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P288 : The effect of PPARa activator containing moisturizer in patients with facial erythema
( Ye Seul Kim ),( Han Eul Lee ),( Gang Mo Lee ),( Je Min An ),( Young Lip Park ),( Moon Kyun Cho ),( Jong Kyung Youm ),( Sang Hoon Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Atopic dermatitis, seborrheic dermatitis, irritant or allergic contact dermatitis, rosacea, and acne are skin diseases that cause repeated facial erythema. Topical steroids are used to treat these dermatologic condition and long term use of topical steroids can cause complication such as skin atrophy, telangiectasia, and steroid induced acneiform eruption. PPARα is known to regulate keratinocyte differentiation and proliferation, and also participates in wound healing and skin inflammation. Objectives: This study is about the effect of PPARα activator containing moisturizers in patients with facial erythema by improving anti-inflammatory action and skin barrier function. Methods: 32 patients were included in this study and they were applied with PPARα activator containing moisturizers in one side of the face, and the other side with moisturizers not containing PPARα activator. They were applied twice a day two days a week and the study was double blinded, body-split study. The patients were checked of skin hydration, TEWL, and erythema the first day of hospital visit and 2 weeks after the study. Clinical photo analysis was done for checking erythema index and the result was assessed with doctor and patient survey. Results: Patients applied with PPARα activator containing moisturizer showed significant decrease of erythema measurement using mexameter, and decreased erythema index from photo analysis. No significant difference was noted in skin hydration and TEWL. Conclusion: We confirmed the effect and safety of PPARα activator containing moisturizers and anticipate it as a useful treatment for patients with facial erythema.
Rat Skin을 이용한 1064 nm Q-switched Nd:YAG 레이저, CO2 레이저, Er:YAG 레이저 조사 후 창상회복 과정에 대한조직학적 비교
김현조 ( Hyun Jo Kim ),이강모 ( Gang Mo Lee ),박영립 ( Young Lip Park ),이종석 ( Jong Suk Lee ),황규왕 ( Kyu Uang Whang ),이성열 ( Sung Yul Lee ) 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.4
Background: Laser therapy for various skin conditions is one of the most common procedures in dermatology. Recently, several articles described the use of 1064 nm Q-switched Nd:YAG lasers for the treatment of benign skinlesions. Such treatment is known to trigger its therapeutic effect through a photoacoustic effect and selectivephotothermolysis effect. However, only a limited number of articles have dealt with the theoretical base of thephotoacoustic effect of the 1064 nm Q-switched Nd:YAG laser. Objective: To compare the wound repair process and nonselective tissue heat damage induced by three differentlaser modalities: the CO2 laser, Er:YAG laser, and 1064 nm Q-switched Nd:YAG laser. Methods: We irradiated the skin of an albino rat (Sprague Dawleyⓡ, 200∼250 g) with CO2, Er:YAG, and 1064nm Q-switched Nd:YAG lasers. Skin biopsy specimens of the irradiated areas were collected on the first, fifth, andtenth day after laser exposure. For histologic analysis, the specimens were stained with the H&E, Verhoff-VanGieson, and Masson’s trichrome protocols. Results: Compared with other laser modalities, rat skin irradiated by the 1064 nm Q-switched Nd:YAG lasershowed the least amount of heat damage and the quickest tissue repair response to the damage. Conclusion: A 1064 nm Q-switched Nd:YAG laser with a photoacoustic effect capable of ablating the epidermisand dermis can be a proper treatment modality for the removal of benign skin lesions. The 1064 nm Q-switchedNd:YAG laser may be considered as an alternative treatment option for the treatment of benign skin lesions.
만성 B형 간염 환자에서 Pegylated 인터페론 알파2a 치료 중 발생한 원형 탈모
김예슬 ( Ye Seul Kim ),이강모 ( Gang Mo Lee ),배유인 ( You In Bae ),박영립 ( Young Lip Park ),이상훈 ( Sang Hoon Lee ) 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.1
Recent studies recommend pegylated interferon alpha2a as the first choice treatment for chronic hepatitis B, especially when the patient is negative for HBeAg. Pegylated interferon alpha is known to show variable side effects including skin symptoms, with alopecia as the most common dermatologic side effect experienced for 10% up to 36%. pcc) Most alopecia cases related to pegylated interferon alpha were presented with telogen effluvium pattern, but alopecia areata cases are reported rarely. In this case, typically localized alopecia areata was presented with pegylated interferon alpha2a treatment in hepatitis B patient, and the course of alopecia areata seemed to be related with administration and discontinuation of pegylated interferon alpha2a. (Korean J Dermatol 2014;52(1):40∼43)
배유인 ( You In Bae ),이강모 ( Gang Mo Lee ),김정은 ( Jung Eun Kim ),이상훈 ( Sang Hoon Lee ),이성열 ( Sung Yul Lee ),박영립 ( Young Lip Park ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.12
Vitiligo universalis is an uncommon variant that is rarely seen. Interestingly, vitiligo universalis often accompanies systemic diseases such as endocrinopathies. A 43-year-old man presented with whole body depigmentation and poliosis affecting most of his scalp and body hair. He had undergone a liver transplant 2 years ago due to liver cirrhosis from a chronic hepatitis B infection and has been treated for diabetes mellitus for several years. Histopathology showed no melanocytes and an absence of epidermal pigmentation on the skin. We herein report a rare case of vitiligo universalis associated with chronic viral hepatitis B. (Korean J Dermatol 2011;49(12):1107~ 1110)