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Protective effects of a novel herbal decoction on focal cerebral ischemia in a rodent model
Kim, Myung-Gyou,Choi, Jae-Hwan,Lim, Jong-Pil,Kim, Dae-Keun,Shin, Tae-Yong,Boo, Yungmin,Kim, Sun-Yeou,Kim, Hocheol,Ha, Eunyoung,Park, Hun-Kuk,Kim, Jeongseon,Lim, Ha-Sup,Kim, Ee-Hwa,Kim, Jeung-Beum,Leem Informa UK (TaylorFrancis) 2007 Neurological research Vol.29 No.suppl1
Lung Transplantation in Six Patients with Idiopathic Pulmonary Artery Hypertension
( Hyeonhwa Kim ),( Dongkwan Kim ),( Sehoon Choi ),( Geundong Lee ),( Dongkyu Oh ),( Hocheol Kim ),( Jaeseung Lee ),( Sungho Jung ),( Pilje Kang ),( Won Kim ),( Seungil Park ),( Sangbum Hong ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Idiopathic pulmonary artery hypertension (IPAH) is an incurable and invariably fatal disease. Lung transplantation is a useful therapeutic option in patients who are unresponsive to medical treatment; however, lung transplantation performed for pulmonary hypertension is associated with significantly high perioperative mortality rates. We report a case series of six patients who underwent lung transplantation for IPAH between October 2008 and June 2021. Patients’ median age was 28.5 years, and the study included 5 of 6 women (83%). Pre-transplantation hemodynamic parameters showed mean right atrial pressure of 12.0±7.1 mmHg and mean pulmonary artery pressure of 62.2±29.5 mmHg. Two of six patients received extracorporeal membrane oxygenation (ECMO) therapy as a bridge to transplantation over 14 and 17 days, and four patients underwent elective transplantation. Two patients required prolonged postoperative venoarterial (V-A) ECMO support. Grade 3 primary graft dysfunction occurred in one patient; however, the clinical course improved following prolonged V-A ECMO therapy. Five patients (83.3%) required intervention for postoperative bleeding control; one of these patients died of uncontrolled bleeding concomitant with disseminated intravascular coagulation, on the 14th postoperative day, and we observed no other perioperative deaths. One patient died of carbapenem-resistant Acinetobacter baumannii bacteremia, a year postoperatively. The 1-month, 6-month, and 1-year survival rates were 83.3%, 83.3%, and 66.7%, respectively. In view of the poor prognosis of IPAH, lung transplantation (1-year mortality rates <40%) merits consideration as a useful therapeutic option in this patient population. However, postoperative bleeding tends to occur in most patients; therefore, close monitoring is important during post-transplantation management.
Bu, Youngmin,Kwon, Sungeun,Kim, Yun Tai,Kim, Mi-Yeon,Choi, Hoyoung,Kim, Jae Goo,Jamarkattel-Pandit, Nirmala,Doré,, Sylvain,Kim, Sung-Hoon,Kim, Hocheol John Wiley Sons, Ltd. 2010 Phytotherapy research Vol.24 No.8
<P>HT008-1 is one of the prescriptions used in Traditional Korean Medicine for the treatment of mental and physical weakness. It is composed of Panax ginseng, Acanthopanax senticosus, Angelica sinensis and Scutellaria baicalensis, which have been reported to have various pharmacological effects on the central nervous system. The study investigated whether HT008-1 has neuroprotective effects in a focal cerebral ischemia rat model. Stroke was induced in rats by 2 h of middle cerebral artery occlusion (MCAo) followed by 22 h of reperfusion. HT008-1 (30, 100 and 300 mg/kg) and the component herbs (300 mg/kg) were administered orally twice at 0 and 2 h after ischemia. Oral administration of 300 mg/kg HT008-1 reduced brain infarction by 45.7%, prolonged the latency time by 24.8% in the rotarod test, and enhanced the score by 17.0% in the balance beam test. Only P. ginseng and S. baicalensis showed protective effects, and HT008-1 showed a greater effect than its component herbs. HT008-1 down-regulated the COX-2 and OX-42 expression in the penumbra region. In conclusion, the results show that HT008-1 may be effective in a rat stroke model by an antiinflammatory mechanism and may improve sensory-motor function by reducing damage in the cortex and caudoputamen. Copyright © 2010 John Wiley & Sons, Ltd.</P>
Epitaxial van der Waals Contacts between Transition-Metal Dichalcogenide Monolayer Polymorphs
Lee, Chang-Soo,Oh, Seung Jae,Heo, Hoseok,Seo, Seung-Young,Kim, Juho,Kim, Yong Hyeon,Kim, Donghwi,Ngome Okello, Odongo Francis,Shin, Hocheol,Sung, Ji Ho,Choi, Si-Young,Kim, Jun Sung,Kim, Jong Kyu,Jo, M American Chemical Society 2019 Nano letters Vol.19 No.3
<P>We have achieved heteroepitaxial stacking of a van der Waals (<I>vdW</I>) monolayer metal, 1T’-WTe<SUB>2</SUB>, and a semiconductor, 2H-WSe<SUB>2</SUB>, in which a distinctively low contact barrier was established across a clean epitaxial <I>vdW</I> gap. Our epitaxial 1T’-WTe<SUB>2</SUB> films were identified as a semimetal by low temperature transport and showed the robust breakdown current density of 5.0 × 10<SUP>7</SUP> A/cm<SUP>2</SUP>. In comparison with a series of planar metal contacts, our epitaxial <I>vdW</I> contact was identified to possess intrinsic Schottky barrier heights below 100 meV for both electron and hole injections, contributing to superior ambipolar field-effect transistor (FET) characteristics, i.e., higher FET mobilities and higher on-off current ratios at smaller threshold gate voltages. We discuss our observations around the critical roles of the epitaxial <I>vdW</I> heterointerfaces, such as incommensurate stacking sequences and absence of extrinsic interfacial defects that are inaccessible by other contact methods.</P> [FIG OMISSION]</BR>
Kim, Hocheol,Jo, Bok Yeon,Kim, Han Soon The Korean Society of Phycology 2017 ALGAE Vol.32 No.4
Microcystis aeruginosa causes harmful algal blooms in the Nakdong River of Korea. We studied the effect of different concentrations and ratios of ammonium ($NH_4{^+}$), nitrate ($NO_3{^-}$), and phosphate ($PO{_4}^{3-}$) on growth of this species in BG-11 medium: each nutrient alone, $NO_3{^-}:NH_4{^+}$ ratio, the N : P ratio with fixed total N (TN), and the N : P ratio with fixed total P (TP). The single nutrient experiments indicated that M. aeruginosa had the highest growth rate at $NH_4{^+}$ and $NO_3{^-}$ concentrations of $500{\mu}M$, and at a $PO{_4}^{3-}$ concentration of $5{\mu}M$. The $NO_3{^-}:NH_4{^+}$ ratio experiments showed that M. aeruginosa had the highest growth rate at a ratio of 1 : 1 when TN was $100{\mu}M$ and $250{\mu}M$, and the lowest growth rate at a ratio of 1 : 1 when the TN was $500{\mu}M$. The N : P ratio with fixed TN experiments indicated that M. aeruginosa had the highest growth rates at 50 : 1, 20 : 1, and 100 : 1 ratios when the TN was 100, 250, and $500{\mu}M$, respectively. In contrast, the N : P ratio with fixed TP experiments showed that M. aeruginosa had the highest growth rates at 200 : 1 ratio at all tested TP concentrations. In conclusion, our results imply that the $NO_3{^-}:NH_4{^+}$ ratio and the $PO{_4}^{3-}$ concentration affect the early stage of growth of M. aeruginosa. In particular, our results suggest that the maximum growth of M. aeruginosa is not simply affected by the $NO_3{^-}:NH_4{^+}$ ratio and the N : P ratio, but is determined by the TN concentration if a certain minimum $PO{_4}^{3-}$ concentration is present.
Correlation between gut microbiota and personality in adults: A cross-sectional study
Kim, Han-Na,Yun, Yeojun,Ryu, Seungho,Chang, Yoosoo,Kwon, Min-Jung,Cho, Juhee,Shin, Hocheol,Kim, Hyung-Lae Elsevier 2018 Brain, behavior, and immunity Vol.69 No.-
<P><B>Abstract</B></P> <P>Personality affects fundamental behavior patterns and has been related with health outcomes and mental disorders. Recent evidence has emerged supporting a relationship between the microbiota and behavior, referred to as brain-gut relationships. Here, we first report correlations between personality traits and gut microbiota. This research was performed using the Revised NEO Personality Inventory and the sequencing data of the 16S rRNA gene in 672 adults. The diversity and the composition of the human gut microbiota exhibited significant difference when stratified by personality traits. We found that personality traits were significantly correlated with diversity of gut microbiota, while their differences were extremely subtle. High neuroticism and low conscientiousness groups were correlated with high abundance of Gammaproteobacteria and Proteobacteria, respectively when covariates, including age, sex, BMI and nutrient intake, were controlled. Additionally, high conscientiousness group also showed increased abundance of some universal butyrate-producing bacteria including Lachnospiraceae. This study was of observational and cross-sectional design and our findings must be further validated through metagenomic or metatranscriptomic methodologies, or metabolomics-based analyses. Our findings will contribute to elucidating potential links between the gut microbiota and personality, and provide useful insights toward developing and testing personality- and microbiota-based interventions for promoting health.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Personality traits were correlated with gut microbiota composition. </LI> <LI> Gammaproteobacteria was increased in high neuroticism group. </LI> <LI> Low conscientiousness group showed increased abundance of Proteobacteria. </LI> <LI> The low conscientiousness group showed decreased abundance of Lachnospiraceae. </LI> </UL> </P>
Kim, Jinmo,Kim, Mi-Yeon,Leem, Kang-Hyun,Moon, Sangkwan,Jamakattel-Pandit, Nirmala,Choi, Hoyoung,Kim, Hocheol,Bu, Youngmin Taylor Francis Health Sciences 2010 NATURAL PRODUCT RESEARCH Vol.24 No.13
<P>Polygonum cuspidatum is a potent anti-oxidant herb that is well known for its various bioactivities. The current study investigates which compound group is most effective, to establish the key compound groups for quality assessment, especially in terms of neuroprotective effects. The roots of P. cuspidatum were extracted with 85% methanol and fractionated with hexane, ethyl acetate, n-butanol and water. Each fraction was applied to an in vitro radical scavenging assay, a lipid peroxidation assay in brain homogenates and an in vivo assay using a transient focal cerebra ischemia model induced by a middle cerebral artery occlusion in a Sprague-Dawley rat. The ethyl acetate fraction was the most effective fraction in both in vitro and in vivo assays, having the highest stilbene and anthraquinone contents. These results suggest that stilbenes and anthraquinones may be key compound groups for the quality assessment of the anti-oxidative and neuroprotective effects of P. cuspidatum.</P>
Mori Folium and Mori Fructus Mixture Attenuates High-Fat Diet-Induced Cognitive Deficits in Mice
Kim, Hyo Geun,Jeong, Hyun Uk,Park, Gunhyuk,Kim, Hocheol,Lim, Yunsook,Oh, Myung Sook Hindawi Publishing Corporation 2015 Evidence-based Complementary and Alternative Medic Vol.2015 No.-
<P>Obesity has become a global health problem, contributing to various diseases including diabetes, hypertension, cancer, and dementia. Increasing evidence suggests that obesity can also cause neuronal damage, long-term memory loss, and cognitive impairment. The leaves and the fruits of <I>Morus alba</I> L., containing active phytochemicals, have been shown to possess antiobesity and hypolipidemic properties. Thus, in the present study, we assessed their effects on cognitive functioning in mice fed a high-fat diet by performing immunohistochemistry, using antibodies against c-Fos, synaptophysin, and postsynaptic density protein 95 and a behavioral test. C57BL/6 mice fed a high-fat diet for 21 weeks exhibited increased body weight, but mice coadministered an optimized Mori Folium and Mori Fructus extract mixture (2 : 1; MFE) for the final 12 weeks exhibited significant body weight loss. Additionally, obese mice exhibited not only reduced neural activity, but also decreased presynaptic and postsynaptic activities, while MFE-treated mice exhibited recovery of these activities. Finally, cognitive deficits induced by the high-fat diet were recovered by cotreatment with MFE in the novel object recognition test. Our findings suggest that the antiobesity effects of MFE resulted in recovery of the cognitive deficits induced by the high-fat diet by regulation of neural and synaptic activities.</P>
Nitrogen dioxide increases the risk of mortality in patients with idiopathic pulmonary
( Hocheol Kim ),( Hee-young Yoon ),( Sun-young Kim ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Purpose: Ambient air pollution is associated with the incidence, survival, acute exacerbation, and lung function changes in patients with idiopathic pulmonary fibrosis (IPF). However, the effect of personal exposure to air pollutant are unknown. This study aimed to investigate the impacts of individual exposure to particulate matter with aerodynamic diameter ≤10 μm (PM10), and nitrogen dioxide (NO2) on mortality in IPF patients. Methods: Total 1114 patients (mean age: 65.7 years, male: 80.5%) who were diagnosed with IPF at Asan Medical Center between 1995 and 2016 were included in this study. Annual-average concentrations of PM10 and NO2 at the address of individual patients were predicted by a national-scaled exposure prediction model based on air pollution concentration from 294 regulatory monitoring sites in 2006. The prediction models was calibrated by clinical (age, sex, the year at diagnosis, body mass index, smoking status, lung function, treatment status) and geographic (percentage of the elderly, educational attainment, gross regional domestic product, total regional population, degree of urbanization) covariates using a Cox proportional hazard model. Results: Median follow-up period was 3.8 years and 765 patients (68.8%) died during follow-up. In a univariate model, PM10 and NO2 were not associated with mortality. However, when prediction model adjusted by clinical and geographic covariates was used, NO2 was significantly associated with the mortality (HR, 1.172 for 10 μg/m3; p=0.039) although PM10 was not (HR, 1.030 for 10 μg/m3; p=0.708). When IPF patients were classified by age (≥65 years vs. <65 years), NO2 levels were significant prognostic factor in the elders (HR, 1.344 for 10 μg/m3; p=0.001), but not in youngers (HR, 1.010 for 10 μg/m3; p=0.945). PM10 was not associated with the mortality in IPF patients regardless of age. Conclusions: Increased exposure of NO2 is associated with an increased risk of mortality in IPF patients, particularly for the elderly.