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- 저자 : James Walsh (검색결과 6 건)
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Simon J. Walsh,Claudia Cosgrove,James C. Spratt,Colm G. Hanratty 대한심장학회 2019 Korean Circulation Journal Vol.49 No.7
Coronary chronic total occlusions (CTOs) are a commonly encountered lesion. These present in a diverse patient population with variable anatomy. Technical success rates of ~90% are achievable for CTO lesions in centers with appropriate expertise. Many lesions can be crossed with wire-based techniques. However, the most anatomically complex and technically challenging lesions will often require more advanced approaches such as retrograde access and/or the application of blunt dissection techniques in the vessel to safely navigate long and/or ambiguous CTO segments. Retrograde dissection and re-entry (RDR) and antegrade dissection and re-entry (ADR) strategies are often needed to treat such lesions. In many circumstances, ADR offers a safe and efficient means to successfully cross a CTO lesion. Therefore, operators must remain cognizant of the risks and benefits of differing technical approaches during CTO percutaneous coronary intervention, particularly when both ADR and RDR are feasible. This article provides an overview of the ADR technique in addition to updated approaches in contemporary clinical practice.
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Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity
Lee, JangEun,Walsh, Matthew C.,Hoehn, Kyle L.,James, David E.,Wherry, E. John,Choi, Yongwon American Association of Immunologists 2014 Journal of Immunology Vol. No.
<P>Fatty acids (FAs) are essential constituents of cell membranes, signaling molecules, and bioenergetic substrates. Because CD8<SUP>+</SUP> T cells undergo both functional and metabolic changes during activation and differentiation, dynamic changes in FA metabolism also occur. However, the contributions of de novo lipogenesis to acquisition and maintenance of CD8<SUP>+</SUP> T cell function are unclear. In this article, we demonstrate the role of FA synthesis in CD8<SUP>+</SUP> T cell immunity. T cell–specific deletion of acetyl coenzyme A carboxylase 1 (ACC1), an enzyme that catalyzes conversion of acetyl coenzyme A to malonyl coenzyme A, a carbon donor for long-chain FA synthesis, resulted in impaired peripheral persistence and homeostatic proliferation of CD8<SUP>+</SUP> T cells in naive mice. Loss of ACC1 did not compromise effector CD8<SUP>+</SUP> T cell differentiation upon listeria infection but did result in a severe defect in Ag-specific CD8<SUP>+</SUP> T cell accumulation because of increased death of proliferating cells. Furthermore, in vitro mitogenic stimulation demonstrated that defective blasting and survival of ACC1-deficient CD8<SUP>+</SUP> T cells could be rescued by provision of exogenous FA. These results suggest an essential role for ACC1-mediated de novo lipogenesis as a regulator of CD8<SUP>+</SUP> T cell expansion, and may provide insights for therapeutic targets for interventions in autoimmune diseases, cancer, and chronic infections.</P>
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Enhancement in solar cell efficiency by luminescent down-shifting layers
Ahmed, Hind A.,Walshe, James,Kennedy, Manus,Confrey, Thomas,Doran, John,McCormack, Sarah.J. Techno-Press 2013 Advances in energy research Vol.1 No.2
In this paper, core-shell semiconductor quantum dots (QDs) CdSeS/ZnS with emission at 490 nm and 450 nm were investigated for their use in luminescent down-shifting (LDS) layers. Luminescent quantum yield (LQY) of the QDs measurements in solution proposed that they were suitable candidates for inclusion in LDS layers. QDs were encapsulated in poly(methyl,methacrylate) (PMMA) polymer matrix and films were fabricated of $134{\pm}0.05$ microns. Selections of organic dyes from BASF Lumogen F range were also investigated for their use as LDS layers; Violet 570 and Yellow 083. The addition of LDS layers containing Violet 570 dye demonstrated a unity LQY when encapsulated within a PMMA matrix. A PV device of an LDS layer of Lumogen Violet 570 deposited on top of a crystalline silicon cell was fabricated where it was demonstrated to increase the efficiency of the cell by 34.5% relative.
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Risk Information Management for Bridges by Integrating Risk Breakdown Structure into 3D/4D BIM
Yang Zou,Arto Kiviniemi,Stephen W. Jones,James Walsh 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.2
With the growing use and rapid development of Building Information Modelling (BIM), an emerging research trend is to adopt BIM to improve construction risk management. However, very few studies exist that can explain how risk information can be managed effectively within 3D/4D BIM environment. To overcome this knowledge gap, this paper focuses on bridge projects, and proposes a new method for risk visualisation and information management through integrating the bridge project’s Risk Breakdown Structure (RBS) into 3D/4D BIM and establishing a linkage between risk data and BIM. It introduces a new framework for the BIM based risk information management system and develops a prototype tool to support the implementation of the proposed approach. The prototype tool allows the identification and documentation of potential risks associated with their affected project construction activities within 3D BIM and the visualisation of identified risks in 4D BIM. A simulated case study taking a steel bridge as an example is provided to illustrate the implementation of the system. The results show that existing risk management techniques such as RBS can be integrated into BIM for risk identification, visualisation and information management and the proposed framework can support the development of BIM based risk management software.
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