http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The Model of the Spatial Database Construction for the Urban Flood Analysis based on the SWMM
Kiuk Kim,Hyunsuk Hwang,Dongho Jung,ShinIl Jeong,Changsoo Kim 한국멀티미디어학회 2009 한국멀티미디어학회 국제학술대회 Vol.2009 No.-
Recently, the damage caused by the inundation has been increased. Research of the prevention of disasters has studied in many fields such as hydrology and civil engineering. However, in the case of the research, the spatial areas of disasters aren't displayed and the history data isn't constructed. Therefore, we propose a spatial database model for the urban flood analysis based on the SWMM and disaster history data. The databases are used to generate the SWMM input data automatically and display dangerous areas of the flood on the digital hazard maps.
The Effect of STAT1 in Mouse Spermatozoa In Vitro
Ki-Uk Kim,Ki-jin Kwon,Kyu-Ho Kang,Won-Ki Pang,Sae-Han Kang,Dong-Ha Shin,Do-Yeal Ryu,Amena Khatun,Md Saidur Rahman,Myung-Geol Pang 한국동물생명공학회(구 한국동물번식학회) 2017 발생공학 국제심포지엄 및 학술대회 Vol.2017 No.10
Mammalian spermatozoa must undergo several physiological modifications both prior to in vivo and in vitro fertilization. These functional/physiological modifications of spermatozoa, called capacitation, are prerequisites for fertilization. Therefore, sperm proteins that modify the aforementioned events could regulate their function and fertilization competence. Signal transducer and activator of transcription 1 (STAT1) is a transcriptional protein reported to have a role in sperm capacitation. However, the function of STAT1 in spermatozoa has not yet been clarified. Therefore, Our study was designed to evaluate the role of the STAT1 using the specific inhibitor, fludarabine (Flu) in mouse spermatozoa. In this in vitro study, mouse spermatozoa were incubated for 30, 60, and 90 min accordingly to investigate the role of STAT1 on sperm capacitation. Our results revealed that the expression levels of STAT1 was significantly decreased at 90 min, perhaps as a consequence of sperm capacitation. Simultaneously, we treated mouse spermatozoa with different doses of a specific inhibitor of STAT1, fludarabine (150μM, 1500μM). Although our results showed that motility/motion kinematics, viability, and capacitation status have no significant difference following exposure to fludarabine, capacitation status tends to increase. Taken together, it is tempting to speculate that STAT1 could be associated with sperm capacitation. However, further studies are needed to discover the underlying mechanisms of STAT1 on sperm capacitation.
Treatments of infl ammatory bowel disease toward personalized medicine
Ki-Uk Kim,Jisu Kim,Wan-Hoon Kim,Hyeyoung Min,Chang Hwan Choi 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.3
Inflammatory bowel disease (IBD), includingulcerative colitis (UC) and Crohn’s disease (CD), is achronic infl ammatory disease characterized by intestinalinfl ammation and epithelial injury. For the treatment of IBD,5-aminosalicylic acids, corticosteroids, immunomodulators,and biologic agents targeting tumor necrosis factor (TNF)-α,α4β7-integrin, and interleukin (IL)-12/23 have been widelyused. Especially, anti-TNF-α antibodies are the fi rst biologicagents that presently remain at the forefront. However,10–30% of patients resist biologic agents, including anti-TNF-α agents (primary non-responder; PNR), and 20–50%of primary responders develop treatment resistance withinone year (secondary loss of response; SLR). Nonetheless,the etiologies of PNR and SLR are not clearly understood,and predictors of response to biologic agents are also notdefi ned yet. Numerous studies are being performed to discoverprediction markers of the response to biologic agents,and this review will introduce currently available therapeuticoptions for IBD, biologics under investigation, and recentstudies exploring various predictive factors related to PNRand SLR.
( Jungseopeom ),( Eunjungcho ),( Donghoonbaek ),( Kyungnamlee ),( Kyunghwashin ),( Mihyunkim ),( Kwanghalee ),( Kiukkim ),( Hyekyungpark ),( Yunsungkim ),( Soonkewpark ),( Seongheoncha ),( Minkilee ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.1
The survival of non-small cell lung cancer (NSCLC) patients with brain metastases is reported to be 3∼6 months even with aggressive treatment. Some patients have very short survival after aggressive treatment and reliable prognostic scoring systems for patients with cancer have a strong correlation with outcome, often supporting decision making and treatment recommendations. A total of one hundred twenty two NSCLC patients with brain metastases who received gamma knife radiosurgery (GKRS) were analyzed. Survival analysis was calculated in all patients for thirteen available prognostic factors and four prognostic scoring systems: score index for radiosurgery (SIR), recursive partitioning analysis (RPA), graded prognostic assessment (GPA), and basic score for brain metastases (BSBM). Results: Age, Karnofsky performance status, largest brain lesion volume, systemic chemotherapy, primary tumor control, and medication of epidermal growth factor receptor tyrosine kinase inhibitor were statistically independent prognostic factors for survival. A multivariate model of SIR and RPA identified significant differences between each group of scores. We found that three-tiered indices such as SIR and RPA are more useful than four-tiered scoring systems (GPA and BSBM). There is little value of RPA class III (most unfavorable group) for the same results of 6-month and 1-year survival rate. Thus, SIR is the most useful index to sort out patients with poorer prognosis. Further prospective trials should be performed to develop a new molecular- and gene-based prognostic index model.