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Ren, Hui,Li, Jun,Liu, Jing-Jing,Guo, Hui-Ling,Jiang, Tao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Objective: This study is conducted to evaluate the effects of anti-HER-2${\times}$anti-CD3 bi-specific antibodies(BsAb) on HER-2/neuover-expressing human colorectal carcinoma cells. Methods: Growth was assessed by MTT assays after exposure of HCT-116 cells to Herceptin, anti-CD3 and BsAb antibodies. Immunocytochemistry was applied to test the HER-2 level of HCT-116. In a nude mouse model, HER-2${\times}$CD3 BsAb was combined with effector cells (peripheral blood lymph cells from normal human being) for observations on in Vivo growth of tumors. Results: Compared with the control group, using effector cells combined with anti-CD3 McAb, Herceptin or HER2${\times}$CD3 BsAb, tumor cell growth in vitro and in vivo was significantly inhibited (P<0.05), most remarkably in the HER2${\times}$CD3 BsAb case. The growth of xenografts with HER2${\times}$CD3 BsAb combined with effector cells was also significantly inhibited when compared with the anti-CD3 McAb or Herceptin groups (P<0.05). Conclusion: HER-2/neu might be a useful target for immunotherapy in colorectal carcinoma, anti-HER2${\times}$anti-CD3 BsAb exerting clear anti-tumor effects.
Wang Hui-Ching,Moi Sin-Hua,Chan Leong-Perng,Wu Chun-Chieh,Du Jeng-Shiun,Liu Pei-Lin,Chou Meng-Chun,Wu Che-Wei,Huang Chih-Jen,Hsiao Hui-Hua,Pan Mei-Ren,Chen Li-Tzong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Personalized genetic profiling has focused on improving treatment efficacy and predicting risk stratification by identifying mutated genes and selecting targeted agents according to genetic testing. Therefore, we evaluated the role of genetic profiling and tumor mutation burden (TMB) using next-generation sequencing in patients with head and neck squamous cell carcinoma (HNSC). The relapse mutation signature (RMS) and chromatin remodeling mutation signature (CRMS) were explored to predict the risk of relapse in patients with HNSC treated with concurrent chemoradiotherapy (CCRT) with platinum-based chemotherapy. Patients in the high RMS and CRMS groups showed significantly shorter relapse-free survival than those in the low RMS and CRMS groups, respectively (p < 0.001 and p = 0.006). Multivariate Cox regression analysis showed that extranodal extension, CCRT response, and three somatic mutation profiles (TMB, RMS, and CRMS) were independent risk predictors for HNSC relapse. The predictive nomogram showed satisfactory performance in predicting relapse-free survival in patients with HNSC treated with CCRT.
Yanyan Ren,Hongfeng Li,Guanglei Wu,Le Yang,Chenhui Zheng,LIUDING WANG,Fang Ren,Hui Xing,HONGJING WU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.2
Al/Fe/Co doped ordered mesoporous carbon (OMC) composites have been synthesized by a facile method, and the influence of dopant on the electromagnetic (EM) and microwave absorption properties was investigated in the frequency range of 2–18 GHz. Compared with Fe/Co– OMC composites, the Al–OMC nanocomposite played a great role in adjusting values and frequency dependence of complex permittivity, which gives rise to significant improved microwave absorption and reduced thickness of the corresponding paraffin wax composites. Reflection loss (RL) values less than -5 dB and -10 dB were obtained in the frequency range of 9.2–18 GHz and 10.7–14.7 GHz with a single thickness of 2.00 mm, respectively. Such enhanced EM wave absorption property of the Al–OMC/paraffin wax composite was ascribed to its superior impedance matching characteristic. Thin thickness, broadband absorption microwave absorbers with Al doped OMC nanocomposites were obtained.
중국 대학생의 인구통계학적 특성에 따른 신체활동량의 차이
임혜걸(Ren, Hui-Jie),이호성(Lee, Ho-Seong),송영은(Song, Young-Eun) 한국체육과학회 2019 한국체육과학회지 Vol.28 No.1
The purpose of this study was to investigate the difference in physical activity according to the demographic characteristics in Chinese university students by using the international physical activity questionnaire (IPAQ). Data collection was surveyed by targeting in 800 university students in S province, china, and date used in this study 712 copied for the final analysis. All collected data were analysed with descriptive statistics analysis, T-test, and one-way ANOVA by using SPSS. The following were main results. First, there was a significant difference in physical activity by their sex (p=.000), age (22 vs. 19; p=.043, 20; p=.004, 21; p=.005 and 23 vs. 20; p=.045, 21; p=.042, respectively), height (170-179㎝ and 180-189㎝ vs. 150-159㎝; p=.015, p=.020, 160-169㎝; p=.000, p=.005, respectively), weight (60-69㎏ and ≥70㎏ vs. 40-40㎏; p=.015, p=.005, 50-59㎏; p=.008, p=.003, respectively) and leisure life (physical activity vs. internet; p=.000, rest; p=.007, etc; p=.000, respectively), but did not significant difference in physical activity by their which blood type (p=.279). Second, there was a significant difference in physical activity by their gender and intensity (High PA vs. Middel PA; p=.000, Low PA; p=.000, Middel PA vs. Low PA; p=.000 in male and female, respectively). These results confirmed that physical activity depending on th demographic characteristics in chinese university students.
Hui-Fang Zhao,Kai Qiu,Guo-Dong Ren,Yong Zhu,Ben-Ke Kuai 한국식물학회 2010 Journal of Plant Biology Vol.53 No.1
A developmentally stunted mutant (dsm1) of Arabidopsis, isolated from an EMS mutant screen, had a pleiotropic phenotype, including repressed germination,retarded growth, delayed flowering, and impaired fertility. Additionally, dsm1 had a lifespan of approximately 160 days, which was more than twice the lifespan of the wild type (Col-0). Fine morphological and anatomical characters, such as the shoot apical meristem, root apical meristem, seed shape, and seed surface, were obviously altered in dsm1. We found that both abscisic acid and zeatin riboside levels were significantly greater in dsm1 than in Col-0 at all stages of development, while the levels of indole-3-acetic acid and gibberellins varied by age. The expressions of some abscisic acid-related genes were higher in dsm1 than in Col-0. These data indicate that DSM1 may play a general role in plant growth and development.
Hui Chen,Shuai Shao,Hao Jiang,Guohai Ren,Pengying Du 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
This paper proposes a current sharing method for interleaved LLC resonant converter with secondary partial energy phase shift regulation. An AC voltage source with phase shift regulation is constructed and in series with main transformer at secondary side to balance the output currents. With secondary regulation ability, the current imbalance caused by the resonant tank tolerance can be compensated. The major part of power is delivered to load by main transformer, and small portion power is converted by the auxiliary parts, therefore, the energy loss of the conversion is almost as high as conventional LLC resonant converter. The steady state operating principle of the proposed converter is analyzed, and a prototype with two phases current sharing ability is built-up based on the theoretical analysis.
Research on Bending Stiffness of the New Sprayer Joint
Ren Li,Zhicheng Xiao,Hui-jun Li,Baohui Li 한국강구조학회 2024 International Journal of Steel Structures Vol.24 No.2
The socket joint are commonly employed in large-span spatial structures; however, its bending stiff ness is limited. Based on the socket joint, this paper proposes an improved and novel sprayer joint that features a more rational force transmission mechanism and have larger bending stiff ness. Firstly, the joint is designed, followed by verifi cation of numerical model and bending stiff ness comparison with socket joint. Secondly, the bending performance of the sprayer joints with various surrounding bolt radii under load conditions is investigated, and the resulting bending moment-rotation curves are obtained. The research fi ndings demonstrate that the force transmission mechanism of the sprayer joint with larger bending stiff ness is more rational. When the surrounding bolt radius is excessively small or the axial tension is excessively high, the bolt prematurely yields, leading to a signifi cant decrease in joint stiff ness. Despite a mere 15% increase in material cost, the bending stiff ness of the new joint is 21.71 times higher than that of the traditional socket joint, and the ultimate bending moment is 5.42 times higher.
A Study on Control Strategy of Electric Power Steering Based on Fuzzy Control
Hui Zhang,Jing Ren,Yanru Zhong,Jian Chen 전력전자학회 2007 ICPE(ISPE)논문집 Vol.- No.-
Intelligent Control, a novel stage of automatic control development, is one of the efficient strategies for the system with nonlinear or imprecise model. This paper has applied Fuzzy Control (FC) technology to AC electric power steering (EPS) system for seeking better control strategies. Proceeding with fuzzy logic, fuzzy rule and fuzzy inference, a kind of control diagram of EPS based on fuzzy control system has been presented, which can be used to solve the nonlinear or imprecise problems of electrical machine control. The paper has established the foundation for further applications of FC technology in EPS domains. The FC system is verified to be feasible by simulation and experiment.
Hui Zhang,Jing Ren,Yanru Zhong,Jian Chen 전력전자학회 2007 ICPE(ISPE)논문집 Vol.- No.-
A prototype, double-DSPs controlled Power Conditioning System (PCS) for Super-conducting Magnetic Energy Storage (SMES), is used for experimental research in dynamic simulation test of power system. The function of SMES is to improve the dynamic performance of a singlemachine infinite bus for power system. The experimental results show that the energy transfer of SMES is done almost immediately depending on the system requirement, and SMES is able to restore system stability for short circuit. The control algorithms for the SMES are simple and implementation has required very a little hardware.