Prognostic factors, failure patterns and survival analysis in patients with resectable oral squamous cell carcinoma of the tongue

Sharma, Kanika,Ahlawat, Parveen,Gairola, Munish,Tandon, Sarthak,Sachdeva, Nishtha,Sharief, Muhammed Ismail The Korean Society for Radiation Oncology 2019 Radiation Oncology Journal Vol.37 No.2

Purpose: There is sparse literature on treatment outcomes research on resectable oral tongue squamous cell carcinoma (OTSCC). The aim of this study was to measure the treatment outcomes, explore the failure patterns, and identify the potential clinicopathological prognostic factors affecting treatment outcomes for resectable OTSCC. Materials and Methods: It is a retrospective analysis of 202 patients with resectable OTSCC who underwent upfront primary surgical resection followed by adjuvant radiotherapy with or without concurrent chemotherapy if indicated. Results: The median follow-up was 35.2 months (range, 1.2 to 99.9 months). The median duration of locoregional control (LRC) was 84.9 months (95% confidence interval, 67.3-102.4). The 3- and 5-year LRC rate was 68.5% and 58.3%, respectively. Multivariate analysis showed that increasing pT stage, increasing pN stage, and the presence of extracapsular extension (ECE) were significantly associated with poorer LRC. The median duration of overall survival (OS) was not reached at the time of analysis. The 3- and 5-year OS rate was 70.5% and 66.6%, respectively. Multivariate analysis showed that increasing pT stage and the presence of ECE were significantly associated with a poorer OS. Conclusion: Locoregional failure remains the main cause of treatment failure in resectable OTSCC. There is scope to further improve prognosis considering modest LRC and OS. Pathological T-stage, N-stage, and ECE are strong prognostic factors. Further research is required to confirm whether adjuvant therapy adds to treatment outcomes in cases with lymphovascular invasion, perineural invasion, and depth of invasion, and help clinicians tailoring adjuvant therapy.

Prognostic factors, failure patterns and survival analysis in patients with resectable oral squamous cell carcinoma of the tongue

Kanika Sharma,Parveen Ahlawat,Munish Gairola,Sarthak Tandon,Nishtha Sachdeva,Muhammed Ismail Sharief 대한방사선종양학회 2019 Radiation Oncology Journal Vol.37 No.2

Purpose: There is sparse literature on treatment outcomes research on resectable oral tongue squamous cell carcinoma (OTSCC). The aim of this study was to measure the treatment outcomes, explore the failure patterns, and identify the potential clinicopathological prognostic factors affecting treatment outcomes for resectable OTSCC. Materials and Methods: It is a retrospective analysis of 202 patients with resectable OTSCC who underwent upfront primary surgical resection followed by adjuvant radiotherapy with or without concurrent chemotherapy if indicated. Results: The median follow-up was 35.2 months (range, 1.2 to 99.9 months). The median duration of locoregional control (LRC) was 84.9 months (95% confidence interval, 67.3–102.4). The 3- and 5-year LRC rate was 68.5% and 58.3%, respectively. Multivariate analysis showed that increasing pT stage, increasing pN stage, and the presence of extracapsular extension (ECE) were significantly associated with poorer LRC. The median duration of overall survival (OS) was not reached at the time of analysis. The 3- and 5-year OS rate was 70.5% and 66.6%, respectively. Multivariate analysis showed that increasing pT stage and the presence of ECE were significantly associated with a poorer OS. Conclusion: Locoregional failure remains the main cause of treatment failure in resectable OTSCC. There is scope to further improve prognosis considering modest LRC and OS. Pathological T-stage, N-stage, and ECE are strong prognostic factors. Further research is required to confirm whether adjuvant therapy adds to treatment outcomes in cases with lymphovascular invasion, perineural invasion, and depth of invasion, and help clinicians tailoring adjuvant therapy.

SUFFICIENT CONDITIONS FOR STARLIKENESS

RAVICHANDRAN, V.,SHARMA, KANIKA Korean Mathematical Society 2015 대한수학회지 Vol.52 No.4

We obtain the conditions on ${\beta}$ so that $1+{\beta}zp^{\prime}(z){\prec}1+4z/3+2z^2/3$ implies p(z) ${\prec}$ (2+z)/(2-z), $1+(1-{\alpha})z$, $(1+(1-2{\alpha})z)/(1-z)$, ($0{\leq}{\alpha}$<1), exp(z) or ${\sqrt{1+z}}$. Similar results are obtained by considering the expressions $1+{\beta}zp^{\prime}(z)/p(z)$, $1+{\beta}zp^{\prime}(z)/p^2(z)$ and $p(z)+{\beta}zp^{\prime}(z)/p(z)$. These results are applied to obtain sufficient conditions for normalized analytic function f to belong to various subclasses of starlike functions, or to satisfy the condition ${\mid}log(zf^{\prime}(z)/f(z)){\mid}$ < 1 or ${\mid}(zf^{\prime}(z)/f(z))^2-1{\mid}$ < 1 or zf'(z)/f(z) lying in the region bounded by the cardioid $(9x^2+9y^2-18x+5)^2-16(9x^2+9y^2-6x+1)=0$.

SUFFICIENT CONDITIONS FOR STARLIKENESS

V. Ravichandran,Kanika Sharma 대한수학회 2015 대한수학회지 Vol.52 No.4

We obtain the conditions on β so that 1+βzp′(z) ≺ 1+4z/3+ 2z2/3 implies p(z) ≺ (2+z)/(2−z), 1+(1−α)z, (1+(1−2α)z)/(1−z), (0 ≤ α < 1), exp(z) or √1 + z. Similar results are obtained by considering the expressions 1+βzp′(z)/p(z), 1+βzp′(z)/p2(z) and p(z)+βzp′(z)/p(z). These results are applied to obtain sufficient conditions for normalized analytic function f to belong to various subclasses of starlike functions, or to satisfy the condition | log(zf′(z)/f(z))| < 1 or |(zf′(z)/f(z))2 −1| < 1 or zf′(z)/f(z) lying in the region bounded by the cardioid (9x2 + 9y2 − 18x + 5)2 − 16(9x2 + 9y2 − 6x + 1) = 0.

Sinonasal teratocarcinosarcoma treated with surgery followed by volumetric modulated radiotherapy: a case report with review of literature

Sarthak Tandon,Munish Gairola,Parveen Ahlawat,Kanika Sharma,Soumitra Barik,Nishtha Sachdeva,Sunil Pasricha,Apeksha Shenoy 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.4

Surgical excision along with use of postoperative radiotherapy forms an integral management of sinonasal teratocarcinosarcoma (SNTCS). However, given the rarity of the tumor, no standardised guidelines, dose, technique and target delineation exist especially in the era of modern radiation delivery techniques. This is a case of 55-year-old male diagnosed as SNTCS treated with radical ethmoidectomy followed by volumetric modulated radiotherapy, showing good local control and acceptable toxicity profile.

RNAi-based transgene conferred extreme resistance to the geminivirus causing apical leaf curl disease in potato

Garima Tomar,S. K. Chakrabarti,Nitya Nanda Sharma,A. Jeevalatha,S. Sundaresha,Kanika Vyas,Wamik Azmi 한국식물생명공학회 2018 Plant biotechnology reports Vol.12 No.3

Potato apical leaf curl disease is an emerging geminiviral disease in tropics and subtropics. It was reported for the first time in the year 1999 in northern plains of India but quickly spread to almost all potato growing regions of the country largely due to prevalence of warmer weather during early crop growth, thereby favoring whitefly vector. The problem of apical leaf curl disease in India became more severe due to lack of seed indexing for this virus in conventional seed production scheme. Although it accounts for major yield loss, there is no conventional source of resistance available in potato against Tomato Leaf Curl New Delhi Virus-Potato (ToLCNDV-Potato) that causes this disease in potato. In the present study, we have investigated the potential use of RNAi for obtaining resistance against this DNA virus in potato. The replication-associated protein gene (AC1) of the virus was used to obtain pathogen-derived resistance. The AC1 gene was PCR amplified from field-infected potato leaves, cloned and sequenced (JN393309). It showed 93% sequence similarity with the AC1 gene of Tomato Leaf Curl Virus-New Delhi (TOLCV-NDe; DQ169056) virus. Transgenic plants encoding the AC1 gene in three different orientations, viz. sense, antisense and hairpin loop, were raised. Transgenic lines when challenge inoculated with ToLCNDV-Potato showed different levels of resistance for all three constructs. Transgene integration and copy number in selected transgenic lines were determined by qPCR and further confirmed by Southern blot analysis. Though a reduction in viral titer was observed in transgenic lines encoding either antisense or hairpin loop constructs of AC1 gene, the latter transgenics showed most significant results as shown by reduction in the level of symptom expression in glasshouse screening as well as real-time data of in vivo virus concentration. In fact, we obtained a few totally asymptomatic transgenic lines with hairpin loop strategy.

Sinonasal teratocarcinosarcoma treated with surgery followed by volumetric modulated radiotherapy: a case report with review of literature

Tandon, Sarthak,Gairola, Munish,Ahlawat, Parveen,Sharma, Kanika,Barik, Soumitra,Sachdeva, Nishtha,Pasricha, Sunil,Shenoy, Apeksha The Korean Society for Radiation Oncology 2018 Radiation Oncology Journal Vol.36 No.4

Surgical excision along with use of postoperative radiotherapy forms an integral management of sinonasal teratocarcinosarcoma (SNTCS). However, given the rarity of the tumor, no standardised guidelines, dose, technique and target delineation exist especially in the era of modern radiation delivery techniques. This is a case of 55-year-old male diagnosed as SNTCS treated with radical ethmoidectomy followed by volumetric modulated radiotherapy, showing good local control and acceptable toxicity profile.

Hair microscopy: an easy adjunct to diagnosis of systemic diseases in children

Bhattarai Dharmagat,Banday Aaqib Zaffar,Sadanand Rohit,Arora Kanika,Kaur Gurjit,Sharma Satish,Rawat Amit 한국현미경학회 2021 Applied microscopy Vol.51 No.1

Hair, having distinct stages of growth, is a dynamic component of the integumentary system. Nonetheless, derangement in its structure and growth pattern often provides vital clues for the diagnosis of systemic diseases. Assessment of the hair structure by various microscopy techniques is, hence, a valuable tool for the diagnosis of several systemic and cutaneous disorders. Systemic illnesses like Comel-Netherton syndrome, Griscelli syndrome, Chediak Higashi syndrome, and Menkes disease display pathognomonic findings on hair microscopy which, consequently, provide crucial evidence for disease diagnosis. With minimal training, light microscopy of the hair can easily be performed even by clinicians and other health care providers which can, thus, serve as a useful tool for disease diagnosis at the patient’s bedside. This is especially true for resource-constrained settings where access and availability of advanced investigations (like molecular diagnostics) is a major constraint. Despite its immense clinical utility and non-invasive nature, hair microscopy seems to be an underutilized diagnostic modality. Lack of awareness regarding the important findings on hair microscopy may be one of the crucial reasons for its underutilization. Herein, we, therefore, present a comprehensive overview of the available methods for hair microscopy and the pertinent findings that can be observed in various diseases.