회지 Vol.16 No.1

목 적 : 근위 대퇴정을 이용한 고령 환자의 대퇴전자간 골절의 치료결과에 대해 보고하고자 한다. 대상 및 방법 : 2001년 4월부터 2002년 2월까지 대전자부에서 소전자에 이르는 횡선골절 및 소전자 주위 분쇄골절로 압박고 나사 고정이 용이하지 않은 전자간 골절, 일반적인 전자간 골절에 대해 근위 대퇴정을 사용해 치료한 80례 중 추시가 가능했던 71례를 대상으로 하였으며, 추시과정 중 골유합 시기, 대퇴경간각, 지연나사의 활강, 수술시간 및 출혈량, 술중 및 술후 합병증 수술시 주의사항을 조사하였다. 결 과 : 평균연령은 77.5세, 평균추시기간은 9개월이었다. Evans의 분류법으로 골절을 분류하여 안정성, 불안정성 골절은 30례, 41례였다. 평균 골 유합 시비는 13.8주였고, 대퇴경간각은 수술직후 131.9 ± 5.21˚, 129.9 ± 6.04˚ 였으며 평균지연나사의 활강은 4.21±4.13㎜였다. 수술시간은 평균 61분, 출혈량은 평균 0.67pint(134cc)였다. 술중 합병증으로는 정복 실패 1례, 원위고정나사 삽입시 피질골 골절 1례, drill bit 파손 1례가 있었으며, 술후 합병증으로는 대퇴 경간각 소실(5도이상) 12례, 경부골절의 발생이 2례, 지연나사의 관절내 돌출 1례였다. 결 론 : 대퇴골 전자부 골절의 치료로 근위 대퇴정은 정확한 삽입 위치, 삽입시의 조심스러운 확공, 지연나사의 연골하 골에 단단하게 고정시키는 등의 주의를 한다면 수술시간, 출혈량 감소 등의 술중 합병증을 줄이고, 견고한 내고정을 통한 조기 보행을 가능하게 하며, 좋은 골유합 등이 기대되므로, 특히 고령, 분쇄골절, 역행성 골절, 골다공증이 심한 경우에서 바람직한 수술방법으로 사료된다. Purpose : To evaluate the treatment results of geriatric intertochanteric fractures using a proximal femoral nail. Materials and Methods : From April 2001 to February 2002, 71 cases of the intertrochanteric fractures involving lesser trochanter, transverse or reverse oblique intertrochanteric fracture. We evaluated the bone union time, neck-shaft angle, lag screw sliding by follow up radiographs, operation time, blood loss and complications. Results : The average age was 77.5 years old, the mean duration of follow-up was 9 months and the mean duration of bone union was 13.8 weeks. The average neck-shaft angle on immediate postop. x-ray was 131.9 ± 5.21˚ and 129.9 ± 6.04˚ at last follow up and the average lag screw sliding was 4.21 ± 4.13㎜. The average operation time was 61 minutes and blood loss was 0.67 pints(134cc). Intraoperative complications were inadequate reduction in one case, difficulty in distal transfixing in one case and drill bit failure in one case and postoperative complications were loss of neck-shaft angle(more than 5 degree) in 12 cases, femur neck fracture in 2 cases and intraarticular cutting out of femur neck screw in one case. Conclusions : The use of the proximal femoral nail could be appropriate for the fixation of communited or reverse oblique intertrochanteric fracture in elderly, osteroporotic patients for early ambulation, preventing shortening and rotation deformity, and reducing operation time and blood loss.

Target Detection and Navigation System for a mobile Robot

Il-Wan Kim,Ho-Sang Kwon,Young-Joong Kim,Myo-Taeg Lim 제어로봇시스템학회 2005 제어로봇시스템학회 국제학술대회 논문집 Vol.2005 No.6

Medicinal Chemistry : FPDHP, a novel anticancer agent, induces cell detachment and caspase-dependent apoptosis in Caki cells

( Jun Soo Park ),( Wan Tae Kim ),( Shin Kim ),( Taeg Kyu Kwon ),( Byeong Churl Jang ),( Eung Seok Lee ),( Jong Wook Park ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-

The inhibition of topoisomerase can suppress the growth of cancer cells and induce apoptosis. The aim of this study was to evaluate the anticancer effects and mechanisms of action of a novel topoisomerase inhibitor, 4-(furan-2-yl)-2-(pyridin-2-yl)-5,6,-dihydro-1,10-phenanthroline (FPDHP). FPDHP suppressed the growth of Caki, A549, HT29 and MDA-MB-231cells, and induced caspase-dependent apoptosis in the Caki cells. In particular, FPDHP also induced caspase-dependent apoptosis and the downregulation of the protein expression levels of cellular FLICE-like inhibitory protein (cFLIP) and the phos-phorylation of Akt in Caki cells. Notably, the overexpression of cFLIP, but not that of Akt, in part, blocked the FPDHP-mediated apoptosis in Caki cells, In addition, FPDHP was further shown to induce the caspase-independent detachment of Caki cells from the culture dish; higher populations of apoptotic cells were observed in the detached cells than in the attached cells. To the best of our Knoweledge, these results collectively demonstrate for the first time that FPDHP has a killing effect on Caki cells, which is mediated through both caspase-dependent apoptosis and caspase-independent cell detachment.

Oleanolic acid acetate inhibits rheumatoid arthritis by modulatin T cell Immune responses and matrix-degrading enzymes

( Jin Kyeong Choi ),( Sung Wan Kim ),( Duk Sil Kim ),( Jong Yeong Lee ),( Soyoung Lee ),( Hyun Mee Oh ),( Yeong Su Ha ),( Jeongsoo Yoo ),( Pil Hoon Park ),( Tae Yong Shin ),( Taeg Kyu Kwon ),( Mun Chu 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with a combination of synovium joint inflammation, synovium hyperplasia, and destruction of cartilage and bone. Oleanolic acid acetate (OM), a com-pound isolated from Vigna angularis, has been known to possess pharmacological activities, including anti-intlarnmetion and anti-bone destruction. In this study, we investigated the effects of OM on RA and the under-lying mechanisms of action by using a type-II collagen-induced arthritis (CIA) mouse model and tumor necrosis factor (TNF)-a-stimulated RA synovial fibroblasts. Oral administration of OM decreased the clinical arthritis symptoms, paw thickness, histologic and radiologic changes, and serum total and anti-type II collagen IgG, IgG1, and IgG2a levels. OAA administration reduced Th1 (fh17 phenotype CD4+ T lymphocyte expansions and in-flarnrnarory cytokine productions in T cell activated draining lymph nodes and spleen, OAA reduced the expres-sion and production of inflammatory mediators, such as cytokines and matrix metalloproteinase (MMP)-1/3, in the ankle joint tissue and RA synovial fibroblasts by down-regulating Akt, mitogen-activated protein kinases, and nuclear factor-KB. Our results clearly support that OAA plays a therapeutic role in RA pathogenesis by modulating helper T cell immune responses and matrix-degrading enzymes. The immunosuppressive effects of OAA were comparable to dexamethasone and ketoprofen. We provide evidences that OM could be a potential therapeutic candidate for RA.

서울시 도로기반시설물 생애주기비용 분석을 위한 DB 구축방안 연구

배윤신,이상염,권완택,전종명,Bae. Yoon Shin,Lee. Sangyum,Kwon. Wan Taeg,Jeon. Jong Myung 한국방재학회 2014 한국방재학회논문집 Vol.14 No.3

현재 서울시 도로시설물은 준공된 지 20년 이상 된 시설물이 전체 시설물의 50% 이상을 차지하고 있으며, 도로포장은 최초 건설 후 20년 이상 공용 중으로 포장의 노후화가 빠르게 진행되고 있는 실정이다. 이에 따라 서울시는 도로기반시설물을 효과적으로 관리하기 위하여 도로관리시스템, 포장관리시스템 등 시설물 관리시스템을 개발 운영하고 있다. 하지만 생애주기비용 분석의 자료로 활용하기 위해서는 세부항목에 대한 DB 구축이 필요하다. 본 연구에서는 서울시 도로기반시설물의 안전확보 및 효과적인 유지관리를 위해 현재 서울시에서 구축한 도로관리시스템 및 기타 시스템들의 DB 구축 현황을 조사분석하여 문제점을 도출하고 선진화된 체계적인 도로관리시스템 파악을 통해 앞으로 서울시 도로기반시스템의 DB 구축 개선방안(현재 서울시 DB의 진단 및 DB 확보방법)을 제시하고자 한다. 이를 통해 향후 수행할 생애주기비용 분석을 효율적으로 수행하기 위한 토대를 마련하는 것을 목적으로 한다. 최종적으로 LCC 분석을 위한 DB구축 방안을 제시하고 LCC 분석 절차를 제안한다. The purpose of this study is to manage road facilities effectively and to make safety ensure consistently in Seoul. To build the effective maintenance management system, it is necessary to investigate various road management systems of Seoul. In addition, the present databases based on management systems of Seoul were analyzed to build compact database of the management system of Seoul. The summary of this study was described and condition of database for LCC analysis was assessed through survey. Finally, the method of obtaining database to develope LCC analysis was suggested and necessary plans of proceeding LCC analysis described.

Inhibitory effect of 1,2,4,5-tetramethoxybenzene on mast cell-mediated allergic inflammation through suppression of IκB kinase complex

( In Gyu Je ),( Hyun Gyu Choi ),( Hui Hun Kim ),( Soyoung Lee ),( Jin Kyeong Choi ),( Sung Wan Kim ),( Duk Sil Kim ),( Taeg Kyu Kwon ),( Tae Yong Shin ),( Pil Hoon Park ),( Dongwoo Khang ),( Sang Hyun 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

As the importance of allergic disorders such as atopic dermatitis and allergic asthma, research on potential drug candidates becomes more necessary, Mast cells play an important role as initiators of allergic responses through the release of histamine; therefore. they should be the target of pharmaceutical development for the manage-ment of allergic inflammation. In our previous study, anti-allergic effect of extracts of Amomum xanthioides was demonstrated. To further investigate improved candidates. 1,2,4,5-tetramethoxybenzene (TMB) was isolate-ed from methanol extracts of A. xanthioides. TMB dose-dependently attenuated the degranulation of mast cells without cytotoxicity by inhibiting calciun influx, TMB decreased the expression of pro-inflammatory cytokines such as tumor necrosis factor-α and interleukin (IL)-4 at both the transcriptional and translational levels. Increased expression of these cytokines was caused by translocation of nuclear factor-KB into the nucleus. and it was hindered by suppressing activation of IKB kinase complex. To confirm the effect ofTMB in viva. the ovalbu-min (OYA)-induced active systemic anaphylaxis (ASA) and IgE-mediated passive cutaneous anaphylaxis (PCA) models were used. In the ASA model, hypothermia was decreased by oral administration ofTMB, which attenu-ated serum histamine. OVA-specific IgE. and IL-4 levels. Increased pigmentation of Evans blue was reduced by TMB in a dose-dependent manner in the PCA model. Our results suggest that TMB is a possible therapeutic candidate for allergic inflammatory diseases that acts through the inhibition of mast cell degranulation and expression of pro-inflammatory cytokines.

Hepatocyte Growth Factor Suppresses Vascular Endothelial Growth Factor-Induced Expression of Endothelial ICAM-1 and VCAM-1 by Inhibiting the Nuclear Factor-κB Pathway

Min, Jeong-Ki,Lee, Young-Mi,Kim, Jeong Hun,Kim, Young-Myeong,Kim, Sung Wan,Lee, Soo-Young,Gho, Yong Song,Oh, Goo Taeg,Kwon, Young-Guen Ovid Technologies Wolters Kluwer -American Heart A 2005 Circulation research Vol.96 No.3

<P>Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are potent angiogenic factors that have been used clinically to induce angiogenesis. However, concerns have been raised about VEGF because of its proinflammatory actions, which include enhancing the adhesion of leukocytes to endothelial cells. We have examined the possible antiinflammatory effects of HGF on the vasculature. HGF, unlike VEGF, did not alter leukocyte adhesion to endothelial cells. Instead it inhibited VEGF-induced leukocyte-endothelial cell interactions and the endothelial expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). In a skin inflammation model, VEGF-treated mice showed a significant increase of leukocytes infiltrated or adherent to the luminal surface of blood vessels, as compared with vehicle- or HGF-treated mice. The VEGF effect was markedly suppressed by coadministration of HGF. RT-PCR and promoter analysis revealed that HGF downregulated VEGF-mediated expression of ICAM-1 and VCAM-1 at the transcriptional level. Furthermore, these inhibitory effects coincided with suppression of IkappaB kinase activity, and this in turn prevented the activation of the inflammatory transcription factor NF-kappaB. Taken together, our results demonstrate that HGF suppresses VEGF-induced inflammation presumably by inhibiting the endothelial NF-kappaB pathway. This suggests that combined treatment with HGF and VEGF could be superior to treatment with either factor alone for enhancing therapeutic angiogenesis while avoiding inflammation.</P>

Inhibitory effect of 1,2,4,5-tetramethoxybenzene on mast cell-mediated allergic inflammation through suppression of IκB kinase complex

Je, In-Gyu,Choi, Hyun Gyu,Kim, Hui-Hun,Lee, Soyoung,Choi, Jin Kyeong,Kim, Sung-Wan,Kim, Duk-Sil,Kwon, Taeg Kyu,Shin, Tae-Yong,Park, Pil-Hoon,Khang, Dongwoo,Kim, Sang-Hyun Elsevier 2015 Toxicology and applied pharmacology Vol.287 No.2

<P><B>Abstract</B></P> <P>As the importance of allergic disorders such as atopic dermatitis and allergic asthma, research on potential drug candidates becomes more necessary. Mast cells play an important role as initiators of allergic responses through the release of histamine; therefore, they should be the target of pharmaceutical development for the management of allergic inflammation. In our previous study, anti-allergic effect of extracts of <I>Amomum xanthioides</I> was demonstrated. To further investigate improved candidates, 1,2,4,5-tetramethoxybenzene (TMB) was isolated from methanol extracts of <I>A. xanthioides</I>. TMB dose-dependently attenuated the degranulation of mast cells without cytotoxicity by inhibiting calcium influx. TMB decreased the expression of pro-inflammatory cytokines such as tumor necrosis factor-α and interleukin (IL)-4 at both the transcriptional and translational levels. Increased expression of these cytokines was caused by translocation of nuclear factor-κB into the nucleus, and it was hindered by suppressing activation of IκB kinase complex. To confirm the effect of TMB <I>in vivo</I>, the ovalbumin (OVA)-induced active systemic anaphylaxis (ASA) and IgE-mediated passive cutaneous anaphylaxis (PCA) models were used. In the ASA model, hypothermia was decreased by oral administration of TMB, which attenuated serum histamine, OVA-specific IgE, and IL-4 levels. Increased pigmentation of Evans blue was reduced by TMB in a dose-dependent manner in the PCA model. Our results suggest that TMB is a possible therapeutic candidate for allergic inflammatory diseases that acts through the inhibition of mast cell degranulation and expression of pro-inflammatory cytokines.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TMB reduced the degranulation of mast cells. </LI> <LI> TMB inhibited the production of pro-inflammatory cytokines. </LI> <LI> TMB suppressed both active and passive anaphylaxis. </LI> <LI> Anti-allergic inflammatory effects of TMB might be due to the blocking IKK complex. </LI> <LI> TMB might be a candidate for the treatment of allergic inflammatory diseases. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>