http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ha Young‐Ran,Jeong Se‐Jin,Jang Chang‐Won,Chang Kyu‐Sik,Kim Hyun‐Woo,Cho Shin‐Hyoung,Lee Hee‐Il 한국곤충학회 2021 Entomological Research Vol.51 No.2
Mosquitoes have adapted to various environmental conditions. Symbionts with mosquitoes impact this adaptation in different environments. In the field, mosquitoes could get exposed to antibiotics during their developmental period, which could reduce or eliminate their symbiotic microbes. However, the side effects of the antibiotics on the ovary and reproductive physiology of the Asian tiger mosquito, Aedes albopictus remains unknown. In this study, we investigated the effects of tetracycline and combinations of rifampicin and tetracycline at environmentally acceptable levels on the reproductive physiology of ovaries in Ae. albopictus. Rifampicin and tetracycline in combination reduced the hatching rate and fertility of Ae. albopictus compared to the untreated control group. These antibiotics induced histopathological damage and reactive oxygen species production in the ovaries. The combination of antibiotics decreased the expression of surface protein of Wolbachia (WSP) in Ae. albopictus. Additionally, the expression of Toll like receptor 2 (TLR2) and Myd88 were triggered by the combinations. The findings demonstrate the detrimental effects of antibiotics, particularly combinations of rifampicin and tetracycline, on the reproductive capacity of Ae. albopictus females.
( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3
Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)
Lee Seoung-Kyun,Yoon Bo-Hyun,Kim Kyungmin,Jung Ha-Ran,Kang Hangoeunbi,Jeong Yuran,Yun Hyunju,Song Jye-Heon,Sea Young-Hwa,Park Suhee 대한우울조울병학회 2023 우울조울병 Vol.21 No.3
Background: This study aimed to examine the influence of the coronavirus disease pandemic 2019 (COVID-19) by comparing the incidences of depression, suicidal ideation, and suicidal attempts before and after the outbreak of the pandemic among community-dwelling older adults. Methods: In total, 9,784 older adults were recruited from 22 counties in Jeollanam-do between 2019 and 2022. Self-reported questionnaires, including sociodemographic factors, suicidal ideation, suicidal attempt, and Geriatric Depression Scale-Short Form Korean version, were used. Results: The proportion of the depression high-risk group tended to increase since the COVID-19 outbreak, increasing to 16.3%, 23.1%, and 25.7% in 2019, 2020, and 2021, respectively; however, decreased to 21.8% in 2022. The incidence of suicidal ideation showed a similar pattern. The incidence of suicidal attempts showed a different pattern, rising to 1.3% and 2.6% in 2019 and 2020, respectively and then falling to 1.1% and 0.8% in 2021 and 2022, respectively. Conclusion: This study examined community-dwelling older adults and their mental states during the COVID-19 pandemic, and found that the risk of depression among older adults increased 1.708-fold in 2020, 1.877-fold in 2021, and 1.599-fold in 2022 compared to that in 2019, the year before the pandemic. Similarly, the risk of suicidal ideation increased by 1.582-fold in 2020, 1.913-fold in 2021, and 1.623-fold in 2022 compared with 2019 data. As the pandemic extended, mental health states improved; however, not to prepandemic levels. Suggesting that older people need continued support to alleviate the negative effects of the COVID-19 pandemic.
Lee, SungGa,Oh, Hyun-Mee,Lim, Won-Bong,Choi, Eun-Ju,Park, Young-Na,Kim, Jeong-Ah,Choi, Ji-Young,Hong, Suk-Jin,Oh, Hee-Kyun,Son, Jong-Keun,Lee, Seung-Ho,Kim, Ok-joon,Choi, Hong-ran,Jun, Chang-Duk Lippincott Williams Wilkins, Inc. 2008 ANTICANCER DRUGS Vol.19 No.5
Glycyrrhiza uralensis (Leguminosae) has long been known as an antiinflammatory agent for gastric ulcers, arthritis, and rheumatism. The flavonoid glycyrol (GC) (10 μg/ml) isolated from G. uralensis dramatically inhibits phorbol ester (phorbol 12-myristate 13-acetate)-induced nuclear factor (NF)-&kgr;B-dependent transcriptional activity, as determined by luciferase reporter activity in human kidney epithelial 293T cells. To investigate global gene expression profiling in cells by GC, we performed high-density oligonucleotide microarrays. Our microarray analyses showed that GC inhibited phorbol ester-induced NF-&kgr;B-dependent transcriptional activity in inflammatory-related gene expression. RT-PCR analysis, based on microarray data, showed that NF-&kgr;B-dependent genes (such as CCL2, CCL7, CD44, and HSPB8 in addition to NF-&kgr;B itself) were significantly downregulated by GC. Treatment with GC (10 μg/ml) inhibited I-&kgr;B degradation induced by phorbol 12-myristate 13-acetate. The microarray data also suggested that GC induces gene expression to p53-dependent apoptosis through endonuclease G, instead of CAD/DFF and AIF/PDCD8, as a downstream-apoptosis factor in human kidney epithelial 293T tumor cells, and induces oncogenes with a suppressor role as an added function.
Analytical simulation of reversed cyclic lateral behaviors of an RC shear wall sub-assemblage
Lee, Han Seon,Jeong, Da Hun,Hwang, Kyung Ran TECHNO-PRESS 2012 COMPUTERS AND CONCRETE Vol.10 No.2
Experimental results of cyclic reversed lateral force test on a two-story reinforced concrete shear wall sub-assemblage are simulated analytically by using the PERFORM-3D program. A comparison of experimental and analytical results leads to the following conclusions: (1) "Shear Wall" and "General Wall" models with "Concrete shear" cannot simulate the pinching phenomena due to shear and show larger amounts of inelastic energy absorption than those in the experiment. (2) Modeling a story-height wall by using two or more "General Wall" elements with "Diagonal shear" in the vertical direction induces the phenomenon of swelling-out at the belly, leading to the erroneous simulation of shear behaviors. In application to tall building structures, it is recommended to use one element of "General Wall" with "Diagonal shear" for the full height of a story. (3) In the plastic hinge area, concrete deformations of analytical models overestimate elongation and underestimate shortening when compared with experimental results.
Ran, Weiguang,Noh, Hyeon Mi,Park, Sung Heum,Lee, Bo Ram,Kim, Jung Hwan,Jeong, Jung Hyun,Shi, Jinsheng Elsevier 2019 Materials research bulletin Vol.117 No.-
<P><B>Abstract</B></P> <P>Er<SUP>3+</SUP>-activated CdMoO<SUB>4</SUB> phosphors were prepared by a traditional high-temperature solid-state method. The crystal structure, photoluminescence (PL) characteristics and performance in non-contact thermometry of as-prepared phosphors were studied in detail. Benefiting from the 3D network structure of CdMoO<SUB>4</SUB> host, the desirable green emission of Er<SUP>3+</SUP>-based phosphors were observed. Especially, based on the thermally coupled energy levels, the obtained phosphors show enhanced emission intensity in high temperatures. When applied to the temperature sensor based on the fluorescence intensity ratio (FIR), the prepared CdMoO<SUB>4</SUB>:0.02Er<SUP>3+</SUP> phosphor show an excellent sensitivity (0.875% K<SUP>−1</SUP>) at 483 K. Therefore, it is demonstrated that the as-prepared Er<SUP>3+</SUP>-activated CdMoO<SUB>4</SUB> phosphors have a promising potential application in both solid-state lighting and non-contact thermometry.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Enhanced emission intensity in high temperatures has been achieved. </LI> <LI> Er<SUP>3+</SUP> doped CdMoO<SUB>4</SUB> phosphor has a potential application in solid-state lighting. </LI> <LI> High sensitivity indicates that CdMoO<SUB>4</SUB>: 0.02Er<SUP>3+</SUP> phosphor can be used in non-contact thermometer. </LI> <LI> Excellent water stability of Er<SUP>3+</SUP> doped CdMoO<SUB>4</SUB> can be used in a complex condition. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Woo Song,Im, Kyung-Ran,Park, Yong-Dae,Sung, Nack-Do,Jeong, Tae-Sook Pharmaceutical Society of Japan 2006 Biological & pharmaceutical bulletin Vol.29 No.2
<P>Acyl-CoA: cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Pentacyclic triterpenes, ursolic acid (1), oleanolic acid (2), and betulinic acid (3) were isolated from the methanol extracts of the leaves of <I>Lycopus lucidus</I> T<SMALL>URCZ</SMALL>. by bioassay-guided fractionation. The structures of compounds 1—3 were elucidated by their spectroscopic data analysis. Among them, betulinic acid (3) exhibited more potent human ACAT-1 and ACAT-2 inhibitory activities with IC<SUB>50</SUB> values of 16.2±0.6 and 28.8±1.3 μ<SMALL>M</SMALL>, respectively.</P>
Jeong, Byung-Chul,Lee, Yong-Soo,Park, Yun-Yong,Bae, In-Ho,Kim, Don-Kyu,Koo, Seung-Hoi,Choi, Hong-Ran,Kim, Sun-Hun,Franceschi, Renny T,Koh, Jeong-Tae,Choi, Hueng-Sik American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.21
<P>Estrogen receptor-related receptor gamma (ERRgamma/ERR3/NR3B3) is a member of the orphan nuclear receptor with important functions in development and homeostasis. Recently it has been reported that ERRalpha is involved in osteoblast differentiation and bone formation. In the present study we examined the role of ERRgamma in osteoblast differentiation. Here, we showed that ERRgamma is expressed in osteoblast progenitors and primary osteoblasts, and its expression is increased temporarily by BMP2. Overexpression of ERRgamma reduced BMP2-induced alkaline phosphatase activity and osteocalcin production as well as calcified nodule formation, whereas inhibition of ERRgamma expression significantly enhanced BMP2-induced osteogenic differentiation and mineralization, suggesting that endogenous ERRgamma plays an important role in osteoblast differentiation. In addition, ERRgamma significantly repressed Runx2 transactivity on osteocalcin and bone sialoprotein promoters. We also observed that ERRgamma physically interacts with Runx2 in vitro and in vivo and competes with p300 to repress Runx2 transactivity. Notably, intramuscular injection of ERRgamma strongly inhibited BMP2-induced ectopic bone formation in a dose-dependent manner. Taken together, these results suggest that ERRgamma is a novel negative regulator of osteoblast differentiation and bone formation via its regulation of Runx2 transactivity.</P>