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Ah-Young Shin,HyeRan Kim,Jongmoon Ahn,Seokhyeon Nahm,Jeong Mee Park,Suk-Yoon Kwon 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
The Cucurbitaceae (Cucurbits) family has 825 species in 118 genera, predominantly distributed in tropical and subtropical regions. Major cucurbit crops including cucumber (Cucumis sativa), melon (Cucumis melo), watermelon (Citrullus lanatus), and squash/pumpkin (Cucumis pepo) are important in the human diet and the rural economy. In recent years, large amount of genome information has been analyzed and reported in major cucurbit crops, such as cucumber, melon, and watermelon. To construct high quality reference genome sequence of Korean melon (Chamoe), genomic and transcriptomic sequence data were generated from Korean native (Gotgam) and elite (SW3) Chamoe inbred line using Illumina HiSeq2000 platform. In case of genome analysis, 4,773 scaffolds covering 98% of Gotgam Chamoe were assembled through de novo genome assembly and reference-based assembly. Large number of simple sequence repeats (SSRs) and single nucleotide polymorphisms (SNPs) were detected between two inbred lines and these markers were used for construction of genetic maps and discrimination of cultivars or species. In addition, genome sequence of other Chamoe and melon including Chang Bougi, Sakata’s Sweet, Prescott Fond Blanc and Banana melon will be constructed by de novo genome analysis. Genetic markers of these will also be detected and used for marker-assisted breeding and further analysis to investigate major traits of Chamoe, fruit color and flesh color. In conclusion, the newly constructed reference genome will provide genome information for comparative genomics and breeding of other cucurbit crops.
Full mouth rehabilitation with iliac bone graft for a patient with traumatic neuroma in mandible
( Hyeran Kim ),( Jin-ho Shin ),( Hong-seo Yang ),( Chan Park ),( Hyun-pil Lim ) 조선대학교 구강생물학연구소 2017 Oral Biology Research (Oral Biol Res) Vol.41 No.1
Damaged sensory nerves in the facial area might show spontaneous recovery. However, imperfect regeneration, such as paresthesia, numbness, and painful pathologic regeneration can occur in some cases. Therefore, iatrogenic nerve damage should be avoided during implant placement in patients with alveolar bone atrophy. For placement of implants in the posterior area of the mandible, the corresponding anatomical structures including the inferior alveolar nerve are of concern. Herein, we presented a case of a patient who developed traumatic neuroma after undergoing full mouth rehabilitation with implants in another hospital. Treatment at our facility included the removal of all implants posterior to the mental foramen, followed by an autogenous iliac bone graft performed on the atrophied alveolar ridge of the mandible. Subsequently, implants were placed in the grafted sites. Finally, the patient showed functional and esthetic results.
다이어트를 하고 있는 여대생들의 변비유병율과 식이섭취상태
이혜란(Hyeran Lee),신윤진(Yoonjin Shin),김양하(Yangha Kim) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.12
본 연구는 다이어트가 여대생들의 변비유병율에 미치는 영향 및 관련요인을 조사하고자 수행되었다. 다이어트 유무에 따라 대조군 116명과 다이어트군 135명으로 나누어 비교하였다. 다이어트군의 평균 신장과 체중은 161.96±4.460 cm, 53.87±6.645 kg이었으며 대조군의 경우는 161.42±4.492 cm, 52.77±7.935 kg으로 서로 유의적인 차이가 없었다. 변비유병율을 살펴보았을 때 대조군이 20.7%, 다이어트군이 61.5%로 대조군에 비해 다이어트군에서 변비유병율이 유의적으로 높게 나타났다 (p<0.001). 대조군의 열량섭취량은 1587.53±276.918 kcal인 것에 비하여, 다이어트군의 열량섭취량은 1450.47±328.94 kcal로 유의적으로 낮게 나타났다. (p<0.001). 대조군의 식이섬유 섭취량은 16.18±3.64 g, 다이어트군의 식이섬유 섭취량은 14.0±3.8 g으로 대조군에 비해 다이어트군에서 식이섬유 섭취량은 유의적으로 낮게 섭취하였다(p<0.001). 대조군의 수분 섭취량은 637.9±149.7 g, 다이어트군에서 수분 섭취량은 595.6±173.3 g으로 다이어트군에서 유의적으로 낮게 섭취하는 것으로 나타났다(p<0.05). 대조군에 비하여 다이어트군에서 단백질, 칼슘, 인, 철분, 나트륨 등의 섭취가 적었다(p<0.05). 변비유병율은 식습관점수, 운동생활습관점수, 식이섬유의 섭취, 수분섭취의 세가지 항목에서 유의적인 음의 상관관계를 나타내었다(p<0.05, p<0.001). 이와 같이 본 연구에서는 다이어트를 하는 여대생에서 변비유병율이 높게 나타났으며 변비유병율을 높이는 관련 요인으로 식이섬유와 수분의 섭취가 확인되었다. This study was conducted to investigate the effects of diet on the nutritional status and constipation rate of female college students. A total of 251 female college students living in Gyeonggi province participated in this study. Dietary intake was ascertained from a 3-day dietary record, including 2 weekdays and 1 weekend day. Anthropometrics, general characteristics, diet experiences, dietary habits and prevalence of constipation were analyzed using a questionnaire. The subjects were divided into two groups, a control group (n=165, 46.2%) and a diet group (n=135, 53.8%). There was no significant difference in age, height, weight or BMI between groups. The prevalence of constipation was higher in the diet group than the control group. The intakes of energy, dietary fiber and water of the diet group were significantly lower than those of the control group. Correlation analysis revealed that the prevalence of constipation was negatively associated with exercise score, dietary fiber intake and water intake. It is postulated that dietary habits might be important factors contributing to constipation. Accordingly, nutrition education aimed to improve intakes of fiber and water may be necessary during weight control periods.
순수 알츠하이머병 치매 환자군과 혼합성 치매 환자군에서 12개월간의 도네페질(Donepezil) 투여에 따른 치료 성적의 비교 평가
강효신(Hyo Shin Kang),안인숙(Inn Sook Ahn),윤지혜(Ji Hae Yun),문유진(Yu Jin Moon),황태영(Tae Young Hwang),이영민(Young Min Lee),김혜란(Hyeran Kim),정재원(Jae Won Chung),김도관(Doh Kwan Kim) 대한노인정신의학회 2010 노인정신의학 Vol.14 No.1
Objectives:The purpose of this study was to compare the efficacy of donepezil treatment between patients with pure Alzheimer’s disease (AD) and Mixed dementia (MD) during a 12-month trial. Methods:A total of 139 patients were recruited for this 52-week study. The effect of donepezil on cognitive function was measured using Alzheimer’s Disease Assessment Scale-cognitive subscale-preliminary Korean version (ADAS-cog-K). Patients’ activities of daily living using the Seoul-Instrumental Activities of Daily Living (S-IADL) and Seoul-Activities of Daily Living (S-ADL);behavioral symptoms using the Korean version Neuropsychiatric Inventory (K-NPI) were measured at baseline, 13-weeks, 26-weeks, 39-weeks and 52-weeks. We defined the responsive patients to donepezil at those who showed a cognitive improvement or no change during the first six-month clinical trial. Results:84 pure AD patients and 34 MD patients were available for intent-to-treat (ITT) last observation carried forward (LOCF) analysis. There was no significant difference between two groups in mean change from baseline in the total ADAS-cog-k, S-ADL, SIADL and K-NPI scores at 52-week. Based on the operational criteria, 60.7% of pure AD patients and 58.8% of MD patients were responders to donepezil. Conclusion:MD patients had similar levels of efficacy with pure AD patients and donepezil was well tolerated in both groups. These results suggest that donepezil is an effective and well-tolerated treatment for MD patients as well as for pure AD patients.
이혜란(Lee Hyeran),강보름(Kang Borum),정혜경(Chung Hye Kyung),도현주(Do Hyun Joo),심지선(Shim Jeeseon),배순화(Bae Soon Hwa),강석민(Kang Seok-Min),신민정(Shin Min-Jeong) 韓國營養學會 2010 Journal of Nutrition and Health Vol.43 No.3
본 연구에서는 우리나라 심부전 환자 78명을 대상으로 식이 섭취 빈도법을 통한 영양소 섭취량 조사를 시행하여 한국인 영양섭취기준과 비교하였으며 그 결과는 다음과 같았다. 1) 에너지와 단백질, 철분의 평균 섭취량은 한국인 영양섭취 기준에 비해 충분히 섭취하고 있었으나 나트륨 섭취가 과다하고, 칼륨 섭취가 부족한 불균형의 영양문제가 파악되었다. 2) 칼슘의 섭취가 부족한 환자들이 상당수 존재하여 심부전 환자의 골연화증 및 골다공증 위험이 높을 가능성이 있음을 확인하였다. 3) 비타민 B₁₂, 엽산의 섭취가 부족하며, 이외 리보플라빈, 나이아신 등의 비타민 섭취 부족의 가능성이 있음을 확인하였다. 4) 70세 이상의 고령 환자에서도 칼륨, 칼슘, 비타민 B₁₂, 엽산의 섭취가 부족한 것으로 나타났고 이러한 부족 현상은 고령 환자에서 더욱 심각한 것으로 파악되었다. 위의 결과로 보아 국내 심부전 환자의 경우 무기질, 비타민 등의 미량 영양소의 섭취 부족이라는 영양문제가 존재하고 있었다. 따라서 이러한 영양 결핍 문제가 지속된다면 심부전 환자의 장기적인 예후에 영향을 미칠 수 있을 것이므로 영양섭취 부족을 해결하기 위한 다각적 측면에서의 영양 섭취 평가 및 영양관리 대책과 지침이 마련되어야 할 것이다. The prevalence of heart failure (HF) is increasing globally and growing evidence has shown that dietary factors play an important role in preventing and improving prognosis of HF. However, little data on nutrient intake in Korean HF patients which are available to develop dietary guidelines for HF. The aims of this study were to estimate nutrient intake in 78 HF patients and evaluate whether the estimated nutrient intake is appropriate compared to dietary reference intake for Koreans. Data are presented as the ratio of actual intake and estimated average requirement (EAR) for each nutrient. The result showed that the average nutrient intakes including total energy and protein met EAR in total patients. However, the deficiencies in mineral and vitamin intakes were found. Moreover, the proportion of subjects with lower intake than EAR was substantial. The results showed that the proportion of male HF patients with inferior intakes to EAR in calcium, potassium (compared to adequate intake: AI), folate and vitamin B₁₂ were 38%, 79%, 38%, and 65%, respectively. Also, the proportion of female HF patients with inferior intakes to EAR in calcium, potassium (compared to AI), folate and vitamin B₁₂ were 35%, 88%, 38% and 40%, respectively. In particular, the elderly with HF (≥ 70 yrs, n = 28) showed more serious deficiencies in calcium, potassium (compared to AI), folate and vitamin B₁₂. In summary, the intakes of potassium, calcium, folate, and vitamin B₁₂ were not sufficient to meet EAR in HF patients. Furthermore, the proportions of subjects with lower intake than EAR in these nutrients were substantial, raising the possibility that these micronutrients may be involved in the pathogenesis of HF. Practical dietary guideline for HF patients is needed to improve prognosis of HF.