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      • SCOPUSKCI등재

        Myelomeningocele defect reconstruction with keystone flaps: vascular rationale for the design and operative technique

        Kushida-Contreras, Beatriz Hatsue,Gaxiola-Garcia, Miguel Angel Korean Society of Plastic and Reconstructive Surge 2021 Archives of Plastic Surgery Vol.48 No.3

        Background Myelomeningocele is a frequently seen condition at tertiary care hospitals. Its treatment involves a variety of plastic reconstructive techniques. Herein, we present a series of myelomeningocele patients treated using keystone flaps. Methods We gathered information regarding soft tissue reconstruction and the use of bilateral keystone flaps to treat myelomeningocele patients. We obtained data from clinical records and recorded the demographic characteristics of mothers and children with the condition. The size, level of defect, and complications detected during the follow-up were analyzed. Results A series of seven patients who underwent bilateral keystone flaps for myelomeningocele closure was analyzed. There were no cases of midline or major dehiscence, flap loss, necrosis, surgical site infections, or cerebrospinal fluid leakage. No revision procedures were performed. Minor complications included one case with minimal seroma and three cases with areas of peripheral dehiscence that healed easily using conventional measures. Conclusions The use of keystone flaps is an adequate option for closure of dorsal midline soft tissue defects related to myelomeningocele. This technique offers predictable results with an acceptable spectrum of complications. Robust blood flow can be predicted based upon anatomical knowledge.

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        Correlation between the Computed Tomography Values of the Screw Path and Pedicle Screw Pullout Strength: An Experimental Study in Porcine Vertebrae

        Ikeura Atsushi,Kushida Taketoshi,Oe Kenichi,Kotani Yoshihisa,Ando Muneharu,Adachi Takashi,Saito Takanori 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.3

        Study Design: Biomechanical study.Purpose: To assess the correlation between the computed tomography (CT) values of the pedicle screw path and screw pull-out strength.Overview of Literature: The correlation between pedicle screw pull-out strength and bone mineral density has been well established. In addition, several reports have demonstrated a correlation between bone mineral density and CT values. However, no previous biomechanical studies investigated the correlation between CT values and pedicle screw pull-out strength.Methods: Sixty fresh-frozen lumbar vertebrae from 6-month-old pigs were used. Before screw insertion, the CT values of the screw path were obtained for each sample. Specimens were then randomly divided into three equal groups. Each group had one of three pedicle screws inserted: 4.0-mm LEGACY (4.0-LEG), 4.5-mm LEGACY (4.5-LEG), or 4.5-mm SOLERA (4.5-SOL) (all from Medtronic Sofamor Danek Inc., Memphis, TN, USA). Each screw had a consistent 30-mm thread length. Axial pull-out testing was performed at a rate of 1.0 mm/min. Correlations between the CT values and pedicle screw pull-out strength were evaluated using Pearson’s correlation coefficient analysis.Results: The correlation coefficients between the CT values of the screw path and pedicle screw pull-out strength for the 4.0-LEG, 4.5-LEG, and 4.5-SOL groups were 0.836 (<i>p</i> <0.001), 0.780 (<i>p</i> <0.001), and 0.873 (<i>p</i> <0.001), respectively. Greater CT values were associated with greater screw pull-out strength.Conclusions: The CT values of the screw path were strongly positively correlated with pedicle screw pull-out strength, regardless of the screw type and diameter, suggesting that the CT values could be clinically useful for predicting pedicle screw pull-out strength.

      • KCI등재후보

        Choosing preferable labels for the Japanese translation of the Human Phenotype Ontology

        Ninomiya, Kota,Takatsuki, Terue,Kushida, Tatsuya,Yamamoto, Yasunori,Ogishima, Soichi Korea Genome Organization 2020 Genomics & informatics Vol.18 No.2

        The Human Phenotype Ontology (HPO) is the de facto standard ontology to describe human phenotypes in detail, and it is actively used, particularly in the field of rare disease diagnoses. For clinicians who are not fluent in English, the HPO has been translated into many languages, and there have been four initiatives to develop Japanese translations. At the Biomedical Linked Annotation Hackathon 6 (BLAH6), a rule-based approach was attempted to determine the preferable Japanese translation for each HPO term among the candidates developed by the four approaches. The relationship between the HPO and Mammalian Phenotype translations was also investigated, with the eventual goal of harmonizing the two translations to facilitate phenotype-based comparisons of species in Japanese through cross-species phenotype matching. In order to deal with the increase in the number of HPO terms and the need for manual curation, it would be useful to have a dictionary containing word-by-word correspondences and fixed translation phrases for English word order. These considerations seem applicable to HPO localization into other languages.

      • Force Control Strategy for Massage Chair Based on Masseur’s Knowhow Data Base

        Tatsuya Teramae,Daisuke Kushida,Fumiaki Takemori,Akira Kitamura 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7

        Recently, the massage chair is used by a lot of people because they were able to use it easily at home. However, a present massage chair only realizes the massage motion, and the physical condition of the user and the massage force is not considered. Then, the professional masseur’s massage process is that the physical condition of the patient is estimated, and the appropriate massage force is decided based on the estimated physical condition, and the decided massage force is realized. This paper proposes the method of applying masseur’s procedure for the massage chair. The realizability of the proposed method is verified by the experimental work using the massage chair.

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        Establishment and application of information resource of mutant mice in RIKEN BioResource Research Center

        Masuya Hiroshi,Usuda Daiki,Nakata Hatsumi,Yuhara Naomi,Kurihara Keiko,Namiki Yuri,Iwase Shigeru,Takada Toyoyuki,Tanaka Nobuhiko,Suzuki Kenta,Yamagata Yuki,Kobayashi Norio,Yoshiki Atsushi,Kushida Tatsu 한국실험동물학회 2021 Laboratory Animal Research Vol.37 No.1

        Online databases are crucial infrastructures to facilitate the wide effective and efficient use of mouse mutant resources in life sciences. The number and types of mouse resources have been rapidly growing due to the development of genetic modification technology with associated information of genomic sequence and phenotypes. Therefore, data integration technologies to improve the findability, accessibility, interoperability, and reusability of mouse strain data becomes essential for mouse strain repositories. In 2020, the RIKEN BioResource Research Center released an integrated database of bioresources including, experimental mouse strains, Arabidopsis thaliana as a laboratory plant, cell lines, microorganisms, and genetic materials using Resource Description Framework-related technologies. The integrated database shows multiple advanced features for the dissemination of bioresource information. The current version of our online catalog of mouse strains which functions as a part of the integrated database of bioresources is available from search bars on the page of the Center ( https://brc.riken.jp ) and the Experimental Animal Division ( https://mus.brc.riken.jp/ ) websites. The BioResource Research Center also released a genomic variation database of mouse strains established in Japan and Western Europe, MoG + ( https://molossinus.brc.riken.jp/mogplus/ ), and a database for phenotype-phenotype associations across the mouse phenome using data from the International Mouse Phenotyping Platform. In this review, we describe features of current version of databases related to mouse strain resources in RIKEN BioResource Research Center and discuss future views.

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