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NGL family PSD-95–interacting adhesion molecules regulate excitatory synapse formation
Kim, Seho,Burette, Alain,Chung, Hye Sun,Kwon, Seok-Kyu,Woo, Jooyeon,Lee, Hyun Woo,Kim, Karam,Kim, Hyun,Weinberg, Richard J,Kim, Eunjoon NATURE AMERICA 2006 NATURE NEUROSCIENCE Vol.9 No.10
Synaptic cell adhesion molecules (CAMs) regulate synapse formation through their trans-synaptic and heterophilic adhesion. Here we show that postsynaptic netrin-G ligand (NGL) CAMs associate with netrin-G CAMs in an isoform-specific manner and, through their cytosolic tail, with the abundant postsynaptic scaffold postsynaptic density–95 (PSD-95). Overexpression of NGL-2 in cultured rat neurons increased the number of PSD-95–positive dendritic protrusions. NGL-2 located on heterologous cells or beads induced functional presynaptic differentiation in contacting neurites. Direct aggregation of NGL-2 on the surface membrane of dendrites induced the clustering of excitatory postsynaptic proteins. Competitive inhibition by soluble NGL-2 reduced the number of excitatory synapses. NGL-2 knockdown reduced excitatory, but not inhibitory, synapse numbers and currents. These results suggest that NGL regulates the formation of excitatory synapses.