http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
NGL family PSD-95–interacting adhesion molecules regulate excitatory synapse formation
Kim, Seho,Burette, Alain,Chung, Hye Sun,Kwon, Seok-Kyu,Woo, Jooyeon,Lee, Hyun Woo,Kim, Karam,Kim, Hyun,Weinberg, Richard J,Kim, Eunjoon NATURE AMERICA 2006 NATURE NEUROSCIENCE Vol.9 No.10
Synaptic cell adhesion molecules (CAMs) regulate synapse formation through their trans-synaptic and heterophilic adhesion. Here we show that postsynaptic netrin-G ligand (NGL) CAMs associate with netrin-G CAMs in an isoform-specific manner and, through their cytosolic tail, with the abundant postsynaptic scaffold postsynaptic density–95 (PSD-95). Overexpression of NGL-2 in cultured rat neurons increased the number of PSD-95–positive dendritic protrusions. NGL-2 located on heterologous cells or beads induced functional presynaptic differentiation in contacting neurites. Direct aggregation of NGL-2 on the surface membrane of dendrites induced the clustering of excitatory postsynaptic proteins. Competitive inhibition by soluble NGL-2 reduced the number of excitatory synapses. NGL-2 knockdown reduced excitatory, but not inhibitory, synapse numbers and currents. These results suggest that NGL regulates the formation of excitatory synapses.
Park, Seho,Koo, Ja Seung,Kim, Gun Min,Sohn, Joohyuk,Kim, Seung Il,Cho, Young Up,Park, Byeong-Woo,Park, Vivian Youngjean,Yoon, Jung Hyun,Moon, Hee Jung,Kim, Min Jung,Kim, Eun-Kyung Korean Cancer Association 2018 Cancer Research and Treatment Vol.50 No.3
<P><B>Purpose</B></P><P>Sentinel lymph node biopsy (SLNB) can be performed when node-positive disease is converted to node-negative status after neoadjuvant chemotherapy (NCT). Tattooing nodes might improve accuracy but supportive data are limited. This study aimed to investigate the feasibility of charcoal tattooing metastatic axillary lymph node (ALN) at presentation followed by SLNB after NCT in breast cancers.</P><P><B>Materials and Methods</B></P><P>Twenty patientswith cytology-proven node metastases prospectively underwent charcoal tattooing at diagnosis. SLNB using dual tracers and axillary surgery after NCT were then performed. The detection rate of tattooed node and diagnostic performance of SLNB were analyzed.</P><P><B>Results</B></P><P>All patients underwent charcoal tattooingwithout significant morbidity. Sentinel and tattooed nodes could be detected during surgery after NCT. Nodal pathologic complete response was achieved in 10 patients. Overall sensitivity, false-negative rate (FNR), negative predictive value, and accuracy of hot/blue SLNB were 80.0%, 20.0%, 83.3%, and 90.0%, respectively. Retrieving more nodes and favorable nodal response were associated with improved performance. The best accuracy was observed when excised tattooed node was calculated together (FNR, 0.0%). Cold/non-blue tattooed nodes of five patients were removed during non-sentinel axillary surgery but clinicopathological parameters did not differ compared to patients with hot/blue tattooed node detected during SLNB, suggesting the importance of the tattooing procedure itself to improve performance.</P><P><B>Conclusion</B></P><P>Charcoal tattooing of cytology-confirmed metastatic ALN at presentation is technically feasible and does not limit SLNB after NCT. The tattooing procedure without additional preoperative localization is advantageous for improving the diagnostic performance of SLNB in this setting.</P>
VDA305-100 권고안에 따른 모델 기반 EPB SW 개발
김세호(Seho Kim),김영철(Yongchul Kim),김홍년(Hongnyeon Kim) 한국자동차공학회 2017 한국자동차공학회 학술대회 및 전시회 Vol.2017 No.11
본 논문은 VDA305-100 권고안에 준하여 차량 ESC EPB 통합 제어기를 위한 모델 베이스 SW개발 과정에서 SIMULINK의 자동 코드 생성 기능을 이용하여 검토되고 적용된 내용들을 그 범위로 한다.
김세호(SeHo Kim),김의찬(EuiChan Kim),김정민(JeongMin Kim),황송이(SongYi Hwang),송종화(JongHwa Song),이성진(SungJ in Lee) 한국디지털포렌식학회 2017 디지털 포렌식 연구 Vol.11 No.3
최근 애플의 맥 운영체제인 macOS 10.12 Sierra와 10.13 High Sierra는 기존의 볼륨 암호화 기법인 FileVault2 외에도 Unified Logging으로 불리는 새로운 로깅 시스템과 APFS 파일 시스템의 적용으로 인해 포렌식 분석이 더욱 어려워진 상황이다. 본 연구에서는 이러한 문제점들에 대응할 수 있는 방법으로 구동 중인 macOS에서 증거를 수집하고 분석할 수 있는 라이브 포렌식 분석 방법을 조사하였다. 또한 조사 결과를 바탕으로 macOS에서 동작하는 라이브 포렌식 분석 도구를 개발하여 이의 적용 가능성에 대해 제안한다. macOS 10.12 Sierra and 10.13 High Sierra, Apple"s Mac operating systems, have made forensic analysis more difficult because of the new logging system called Unified Logging and APFS file system in addition to FileVault2, which is the existing volume encryption technology. In this study, we investigated a live forensic analysis method that can collect and analyze evidence in running macOS as a way to cope with these problems. Based on the results of the research, we also developed a live forensic analysis tool that runs on macOS and propose its applicability.