Eosinophils Regulate Type 2 Immune Responses Following Infection with the Nematode Trichinella spiralis

Jayoung Koo Koo,YunJae Jung 대한바이러스학회 2016 Journal of Bacteriology and Virology Vol.46 No.4

Eosinophils Regulate Type 2 Immune Responses Following Infection with the Nematode Trichinella spiralis

Koo, Jayoung Koo,Jung, YunJae 대한미생물학회 2016 Journal of Bacteriology and Virology Vol.46 No.4

Eosinophils are multifunctional leukocytes implicated in protection against helminth infections. Although eosinophils comprise between 1~5% of peripheral blood leukocytes, they primarily reside in the gastrointestinal tract under homeostatic conditions, and rapidly proliferate upon parasitic infection. Intestinal infection with Trichinella spiralis (T. spiralis) induces eosinophilia when the parasite enters the larval stages and larvae finally migrate to the skeletal muscle. Eosinophils are known to mediate parasite death through antibody-dependent cellular cytotoxicity. In this study, we aimed to address the functional significance of eosinophils in the intestinal phase of T. spiralis infection by analysis of immune responses in the Peyer's patch (PP) of infected BALB/c and eosinophil-ablated ${\Delta}dblGATA$ mice. Trafficking of eosinophils to the PP was significantly increased, with upregulation of interleukin-5 at 14 days post infection. Eosinophil deficiency led to a significant augmentation of serum immunoglobulin (Ig) M and IgG1 antibody levels. In accordance with this, $IgG1^+$ B cells in the PP were substantially increased in ${\Delta}dblGATA$ mice compared to that in BALB/c mice. Transforming growth $factor-{\beta}$ expression in the PP of infected ${\Delta}dblGATA$ mice was significantly decreased compared to that in BALB/c mice, whereas the number of T. spiralis larvae in the diaphragm was increased. Taken together, these findings indicate that eosinophils contribute to the regulation of Th2 immune responses, and protect the host from T. spiralis attempting to establish larvae in the skeletal muscle.

자운지구 유역의 강우계급별 부유물질 저감 효과 분석

구자영 ( Jayoung Koo ),이서로 ( Seoro Lee ),최유진 ( Yujin Choi ),양동석 ( Dongseok Yang ),성윤수 ( Yunsoo Sung ),임경재 ( Kyoungjae Lim ) 한국농공학회 2017 한국농공학회 학술대회초록집 Vol.2017 No.-

우리나라 고랭지 밭의 63.4%를 차지하고 있는 강원도 고랭지 밭은 47.7%가 강우시 다량의 토양과 양분이 유실되기 쉬운 15%이상의 급경사지에 분포되어 있다. 더욱이 하천의 최상류에 위치한 강원도 고랭지 밭에서 유실되는 토양은 하류 하천에 도달하기까지 체류시간이 긴 특성을 지니고 있어 탁수 및 부영양화의 장기화를 야기한다. 환경부에서는 탁수와 유실되는 토양을 제어하기 위하여 2007년 5월 소양호, 도암호, 임하호 유역에 대해 수질환경보전법에 따라 비점오염관리지역으로 지정하였다. 이후 소양호 유역은 다양한 탁수저감사업, 흙탕물저감사업 등 다양한 비점오염원 저감사업 기반의 지속적인 관리를 통해 2014년 12월 비점오염원관리지역에서 해제되었으나, 소양호 상류지역의 흙탕물 발생과 비점오염원의 배출은 기대만큼 저감되지 않아 2015년 10월 소양호 상류지역 중 만대지구, 가아지구, 자운지구에 대하여 비점오염원관리지역으로 재지정되었다. 이에 본 연구의 목적은 소양호 상류지역의 비점오염관리지역 중 하나인 자운지구를 대상으로 비점오염원 저감사업에 따른 비점오염 저감효과가 유역단위에서 어느정도인지 분석하는데 있다. 본 연구에서는 자운지구에 대하여 2010년과 2014년에 모니터링한 자료를 활용하였으며, 강수량의 차이에서 발생하는 불확실성을 완화하고자 10 mm 미만, 10 mm 이상∼30 mm 미만, 30 mm 이상∼50 mm 미만, 50 mm 이상의 강우계급별로 나누어 부유물질을 비교 분석하였다. 그 결과 자운지구 유역의 부유물질 저감 효과는 68.3∼82.4%로 나타났다. 비점오염원 저감효과는 장기간에 거쳐 서서히 나타나는 것으로 미루어 볼 때 시간이 경과함에 따라 더욱 증가할 것으로 예상된다. 그러나 비점오염원이 어떠한 경향으로 어느 정도까지 줄어들지는 미지수이므로, 지속적인 모니터링 사업을 통해 최적관리기법 도입에 따른 저감효과를 장기적으로 조사할 필요가 있다.

Open Source GIS를 활용한 QAPEX 분석 시스템 개발

구자영 ( Jayoung Koo ),정재학 ( Jaehak Jeong ),양동석 ( Dongseok Yang ),최순군 ( Soonkun Choi ),임경재 ( Kyoungjae Lim ) 한국농공학회 2018 한국농공학회 학술대회초록집 Vol.2018 No.-

Agricultural Policy/Environmental eXtender(APEX) 모델은 다양한 영농활동을 반영할 수 있어 최적관리기법 평가 적용 모형으로 분류되는 모델이다. APEX 모델에 대한 대표적인 사용자 인터페이스 개발 모델에는 윈도우 기반의 WinAPEX이 있으며, 이 후 ArcAPEX, i_APEX 등 다양한 형태로 개선되어왔다. 그러나 ArcGIS 소프트웨어에서 구동되는 ArcAPEX 인터페이스는 유료의 라이센스를 필요로 하여 폭넓은 활용에는 한계가 있다. 이에 본 연구의 목적은 오픈 소스 기반의 GIS 소프트웨어와 APEX 모델을 연계하여 APEX 모델의 새로운 인터페이스인 QAPEX 분석 시스템을 개발하는 데 있다. QAPEX 분석 시스템은 오픈 소스 기반의 GIS인 Quantum GIS(QGIS) 소프트웨어를 기반으로 개발되어 다양한 GIS 기능을 제공하며 활용할 수 있다. 본 연구에서 개발된 QAPEX 분석 시스템의 인터페이스에서는 ArcAPEX 인터페이스와 유사한 기능을 제공하고 있으며, 유역의 세분화 과정은 ArcAPEX 인터페이스보다 세분화되어 정밀한 수문 및 수질 모의가 가능하도록 하였다. 또한 최적관리기법의 적용이 가능한 인터페이스 기능이 추가되어 있으며, 유황곡선 및 오염부하지속곡선과 같이 시각적으로 모의 결과를 해석할 수 있는 기능이 추가되었다. 따라서 QAPEX 분석 시스템은 오픈 소스 기반으로 모델 확장성이 우수하며, 향후 최적관리기법 적용에 따른 비점오염물질의 저감 효과를 분석하는 등 비점오염원 관리를 위한 국가 정책자료를 도출하는 데 유용한 도구로 활용 될 것으로 기대된다.

ANTECEDENTS OF PART-TIME SALES ASSOCIATES TURNOVER INTENTION IN APPAREL RETAILING

Mijeong Noh,Kim K. P. Johnson,Jayoung Koo 글로벌지식마케팅경영학회 2015 Global Fashion Management Conference Vol.2015 No.06

Our research focused on the development of a conceptual model of the turnover intention of part-time sales associates working in apparel retailing to enhance understanding of the issue and thus, provide information to apparel retailers to curtail the loss of human resources. The model consists of input variables and outcomes. Input variables were personal characteristics, work engagement, and work effort. Outcome variables were job performance, job satisfaction, burnout, and employee turnover. A convenience sample of 294 part-time workers completed an online questionnaire. Structural equation modeling was used to test hypotheses regarding antecedents to turnover intention. This study revealed that self-efficacy and work competencies indirectly influenced intention to turnover because they influenced work engagement, which in turn positively affected work effort. Work effort and work engagement directly influenced job performance, which in turn impacted job satisfaction. The data also indicated a negative relationship between job satisfaction and burnout. Burnout had a direct influence on turnover intention. As a research limitation, our data came from a purposive sample. A random sample of part-time associates is needed to generalize findings. This study provides numerous implications for future research with regard to additional variables impacting work effort, work engagement, job satisfaction, and turnover intention.

연속간행물 관리에 적용되는 업무조직구조의 유형

구자영 韓國圖書館學會 1985 圖書館學 Vol.12 No.1

The present study aims at identifying the nature of the organizational patterns for serial management and thus providing an assistance for decision-making in regards to how the serials in an individual library be processed. The premise of the paper is that effective management is ensued from adopting proper organizational arrangement. In the first part, attempts are made to bring to the force the problems inherent in serial management and the efforts made for possible solutions. The main portion of the paper eximines the two outstanding patterns; namely, the decentralized arrangement patterned after the traditional functions of a library and the centralized one integrating such functions as acquisition, cataloging and information service. Both are examined in light of nature, development, applicability, strengths and weeknesses. Automation is viewed as a strong force for a change in organizing serial work as it has already brought about organizational change in some large libraries. The general conclusion is that a large collection(5,000 active titles or more) has much to benefit from a separate, specialized department which integrates the related functions; and the smaller collection can be effectively treated like the rest of the library materials, assigning a specific unit responsible for serial work and promoting an informal communication activities which would bring about coordination and cooperation for the free flow of serial work

연구개발을 지원하는 정보 선별 전략: 정보분석센터개념의 현실적 적용

구자영 韓國圖書館學會 1987 圖書館學 Vol.13 No.1

The present study aims at figuring out the potential benefits occured from the practical applications of the information analysis center concept in Korea. The R&D requirements in Korea at the moment is such that the highly specialized and sophisticated information services are essential. With the general information infrastructure still embryonic the best possible answer is sought in a specialized tried-out method, namely, the information analysis center which is to be planned and serviced as an integral part of a specific research project. The article examines the information exchange activities of scientists; the backgrounds of the development of the information analysis center concept into "a technical institute"; the processess of information analyses and evaluations; the effects and values of an analysis center; and the applicabilities of the information analysis center concept with a special regard to the developing country's needs. The conclusion confirms of the potential benefits of the information analysis center type facilities for the current needs of the Korean research and development environments

한국에 관한 사회과학연구:한국학연구를 위한 문헌고찰

구자영 韓國圖書館學會 1975 圖書館學 Vol.4 No.1

The present study is a literature survey aimed at providing a means to improve the bibliographic apparatuses for Korean studies. The need for a study like this has proven urgent with the promotion of Korean studies both within and without in recent years. The study examines the social science literature on Korea produced in English between 1876 and 1945(A study is under way for literature since 1945 also). Selection of the titles for investigation, was made on the basis of the relative importance of the works confirmed after reading book reviews and examining a variety of bibliographies. Each title selected was examined in terms of its subject matter, contribution to the discipline it belongs, references cited, relations with similar works in the field, and bibliographic features. Published books, dissertations both published or not published, and periodicals are included. Primarily a critical review it is also designed to provide background information of the present status of Korean studies and the historical development of Western studies on Korea, Special attenttion is given to the factors contributing to the foundations of the modern Western scholarchip on Korea in the late 19th century

정부간행물 정리에 있어서의 보존문서 분류법 적용에 관한 연구

구자영 韓國圖書館學會 1981 圖書館學 Vol.8 No.1

The study aims at bringing to the attentions of Korean librarians the ways and means with government publications, which had hardly been brought to the scene yet. It deals with the characteristics of archives and the nature of an archival arrangement based on "the principle of provenance" ; the three major devices in use for organizing government publications; and introduction to two sample classification systems. The study concludes with a notion that a vast reservoir of information sources(government publications) should be tapped and put to the use of researchers without delays inherent in library processing. It advocates an archival arrangement for economy and efficiency

연속간행물 관리에 적용되는 업무조직 구조의 유형

구자영,Koo Jayoung 한국문헌정보학회 1985 한국문헌정보학회지 Vol.12 No.-

The present study aims at identifying the nature of the organizational patterns for serial management and thus providing an assitance for decision-making in regards to how the serials in an individual library be processed. The premise of the paper is that effective management is ensued from adopting proper organizational arrangement. In the first part. attempts are made to bring to the fore the problems inherent in serial management and the efforts made for possible solutions. The main portion of the paper eximines the two outstanding patterns; namely, the decentralized arrangement patterned after the traditional functions of a library and the centralized one integrating such functions as acquisition, cataloging and information service. Both are examined in light of nature, development, applicability, strengths and weeknesses. Automation is viewed as a strong force for a change in organizing serial work as it has already brought about organizational change in some large libraries. The general conclusion is that a large collection(5,000 active titles or more) has much to benefit from a separate, specialized department. which integrates the related functions; and the smaller collection can be effectively treated like the rest of the library materials, assigning a specific unit responsible for serial work and promoting an informal communication activities which would bring about coordination and coorperation for the free flow of serial work.