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Synthesis of Poly(isocyanic acid)[PICA] through a Precursor Polymer
Liou, Kwangkyoung 선문대학교 첨단과학기술연구소 1997 첨단과학기술연구소 논문집 Vol.2 No.-
PICA - poly(isotyanic acid)가 처음으로 합성되고 연구되었다. 이의 합성은 먼저 precursor 고분자인 Poly(alkoxymethyl isoryanate)를 합성하고 가수분해하여 얻게 되는데, 합성된 PICA는 흰색의 섬유상 물질로 실험한 모든 용매에 용해되지 않았다. 13C-MAS NMR 스펙트럼은 δ=151.01 ppm에서 하나의 peak을 갖고 IR 스펙트럼은 4개의 주 peak과 3개의 보조 peak을 갖는데 모두 아마이드나 우레아의 peak들로 설명된다. 이 고분자는 질소 분위기에서 200℃ 까지 안정하고 이 온도 이상에서는 cyanuric 혹은 cyanic acid로 분해가 일어난다. The first synthesis and characterization of poly(isocyanic acid([PICA] is reported. The preparation involves the hydrolysis of a precursor poly(alkoxy isocyanates). The material is a white, fibrous solid which is insoluble in all tested solvents. Its ^(13)C-MAS NMR spectrum shows a single resonance at 151.01 ppm and its IR spectrum shows only four major and three minor bands, all assignable to amide/urea modes of the backbone. The polymer is thermally stable under nitrogen gas to 200 ℃, where it "unzips" to cyanuric and cyanic acids.
Lithium Ion Polymer Electrolyte Based on Poly(ethylene oxide)와 Poly(vinyl chloride)
류광경 선문대학교 중소기업기술지원연구소 1997 선문공대 연구/기술 논문집 Vol.2 No.1
The level of awareness and actual implementation of integration and computerization in the construction industry is growing. However, it is not clear at this point how to assess the extent of their impact and to identify in which ways they better support the construction projects related to their success. The objectives of this research are the development of a model to evaluate the impact of integration and computerization on construction projects and the recommendation of guidelines for companies in identifying suitable ways for them to incorporate integration and computerization into their operation. The developed conceptual model has been found robust enough to be used as a benchmarking tool in evaluating the performance of the construction process and to strategize its future operation.
Homology Modeling and Docking Studies of Streptomyces peucetius CYP147F1 as Limonene Hydroxylase
( Bhattarai Saurabh ),( Kwangkyoung Liou ),( Tae Jin Oh ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.7
Homology modeling of Streptomyces peucetius CYP147F1 was constructed using three cytochrome P450 structures, CYP107L1, CYPVdh, and CYPeryF, as templates. The lowest energy SPCYP147F1 model was then assessed for stereochemical quality and side-chain environment by Accelrys Discovery Studio 3.1 software. Further activesite optimization of the SPCYP147F1 was performed by molecular dynamics to generate the final SPCYP147F1 model. The substrate limonene was then docked into the model. The model-limonene complex was used to validate the active-site architecture, and functionally important residues within the substrate recognition site were identified by subsequent characterization of the secondary structure. The docking of limonene suggested that SPCYP147F1 would have broad specificity with the ligand based on the two different orientations of limonene within the active site facing to the heme. Limonene with C7 facing the heme with distance of 3.4 A from the Fe was predominant.
Generation of sugar modified-doxorubicin from engineered strain of Streptomyces peucetius
Sailesh Malla,Kwangkyoung Liou,Kyung Sohng 한국당과학회 2008 한국당과학회 학술대회 Vol.2008 No.1
Combinatorial biosynthesis is an alternative way for accessing naturally unavailable natural products or improving activity of already existing biomolecules by their modification. Biosynthesis of different deoxy-aminosugar and its attachment to the same or different anthracyclinone aglycones in vivo would lead to the formation of novel anthracycline compounds. Unlike doxorubicin, anthracyclines with N-alkylated sugar moieties were weakly mutagenic or not mutagenic at all in both bacterial and mammalian cells. Disruption of glycosyltransferase gene, dnrS, involved in the biosynthesis of the doxorubicin from Streptomyces peucetius ATCC 27952 led to accumulation of a non-glycosylated intermediate ε-rhodomycinone. Complementation experiment was carried out to introduce L-rhodosamine sugar for the production of rhodosaminyl-doxorubicin. Chromosomal integration of desVI encoding N,N-dimethyltransferase from Streptomyces venezuelae and aknS encoding glycosyltransferase along with its auxiliary gene aknT from Streptomyces galilaeus in the dnrS disruptant of S. peucetius led to formation of rhodosaminyl-doxorubicin.