http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Kang Mingming (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Mingming Qiu,Lei Wang,Xiaoyu Mu,Wei Yu,Kang Huang 한국자동차공학회 2024 International journal of automotive technology Vol.25 No.2
The energy effi ciency of intelligent networked connected electric vehicle (EV) is directly related to its velocity. Aiming atthe infl uence of real-time traffi c fl ow information on road speed interval, a two-layer speed planning method is proposed. The upper layer extracts the road speed interval according to the traffi c fl ow information, and based on cellular automata andconfi dence interval theory, traffi c information rules are introduced, and a road speed interval extraction method consideringtraffi c density information is established. The lower layer is used to obtain energy-optimal cruising velocity profi le. Takingthe road speed interval as the variable boundary constraint, a dynamic programming algorithm that changes the state quantityboundary in real time is designed, which realizes the effi cient acquisition of the energy-optimized velocity trajectory. To verify the eff ectiveness of proposed approach, the simulation model is formulated based on using collected real traffi cinformation. The simulation results demonstrate that, compared with the conventional constant speed cruising strategy anddynamic programming (DP) strategy based on road speed interval, the strategy proposed in this study not only improvesenergy effi ciency and reduces computing time signifi cantly, but also can predict the traffi c conditions ahead to avoid largefl uctuations in velocity. Besides, the biggest signifi cance of this study is the designed economic velocity planning algorithmbased on real-time traffi c density information improves the adaptability of intelligent networked connected EV controlstrategy to actual traffi c conditions, and extends the optimization dimension of eco-driving.
-
Nan Kang,Yinli Zhang,Shichao Guo,Ran Chen,Fangzhou Kong,Shuchun Wang,Mingming Yuan,Rongrong Chen,Danhua Shen,Jianliu Wang 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3
Purpose The unique chromosomal rearrangements of endometrial stromal sarcoma (ESS) make it possible to distinguish high-grade ESS (HGESS) and low-grade ESS (LGESS) from the molecular perspective. Analysis of ESS at the genomic and transcriptomic levels can help us achieve accurate diagnosis of ESS and provide potential therapy options for ESS patients.Materials and Methods A total of 36 ESS patients who conducted DNA- and/or RNA-based next-generation sequencing were retrospectively enrolled in this study. The molecular characteristics of ESS at genomic and transcriptomic levels, including mutational spectrum, fusion profiles, gene expression and pathway enrichment analysis and features about immune microenvironment were comprehensively explored.Results <i>TP53</i> and <i>DNMT3A</i> mutations were the most frequent mutations. The classical fusions frequently found in <i>HGESS</i> (<i>ZC3H7B-BCOR</i> and <i>NUTM2B-YWHAE</i>) and LGESS (<i>JAZF1-SUZ12</i>) were detected in our cohort. <i>CCND1</i> was significantly up-regulated in HGESS, while the expression of <i>GPER1</i> and <i>PGR</i> encoding estrogen receptor (ER) and progesterone receptor (PR) did not differ significantly between HGESS and LGESS. Actionable mutations enriched in homologous recombination repair, cell cycle, and phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathways were detected in 60% of HGESS patients. Genes with up-regulated expression in HGESS were significantly enriched in five immune-related pathways. Most HGESS patients (85.7%) had positive predictors of immunotherapy efficacy. Moreover, immune microenvironment analysis showed that HGESS had relatively high immune infiltration. The degree of immune infiltration in HGESS patients with <i>ZC3H7B-BCOR</i> fusion was relatively higher than that of those with <i>NUTM2B-YWHAE</i> fusion.Conclusion This study investigated the molecular characteristics of ESS patients at the genomic and transcriptomic levels and revealed the potentially high sensitivity of targeted therapy and immunotherapy in a subset of HGESS with specific molecular features, providing a basis for guiding decision-making of treatment and the design of future clinical trials on precision therapy.
-
Xu Xiaojing,Zhou Yijun,Wei Shanjun,Ren Dongtao,Yang Min,Bu Huahu,Kang Mingming,Wang Junli,Feng Jinchao 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.4
Superoxide dismutases (SODs) constitute the first line of cellular defense against oxidative stress in plants. SODs generally occur in three different forms with Cu/Zn, Fe, or Mn as prosthetic metals. We cloned the full-length cDNA of the Thellungiella halophila Cu/Zn-SOD gene ThCSD using degenerate RT-PCR and rapid amplification of cDNA ends (RACE). Sequence analysis indicated that the ThCSD gene (GenBank accession number EF405867) had an open reading frame of 456 bp. The deduced 152-amino acid polypeptide had a predicted molecular weight of 15.1 kDa, an estimated pI of 5.4, and a putative Cu/Zn-binding site. Recombinant ThCSD protein was expressed in Escherichia coli and assayed for SOD enzymatic activity in a native polyacrylamide gel. The SOD activity of ThCSD was inactivated by potassium cyanide and hydrogen peroxide but not by sodium azide, confirming that ThCSD is a Cu/Zn-SOD. Northern blotting demonstrated that ThCSD is expressed in roots, stems, and leaves. ThCSD mRNA levels increased by about 30-fold when plants were treated with sodium chloride (NaCl), abscisic acid (ABA), and indole-acetic acid (IAA) and by about 50-fold when treated with UVB light. These results indicate that ThCSD is involved in physiological pathways activated by a variety of environmental conditions.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
