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Ramírez-Patiño Ramiro,Figuera Luis Eduardo,Puebla-Pérez Ana María,Delgado-Saucedo Jorge Ivan,Legazpi-Macias María Magdalena,Mariaud-Schmidt Rocio Patricia,Ramos-Silva Adriana,Gutiérrez-Hurtado Itzae A 대한의학회 2013 Journal of Korean medical science Vol.28 No.11
The endothelial nitric oxide synthase (eNOS) gene plays an important role in several biological functions. Polymorphisms of the eNOS gene have been associated with cancer. It has been suggested that the VNTR 4 a/b polymorphism may affect the expression of eNOS and contributes to tumor promotion in the mammary gland. We examined the role of the eNOS4 a/b polymorphism by comparing the genotypes of 281 healthy Mexican women with the genotypes of 429 Mexican women with breast cancer (BC). The observed genotype frequencies for control and BC patients were 0.6% and 0.7% for a/a (polymorphic); 87% and 77% for a/a (wild type); and 12% and 22% for a/b respectively. We found that the odds ratio (OR) was 1.9, with a 95% confidence interval (95%CI) of 1.29-2.95, P=0.001 for genotypes a/a-a/b, b/c. The association was also evident when comparing the distribution of the a/a-a/b genotypes in patients with high levels of glutamate-oxaloacetate transaminase (SGOT) (OR, 1.93; 95% CI, 1.14-3.28; P=0.015); undergoing menopause with high levels of SGOT (OR, 2.0; 95% CI, 1.1-3.84); and with high levels of glutamic-pyruvic transaminase (SGPT) (OR, 3.5; 95% CI, 1.56-8.22). The genotypes a/a-a/b are associated with BC susceptibility in the analyzed samples from the Mexican population.
Adaptive Super Twisting Control of a Dual-rotor VTOL Flight System Under Model Uncertainties
Jorge M. Arizaga,Jose. R. Noriega,L. A. Garcia-Delgado,Herman Castaneda 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.6
This paper addresses an adaptive super twisting control for a dual-rotor flight system subject to uncertainties. The system can perform vertical take-off and landing, roll and yaw movements. The dynamical model is described under the Euler-Lagrange approach, where a characterization of the thrust and the torque of the rotors is included. However, uncertainties such as friction and unmodeled dynamics remain. To overcome these problems, a class of adaptive sliding mode control is designed, which is robust to bounded uncertainties and external perturbations, offers reduced chattering, and not overestimate the control gain. Furthermore, the closed-loop stability is analyzed. Finally, simulation and experimental validation, and a comparison versus other standard control approaches illustrate the feasibility and usefulness of the proposed controller.
María Eugenia Jaramillo-Flores,Herry Heriyati Permady,Ana Maria Puebla-Pérez,Eduardo Padilla,Eugenia del Carmen Lugo-Cervantes,Jorge Ivan Delgado-Saucedo,Eva Ramón-Gallegos 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.5
Ditaxis heterantha seeds are used as spices for flavoring and coloring food. Two new apocarotenoids derived from the seeds, heteranthin and ditaxin, were evaluated for their in vitro cytotoxic effects in murine lymphoma cells lines. Bioabsorption in mice and preventive and antitumor effects of the apocarotenoids were determined. Ditaxin and heteranthin showed cytotoxic effects in vitro against murine malignant cells and normal splenocyte cells. The 50% inhibitory concentration (IC_50) for ditaxin in splenocytes was 0.1825 mM; in L5178Y, the IC_50 was 0.1923 mM. The heteranthin IC_50 in splenocytes was 0.1325 mM; in L5178Y, the value was 0.3889 mM. The maximum ditaxin plasma concentration was found after 2 hours of administration (mean±standard deviation, 7.5±2.05 μg/mL). Oral administration of the D. heterantha extract (100 mg/kg per day) for 14 days after the L5178Y lymphoma cell implantation showed no significant effect compared with groups that were not pretreated. However, tumor inhibition in groups treated intraperitoneally before inoculation with the L5178Y cells showed a significant difference (P<.001) compared with the groups not pretreated.
Numerical and experimental modelization of the two-phase mixing in a small scale stirred vessel
Sylvana Varela,Manuel Martínez,Jorge A. Delgado,Cyril Godard,Daniel Curulla-Ferré,Jordi Pallares,Anton Vernet 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.60 No.-
The numerical prediction of mass transfer rates of gas components within the liquid phase in a stirred two-phase flow reactor is presented. Experiments have been conducted to determine the flow regime and the number and sizes of the bubbles formed under different conditions. The dynamic field of the two-phase flow was obtained through numerical simulations. Bubbles with the experimentally measured diameter were released from the free surface and tracked numerically to compute the particle Reynolds number, which is used to determine the mass transfer rates. The unbaffled reactor provides mass transfer rates 30% larger than the baffled reactor for the bubbly flow. Mass transfer rates drop about 65% when the emulsion is formed. Therefore, above the critical rotation rate at which the emulsion forms for the unbaffled reactor, the baffled configuration provides larger mass transfer rates. The results indicate that even for the most unfavorable case mass transfer is not the limiting step, as 90% of the equilibrium concentration is reached in 10 s.