複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

Poster Session : PS 0983 ; Clinical Impact of Periampullary Diverticulum as Risk Factor of the Post-Ercp Pancreatitis

( Jai Hoon Yoon ),( Eun Jin Kim ),( Hyo Sun Kim ),( Sang Hyun Park ),( Chang Seok Bang ),( Yeon Soo Kim ),( Ki Tae Suk ),( Gwang Ho Baik ),( Jin Bong Kim ),( Dong Joon Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is now the therapeutic modality for biliary as well as pancreatic diseases.The risk of Post-ERCP pancreatitis, according to the types of PD was not elucidated. The aim of this study was to investigate risk factors for post-ERCP pancreatitis, including three types of PD. Methods: This study included a total of 306 ERCPs. 93 (30%) patients with PEP, and 213 (69%) patients without PEP were enrolled. The correlation between PEP and risk factors, including PD, angle of common bile duct (CBD), endoscopic sphincterotomy (EST), canulation time, procedure time, and three types of PD were investigated by univariate and multivariate analyses. PD were classifi ed into three types by the location of ampulla of Vater: type 1 (n= 6), inside the diverticulum; type 2 (n= 79), on the margin of diverticulum; type 3 (n= 44), outside the diverticulum Results: In univariate analysis, all types of PD, type 1 PD, type 2 PD, type 3 PD had variable results for PEP (Odd ratio= 1.539, 0.898, 4.866, 0.178; p= 0.096, 0.903, 0.001, 0.001, respectively). Canulation time and total procedure time were signifi cantly related with PEP (p= 0.003, and 0.001, respectively). Age-sex adjusted multivariate analysis showed age, type 2 PD, and canulation time as independent risk factors for PEP (OR= 0.987, 6.862, and 1.046; p-values= 0.451, 0.001, and 0.006, respectively). Type 2 PD and canulation time had meaning results (AUROC= 0.675 and 0.640; p=0.001 and 0.010, respectively), followed by all types of PD, type 1 PD, and type 3 PD (AUROC= 0.495, 0.498, and 0.336; p=, 0.895, 0.965, and 0.002, respectively). Conclusions: Type 2 PD and canulation time were more potent risk factors of PEP than other factors. Prospective randomized control study in multi-center was required.

Original Article : Comparison of the Eradication Rate between 1- and 2-Week Bismuth-Containing Quadruple Rescue Therapies for Helicobacter pylori Eradication

( Jai Hoon Yoon ),( Gwang Ho Baik ),( Yeon Soo Kim ),( Ki Tae Suk ),( Woon Geon Shin ),( Kyung Ho Kim ),( Kyoung Oh Kim ),( Cheol Hee Park ),( Il Hyun Baik ),( Hyun Joo Jang ),( Jin Bong Kim ),( Sea H The Editorial Office of Gut and Liver 2012 Gut and Liver Vol.6 No.4

Background/Aims: First-line therapies against Helicobacter pylori, including proton pump inhibitors (PPIs) plus two antibiotics, may fail in up to 20% of patients. ``Rescue`` therapy is usually needed for patients who failed the first-line treatment. This study evaluated the eradication rate of bismuth-containing quadruple rescue therapy over a 1- or 2-week period. Methods: We prospectively investigated 169 patients with a persistent H. pylori infection after the first-line triple therapy, which was administered from October 2008 to March 2010. The patients were randomized to receive a 1- or 2-week quadruple rescue therapy (pantoprazole 40 mg b.i.d., tripotassium dicitrate bismuthate 300 mg q.i.d., metronidazole 500 mg t.i.d., and tetracycline 500 mg q.i.d.). After the ``rescue`` therapy, the eradication rate, compliance, and adverse events were evaluated. Results: The 1-week group achieved 83.5% (71/85) and 87.7% (71/81) eradication rates in the intention to treat (ITT) and per-protocol (PP) analyses, respectively. The 2-week group obtained 87.7% (72/84) and 88.9% (72/81) eradication rate in the ITT and PP analyses, respectively. There was no significant difference in the eradication rate, patient compliance or rate of adverse events between the two groups. Conclusions: One-week bismuth-containing quadruple therapy can be as effective as a 2-week therapy after the failure of the first-line eradication therapy. (Gut Liver 2012;6:434-439)

Successful one-step endoscopic treatment of esophageal web of plummer-vinson syndrome and concomitant gastric carcinoid

Hoon Jai Chun,Kwang Gyun Lee,Ju Hyung Kim,Jong Jin Hyun,Eun Sun Kim,Sung Chul Park,Sang Hoon Park,Bo Ra Keum,Yeon Seok Seo,Yoon Tae Jeen,Soon Ho Um,Chang Duck Kim,Ho Sang Ryu 대한내과학회 2009 대한내과학회 추계학술대회 Vol.2009 No.-

Electron Microscopic Evaluation of Adhesion of Helicobacter pylori to the Gastric Epithelial Cells in Chronic Gastritis

(Hoon Jai Chun),(Dong Kyu Park),(Chul Hee Park),(Jae Hong Park),(Yoon Tae Jeen),(Soon Ho Um),(Sang Wo Lee),(Jai Hyun Choi),(Chang Duck Kim),(Ho Sang Ryu),(Jin Hai Hyun),(Yang Seok Chae),(Chang Sub Uhm 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.1

N/A Background : The adhesion of H. pylori to the gastric epithelial cells may be an essential step for the pathophysiology of various H. pylori-induced gastrointestinal diseases. The purpose of this study was to investigate the ultrastructural relation of H. pylori and gastric epithelial cells in their adhesion. Methods : Endoscopic biopsy of gastric antrum and body was performed from 15 patients (9 men, 6 women) with chronic gastritis and H. pylori infection. The specimens were processed for electron microscopy and observed with a transmission electron microscope (Hitachi H-600). Results : On the basis of morphological appearances, the adhesions of H. pylori to the gastric epithelial cells were categorized into three types, filamentous connection, adhesion pedestals and membrane fusion. Coccoid and undetermined forms adhered mainly by the filamentous connection, whereas the bacillary forms adhered primarily by the adhesion pedestals and membrane fusion. Conclusion : Various types of adhesion were associated with H. pylori and gastric epithelium. Further studies are needed to evaluate the influence of different types of adhesion to the pathophysiology of H. pylori.

Successful one-step endoscopic treatment of esophageal web of plummer-vinson syndrome and concomitant gastric carcinoid (초)

Hoon Jai Chun,Kwang Gyun Lee,Juh Yung Kim,Jong Jin Hyun,Eun Sun Kim,Sung Chul Park,Sang Hoon Park,Bo Ra Keum,Yeon Seok Seo,Yoon Tae Jeen,Soon Ho Um,Chang Duck Kim,Ho Sang Ryu 대한내과학회 2009 대한내과학회지 Vol.77 No.4S

에 감염된 십이지장궤양 환자에서 HLA - DQB1 의 역할

전훈재(Hoon Jai Chun),이상우(Sang Woo Lee),현진해(Jin Hai Hyun),이성준(Sung Joon Lee),진윤태(Yoon Tae Jeen),이홍식(Hong Sik Lee),송치욱(Chi Wook Song),엄순호(Soon Ho Um),최재현(Jai Hyun Choi),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu 대한소화기학회 2002 대한소화기학회지 Vol.39 No.4

Background/Aims: Helicobacter pylori (H. pylori) infection is associated with gastroduodenal ulcer and gastric cancer only in a small proportion of infected subjects. Both virulence factors of H. pylori strains and host immune responses have been suggested to play an important role in the development of such lesions. HLA has been considered as an important host factor in many diseases. The aim of this study was to examine the HLA-DQ loci among duodenal ulcer patients with H. pylori infection as potential host genetic factors related to the development of duodenal ulcer. Methods: Thirty-two duodenal ulcer patients and 74 controls who had endoscopic chronic gastritis were studied. HLA-DQA1 and HLA-DQB1 genotypes were determined by polymerase chain reaction using sequence specific oligonucleotide probes (PCR-SSOP) with peripheral bloods obtained from the patients and controls. Results: HLA-DQA1 distribution pattern of the patients showed no significant difference from that of the controls. However, the frequency of HLA DQB1*04 was quite lower in the patients than in the controls (p=0.02). Conclusions: The HLA-DQA1 does not seem to contribute to the disease susceptibility, whereas HLA DQB1*04 may contribute to the protection from duodenal ulcer in H. pylori infected subjects. (Korean J Gastroenterol 2002;39:254-259)

간, 췌장 질환에서 Necroptosis

윤재훈 ( Jai Hoon Yoon ),전대원 ( Dae Won Jun ),최호순 ( Ho Soon Choi ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.4

Cell death is an integral part of life of an organism that is necessary to maintain organs and tissues. Apoptosis, autophagy, and necrosis were noted as three morphologically distinct types of cell death. Apoptosis is a well identified process that is driven by programmed molecular mechanism. Until now, the investigators believed that necrosis was not a programmed molecular event. However, recently, an alternative death pathway called ‘necroptosis’ was delineated and proposed as a form of ‘programmed necrosis’. According to the recent recommendations by the Nomenclature Committee of Cell Death, this term denotes necrotic cell death dependent on receptor-interacting protein kinase (RIPK3). Its role in a variety of diseases, such as ischemia-perfusion injury, infection, inflammatory bowel disease, pancreatitis, steatohepatitis etc., is being elucidated. Necroptosis is currently attracting the attention of the scientific community. Herein we discuss the clinical implications and the role of necroptosis in gastrointestinal tract focusing on liver and pancreatic diseases. (Korean J Gastroenterol 2014;64:182-188)

담도암의 진단과 치료의 최신 지견

윤재훈 ( Jai Hoon Yoon ) 대한췌장담도학회 2022 대한췌담도학회지 Vol.27 No.1

현재 담도암에서 항암 치료의 효과는 면역항암제 등 치료적 대안을 찾으며 발전하고 있지만 아직 미흡하다고 할 수 있다. 수술이 불가한 담도암 환자에서 1차 요법으로 gemtitabin과 cisplatin의 병합 항암요법을 우선적으로 추천한다. 최근 치료 성적의 향상을 위해 albumin-bound paclitaxel을 추가하여 사용하는 것도 고려할 수 있다. 전신 상태가 좋지 않은 환자의 경우 capecitabine이나 gemcitabine 단독요법, 5-FU과 lecovorin 병합요법을 1차 항암 치료로 고려할 수도 있다. 2차 치료요법으로는 fluorouracil, leucovorin, and oxaliplatin (FOLFOX)을 사전신청요법으로 우선적으로 고려해 볼 수 있다. 최근 표적치료 및 면역 치료의 일환으로 IDH1와 FGFR 억제제의 연구 결과를 기대할 수 있고, pembrolizumab, nivolumab의 사용을 고려할 수도 있다. 현재까지 담도암 환자에서 수술 후 항암화학요법은 필요할 것으로 생각되나, 근거가 부족한 상태로 재발 위험성과 환자 전신 상태를 고려한 개별화된 접근이 필요하다. Biliary tract cancer (BTC) are highly aggressive and fatal malignancies. As one of the leading cause of death in Republic of Korea, BTC amoung various malignancies has been one of major public health concerns in the country. Although BTCs, including intrahepatic, perihilar, and distal cholangiocarcinoma, are relatively low-incidence malignancies compared to other cancer, but they represent a major health problem in endemic areas like Korea and Asia contries; moreover, the incidence of intrahepatic cholangiocarcinoma is rising globally. Surgery is the only curative treatment. The optimal surgical approach depends on the anatomical site of the primary tumour, and the best outcomes are achieved through management by specialist multidisciplinary team. Unfortunately, most patients present with locally advanced or metastatic disease. Only up to 20% of patients are diagnosed in early-stage, suitable for the curative surgery. Despite the surgery performed with potentially-curative intent, recurrence rates are high, around 60-70% of patients expected to have disease recurrence. In this review, we present an update of the causes, diagnosis, and treatment with a focus on chemotherapy of BTC. Korean J Pancreas Biliary Tract 2022;27(1):40-46

비만의 내시경 치료

윤재훈 ( Jai Hoon Yoon ),이항락 ( Hang Lak Lee ) 대한내과학회 2019 대한내과학회지 Vol.94 No.1

Obesity and metabolic syndrome affect ~40% of individuals in the United States alone. They are significant conditions that can cause severe economic problems. Obesity is also a global issue, with ~400 million obese adults worldwide. Moreover, the number of overweight children is increasing. Bariatric surgery is the gold standard treatment for obesity; however, endoscopic approaches may have a significant role in improving metabolic syndrome and achieving weight loss. Many endoscopic methods have been introduced, some of which are currently available and some that are undergoing experimentation. Endoscopists have a role in the treatment of obesity because endoscopic therapies are expected to become safer and more efficacious in the coming years. Endoscopic bariatric therapies can be categorized as space occupying, malabsorption, and gastric volume reduction. In this review, we summarize the currently available endoscopic procedures. (Korean J Med 2019;94:5-10)