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Low-Powered pH-Stable Nano-electrokinetically Enhanced Lateral Flow Assay for COVID-19 Antigen Test
Kim Kang Hyeon,유용경,Lee Na Eun,Lee Junwoo,Kim Cheonjung,Lee Seungmin,Kim Jinhwan,Park Seong Jun,Lee Dongtak,이상원,Kim Hyungseok,허돈,Yoon Dae Sung,Lee Jeong Hoon 한국바이오칩학회 2023 BioChip Journal Vol.17 No.3
Lateral fl ow assay (LFA) is a popular diagnostic system used in point-of-care testing (POCT) due to its low cost and portability. However, LFA has limited sensitivity and detection limits, making it challenging to detect low virus titers. Preconcentration through nano-electrokinetic (NEK) techniques have been proposed as a promising solution to improve the sensitivity of LFA. Nevertheless, the acidic conditions used in NEK operations may reduce the specifi city and sensitivity of LFA immunoassays. To address these limitations, an integrated LFA kit, the NEK-enhanced LFA (PcNEK–LFA), has been introduced. This kit features a pH-controlled structure designed to facilitate sample preconcentration. Biomarkers and AuNPs are electrokinetically preconcentrated in the PcNEK–LFA platform to increase the concentration of the test line and Ag–Ab binding events, resulting in enhanced performance. The pH-controlled PcNEK–LFA platform was evaluated using salivary human chorionic gonadotropin beta (β-hCG) and COVID-19 Ag samples, achieving a preconcentrating factor of approximately 10 and a sensitivity enhancement of 55.42%, and a preconcentrating factor greater than 10, respectively. The pH-controlled PcNEK–LFA platform provides an eff ective solution to overcome the limitations of LFA for POCT. In addition, it improves its sensitivity and detection limit, signifi cantly enhancing the accuracy and reliability of POCT, particularly for COVID-19 screening tests. As a result, this platform may play a pivotal role in addressing current and future healthcare challenges, facilitating rapid diagnosis and treatment of infectious diseases.
Believable interaction with a quasi-tangible tabletop interface
Lee, Jangho,Lee, Jun,Kim, HyungSeok,Kim, Jee-In John Wiley Sons, Ltd. 2007 Computer Animation and Virtual Worlds (Print) Vol.18 No.2
<P>In this paper, we present a believable interaction mechanism for manipulation multiple objects in ubiquitous/augmented virtual environment. A believable interaction in multimodal framework is defined as a persistent and consistent process according to contextual experiences and common-senses on the feedbacks. We present a tabletop interface as a quasi-tangible framework to provide believable processes. An enhanced tabletop interface is designed to support multimodal environment. As an exemplar task, we applied the concept to fast accessing and manipulating distant objects. A set of enhanced manipulation mechanisms is presented for remote manipulations including inertial widgets, transformable tabletop, and proxies. The proposed method is evaluated in both performance and user acceptability in comparison with previous approaches. The proposed technique uses intuitive hand gestures and provides higher level of believability. It can also support other types of accessing techniques such as browsing and manipulation. Copyright © 2007 John Wiley & Sons, Ltd.</P>
Lee, Hyungseok,Han, Wonil,Kim, Hyeonji,Ha, Dong-Heon,Jang, Jinah,Kim, Byoung Soo,Cho, Dong-Woo American Chemical Society 2017 Biomacromolecules Vol.18 No.4
<P>The liver is an important organ and plays major roles in the human body. Because of the lack of liver donors after liver failure and drug-induced liver injury, much research has focused on developing liver alternatives and liver in vitro models for transplantation and drug screening. Although numerous studies have been conducted, these systems cannot faithfully mimic the complexity of the liver. Recently, three-dimensional (3D) cell printing technology has emerged as one of a number of innovative technologies that may help to overcome this limitation. However, a great deal of work in developing biomaterials optimized for 3D cell printing-based liver tissue engineering remains. Therefore, in this work, we developed a liver decellularized extracellular matrix (dECM) bioink for 3D cell printing applications and evaluated its characteristics. The liver dECM bioink retained the major ECM components of the liver while cellular components were effectively removed and further exhibited suitable and adjustable properties for 3D cell printing. We further studied printing parameters with the liver dECM bioink to verify the versatility and fidelity of the printing process. Stem cell differentiation and HepG2 cell functions in the liver dECM bioink in comparison to those of commercial collagen bioink were also evaluated, and the liver dECM bioink was found to induce stem cell differentiation and enhance HepG2 cell function. Consequently, the results demonstrate that the proposed liver dECM bioink is a promising bioink candidate for 3D cell printing based liver tissue engineering.</P>