http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Bispecific Antibody-Bound T Cells as a Novel Anticancer Immunotherapy
Cho Jaewon,Tae Nara,Ahn Jae-Hee,Chang Sun-Young,Ko Hyun-Jeong,Kim Dae Hee 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.5
Chimeric antigen receptor T (CAR-T) cell therapy is one of the promising anticancer treatments. It shows a high overall response rate with complete response to blood cancer. However, there is a limitation to solid tumor treatment. Additionally, this currently approved therapy exhibits side effects such as cytokine release syndrome and neurotoxicity. Alternatively, bispecific antibody is an innovative therapeutic tool that simultaneously engages specific immune cells to disease-related target cells. Since programmed death ligand 1 (PD-L1) is an immune checkpoint molecule highly expressed in some cancer cells, in the current study, we generated αCD3xαPD-L1 bispecific antibody (BiTE) which can engage T cells to PD-L1+ cancer cells. We observed that the BiTE-bound OT-1 T cells effectively killed cancer cells in vitro and in vivo. They substantially increased the recruitment of effector memory CD8+ T cells having CD8+CD44+CD62Llow phenotype in tumor. Interestingly, we also observed that BiTE-bound polyclonal T cells showed highly efficacious tumor killing activity in vivo in comparison with the direct intravenous treatment of bispecific antibody, suggesting that PD-L1-directed migration and engagement of activated T cells might increase cancer cell killing. Additionally, BiTE-bound CAR-T cells which targets human Her-2/neu exhibited enhanced killing effect on Her-2-expressing cancer cells in vivo, suggesting that this could be a novel therapeutic regimen. Collectively, our results suggested that engaging activated T cells with cancer cells using αCD3xαPD-L1 BiTE could be an innovative next generation anticancer therapy which exerts simultaneous inhibitory functions on PD-L1 as well as increasing the infiltration of activated T cells having effector memory phenotype in tumor site.
( Jaewon Lee ),( Soo Ick Cho ),( Byung Jun Kim ),( Ung Sik Jin ),( Hak Chang ),( Kyung Won Minn ),( Kwang Hyun Cho ),( Je-ho Mun ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Malignant melanoma (MM) is a lethal and common skin cancer in the Western countries. However, there has been a paucity of literature regarding risk factors concerning prognosis of patients with MM who underwent surgical excision in Korea. Objectives: To investigate predictive factors for local recurrence and metastasis who underwent surgical treatment for MM in a single tertiary level hospital in Korea Methods: 202 patients underwent curative surgery for MM during January 1998 and December 2014 were analyzed. We retrospectively investigated risk factors for local recurrence, metastasis, and death of MM patients after surgery. Results: During a mean follow-up period of 40.54±35.16 months (Mean±SD, Range 1-201 months), 19 patients (9.41%) developed local recurrence and 46 patients (22.77%) had distant metastasis after surgery. Four patients (1.98%) had both local recurrence and distant metastasis. Regarding distant metastasis, tumor thickness and increased mitotic number were associated with risk for distant metastasis in multivariate analysis. In terms of local recurrence, tumor thickness (T4 vs. T1) was found a significant risk factor. In survival analysis, patients with distant metastasis and patients with both local recurrence and distant metastasis showed poor prognosis. Conclusion: Our data revealed tumor thickness and increased mitotic count are the significant factors for worse prognosis.
SooChurl Cho,HeeJeong Yoo,Mira Park,InHee Cho,BoongNyun Kim,JaeWon Kim,MinSup Shin,TaeWon Park,JungWoo Son,UnSun Chung,HyoWon Kim,YoungHui Yang,JeOuk Kang,SoYoung Yang,SoonAe Kim 대한신경정신의학회 2011 PSYCHIATRY INVESTIGATION Vol.8 No.1
Objective-Communication problems are a prevalent symptom of autism spectrum disorders (ASDs), which have a genetic background. Although several genome-wide studies on ASD have suggested a number of candidate genes, few studies have reported the association or linkage of specific endophenotypes to ASDs. Methods-Forty-two Korean ASD patients who showed a language delay were enrolled in this study with their parents. We performed a genome-wide scan by using the Affymetrix SNP Array 5.0 platform to identify candidate genes responsible for language delay in ASDs. Results-We detected candidate single-nucleotide polymorphisms (SNPs) in chromosome 11, rs11212733 (p-value=9.76×10-6) and rs7125479 (p-value=1.48×10-4), as a marker of language delay in ASD using the transmission disequilibrium test and multifactor dimensionality reduction test. Conclusion-Although our results suggest that several SNPs are associated with language delay in ASD, rs11212733 we were not able to observe any significant results after correction of multiple comparisons. This may imply that more samples may be required to identify genes associated with language delay in ASD.
조재원(Jaewon Cho),이재열(Jae-Yel Yi) 한국진공학회(ASCT) 1999 Applied Science and Convergence Technology Vol.8 No.1
여러 가지 방법의 plasma 표면 처리와 산화 공정이 SiO₂-Si(100) 계면에 미치는 물리적 영향을 angle resolved uv-photoelectron spectroscopy(ARUPS)를 이용하여 연구하였다. 표면은 ex situ 방법과 함께 in situ 수소 플라즈마를 이용하여 처리되어 졌으며, 이것은 고진공 고온 열 처리 방법과 비교되어졌다. ARUPS 빛띠 상에 나타난 산화물 가전자 띠에 대한 특징적인 peak 위치는 표면 처리 및 산화 공정 방법에 따라 이동하였다. 이러한 peak의 이동은 Si에서의 띠휨에 의한 것으로 분석되어졌다. 또한 peak 이동의 원인으로 Si-SiO₂ 계면에 형성된 결점과 표면 처리 공정에 따라 달라지는 표면 거칠기 등을 고려할 수 있었다. 여러 공정에 대한 ARUPS 결과를 비교함으로써 Si-SiO₂ 계면 결합이 표면 처리 및 산화 방법에 깊이 관련되어 있음을 결론지을 수 있었다. 산소 plasma 공정은 가장 작은 band bending을 보여주었다. The effect of different plasma surface preparation and oxidation processes for the formation of SiO₂-Si(100) interfaces was studied using angle resolved uv-photoelectron spectroscopy. The surface preparation processes included ex situ preclean as well as in situ hydrogen plasma, which were compared to the processes of UHV annealing at high temperature. The spectral position of the oxide valence band features, with respect to the Fermi level, were found to shift according to the different processes of surface preparation and oxidation. The shifts were analyzed in terms of band bending in the Si. Origins of the spectral shifts were considered to include defects at the SiO₂-Si interfaces and surface morphology(roughness) dependent on the surface preparation processes. From comparison of the ARUPS results of the various processes, it was concluded that the interface bonding of the silicon oxide-Si(100) was dependent on the oxidation process and the surface preparation. The O-plasma process showed the lowest band bending.
직접분사식 가솔린엔진의 피스톤 상면 형상이 성층화 연소에 미치는 영향
송재원(Jaewon Song),김미로(Miro Kim),조한승(Hanseong Cho),여진구(Jinku Yeo),조남효(Nam-Hyo Cho) 한국자동차공학회 2001 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2001 No.5_1
A study to investigate the influence of the piston top face configuration on the combustion stability is presented using CFD analysis and single cylinder GDI engine. Initial configuration of the GDI piston was designed by CFD analysis and further parametric studies of the design factors on the piston top face were carried out through the single cylinder GDI engine test. It was found that both the geometries of the piston top face and the compression ratio have influences on the combustion stability. Of interest is that the design factors of the GDI piston to prevent mixture diffusion out of the piston bowl have important roles for the stable combustion at the stratified mixture condition. Also the relationship between spray impingement and flow pattern in a GDI piston bowl should be considered to design an optimal bowl configuration for stable stratified combustion.
SooChurl Cho,JungWoo Son,BoongNyun Kim,JaeWon Kim,HeeJeong Yoo,JunWon Hwang,DaeYeon Cho,UnSun Chung,TaeWon Park 대한신경정신의학회 2012 PSYCHIATRY INVESTIGATION Vol.9 No.3
Objective-The purpose of this study was to investigate the association between the T102C polymorphism in the serotonin 2A receptor gene and attention-deficit/hyperactivity disorder (ADHD) in Korean patients. Methods-A total of 189 Korean children with ADHD as well as both parents of the ADHD children and 150 normal children participated in this study. DNA was extracted from blood samples from all of the subjects, and genotyping was conducted. Based on the allele and genotype information obtained, case-control analyses were performed to compare the ADHD and normal children, and Transmission disequilibrium tests (TDTs) were used for family-based association testing (number of trios=113). Finally, according to the significant finding which was showed in the case-control analyses, the results of behavioral characterastics and neuropsychological test were compared between ADHD children with and without the C allele. Results-In the case-control analyses, statistically significant differences were detected in the frequencies of genotypes containing the C allele (χ2=4.73, p=0.030). In the family-based association study, TDTs failed to detect linkage disequilibrium of the T102C polymorphism associated with ADHD children. In the ADHD children, both the mean reaction time and the standard deviation of the reaction time in the auditory continuous performance test were longer in the group with the C allele compared to the group without the C allele. Conclusion-The results of this study suggest that there is a significant genetic association between the T102C polymorphism in the serotonin 2A receptor gene and ADHD in Korean children.
조중석 ( Jungseok Cho ),유승진 ( Seungjin You ),정유진 ( Yoojin Jeong ),김진주 ( Jinzoo Kim ),남제원 ( Jaewon Nam ),조두산 ( Doosan Cho ) 한국정보처리학회 2015 한국정보처리학회 학술대회논문집 Vol.22 No.1
전기전자, 정보통신 둥 디지털/정보화 시대를 주도하는 산업의 핵심제품으로 혁신적 방식으로 기존의 전기신호처리 및 정보기억 기능을 대체할 새로운 메모리 반도체 개발기술이 요구되고 있다. 반도체 소자를 이용하여 디지털 정보를 기억하는 소자 가운데 기존의 DRAM과 플래시 메모리를 발전시켜 새로운 물질이나 구조를 사용하는 반도체 정보기억 소자 개발 기술이 필요하다.
( Soo Ick Cho ),( Jaewon Lee ),( Jin Lim ),( Jong Seo Park ),( Miso Kim ),( Tae-yong Kim ),( Tae Min Kim ),( Kyung-hun Lee ),( Bhumsuk Keam ),( Sae-won Han ),( Je-ho Mun ),( Kwang Hyun Cho ),( Seong J 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Pruritus is very common symptom in patients under anti-cancer therapy. However, the characteristics of pruritus according to anti-cancer agents have not been known well. Objectives: To ascertain the characteristics of pruritus induced by targeted anti-cancer agents using a questionnaire-based survey. Methods: Questionnaires included numerical rating scale (NRS) for itching, 5-D itch scale and skin dryness. Medical records of anticancer treatment, including cancer types and types of anticancer agents, were reviewed. Results: Total 374 cancer patients finished the survey, of which 107 (28.6%) were treated with targeted therapy. Two hundreds and five (54.8%) patients had pruritus, of which 65 (31.7%) were under targeted therapy. Epidermal growth factor receptor inhibitors (EGFRIs) users showed highest prevalence of itching (77.3%) and score of NRS for itching. 5-D itch score was also highest in subjects of EGFRIs, particularly in items of duration, degree, disability and distribution. Patients of EGFRIs showed high prevalence of itching on face, chest, buttocks and upper arms. Skin dryness in EGFRIs showed strongest relationship with 5-D itch scale score. Conclusion: Patients receiving EGFRIs suffered from pruritus frequently and severely. They not only experienced long-lasting and intense itching causing sleep discomfort, also had specific body sites of itching. Clinicians should pay attention to unusual features of itching according to types of targeted therapy.