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Experimental and numerical verification of hydraulic displacement amplification damping system
Tracy Sau-Kwai Chung,Eddie Siu-Shu Lam,Bo Wu,You-Lin Xu 국제구조공학회 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.33 No.1
Hong Kong is now recognized as an area of moderate seismic hazard, but most of the buildings have been designed with no seismic provision. It is of great significance to develop effective and practical measures to retrofit existing buildings against moderate seismic attacks. Researches show that beam-column joints are critical structural elements to be retrofitted for seismic resistance for reinforced concrete frame structures. This paper explores the possibility of using a Hydraulic Displacement Amplification Damping System (HDADS), which can be easily installed at the exterior of beam-column joints, to prevent structural damage against moderate seismic attacks. A series of shaking table tests were carried out with a 1/3 prototype steel frame have been carried out to assess the performance of the HDADS. A Numerical model representing the HDADS is developed. It is also used in numerical simulation of the shaking table tests. The numerical model of the HDADS and the numerical simulation of the shaking table tests are verified by experimental results.
Mikhail Novikov,Kwai Lin Thong,Nur Izzurianna Mohd Zazali,Sharifah Bee Abd Hamid 한국섬유공학회 2018 Fibers and polymers Vol.19 No.3
The efficacy of antimicrobial treatment of cotton fabrics depends on various parameters of the coating process, such as the chemical nature and concentration of the antimicrobial agent, the composition of the crosslinking formulation, and the curing temperature. The inclusion complex of triclosan with β-cyclodextrin (βCD) was synthesized and characterized by FTIR, XRD, NMR, Raman, SEM, and TGA. The minimum inhibitory concentration and minimum bactericidal concentration of the complex against Klebsiella pneumoniae and Staphylococcus aureus were compared to those of its precursor. A multifactorial study included an evaluation of the effects of triclosan complexation with β-cyclodextrin, a comparison between the glyoxal and tetracarboxylic acid as crosslinkers, an investigation of the effect of crosslinker and catalyst concentrations, and a comparison of curing at 120 oC and 180 oC. The cotton was characterized by FTIR-ATR, the micrographs of treated samples were obtained by SEM and the weight add-on was calculated. The bactericidal properties were determined according to AATCC-147. The correlation between the coating process parameters and the antimicrobial efficacy was determined. The optimal combination leading to the highest weight add-on and the antimicrobial coating that was most durable to multiple detergent washes at an elevated temperature was the use of complexed triclosan grafted onto the cotton in the presence of tetracarboxylic acid, followed by curing at 180 oC. The curing temperatures were 120 oC (P=0.002) and 180 oC (P=0.008), catalysts were 1 % and 2 % aluminium sulfate and sodium hypophosphite (P<0.001), and the crosslinkers were 5 % and 10 % glyoxal and butanetetracarboxylic acid (P<0.001); these parameters significantly enhanced the antimicrobial properties of the treated fabrics. The study showed that βCD did not have antimicrobial activity, while the βCD/ triclosan-treated textile exhibited potential antimicrobial properties. Overall, the bactericidal activity of fabrics can be enhanced by using βCD/triclosan with 10 % butanetetracarboxylic acid as a cross-linker and 5 % sodium hypophosphite as a catalyst at a curing temperature of 180 oC.
Goot-Heah, Khor,Kwai-Lin, Thong,Froemming, Gabriele Ruth Anisah,Abraham, Mannil Thomas,Rosdy, Nik Mohd Mazuan Nik Mohd,Zain, Rosnah Binti Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Background: Oral cancer has become one of the most prevalent cancers worldwide and human Papillomavirus is one of the risk factors for developing oral cancer. For this study HPV18 was chosen as it is one of the high risk HPV types and may lead to carcinogenesis. However, prevalence of HPV18 infection in Oral Squamous Cell Carcinoma in Malaysia remains unclear. Objective: This study aimed to investigate the viral load of HPV18 DNA in OSCC and potentially malignant lesions using saliva samples. Materials and Methods: Genomic DNAs of thirty saliva samples of normal subjects and thirty saliva samples compromised of 16 samples from potentially malignant lesions and 14 of OSCC patients were amplified for HPV18 DNA using a nested polymerase chain reaction analysis. All PCR products were then analyzed using the Bioanalyzer to confirm presence of HPV18 DNA. Result: From thirty patients examined, only one of 30 (3.3%) cases was found to be positive for HPV18 in this study. Conclusion: The finding of this study revealed that there is a low viral detection of HPV18 in Malaysian OSCC by using saliva samples, suggesting that prevalence of HPV18 may not be important in this group of Malaysian OSCC.
Experimental and numerical verification of hydraulic displacement amplification damping system
Chung, Tracy Sau-Kwai,Lam, Eddie Siu-Shu,Wu, Bo,Xu, You-Lin Techno-Press 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.33 No.1
Hong Kong is now recognized as an area of moderate seismic hazard, but most of the buildings have been designed with no seismic provision. It is of great significance to develop effective and practical measures to retrofit existing buildings against moderate seismic attacks. Researches show that beam-column joints are critical structural elements to be retrofitted for seismic resistance for reinforced concrete frame structures. This paper explores the possibility of using a Hydraulic Displacement Amplification Damping System (HDADS), which can be easily installed at the exterior of beam-column joints, to prevent structural damage against moderate seismic attacks. A series of shaking table tests were carried out with a 1/3 prototype steel frame have been carried out to assess the performance of the HDADS. A Numerical model representing the HDADS is developed. It is also used in numerical simulation of the shaking table tests. The numerical model of the HDADS and the numerical simulation of the shaking table tests are verified by experimental results.
Screening of Differential Promoter Hypermethylated Genes in Primary Oral Squamous Cell Carcinoma
Khor, Goot Heah,Froemming, Gabrielle Ruth Anisah,Zain, Rosnah Binti,Abraham, Mannil Thomas,Thong, Kwai Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20
Background: Promoter hypermethylation leads to altered gene functions and may result in malignant cellular transformation. Thus, identification of biomarkers for hypermethylated genes could be useful for diagnosis, prognosis, and therapeutic treatment of oral squamous cell carcinoma (OSCC). Objectives: To screen hypermethylated genes with a microarray approach and to validate selected hypermethylated genes with the methylation-specific polymerase chain reaction (MSPCR). Materials and Methods: Genome-wide analysis of normal oral mucosa and OSCC tissues was conducted using the Illumina methylation microarray. The specified differential genes were selected and hypermethylation status was further verified with an independent cohort sample of OSCC samples. Candidate genes were screened using microarray assay and run by MSPCR analysis. Results: TP73, PIK3R5, and CELSR3 demonstrated high percentages of differential hypermethylation status. Conclusions: Our microarray screening and MSPCR approaches revealed that the signature candidates of differentially hypermethylated genes may possibly become potential biomarkers which would be useful for diagnostic, prognostic and therapeutic targets of OSCC in the near future.
Involvement of CELSR3 Hypermethylation in Primary Oral Squamous Cell Carcinoma
Khor, Goot Heah,Froemming, Gabrielle Ruth Anisah,Zain, Rosnah Binti,Abraham, Thomas Mannil,Lin, Thong Kwai Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.1
Background: Promoter hypermethylation is a frequent epigenetic mechanism for gene transcription repression in cancer and is one of the hallmarks of the disease. Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) contributes to cell contact-mediated communication. Dysregulation of promoter methylation has been reported in various cancers. Objectives: The objectives of this study were to investigate the CELSR3 hypermethylation level in oral squamous cell carcinomas (OSCCs) using methylation-sensitive high-resolution melting analysis (MS-HRM) and to correlate CELSR3 methylation with patient demographic and clinicopathological parameters. Materials and Methods: Frozen tissue samples of healthy subjects' normal mucosa and OSCCs were examined with regard to their methylation levels of the CELSR3 gene using MS-HRM. Results: MS-HRM analysis revealed a high methylation level of CELSR3 in 86% of OSCC cases. Significant correlations were found between CELSR3 quantitative methylation levels with patient ethnicity (P=0.005), age (P=0.024) and pathological stages (P=0.004). A moderate positive correlation between CELSR3 and patient age was also evident (R=0.444, P=0.001). Conclusions: CELSR3 promoter hypermethylation may be an important mechanism involved in oral carcinogenesis. It may thus be used as a biomarker in OSCC prognostication.