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Kazunori Toyoda,Hiroshi Yamagami,Masatoshi Koga 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.3
Development of direct oral anticoagulants and their antidotes has led to the need to reconsider the eligibility of acute stroke patients who have been taking oral anticoagulants for intravenous thrombolysis. Officially authorized Japanese guidelines on this issue were revised twice at the time of approval for clinical use of direct oral anticoagulants and idarucizumab, a specific reversal agent for dabigatran. A unique recommendation in the latest Japanese clinical guides was that thrombolysis can be recommended if the time of the last dose of direct oral anticoagulants exceeds 4 hours and if commonly available anticoagulation markers are normal or subnormal, i.e., international normalized ratio of prothrombin time <1.7 and activated partial thromboplastin time <1.5 times the baseline value (≤40 seconds only as a guide). These criteria are partly supported by the findings of domestic multicenter and single-center surveys that symptomatic or asymptomatic intracranial hemorrhage following thrombolysis was rare under the conditions of the criteria. Even for dabigatran users, stroke thrombolysis can be considered without pretreatment by idarucizumab if patients meet the above criteria. If not, direct mechanical thrombectomy can be considered without pretreatment by idarucizumab or thrombolysis, and use of idarucizumab, followed immediately by thrombolysis, can be considered only when thrombectomy cannot be quickly performed. These clinical guides are practical and to some extent economical, but they have some limitations, including lack of corroborating information from sufficient numbers of relevant cases. The guides will be further modified based on the results of future research.
Yeonwon Kim,Kazunori Koga,Masaharu Shiratani 한국물리학회 2020 Current Applied Physics Vol.20 No.1
We investigated the effect of hydrogen dilution on the Si cluster volume fraction of hydrogenated amorphous films by varying the hydrogen dilution ratio at 0.5 Torr and compared it to that obtained at pure silane discharge at 0.3, 0.4, and 0.5 Torr. The correlation between the plasma emission characteristic, deposition rate, and cluster volume fraction in the hydrogen dilution plasma was described. The cluster volume fractions of films under hydrogen dilution conditions were similar to those of the pure silane but showed a higher deposition rate. The results suggest that under hydrogen dilution conditions, it is possible to maintain a higher deposition rate with a lower cluster incorporation rate.
Effect of Sulfur Doped TiO2 on Photovoltaic Properties of Dye-Sensitized Solar Cells
Hyunwoong Seo,남상훈,Naho Itagaki,Kazunori Koga,Masaharu Shiratani,부진효 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.4
In a dye-sensitized solar cell (DSC), a nano-porous semiconductor layerplays an important role in the performance. It determines open-circuitvoltage and it affects the dye adsorption capacity and charge transfer,which are closely associated with photocurrent and overall performance. TiO2 is the most proper material for nano-porous layer since the firstdevelopment of DSCs. This work focuses on the enhancement of TiO2by doping. Sulfur (S) doping enhances charge transfer and the photoconversionof TiO2. Therefore, the increase in photocurrent andefficiency is expected by S doping. S is doped into TiO2 by hydrolysismethod. The amount of S is varied and their photo-responses areverified. The most effective S doped TiO2 is applied to DSCs. Overallperformance of DSC is enhanced by the addition of S doped TiO2. Especially, the photocurrent is much increased by the improvement oncharge transfer, electron lifetime, and photo-conversion. The photovoltaicproperties of DSCs are investigated with various ratios of undoped and Sdoped TiO2. Finally, a DSC based on undoped and S doped TiO2 ratio of1:1 has the highest efficiency, better than that of a standard DSC basedon undoped TiO2.
Hiroya Sakaguchi,Toshitatsu Takao,Yoshitaka Takegawa,Yuki Koga,Kazunori Yamanaka,Masataka Sagata,Shinwa Tanaka,Yoshinori Morita,Takashi Toyonaga,Yuzo Kodama 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.1
Background/Aims: Application of polyglycolic acid (PGA) sheets using fibrin glue in post-endoscopic submucosal dissection (ESD)ulcers to prevent bleeding has been reported to be difficult with the conventional delivery method because of gravity. This studyassessed the usefulness of the envelope-based delivery system with and against gravity in living pigs. Methods: PGA sheets were applied on post-ESD ulcers with and against gravity six times each using the conventional and envelopemethods, respectively. The PGA sheet delivery time and the endoscopic and histological findings of the treated ulcer floors werecompared. Results: With gravity, the median PGA sheet application time was 1.00 (0.68–1.30) min/cm2 and 0.32 (0.18–0.52) min/cm2 with theconventional and envelope techniques (p=0.002), respectively, and against gravity, it was 1.20 (1.13–1.63) min/cm2 and 0.50 (0.39–0.58) min/cm2 (p=0.002), respectively. Against gravity, the endoscopic and histological findings revealed that the conventional grouphad insufficient fixation of the PGA sheets, but the envelope groups had sufficient fixation. The results with gravity were similarbetween the groups. Conclusions: The envelope method makes it possible to deliver PGA sheets to the stomach quickly and cover ulcers appropriatelyboth with and against gravity in living pigs.