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Induction of Apoptosis by Immature Plum in Human Hepatocellular Carcinoma
유미희,Hyo Gwon Im,김혁일,이인선 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.3
In the present study, the effect of an extract of immature Prunus salicina Lindl. cv. Soldam fruit on the viability and induction of apoptosis in human hepatocellular carcinoma HepG2 cells was investigated. The results showed that in comparison with other cancer cells, the growth inhibition exerted by immature plum extracts was greatest in HepG2. Apoptosis in HepG2 cells mediated by immature plums was associated with “death receptor signaling.” Immature plum extracts significantly increased the activation of caspase-8, -10, and -3 and expression of the caspase-3 target proteins α-fodrin (induces membrane blebbing and cell shrinkage), poly(ADP-ribose) polymerase (a nuclear enzyme that is involved in DNA repair following DNA nicks), and DNA fragmentation factor (induces apoptotic DNA fragmentation). The total yield of identified polyphenols in immature plum extract was 10g/kg dry weight. The major components, (−)-epicatechin and (−)-gallocatechin gallate, were 34.7% and 28.6% of total polyphenols, respectively. (+)-Catechin, (−)-epicatechin gallate, and (−)-catechin gallate were also found. On the basis of these results, the immature plum (P. salicina Lindl. cv. Soldam) and its active compound, (−)-epicatechin, are expected to be a natural resource for developing novel therapeutic agents for cancer prevention and treatment.
해상풍력 발전사업의 원만한 이해관계자 협의를 위한 절차적 개선방향 - 어업손실보상 근거와 기준을 중심으로
임현지(Im, Hyun-Ji),윤성권(Yun, Seong-Gwon),권필석(Kwon, Pil-Seok),문효동(Moon, Hyo-Dong),김윤성(Kim, Yun-Soung) 강원대학교 비교법학연구소 2021 환경법과 정책 Vol.27 No.-
2050년 탄소중립 달성을 위해서는 재생에너지 확대가 필수적이며, 특히 해상풍력은 규모면에서 설치 잠재량이 크다. 그러나 많은 해상풍력 사업지에서 주민, 어업인들의 반대로 갈등을 겪고 있으며, 상당히 긴 인허가 기간이 소요되고 있어 보급 실적이 저조하다. 사업자와 주민·어업인 간 갈등은 협의 과정에서 이해관계자의 의견수렴이나 보상 관련 법과 절차가 불분명하여 발생하는 경우가 많다. 해상풍력 발전사업의 이해관계자 협의는 보상, 지원, 이익공유로 분류할 수 있으며 이 연구는 특히 어업손실보상에 대한 문제를 검토하였다, 이 연구는 법·절차적 측면에서 「전기사업법」, 「전원개발촉진법」, 「공익사업을 위한 토지 등의 취득 및 보상에 관한 법률」, 「수산업법」 등 관련법 검토를 통해, 해상풍력 개발사업에서 어업손실보상협의의 법적 근거가 미비하고 현행 보상 기준이 미흡함을 밝혔다. 또한 덴마크 「수산업법」 및 대만 「어업법」, 영국 「해상풍력 협의지침」, 국내 「도시개발법」 등 국내외 관련 법제를 비교분석하여 현행 문제에 대한 개선방향을 도출하였다. 결론적으로, 이 연구는 「풍력발전 보급촉진 특별법(안)」에 어업손실보상 협의의 법적 근거를 보완하고, 어업인, 사업자, 정부 등 이해관계자가 합의한 어업영향 조사 및 보상협의 기준 혹은 지침을 마련할 것을 제안한다. In order to achieve carbon neutrality goal by 2050, the expansion of renewable energy is essential. In particular, offshore wind power has a large installation potential in terms of scale. However, offshore wind power is scarcely distributed in Korea, because various offshore wind farms in Korea are experiencing local conflicts due to opposition from residents and fishermen. Conflicts between developers and local fishermen often arise because the laws and procedures related to the compensation of stakeholders are unclear during the consultation process. Stakeholder consultations in offshore wind power projects can be classified into compensation, support, and benefit-sharing, and this study specifically reviewed the issue of compensation for fishing losses. In terms of legal and procedural aspects, this study examines related laws such as the 「Electricity Business Act」, 「Power Development Promotion Act」, 「Act on Acquisition of and Compensation for Land, Etc. for Public Works Projects」 and 「Fisheries Act」, and examines the defect of the legal basis for negotiating compensation for fisheries and the lack of compensation evaluation standards in offshore wind power development projects. In addition, by comparing and analyzing domestic and foreign related laws such as the Danish and Taiwanese Fisheries Act, the UK Offshore Wind Power Consultation Guideline, and the domestic 「Urban Development Act」, improvement directions for the current problems were derived. In conclusion, this study proposes to supplement the legal basis for consultation on compensation for fisheries in the 「Special Act on the Promotion of Wind Power Generation」, and to prepare a standard/guideline for compensation and fishery impact investigation agreed upon by all stakeholders including fishermen, developers, and the government.
Induction of Apoptosis by Immature Plum in Human Hepatocellular Carcinoma
Yu, Mi-Hee,Im, Hyo-Gwon,Kim, Hyuk-Il,Lee, In-Seon The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3
In the present study, the effect of an extract of immature Prunus salicina Lindl. cv. Soldam fruit on the viability and induction of apoptosis in human hepatocellular carcinoma HepG2 cells was investigated. The results showed that in comparison with other cancer cells, the growth inhibition exerted by immature plum extracts was greatest in HepG2. Apoptosis in HepG2 cells mediated by immature plums was associated with "death receptor signaling." Immature plum extracts significantly increased the activation of caspase-8, -10, and -3 and expression of the caspase-3 target proteins a-fodrin (induces membrane blebbing and cell shrinkage), poly(ADP-ribose) polymerase (a nuclear enzyme that is involved in DNA repair following DNA nicks), and DNA fragmentation factor (induces apoptotic DNA fragmentation). The total yield of identified polyphenols in immature plum extract was 10 g/kg dry weight. The major components, (-)-epicatechin and (-)-gallocatechin gallate, were 34.7% and 28.6% of total polyphenols, respectively. (+)-Catechin, (-)-epicatechin gallate, and (-)-catechin gallate were also found. On the basis of these results, the immature plum (P. salicina Lindl. cv. Soldam) and its active compound, (-)-epicatechin, are expected to be a natural resource for developing novel therapeutic agents for cancer prevention and treatment.
Yu, Mi Hee,Im, Hyo Gwon,Lee, Syng-Ook,Sung, Chang,Park, Dong-Cheol,Lee, In-Seon Informa Healthcare 2007 International journal of food sciences and nutriti Vol.58 No.1
<P> The goal of this study was to evaluate the anticancer effect of Prunus salicina Lindl. cv. Soldam at three maturity stages (immature, midmature and mature stages). Previous studies have shown that this fruit (plums) possesses hematopoiesis effects, prevents osteoporosis and has anti-mutagenic effects. An acetone extract of immature P. salicina Lindl. cv. Soldam fruit contained higher levels of total phenolics and condensed tannins than midmature and mature plums. The results showed that an acetone extract of immature plums possesses cytotoxic effects, which are related to the activity of the total polyphenols in the fruits. Apoptosis in MDA-MB-231 cells mediated by the immature plums was associated with an increase in Bax levels and a reduction in Bcl-2 levels and the cleavage of caspase 3, caspase 7, caspase 9 and poly-(ADP-ribose) polymerase. These results indicate that immature fruit of P. salicina Lindl. cv. Soldam can be regarded as a safe and promising new dietary source for decreasing the risk of developing breast cancer.</P>
유미희(Mi-Hee Yu),임효권(Hyo-Gwon Im),임남경(Nam-Kyung Im),황은영(Eun-Young Hwang),최준혁(Jun-Hyeok Choi),이은주(Eun-Ju Lee),김종부(Jong-Boo Kim),이인선(In-Seon Lee),서화정(Hwa-Jeong Seo) 한국식품과학회 2009 한국식품과학회지 Vol.41 No.4
본 연구에서는 김치에서 분리한 유산균이 ACE 억제효과와 본태성 고혈압쥐의 혈압에 미치는 영향을 조사하였다. 김치에서 분리한 유산균의 배양액 및 lysozyme법, sonication법, solvent extract 법으로 균체를 추출하여 ACE 억제효과를 살펴본 결과, 배양액 보다는 균체를 이용하여 추출한 추출물에서 공시균주에 비해 ACE 억제효과가 높은 것으로 확인되었다. 균체 추출시료 중 LG 7, 8, 42가 전반적으로 높은 ACE 억제효과를 나타내어 이들의 균체를 본태성 고혈압쥐(SHR)에게 4주간 투여한 결과, WKY 대조군(I)이 4주간 81 g 정도의 체중 증가를 보인 반면, SHR 대조군(V)은 52 g 정도의 체중 증가를 보여 정상혈압 쥐에 비해 고혈압 쥐의 체중의 증가가 낮은 것으로 나타났으며, 유산균의 장기투여가 고혈압 쥐의 체중 및 장기무게에 유의적인 영향을 주지 않았다. 혈청 중 총 콜레스테롤 농도와 중성지질 농도는 SHR 대조군(V)에 비해 유산균 투여군(X, XI)에서 약간 감소하는 경향을 보였으나 유의적인 차는 아니었으며, SHR에 LG 42 유산균을 섭취시킴으로서 총 콜레스테롤과 중성지질의 농도는 감소하고, HDL 콜레스테롤의 농도는 증가하는 것으로 나타났다. 유산균 투여 후 4주째의 최종 혈압을 비교한 결과, LG 42를 투여함에 따라 기준혈압에 비해 농도 의존적(1×10sup{7}, 1×10sup{9} cfu/mL)으로 각각 12, 27% 감소하였다. This study was conducted to evaluate the anti-hypertensive effect of Lactobacillus sp. isolated from Kimchi by examining its effects on renal angiotensin-converting enzyme (ACE) inhibitory activity, lipid components and blood pressure using the spontaneously hypertensive rat (SHR) system. Most Lactobacillus sp. extracts (lysozyme, sonication and ethyl acetate extracts) showed higher capacities for the inhibition of ACE activity than those of cultured media. Particularly, LG 7, 8 and 42 of Lactobacillus sp. showed the strongest inhibitory activity among the Lactobacillus sp. extracts. The concentrations of total cholesterol and triglycerides in the serum were lower in the Lactobacillus sp. administration groups than in the control group, but these differences were not significant. The HDL-cholesterol concentrations of the LG 42 administration groups (IX, X) were significantly higher than that of the control group. At 4 weeks, the systolic blood pressure (SBP) in the LG 42 Lactobacillus sp. (1×109 cfu/mL) group (XI) was about 27% lower than that of the control group (V). No adverse effects were observed on the liver and there was no difference in the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values among groups. The results of this study suggest that long term consumption of LG 42 Lactobacillus sp. may be beneficial to the prevention of high blood pressure.