Caregiver’s vision of bedding textiles for elderly

Ann Blaylock,Floriana Constantin,Loredana Ligabue,Licia Bocaletti,Barbora Siroka,Jan Siroky,Tom Wright,Thomas Bechtold 한국의류학회 2015 Fashion and Textiles Vol.2 No.1

Senior citizens have specific needs for bedding, clothing, hygiene and medical textiles that are an essential part of their daily life. The “Textiles for Ageing Society (TAGS)” project deals with these specific demands. Caregivers from 6 European countries were asked by means of a semi-structured interview, how bedding textiles can contribute to daily care work. We found that better design could support care work substantially. As examples, in the short term, better design of colour and style should avoid a hospital like appearance, and better control of bed climate will improve a resident’s sleep quality. Long term developments are prevented by a number of barriers. Introduction of new bedding concepts is retarded by the fragmented situation between the elderly, care givers, purchasers, manufacturers, researchers, care organisations and politics which needs to be overcome. Caregivers as experts must be heard and their needs must be transformed into more appropriate, cost effective designs of bedding textiles, which can support to the quality of residents in care homes substantially. More intelligent textiles substantially could contribute to support care workers, however their potential has not been exploited yet.

Device design rules and operation principles of high-power perovskite solar cells for indoor applications

Ann, Myung Hyun,Kim, Jincheol,Kim, Moonyong,Alosaimi, Ghaida,Kim, Dohyung,Ha, Na Young,Seidel, Jan,Park, Nochang,Yun, Jae Sung,Kim, Jong H. Elsevier 2020 Nano energy Vol.68 No.-

<P><B>Abstract</B></P> <P>In this work, we report on the design principles of high-power perovskite solar cells (PSCs) for low-intensity indoor light applications, with a particular focus on the electron transport layers (ETLs). It was found that the mechanism of power generation of PSCs under low-intensity LED and halogen lights is surprisingly different compared to the 1 Sun standard test condition (STC). Although a higher power conversion efficiency (PCE) was obtained from the PSC based on mesoporous-TiO<SUB>2</SUB> (m-TiO<SUB>2</SUB>) under STC, compared to the compact-TiO<SUB>2</SUB> (c-TiO<SUB>2</SUB>) PSC, c-TiO<SUB>2</SUB> PSCs generated higher power than m-TiO<SUB>2</SUB> PSCs under low-intensity (200–1600 Lux) conditions. This result indicates that high PCE at STC cannot guarantee a reliable high-power output of PSCs under low-intensity conditions. Based on the systemic characterization of the ideality factor, charge recombination, trap density, and charge-separation, it was revealed that interfacial charge traps or defects at the electron transport layer/perovskite have a critical impact on the resulting power density of PSC under weak light conditions. Based on Suns-<I>V</I> <SUB>OC</SUB> measurements with local ideality factor analyses, it was proved that the trap states cause non-ideal behavior of PSCs under low-intensity light conditions. This is due to the additional trap states that are present at the m-TiO<SUB>2</SUB>/perovskite interface, as confirmed by trap-density measurements. Based on Kelvin probe force microscopy (KPFM) measurements, it was confirmed that these traps prohibit efficient charge separation at the perovskite grain boundaries when the light intensity is weak. According to these observations, it is suggested that for the fabrication of high-power PSCs under low-intensity indoor light, the interface trap density should be lower than the excess carrier density to fill the traps at the perovskite's grain boundaries. Finally, using the suggested principle, we succeeded in demonstrating high-performance PSCs by employing an organic ETL, yielding maximum power densities up to 12.36 (56.43), 28.03 (100.97), 63.79 (187.67), and 147.74 (376.85) <I>μ</I>W/cm<SUP>2</SUP> under 200, 400, 800, and 1600 Lux LED (halogen) illumination which are among the highest values for indoor low-intensity-light solar cells.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The device design principles of high-power perovskite solar cells for indoor light applications were investigated. </LI> <LI> For high-power under indoor light, trap density should be lower than excess carrier density. </LI> <LI> Perovskite solar cells with high-power density up to 376.85 <I>μ</I>W/cm2 under indoor light were demonstrated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>In this work, the device design rules for achieving high-power perovskite solar cells under indoor light are suggested based on the device operation principle under low intensity light conditions.</P> <P>[DISPLAY OMISSION]</P>

Increased pore size of scaffolds improves coating efficiency with sulfated hyaluronan and mineralization capacity of osteoblasts

Jan Krieghoff,Ann-Kristin Picke,Juliane Salbach-Hirsch,Sandra Rother,Christiane Heinemann,Ricardo Bernhardt,Christian Kascholke,Stephanie Möller,Martina Rauner,Matthias Schnabelrauch,Vera Hintze,Diete 한국생체재료학회 2020 생체재료학회지 Vol.24 No.1

Background: Delayed bone regeneration of fractures in osteoporosis patients or of critical-size bone defects after tumor resection are a major medical and socio-economic challenge. Therefore, the development of more effective and osteoinductive biomaterials is crucial. Methods: We examined the osteogenic potential of macroporous scaffolds with varying pore sizes after biofunctionalization with a collagen/high-sulfated hyaluronan (sHA3) coating in vitro. The three-dimensional scaffolds were made up from a biodegradable three-armed lactic acid-based macromer (TriLA) by crosspolymerization. Templating with solid lipid particles that melt during fabrication generates a continuous pore network. Human mesenchymal stem cells (hMSC) cultivated on the functionalized scaffolds in vitro were investigated for cell viability, production of alkaline phosphatase (ALP) and bone matrix formation. Statistical analysis was performed using student’s t-test or two-way ANOVA. Results: We succeeded in generating scaffolds that feature a significantly higher average pore size and a broader distribution of individual pore sizes (HiPo) by modifying composition and relative amount of lipid particles, macromer concentration and temperature for cross-polymerization during scaffold fabrication. Overall porosity was retained, while the scaffolds showed a 25% decrease in compressive modulus compared to the initial TriLA scaffolds with a lower pore size (LoPo). These HiPo scaffolds were more readily coated as shown by higher amounts of immobilized collagen (+ 44%) and sHA3 (+ 25%) compared to LoPo scaffolds. In vitro, culture of hMSCs on collagen and/or sHA3-coated HiPo scaffolds demonstrated unaltered cell viability. Furthermore, the production of ALP, an early marker of osteogenesis (+ 3-fold), and formation of new bone matrix (+ 2.5-fold) was enhanced by the functionalization with sHA3 of both scaffold types. Nevertheless, effects were more pronounced on HiPo scaffolds about 112%. Conclusion: In summary, we showed that the improvement of scaffold pore sizes enhanced the coating efficiency with collagen and sHA3, which had a significant positive effect on bone formation markers, underlining the promise of using this material approach for in vivo studies.

Marketing mix induced word-of-mouth and its impact on consumer responses in a service industry

( Anne Martensen ),( Jan Mouritsen ) 한국품질경영학회 2015 한국품질경영학회 학술대회 Vol.2015 No.2

Purpose - It is well-know that a company’s marketing activities influence people’s brand attitudes and choices. However, a company’s marketing activities also create Word-of-Mouth (WOM) communication, where consumers share information, experiences and recommendations about a brand. The purpose of this paper is to extend Keller and Lehman’s (2003) Brand Value Chain model by a social dimension in form of WOM communication, allowing a consumer’s individual brand attitude and choice to be influenced by other consumers’ interpretation of the company’s marketing activities. Methodology/approach - A survey with almost 400 consumers about a large Danish broadband service provider is conducted that gives evidence for the extended Keller and Lehman’s (2003) Brand Value Chain model. Findings - This study demonstrates that the marketing activities influence consumer responses directly, but that the effect can be amplified if the marketing activities are taken into a social context that initiates WOM communication. WOM ``translates`` marketing activities to reliable information and knowledge which can change consumers`` individual attitude towards the brand and influence the choice either positively or negatively. Findings show that marketing activities differ in their ability to induce positive WOM (PWOM) and negative WOM (NWOM), and that PWOM and NWOM in turn have asymmetrical impact on consumers’ responses. Research limitations - The study is limited to a large Danish broadband service provider. Practical implications - Designing the marketing activities so they both initiates WOM and influences consumer responses directly, increases the variations and complexity of its composition. This makes it a managerial challenge to prioritize the marketing investments but also to integrate WOM as a new marketing activity that needs to be managed. Successfully planned and implemented companies may benefit by multiplying the effectiveness of marketing activities and thus improve business performance. Originality/value - This paper provides new insights about how WOM is constructed; which marketing activities primarily create PWOM and which primarily reduce NWOM. WOM is a translator of marketing activities and amplifies the activities effectiveness, why brands may be created as much out of WOM as out of marketing activities.

Prevalence of Monogenic Causes in Pediatric Patients with Nephrolithiasis or Nephrocalcinosis

Braun, Daniela Anne,Lawson, Jennifer Ashley,Gee, Heon Yung,Halbritter, Jan,Shril, Shirlee,Tan, Weizhen,Stein, Deborah,Wassner, Ari J.,Ferguson, Michael A.,Gucev, Zoran,Fisher, Brittany,Spaneas, Leslie American Society of Nephrology 2016 CLINICAL JOURNAL- AMERICAN SOCIETY OF NEPHROLOGY Vol.11 No.4

<P>Background and objectives Nephrolithiasis is a prevalent condition that affects 10%-15% of adults in their lifetime. It is associated with high morbidity due to colicky pain, the necessity for surgical intervention, and sometimes progression to CKD. In recent years, multiple monogenic causes of nephrolithiasis and nephrocalcinosis have been identified. However, the prevalence of each monogenic gene in a pediatric renal stone cohort has not yet been extensively studied. Design, setting, participants, & measurements To determine the percentage of cases that can be explained molecularly by mutations in one of 30 known nephrolithiasis/nephrocalcinosis genes, we conducted a high-throughput exon sequencing analysis in an international cohort of 143 individuals <18 years of age, with nephrolithiasis (n=123) or isolated nephrocalcinosis (n=20). Over 7 months, all eligible individuals at three renal stone clinics in the United States and Europe were approached for study participation. Results We detected likely causative mutations in 14 of 30 analyzed genes, leading to a molecular diagnosis in 16.8% (24 of 143) of affected individuals; 12 of the 27 detected mutations were not previously described as disease causing (44.4%). We observed that in our cohort all individuals with infantile manifestation of nephrolithiasis or nephrocalcinosis had causative mutations in recessive rather than dominant monogenic genes. In individuals who manifested later in life, causative mutations in dominant genes were more frequent. Conclusions We present the first exclusively pediatric cohort examined for monogenic causes of nephrolithiasis/nephrocalcinosis, and suggest that important therapeutic and preventative measures may result from mutational analysis in individuals with early manifestation of nephrolithiasis or nephrocalcinosis.</P>

Mutations in <i>MAPKBP1</i> Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis

Macia, Maxence S.,Halbritter, Jan,Delous, Marion,Bredrup, Cecilie,Gutter, Arthur,Filhol, Emilie,Mellgren, Anne E.C.,Leh, Sabine,Bizet, Albane,Braun, Daniela A.,Gee, Heon Y.,Silbermann, Flora,Henry, Ch University of Chicago Press [etc.] 2017 American journal of human genetics Vol.100 No.2

<P>Nephronophthisis (NPH), an autosomal-recessive tubulointerstitial nephritis, is the most common cause of hereditary end-stage renal disease in the first three decades of life. Since most NPH gene products (NPHP) function at the primary cilium, NPH is classified as a ciliopathy. We identified mutations in a candidate gene in eight individuals from five families presenting late-onset NPH with massive renal fibrosis. This gene encodes MAPKBP1, a poorly characterized scaffolding protein for JNK signaling. Immunofluorescence analyses showed that MAPKBP1 is not present at the primary cilium and that fibroblasts from affected individuals did not display ciliogenesis defects, indicating that MAPKBP1 may represent a new family of NPHP not involved in cilia-associated functions. Instead, MAPKBP1 is recruited to mitotic spindle poles (MSPs) during the early phases of mitosis where it colocalizes with its paralog WDR62, which plays a key role at MSP. Detected mutations compromise recruitment of MAPKBP1 to the MSP and/or its interaction with JNK2 or WDR62. Additionally, we show increased DNA damage response signaling in fibroblasts from affected individuals and upon knockdown of <I>Mapkbp1</I> in murine cell lines, a phenotype previously associated with NPH. In conclusion, we identified mutations in <I>MAPKBP1</I> as a genetic cause of juvenile or late-onset and cilia-independent NPH.</P>

Control Parameter Analysis for an SRM Inverter for Range Extender Units with Integrated DC–DC Converter

Götz Georg Tobias,Kolbe Jan,von Hoegen Anne,De Doncker Rik W. 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.3

In modern electrical traction drives, a variable dc-link voltage can be applied to increase efficiency in partial load. A dc-dc converter can supply a variable dc-link voltage and transfer energy between the battery and the dc-link. Hybrid cars combine the advantages of long driving ranges with the partial zero-emission operation. In series-hybrid drive trains, a switched reluctance machine can be used as a generator for the range extender unit. This paper presents at first the mechanism of energy transfer between the battery and the dc-link. Further, a control parameter analysis of an inverter topology for a switched reluctance machine, which combines the dc-dc converter for the power transfer between the battery and the dc-link with the inverter for the generator, is investigated. For this analysis, the control parameters turn-on, freewheeling and turn-off angle are varied to test the controllability of the energy transfer between these two components. The simulation results of the presented analysis are finally validated with measurements on the test bench.

A NOVEL FEED ADDITIVE (PROVIFEEDTMNOSPOT) WITH POTENTIAL FOR CONTROLING WHITE SPOT SYNDROME VIRUS (WSSV) OUTBREAKS

Joao J. Dantas-Lima,Jeroen Baeyens,Jan Anne,Tina Rogge 한국수산과학회 양식분과 2015 한국수산과학회 양식분과 학술대회 Vol.2015 No.5