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Lee, Sun-Hyo,Park, Samel,Lee, Jung-Won,Hwang, Il-Woong,Moon, Hyung-Jun,Kim, Ki-Hwan,Park, Su-Yeon,Gil, Hyo-wook,Hong, Sae-Yong The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.7
<P>Pesticide formulation includes solvents (methanol and xylene) and antifreeze (ethylene glycol) whose metabolites are anions such as formic acid, hippuric acid, and oxalate. However, the effect of the anion gap on clinical outcome in acute pesticide intoxication requires clarification. In this prospective study, we compared the anion gap and other parameters between surviving versus deceased patients with acute pesticide intoxication. The following parameters were assessed in 1,058 patients with acute pesticide intoxication: blood chemistry (blood urea nitrogen, creatinine, glucose, lactic acid, liver enzymes, albumin, globulin, and urate), urinalysis (ketone bodies), arterial blood gas analysis, electrolytes (Na<SUP>+</SUP>, K<SUP>+</SUP>, Cl<SUP>-</SUP> HCO<SUB>3</SUB><SUP>-</SUP>, Ca<SUP>++</SUP>), pesticide field of use, class, and ingestion amount, clinical outcome (death rate, length of hospital stay, length of intensive care unit stay, and seriousness of toxic symptoms), and the calculated anion gap. Among the 481 patients with a high anion gap, 52.2% had a blood pH in the physiologic range, 35.8% had metabolic acidosis, and 12.1% had acidemia. Age, anion gap, pesticide field of use, pesticide class, seriousness of symptoms (all <I>P</I> < 0.001), and time lag after ingestion (<I>P</I> = 0.048) were significant risk factors for death in univariate analyses. Among these, age, anion gap, and pesticide class were significant risk factors for death in a multiple logistic regression analysis (<I>P</I> < 0.001). In conclusions, high anion gap is a significant risk factor for death, regardless of the accompanying acid-base balance status in patients with acute pesticide intoxication.</P>
만성 신부전 환자에서 은단 복용과 동반되어 발생한 전신적 은 중독증
길효욱 ( Gil Hyo Ug ),이준영 ( Lee Jun Yeong ),권순효 ( Kwon Sun Hyo ),조원영 ( Jo Won Yeong ),박종근 ( Park Jong Geun ),양종오 ( Yang Jong O ),이은영 ( Lee Eun Yeong ),홍세용 ( Hong Se Yong ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.2
Generalized hyperpigmentation has a wide range of causes, including endocrine diseases, including endocrine diseases, uremia, drugs, and heavy metals. Cutaneous pigmentation observed in 70% of uremic patients on hemodialysis. However, it is clinically difficult to define the exact cause of hyperpigmentation in chronic renal failure patients. We experienced a case of cutaneous hyperpigmentation caused by generalized argyria in chronic hemodialysis patient. A 38-year-old male patient presented with slowly progressive blue-black discoloration of skin. He had been on maintenance hemodialysis for 5 yars and took sliver pills 36 g daily during 2.5 years to relieve thirst. The other source of silver exposure could not be determined. Pathologic examination of skin biopsy specimen showed focal deposits of fine, uniform, brownish granules along the basement membrane zone of hair in the dermis, which is characteristic findings of argyria. The silver deposits were also confirmed by increase in serum silver level and silver amount in liver and skin tissue. Argyria should be suspected in chronic hemodialysis patients presenting with a diffuse bluish-gray discoloration of the skin and nails and evaluated carefully by skin biopsy with quantitation of tissue silver level. (Korean J Nephrol 2004;23(2):345-348)
목이 있는 폴립형 위장관 기질종양에 의해 유발된 위십이지장 중첩증
석효선 ( Hyo Sun Seok ),손정일 ( Chong Il Shon ),서현일 ( Hyun Il Seo ),최영길 ( Young Ghil Choi ),정원길 ( Won Gil Chung ),원현선 ( Hyun Sun Won ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.5
The gastrointestinal stromal tumor (GIST) is a mesenchymal tumor of the digestive tract showing differentiation along the line of interstitial cell of Cajal. The most GISTs in the stomach generally show the appearance of submucosal tumors. It is rare for GISTs to appear as a pedunculated polypoid lesion on endoscopy. We experienced a case of a 51-year-old man who had a pedunculated polypoid GIST. He was admitted to our hospital for nausea, vomiting, melena and severe anemia (hemoglobin 3.4 g/dL, hematocrit 10.8%). An upper endoscopy showed gastroduodenal intussusception due to a pedunculated polypoid mass. This report presents a rare case of endoscopically proven gastroduodenal intussusceptions due to pedunculated polypoid GIST in the stomach. (Korean J Gastroenterol 2012;59:372-376)
Joon-Kook Kwon,Kyoung-Sub Park,Hyo-Gil Choi,Sun-Yi Lee,K. Bekhzod,Mi-Ran Hwang,Nam-Jun Kang 경상대학교 농업생명과학연구원 2013 농업생명과학연구 Vol.47 No.1
This experiment was carried out to determine the effect of different spectrum conversion greenhouse films (red, blue, red+blue) to changing microclimate and subsequent effect on growth and quality of lettuce (Lactuca sativa L.), tomato (Solanum lycopersicum L.), and melon (Cucumis melo L.) Transmission of PAR (photosynthetic active radiation, 400-700 nm) under red, blue, and blue+red (BR) films was higher by 7.2, 7.6, and 5.8%, respectively, as compared with control greenhouse film. Light transmission in the 300-1100 nm wave band was 91.6% and 91.3% under red and blue films, respectively, compared to 86.4% under control film. Mean daytime temperature in greenhouse was slightly higher in red and blue film and mean night time temperature was higher in BR film. There were no significant differences in relative humidity among the films. Number of leaves and plant fresh weight of lettuce were higher under BR film. Total number of marketable tomato fruits was greater under blue and BR film and fruit weight was heavier under red and blue film compared to control film. Under BR and red film melon fruit weight was increased by 140 g and 80 g respectively, as compared to control film. Sugar content in melon and tomato fruits was not affected by covering films.
( Hyo Sun Choi ),( Choun Gil Sohn ),( Dong Il Park ),( Jung Ho Park ),( Woo Kyu Jeon ),( Byung Il Kim ),( Yong Kyun Cho ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Endoscopic biopsy is necessary to confirm histopathologic diagnosis. Until now, six to eight biopsies were recommended for optimal diagnosis. Multiple biopsies may produce some problems such as increased risk of bleeding and increased workload to endoscopists, pathologists, and even to patients. The aim of this study was to clarify the optimal number of endoscopic biopsy specimens in the diagnosis of advanced gastric and colonic cancer. Methods: Patients who were diagnosed as advanced gastric or colon cancer endoscopically and pathologically in our hospital were included in this study. Seven biopsy specimens were obtained in serial number, five from the viable tissue of cancer margin and two from the ulcer debris during the endoscopy. An experienced pathologist evaluated each specimen and diagnosed. Results: A total 89 patients were enrolled, 59 advanced gastric cancer patients and 30 advanced colon cancer patients. The positive diagnosis rate of first specimen was 80.9%, and cumulative rates of second and third one were 92.1% and 96.6%. Further additional biopsy did not increase and cumulative rates of pathologic diagnosis. Positive diagnosis rates form the ulcer debris were relatively low, 60.7% and 59.6% and cumulative diagnostic yield was 71.9%. Conclusions: To make diagnosis pathologically in advanced gastric or colon cancer, three biopsy specimens were enough. Further biopsy did not make additional diagnostic yield. We recommend three or four biopsies from the viable tissue in advanced gastric or colon cancer to make efficacious diagnosis and reduce complications.
( Hyo Jung Cho ),( Gil Ho Lee ),( So Young Yoon ),( Jin Young Nam ),( Jeong Mi Kim ),( Do Wan Kim ),( Jae Youn Cheong ),( Sung Won Cho ),( Soon Sun Kim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Exosome plays important role in cell-to-cell communication. MicroRNAs in tumor-derived exosome appear to play an important role in cancer progression. The present study explored the differentially expressed microRNA profiles between hepatocellular carcinoma (HCC)-derived exosome (HEX) and normal hepatocyte-derived exosome (NEX) and investigated the target genes for microRNAs in HEX by using network analysis. Methods: Exosomes were isolated from human HCC cell lines (Hep3B and Huh-7) and immortalized normal hepatocyte cell line (THLE-2). Exosomal small RNAs were extracted and differentially expressed exosomal microRNAs between HEX and NEX were screened by using Ilumina Hiseq2000 deep sequencing. Ingenuity Pathway Analysis (IPA) software was used to identify the microRNA regulatory network analysis. Results: A total of 1,830 differentially expressed microRNAs in HEX were identified by deep sequencing. Among them, top 30 up-regulated and top 30 down-regulated exosomal microRNAs were identified in each Huh-7 and Hep3B. By using the differentially expressed microRNA profiles, network analyses were performed. Finally, SMAD3, IFNGR1, and WWP1 were identified as over-expressed hub gene in target network in Hep3B derived exosomal microRNA, while IGF1R, RAC1, and TNF were predicted as over-expressed hub gene in Huh-7 derived exosomal microRNA network. Conclusions: In conclusion, HCC derived exosomal microRNAs could have a central role in HCC progression by acting on the oncogenic pathways. Several key genes for HCC progression were successfully identified by regulatory network analysis of microRNA in HCC derived exosome.
( Hyo Jung Cho ),( Gil Ho Lee ),( So Young Yoon ),( Min Jae Yang ),( Jae Chul Hwang ),( Jin Hong Kim ),( Jae Youn Cheong ),( Sung Won Cho ),( Soon Sun Kim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: There is little evidence about the effect on risk of diabetes mellitus (DM) development according to change in nonalcoholic fatty liver disease (NAFLD) status over time. We attempted to analyze the DM risk according to change in NAFLD status. Methods: A total of 10,141 individuals for whom routine healthcare assessment was performed were reviewed, and 2,816 subjects were included. NAFLD was assessed using abdominal ultrasonography and fatty liver index. The included subjects were categorized into four groups according to changes in NAFLD status over time: persistent NAFLD, resolved NAFLD, incident NAFLD, and never NAFLD groups. Results: Subjects were categorized according to change in NAFLD status as follows: 702 subjects into the persistent NAFLD group, 157 subjects into the resolved NAFLD group, 505 subjects into the incident NAFLD group, and 1,452 subjects into the never NAFLD group. Multivariate Cox regression analysis revealed that in addition to old age, higher fasting plasma glucose, and higher alanine aminotransferase level, incident NAFLD (hazard ratio = 1.94, 95% confidence interval = 1.08-3.49, P=0.027) and persistent NAFLD (hazard ratio = 3.76, 95% confidence interval = 2.16-6.55, P<0.001) were independent risk factors for predicting DM development, whereas the risk of resolved NAFLD was not significantly different from that of never NAFLD. fatty liver index could reproduce the result acquired by ultrasonography. Conclusions: This study demonstrated that future DM risk could be influenced by changes in NAFLD status over time. Resolution of NAFLD could reduce the risk of future DM develop ment, while the development of new NAFLD could increase the risk of DM development.