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Park, Chulmin,Kwon, Eun-Young,Choi, Su-Mi,Cho, Sung-Yeon,Byun, Ji-Hyun,Park, Jung Yeon,Lee, Dong-Gun,Kang, Jin Han,Shin, Jinhwan,Kim, Hun TaylorFrancis 2017 Human vaccines & immunotherapeutics Vol.13 No.5
<P><B>ABSTRACT</B></P><P>Animal models facilitate evaluation of vaccine efficacy at relatively low cost. This study was a comparative evaluation of the immunogenicity and protective efficacy of a new 13-valent pneumococcal conjugate vaccine (PCV13) with a control vaccine in a mouse model.</P><P>After vaccination, anti-capsular antibody levels were evaluated by pneumococcal polysaccharide (PnP) enzyme-linked immunosorbent assay (ELISA) and opsonophagocytic killing assay (OPA). Also, mice were challenged intraperitoneally with 100-fold of the 50% lethal dose of <I>Streptococcus pneumoniae</I>.</P><P>The anti-capsular IgG levels against serotypes 1, 4, 7F, 14, 18C, 19A, and 19F were high (quartile 2 >1,600), while those against the other serotypes were low (Q2 ≤ 800). Also, the OPA titres were similar to those determined by PnP ELISA. Comparative analysis between new PCV13 and control vaccination group in a mouse model exhibited significant differences in serological immunity of a few serotypes and the range of anti-capsular IgG in the population. Challenge of wild-type or neutropenic mice with serotypes 3, 5, 6A, 6B, and 9V showed protective immunity despite of induced relatively low levels of anti-capsular antibodies. With comparison analysis, a mouse model should be adequate for evaluating serological efficacy and difference in the population level as preclinical trial.</P>
인증규정을 고려한 KLA-100항공기 고양력장치 최적화 설계
박진환(Jinhwan Park),Maxim Tyan,Nhu Van Nguyen,김상호(Sangho Kim),이재우(Jae-woo Lee) 한국항공우주학회 2013 韓國航空宇宙學會誌 Vol.41 No.8
고양력장치는 항공기의 이착륙 및 실속성능에 큰 영향을 미친다. 그러므로, 이 논문에서는 주어진 2차원 플랩 형상에 대하여 가장 최적화된 플랩 위치와 변위각을 얻는 슬롯티드플랩 설계 최적화 프로세스을 제안하였다. 플랩 변위각 및 Gap, Overlap을 양력을 증가시키는 주요 변수로 생각하였고, 정확한 해석결과를 위해 공력해석 소프트웨어로 ANSYS Fluent 13.0.0®을 사용하였다. 최적화된 형상은 SQP(Sequential Quadratic Programming) 알고리즘을 통해 도출됐으며, 최적화된 플랩과 함께 ADSP(Aircraft Design Synthesis Program) in-house 성능해석 코드를 사용하여 항공기의 성능을 시험하였고, 이착륙 거리, 실속속도 등의 성능변수들이 KAS-VLA 인증규정을 만족하는 결과를 얻었다. High-lift devices have a major influence on takeoff, landing and stall performance of an aircraft. Therefore, a slotted flap design optimization process is proposed in this paper to obtain the most effective flap configuration from supported 2D flap configuration. Flap deflection, Gap and Overlap are considered as main contributors to flap lift increment. ANSYS Fluent 13.0.0® is used as aerodynamic analysis software that provides accurate solution at given flight conditions. Optimum configuration is obtained by Sequential Quadratic Programing (SQP) algorithm. Performance of the aircraft with optimized flap is estimated using Aircraft Design Synthesis Program (ADSP), the in-house performance analysis code. Obtained parameters such as takeoff, landing distance and stall speed met KAS-VLA airworthiness requirements.