http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Maoliang Hu,Fei Wang,Bo Jiang,Huasheng Wang,Yile Liu,Zesheng Ji 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.6
Al–5Ti–1B grain refiner was successfully prepared with the reaction of Ti chips produced during machining and KBF4inpure aluminum melt. In order to illustrate the reaction mechanism of Ti chips, the effect of different feeding ways and reactiontimes of Ti chips on microstructure and refining performance of Al–5Ti–1B was systematically investigated by opticalmicroscope, scanning electron microscopy and X-ray diffractometer. The results show that, in three feeding ways, includingadding Ti chips firstly, adding KBF4firstly and adding both Ti chips and KBF4in the form of prefabricated blocks, the bestrefining performance of Al–5Ti–1B is the feeding way of using the prefabricated block. TiB2and TiAl3as effective heterogeneousnuclei are formed simultaneously around the Ti chips. The average grain size of pure aluminum is refined to about206.80 μm. The reaction time mainly affects the dissolution process of Ti chips and the average size of TiAl3. With the reactiontime from 60 min to 90 min and then to 120 min, the average size of TiAl3increases from 10.74 μm to 14.30 μm and thento 15.39 μm. During the dissolution process, Ti chips undergo a transition from a thermal isolation layer to a supersaturatedzone of Ti atoms. Based on the analysis of the dissolution process of Ti chips, the dissolution model is proposed. Al–5Ti–1B has the best refining performance at 90 min of the reaction time, which can refine pure aluminum to about 223.65 μm.
MMP1 rs1799750 Single Nucleotide Polymorphism and Lung Cancer Risk: A Meta-analysis
Hu, Jiang,Pan, Jun,Luo, Zhi-Guo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Background: Numerous studies have investigated the association of matrix metalloproteinase 1 (MMP1) rs1799750 single nucleotide polymorphism with lung cancer susceptibility, but the findings are inconsistent. Therefore, we performed a meta-analysis to comprehensively evaluate any possible association. Methods: We searched publications from MEDLINE, EMBASE and CNKI databases which assessed links between the MMP1 rs1799750 polymorphism and lung cancer risk. We calculated the pooled odds ratio (OR) and its 95% confidence interval (95%CI) using either fixed-effects or random-effects models. Results: The meta-analysis was based on 9 publications encompassing 4,823 cases and 4,298 controls. The overall results suggested there was a significant association between the MMP1 rs1799750 polymorphism and lung cancer risk (1G vs. 2G: OR = 0.83, 95%CI = 0.73-0.94; 1G1G vs. 2G2G: OR = 0.73, 95%CI = 0.59-0.92; 1G1G vs. 1G2G/2G2G: OR = 0.87, 95%CI = 0.79-0.97; 1G1G/1G2G vs. 2G2G: OR = 0.78, 95%CI = 0.64-0.95). In the subgroup analysis by ethnicity, the association was still obvious in Asians (all P values < 0.05), but there was no association in Caucasians (all P values > 0.05). Conclusions: The MMP1 rs1799750 polymorphism is associated with decreased lung cancer risk, and a race-specific effect may exist in this association.
Cytotoxic triterpene glycosides from the roots of Sanguisorba officinalis
Jiang Hu,Yan Song,Hui Li,Benshou Yang,Xia Mao,Yongmao Zhao,Xiaodong Shi 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Phytochemical investigation of the ethanolextract of the roots of Sanguisorba officinalis resulted inthe isolation of three new triterpene glycosides, 3b-[(a-Larabinopyranosyl)oxy]-19a,23-dihydroxyolean-12-en-28-oicacid 28-[6-O-acetyl-b-D-glucopyranosyl] ester (1),2a,3b,19a,23-tetrahydroxyurs-12-en-28-oic acid 28-[6-Oacetyl-b-D-glucopyranosyl] ester (2), and 3b-[(a-L-arabinopyranosyl)oxy]-19a-hydroxyurs-12,20(30)-dien-28-oicacid 28-[6-O-acetyl-b-D-glucopyranosyl] ester (3). All thetriterpene glycosides exhibited the significant cytotoxicpotential with low IC50 values (IC50\5.0 lM) against sixtumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCIH460,and BGC-823).
Chemical Components of Dendrobium polyanthum
Hu, Jiang-Miao,Zhao, You-Xing,Miao, Ze-Hong,Zhou, Jun Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.9
A new tetrahydroanthracene, 3,6,9-trihydroxy-3,4-dihydroanthracen-1(2H)-one (1), six phenolics, moscatilin (2), gigantol (3), batatasin (4), moscatin (5), 9,10-dihydromoscatin (6), 10-dihydrophenanthrene-2,4,7-triol (7), and a sesquiterpenoid, corchoionoside C (8), together with two sterols $\beta$-sitosterol (9) and daucosterol (10), were isolated from the stems of Dendrobium polyanthum. Compounds 1 and 2 were assessed for cytotoxic activity against two human tumor cell lines (A549 and HL-60).
Cytotoxic triterpenoids from Saussurea phyllocephala
Jiang Hu,Yan Song,Benshou Yang,Xiang Zuo,Xiao Mao,Xiaodong Shi 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.12
Three new triterpenoids, 11a-hydroxy-lup-20(29)-ene-3b-palmitate (1), 28-hydroxy-20-oxo-30-norlupane-3b-palmitate (2), and 1b,11a,28-tyrihydroxy oleana-9(11),12-dien-3b-palmitate (3), together with threeknown compounds were isolated from the 95 % EtOHextract of Saussurea phyllocephala. The structures of thenew compounds were elucidated on the basis of 1D and 2DNMR (COSY, HMQC, HMBC and NOESY) analyses. Allthe triterpenoids were in vitro evaluated for their cytotoxicactivities. Compound 1–3 exhibited the significant cytotoxicactivities with low IC50 values (IC50\4.0 lM)against six tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCI-H460 and BGC-823).
Four New Antioxidant Phenylpropanoid Glycosides from Microlepia pilosissima
Jiang Hu,Xiaodong Shi,Jiangang Chen 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.12
Four new phenylpropanoid glycosides, 9-O-[β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranosyl]-3,4-dimethoxy-cinnamic acid (1), 9-O-[β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranosyl]-4-methoxycinnamic acid (2), 9-O-α-L-rhamnopyranosyl-3,4-dimethoxy-cinnamic acid (3), and 9-O-[6-Oacetyl-β-D-glucopyranosyl]-4-methoxy-cinnamic acid (4), together with three known compounds 9-O-α-L-rhamnopyranosyl-4-hydroxy-cinnamic acid (5), 9-O-β-D-glucopyranosyl-4-methoxycinnamic acid (6), and 9-O-β-D-glucopyranosyl-3,4-dimethoxy-cinnamic acid (7) were isolated from the 70% EtOH extract of the dry fronds of Microlepia pilosissima. Their chemical structures were elucidated by spectroscopic analysis. Moreover, 1 and 2 exhibited comparable scavenging activities with (±)-α-tocopherol against DPPH radicals, while compounds 3-7 displayed moderate antioxidant activities.
Jiang, Hu-Lin,Kim, You-Kyoung,Lee, Sun-Mi,Park, Mi-Ran,Kim, Eun-Mi,Jin, Yong-Mei,Arote, Rohidas,Jeong, Hwan-Jeong,Song, Soo-Chang,Cho, Myung-Haing,Cho, Chong-Su 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.4
Hydrogels are widely used in drug delivery systems because they can control the release and thereby enhance the efficiency of locally delivered bioactive molecules such as therapeutic drugs, proteins, or genes. For gene delivery, localized release of plasmid DNA or polymer/DNA complexes can transfect cells and produce sustained protein production. We tested the galactosylated chitosan-graft-polyethylenimine (GC-g-PEI)/DNA complexes-loaded poly(organophosphazene) thermosensitive biodegradable hydrogel as a hepatocyte targeting gene delivery system. The poly(organophosphazene) hydrogel loaded with GC-g-PEI/DNA complexes showed low cytotoxicity and higher transfection efficiency than PEI/DNA complexes, as well as good hepatocyte specificity in vitro and in vivo. Our results indicate that poly(organophosphazene) hydrogels loaded with GC-g-PEI/DNA complexes may be a safe and efficient hepatocyte targeting gene delivery system.
Chemical Components of Dendrobium polyanthum
Jiang-Miao Hu,You-Xing Zhao,Ze-Hong Miao,Jun Zhou 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.9
A new tetrahydroanthracene, 3,6,9-trihydroxy-3,4-dihydroanthracen-1(2H)-one (1), six phenolics, moscatilin (2), gigantol (3), batatasin (4), moscatin (5), 9,10-dihydromoscatin (6), 10-dihydrophenanthrene-2,4,7-triol (7), and a sesquiterpenoid, corchoionoside C (8), together with two sterols β-sitosterol (9) and daucosterol (10), were isolated from the stems of Dendrobium polyanthum. Compounds 1 and 2 were assessed for cytotoxic activity against two human tumor cell lines (A549 and HL-60).
Alginate-Coated Thiolated Chitosan Microspheres for an Oral Drug Delivery System In Vitro
Jiang, Hu Lin,Arote, Rohidas B.,Quan, Ji Shan,Yoo, Mi Kyong,Kim, You Kyoung,Kim, In Yong,Hong, Zhong Shan,Lee, Hong Gu,Jin, Xun,Choi, Yun Jaie,Cho, Chong Su Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.342 No.-
<P>Thiolated polymers have been studied by many researchers because of the mucoadhesive properties of thiol group. Alginate is a natural and biocompatible polymer that has been widely used in drug delivery. In this study, thiolated chitosan microspheres (TCMs) were prepared by ionic gelation process with tripolyphosphate and then, the bovine growth hormone (BGH) was loaded as a model drug. Finally, the BGH-loaded TCMs (BTCMs) were coated with alginate to improve the stability in gastrointestinal (GI) track. The alginate-coated BTCMs (ABTCMs) were observed as spherical shapes. The average particle sizes of ABTCMs were 6.97±0.55 -m and the sizedistribution was shown uniformly. Release of BGH from ABTCMs was decreased by coating with alginate and increased rapidly with the change in medium pH from 1.2 to 7.4. Results indicate that the ABTCMs have a potential as a drug carrier for oral drug delivery.</P>