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- 저자 : Jiabing Wang (검색결과 4 건)
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Wang Jieqiong,Li Zegeng,Zheng Lili,Tong Jiabing,Wang Chuanbo 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-
Circular RNAs (circRNAs) have been reported to be related to the initiation and progression of chronic obstructive pulmonary disease (COPD) by affecting the function of human bronchial epithelial cells (HBECs). Here, we aimed to investigate the function and mechanism of circ_0006872 in regulating COPD process using cigarette smoke extract (CSE)-induced 16HBEC in vitro. The results showed that circ_0006872 was increased in smokers without or with COPD, especially in smokers with COPD. Also, its expression was dose-dependently up-regulated by CSE exposure in 16HBECs. Functionally, circ_0006872 knockdown dramatically attenuated CSE-evoked proliferation arrest, apoptosis, inflammatory response and oxidative stress in 16HBECs. Mechanistically, circ_0006872/miR-485-3p/cyclin-dependent kinase inhibitor 1B (CDKN1B) formed a competitive endogenous RNA (ceRNA) network. CDKN1B was increased and miR-485-3p was decreased in COPD patients and CSE-induced 16HBECs. MiR-485-3p overexpression or CDKN1B knockdown protected 16HBEC against CSE-induced 16HBEC injury mentioned above. Moreover, rescue experiments showed that circ_0006872 regulated CSE-induced 16HBEC injury via miR-485-3p/CDKN1B axis. Circ_0006872 silencing protected against CSE-induced bronchial epithelial cell injury via miR-485-3p/CDKN1B axis, suggesting the potential application of circ_0006872 in preventing cigarette smoke-induced COPD.
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Jiabing Wang,Linlang Zeng,Kun Yang Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.6
The printed circuit heat exchanger (PCHE) with airfoil fins has the benefits of high compactness, high efficiency and superior heat transfer performance. A novel multi-objective optimization approach is presented to design the airfoil fin PCHE in this paper. Three optimization design variables (the vertical number, the horizontal number and the staggered number) are obtained by means of dimensionless airfoil fin arrangement parameters. And the optimization objective is to maximize the Nusselt number (Nu) and minimize the Fanning friction factor (f). Firstly, in order to investigate the impact of design variables on the thermal-hydraulic performance, a parametric study via the design of experiments is proposed. Subsequently, the relationships between three optimization design variables and two objective functions (Nu and f) are characterized by an improved particle swarm optimization-backpropagation artificial neural network. Finally, a multi-objective optimization is used to construct the Pareto optimal front, in which the non-dominated sorting genetic algorithm II is used. The comprehensive performance is found to be the best when the airfoil fins are completely staggered arrangement. And the best compromise solution based on the TOPSIS method is identified as the optimal solution, which can achieve the requirement of high heat transfer performance and low flow resistance.
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Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer
Zehua Wang,Jianwen Gao,Jiabing Zhou,Haiou Liu,Congjian Xu 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.2
Objective: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP inhibitor, has an anti-tumor effect on high grade serous ovarian cancer, but its effects on cellular senescence have not been reported. This study intends to explore the role of olaparib in the regulation of senescence in ovarian cancer cells. Methods: The effects of olaparib on the senescence of ovarian cancer cells were detected by using the senescence-associated β-galactosidase (SA-β-Gal) and senescence-associated heterochromatin aggregation (SAHF). Quantitative real-time polymerase chain reaction was used to analyze the senescence-associated secretory phenotype (SASP). Cell cycle and apoptosis were detected by flow cytometry. The effect of olaparib on tumor growth was analyzed in a nude mouse xenograft transplantation model. Results: Long-term (6 days) treatment with olaparib (5 μM) significantly inhibited the growth of ovarian cancer cells, leading to arrest the cell cycle at G0/G1 phase, significant increase the number of positive SA-β-Gal stained cells and positive SAHF cells. The expression of P16 and retinoblastoma protein (p-RB) were significantly enhanced in SKOV3 cells under olaparib treated, meanwhile, the expression of P53 and p-RB were upregulated in A2780 cells. In OVCAR-3 cells, the expression of P53 was downregulated and p-RB was upregulated. Mice with SKOV3 xenograft transplantation was given olaparib (10 mg/kg/day) via abdominal cavity administration, the tumor volume was reduced (p<0.01). Conclusion: Continuous low dosage administration of olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer.
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Shuancang Yu,Xiaoyi Wang,Xiuyun Zhao,Deshuang Zhang,Yangjun Yu,Jiabing Xu,Fenglan Zhang 한국유전학회 2010 Genes & Genomics Vol.32 No.5
Pak‐choi (Brassica rapa L. ssp. chinensis Makino) is one of the most important vegetable, especially in southern China. Morphological traits of Pak‐choi vary widely, and the genetic basis of these variations is largely undescribed. In this study,we evaluated eighty Pak‐choi accessions for genetic diversity based on 29 morphological descriptors and 20 microsatellite (SSR) loci. Our data reveal a high level of diversity in this set of Pak‐choi accessions. Euclidean distance was used for cluster analysis. The UPGMA dendrogram grouped the Pakchoi accessions into five major clusters based on morphological characteristics. As expected, similar morphological characteristics grouped together in cluster branches. Further,population structure was explored to identify subpopulations based on allele frequency. Five groups were identified, and showed considerable correlation with the morphological clusters. Associations between SSR markers and agronomic traits were further investigated using a non‐parametric Kruskal–Wallis K‐test and six additional parametric models. Significant associations were found between 18 SSR loci and 28 morphological traits. This study provides evidence that marker‐trait associations can be validated in segregating populations and exploited through marker‐assisted selection.
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