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( Yoon Ho Ko ),( Myung Ah Lee ),( Yeong Seon Hong ),( Kyung Shik Lee ),( Hyun Jin Park ),( Ie Ryung Yoo ),( Yeon Sil Kim ),( Young Kyoon Kim ),( Keon Hyun Jo ),( Young Pil Wang ),( Kyo Young Lee ),( J 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.3
Background: Second-line chemotherapy offers advanced non-small cell lung cancer (NSCLC) patients a small, but significant increase in survival. Docetaxel is usually administered as a 3-week schedule, yet there is significant toxicity with this therapy. Therefore, a weekly schedule has been explored in several previous trials. In this retrospective study, we compared the efficacy and safety of a weekly schedule and a 3-week schedule of docetaxel monotherapy in a second-line setting. Methods: Docetaxel was administered as 75 mg/m2 on day 1 every 3 weeks or as 37.5 mg/m2 on day 1 and 8 every 3 weeks until disease progression or severe toxicity developed. Results: From October 2003 to March 2006, a total of 37 patients received docetaxel monotherapy and 36 patients could be evaluated. A total of 135 cycles were administered and then evaluated. The median overall survival was 13.3 months (95% confidence interval: 6.3~20.3) for the weekly schedule and 10.7 months (95% confidence interval: 8.3~13.0) for the 3-week schedule (p=0.41). The median time to progression was 3.0 months (95% confidence interval: 1. 9~4.0) and 2.8 months (95% confidence interval: 1.0~4.6), respectively (p=0.41). The response rate was 16.7% for the weekly schedule and 21.1% for the 3-week schedule. The major form of hematologic toxicity was grade 3-4 neutropenia (3-week: 38.9%, weekly: 9.5%). The non-hematologic toxicities were similar between the two schedules. There were no treatment-related deaths. Conclusions: A docetaxel weekly schedule was very tolerable and it had comparable activity to that of the 3-week docetaxel schedule. Considering the efficacy and tolerability, a docetaxel weekly schedule can be an alternative schedule for the standard treatment of NSCLC in a second-line setting.
Implementation of 100CMM Thermal Storage Combustion Oxidizer for VOCs Reduction
Dal-Hwan Yoon,Dal-Hwan Yoon,Beom-Soon Han,Tae-Yeung Lim,Eun-Chan Yang,Yeong-Woong Keon,Hyeon-Woo An,Chan-Ho Kim,Sung-Chan Kang,Min-Ki Jung,Jong-Geun Kim,Hwi-Chan Oh,Chan-Hyouk Jeon,Min-Su Jeon,A-Yeon 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11
The heat storage type combustion oxidation device is a system capable of treating VOCs (Volatile Organic Compounds) discharged to the atmosphere at 95% or more. Aromatic hydrocarbons such as benzene are strong carcinogenic substances that cause leukemia, central nervous disorder, and chromosomal abnormalities, and hydrochloride causes destruction of the ozone layer and global warming. This VOCs reduction technology is expected to reduce the number of harmful substances generated for many operating and working conditions. This paper implements a 100CMM Regenerative Thermal Oxidation (RTO) device to reduce air pollution in VOCs generating sites. The carbon-free system is evaluated by measuring the concentration of the VOCs emission gas according to the operating conditions of the production process, analyzing and measuring the THC (Total Hydro-carbons) concentration change. As a result, through the 100CMM RTO experiment, stable RTO driving, renewable energy measurement, and hydrocarbons and nitrogen oxides can be reduced.
노건철,장민규,제덕근,최윤식,정영득,Noh, Keon-Cheol,Jang, Min-Kyu,Je, Deok-Keun,Choi, Yoon-Sik,Jeong, Yeong-Deuk 한국금형공학회 2014 한국금형공학회지 Vol.8 No.1
Plastic products are producted more than 70% of total processes by the injection molding. The injection molding process has 4 processes such as filling, packing, cooling and ejecting. It spends most of times in the cooling process. Therefore, it is important to control the mold temperature in producing plastic products. The time and system of cooling affect the product's quality and productivity. Especially, cooling time has about 60% of total injection cycle time. Therefore, we can improve a productivity by shortening cooling time. This study shows comparative study about cooling efficiency of spiral channel and baffle and observed the variation of time to freeze of molding As the result of CAE experiments, cooling rate by spiral channel had faster than baffle and as freeze time was decreased. Results of this study will be used widely to design for cooling system of injection mold.
Yang, Seung Man,Park, Seung Bin,So, Jae Hyun,Yoon, Keon Yeong 한국화학공학회 1999 Korean Journal of Chemical Engineering Vol.16 No.2
In this research, porous inorganic membranes for hydrogen separation were prepared with α-alumina support by multi-step pore modification method. Porous inorganic membranes were made by three consecutive steps : sol-gel method, in-situ hydrolysis of tetraethylorthosilicate (TEOS) and soaking and vapor deposition (SVD) method. In order to enhance the hydrogen selectivity, we used nickel (Ni) and palladium (Pd) particles in the first and final pore modification steps. Although both nickel and palladium induced surface diffusion, palladium was shown more effective for hydrogen selective adsorption than nickel. This multi-step method preduced porous membranes with a moderate hydrogen selectivity and excellent hydrogen permeability at high temperature up to 773 K and at transmembrane pressure (ΔP) as high as 310 kPa The separation factor of hydrogen relative to nitrogen was maintained at about 7 even when the transmembrane pressure was 70 kPa, and the hydrogen permeability was still much higher than that of non-porous polymeric membranes. Furthermore, the distributions of nickel and palladium within the intermediate layer formed at the membrane cross-section were examined by scanning electron microscopy (SEM) and energy dispersive X-ray analysis.