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Yun, Seokhwan,Shin, Tae-Hyun,Lee, Jae-Hyun,Cho, Mi Hyeon,Kim, Il-Sun,Kim, Ji-wook,Jung, Kwangsoo,Lee, Il-Shin,Cheon, Jinwoo,Park, Kook In American Chemical Society 2018 NANO LETTERS Vol.18 No.2
<P>Cell-based therapies are attractive for treating various degenerative disorders and cancer but delivering functional cells to the region of interest in vivo remains difficult. The problem is exacerbated in dense biological matrices such as solid tissues because these environments impose significant steric hindrances for cell movement. Here, we show that neural stem cells transfected with zinc-doped ferrite magnetic nanoparticles (ZnMNPs) can be pulled by an external magnet to migrate to the desired location in the brain. These magnetically labeled cells (Mag-Cells) can migrate because ZnMNPs generate sufficiently strong mechanical forces to overcome steric hindrances in the brain tissues. Once at the site of lesion, Mag-Cells show enhanced neuronal differentiation and greater secretion of neurotrophic factors than unlabeled control stem cells. Our study shows that ZnMNPs activate zinc-mediated Wnt signaling to facilitate neuronal differentiation. When implemented in a rodent brain stroke model, Mag-Cells led to significant recovery of locomotor performance in the impaired limbs of the animals. Our findings provide a simple magnetic method for controlling migration of stem cells with high therapeutic functions, offering a valuable tool for other cell-based therapies.</P>
Yang Jinyoung,Hyeon Seokhwan,Baek Jin Yang,Kang Min Seo,Lee Keon Young,Lee Young Ho,Huh Kyungmin,Cho Sun Young,Kang Cheol-In,Chung Doo Ryeon,Peck Kyong Ran,Won Gunho,Lee Hye Won,Kim Kwangwook,Hwang In 대한의학회 2023 Journal of Korean medical science Vol.38 No.27
Tixagevimab/cilgavimab is a monoclonal antibody used to prevent coronavirus disease 2019 among immunocompromised hosts and maintained neutralizing activity against early omicron variants. Omicron BN.1 became a dominant circulating strain in Korea early 2023, but its susceptibility to tixagevimab/cilgavimab is unclear. We conducted plaque reduction neutralization test (PRNT) against BN.1 in a prospective cohort (14 patients and 30 specimens). BN.1 PRNT was conducted for one- and three-months after tixagevimab/ cilgavimab administration and the average PRNT ND50 of each point was lower than the positive cut-off value of 20 (12.9 ± 4.5 and 13.2 ± 4.2, respectively, P = 0.825). In the paired analyses, tixagevimab/cilgavimab-administered sera could not actively neutralize BN.1 (PRNT ND50 11.5 ± 2.9, P = 0.001), compared with the reserved activity against BA.5 (ND50 310.5 ± 180.4). Unlike virus-like particle assay, tixagevimab/cilgavimab was not active against BN.1 in neutralizing assay, and would not be effective in the present predominance of BA.2.75 sublineages.
폐 전지로부터 재활용 과정을 통한 란타넘, 네오디뮴 회수에 관한 연구
채병만(Byungman Chae),이석환(Seokhwan Lee),김득현(Deuk-Hyeon Kim),서은주(Eun-Ju Seo),김현일(Hyunil Kim),이승환(Seunghwan Lee),이상우(Sangwoo Lee) 한국청정기술학회 2020 청정기술 Vol.26 No.2
본 연구에서는 유기금속 회수를 한 전기차 폐배터리 부산물의 재활용에 관하여 연구하였다. 폐배터리 부산물에는 희토류들이 남아있으나, 부산물의 형태로는 소재로서의 가치가 없기에 정제과정을 거쳐 희토류 산화물로 회수하였다. 희토류침전분말 형태의 부산물을 30% 수산화나트륨을 이용하여 가공이 편한 수산화물로 변환한 뒤, 옥살산의 용해도 차이를 이용하여 남아 있는 불순물을 정제한 뒤, D2EHPA(Di-(2-ethylhexyl) phosphoric acid)를 사용하여 이트륨을 분리하였다. 과망가니즈산 칼륨을 이용하여 세륨을 분리, PC88A (2-ethylhexylphosphonic acid mono-2-ethylhexyl ester)를 사용하여 란타넘과 네오디뮴을 분리하였다. 그 후 800°C의 온도에서 소성하여 란타넘, 네오디뮴 산화물로 재생하는 방법을 확인하였다. In this paper, the recycling of waste Ni-MH battery by-products for electric vehicle is studied. Although rare earths elements still exist in waste Ni-MH battery by-products, they are not valuable as materials in the form of by-products (such as an insoluble substance). This study investigates the recovering of rare earth oxide for solvent extraction A/O ratio, substitution reaction, and reaction temperature, and scrubbing of the rare earth elements for high purity separation. The by-product (in the form of rare earth elements insoluble powder) is converted into hydroxide form using 30% sodium hydroxide solution. The remaining impurities are purified using the difference in solubility of oxalic acid. Subsequently, Yttrium is isolated by means of D2EHPA (Di-[2-ethylhexyl] phosphoric acid). After cerium is separated using potassium permanganate, lanthanum and neodymium are separated using PC88A (2-ethylhexylphosphonic acid mono-2-ethylhexyl ester) and it is calcinated at a temperature of 800°C. As a result of the physical and chemical measurement of the calcined lanthanum and neodymium powder, it is confirmed that the powder is a microsized porous powder in an oxide form of 99.9% or more. Rare earth oxides are recovered from Ni-MH battery by-products through two solvent extraction processes and one oxidation process. This study has regenerated lanthanum and neodymium oxide as a useful material.
Lee Seungjin,Reo Seung Hyeon,Kim Seokjoon,Kim Seokhwan,이은성,Cha Byung Seok,Shin Jiye,한진주,Ahn So Min,신한승,Park Ki Soo 한국바이오칩학회 2024 BioChip Journal Vol.18 No.1
In this study, Staphylococcus aureus (S. aureus ) was detected using a system that combined direct loop-mediated isothermal amplification (LAMP) and lateral flow assays (LFA). This technology relies on sequence-specific hybridization in LFA; furthermore, it has high specificity and addresses the limitations associated with nonspecific amplification in general colori- metric LAMP. In addition, a direct boiling method was adopted to streamline DNA extraction and enable simple detection. The established technology was used to successfully detect S. aureus at a concentration as low as 10 2 colony-forming unit/ mL, without cross-reactivity with other strains. The practical applicability of this technology was demonstrated by analyzing real samples such as beef jerky, cabbage, and eggshell, which were artificially spiked with S. aureus . This developed system may be beneficial with regard to operational simplicity, short analysis time, and high detection performance, which would enable its application in point-of-care settings and as a novel platform for detecting various pathogens.