http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Hua-Pin Huang (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Chen, Chen,Lv, Guang,Huang, Xin,Liao, Xue Pin,Zhang, Wen Hua,Shi, Bi Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.2
In this study, the homogenous Pd nanoparticles (Pd NPs) were first prepared with bayberry tannin (BT) as the stabilizers. Subsequently, the obtained bayberry tannin-stabilized Pd nanoparticles (BT-Pd) were immobilized onto ${\gamma}-Al_2O_3$ to prepare heterogeneous ${\gamma}-Al_2O_3$-BT-Pd catalysts. Fourier Transformation Infrared Spectrum (FTIR) and X-ray Photoelectron Spectroscopy (XPS) analyses confirmed that the Pd NPs were well stabilized by the phenolic hydroxyl groups of BT. Transmission Electron Microscopy (TEM) observation indicated that the diameter of the Pd NPs can be effectively controlled in the range of 4.2-16.0 nm by varying the amount of BT. It is found that the ${\gamma}-Al_2O_3$-BT-Pd catalysts exhibit highly activity for various olefin hydrogenations. For example, the initial TOF (turnover frequency) of the ${\gamma}-Al_2O_3$-BT-Pd in the allyl alcohol hydrogenation is as high as $12804 mol{\cdot}mol^{-1}{\cdot}h^{-1}$. Furthermore, the ${\gamma}-Al_2O_3$-BT-Pd can be reused 5 times without significant loss of activity, exhibiting a superior reusability as compared with conventionally prepared ${\gamma}-Al_2O_3$-Pd catalysts.
-
Chang-Yun Liu,Ji-Lan Lin,Shu-Yan Feng,Chun-Hui Che,Hua-Pin Huang,Zhang-Yu Zou 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.1
Background and Purpose Mutations in the FIG4 gene have been linked to amyotrophic lateral sclerosis (ALS) type 11 in Caucasian populations. The purpose of this study was to identify FIG4 variants in a cohort of 15 familial ALS (FALS) indexes and 275 sporadic ALS (SALS) patients of Han Chinese origin. Methods All 23 exons of FIG4 were sequenced using targeted next-generation sequencing. An extensive literature review was performed to detect genotype-phenotype associations of FIG4 mutations. Results No FIG4 variants were identified in the FALS patients. One novel heterozygous missense variant (c.352G>T [p.D118Y]) and one novel heterozygous nonsense variant (c.2158G>T [p.E720X]) in FIG4 were identified in two SALS patients. The p.E720X variant is interpreted as likely pathogenic while the p.D118Y variant is a variant of uncertain significance. The patient carrying the p.E720X mutation developed lower-limb-onset slowly progressive ALS, and survived for 11.5 years. The patient harboring the FIG4 p.D118Y variant also presented with progressive ALS, with the score on the ALS Functional Rating Scale–Revised (ALSFRS-R) decreasing by 0.4 per month. The rate of decrease in the ALSFRS-R scores from symptom onset to diagnosis seemed to be lower in the patients carrying FIG4 variants than the no-FIG4-mutation ALS patients in this study. Conclusions Our findings suggest that ALS patients carrying FIG4 mutations are not common in the Chinese population and are more likely to exhibit slow progression.
-
( Ming-lung Yu ),( Chao-hung Hung ),( Yi-hsiang Huang ),( Cheng-yuan Peng ),( Chun-yen Lin ),( Pin-nan Cheng ),( Rong-nan Chien ),( Shih-jer Hsu ),( Chen-hua Liu ),( Jee-fu Huang ),( Chung-feng Huang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The current study aims to elucidate the treatment efficacy (defined as undetectable HCV RNA throughout 12 weeks of post-treatment follow-up, SVR12) and safety DCV/ASV plus ribavirin for 12 weeks in HCV-1b patients without NS5A RAS. Methods: This is a single-arm, open-label phase 2 study. Seventy directly acting antivirals (DAA)-naïve HCV-1b patients without L31/Y93 RAS are planned to receive daclatasvir (60 mg/ day) and asunaprevir (100 mg twice daily) plus weight-based ribavirin (1000-1200 mg/day) for 12 weeks. After treatment they were followed up for 12 weeks. Results: As of 31 Oct 2017, 58 eligible patients are allocated to treatment, with a mean age of 59.3 years and female predominance (67.2%, 39/58). The mean HCV RNA was 5.87+0.77 log10 IU/mL; 23 patients (39.7 %) had significant hepatic fibrosis (>F2). In the modified intention-to-treat analysis, the rate of undetectable HCV at week 1, week 2, week 4, week 8 and endof- treatment was 25 % (14/56), 84.8 % (39/46), 100 % (46/46), 100 % (38/38) and 100 % (27/27), respectively. Undetectable HCV RNA were observed in all of the patients with HCV RNA assessable 4 weeks (SVR4, 18/18) and 12 weeks (SVR12, 12/12) post treatment. None of the 18 patients who completed the 12-week treatment experienced relapse during post-treatment follow-up. The most common adverse event was fatigue (78.3 %), followed by pruritus (65.2 %) and dizziness (52.2 %), of which were considered as ribavirin related. None of the participating subjects withdrew treatment or follow-up throughout the trial peroid. Three serious adverse events were reported which included urosepsis, appendicitis and left ureteral stone. All were unrelated to the investigating drugs. Conclusions: 12 weeks of DCV/ASV plus ribavirin was highly effective and safe in HCV-1b patients without NS5A RAS in the interim analysis. The satisfactory results would be anticipated in the full patient set.
-
Lo, Li,Belt, Simon T.,Lattaud, Julie,Friedrich, Tobias,Zeeden, Christian,Schouten, Stefan,Smik, Lukas,Timmermann, Axel,Cabedo-Sanz, Patricia,Huang, Jyh-Jaan,Zhou, Liping,Ou, Tsong-Hua,Chang, Yuan-Pin Elsevier 2018 Earth and planetary science letters Vol.488 No.-
<P><B>Abstract</B></P> <P>Recent reduction in high-latitude sea ice extent demonstrates that sea ice is highly sensitive to external and internal radiative forcings. In order to better understand sea ice system responses to external orbital forcing and internal oscillations on orbital timescales, here we reconstruct changes in sea ice extent and summer sea surface temperature (SSST) over the past 130,000 yrs in the central Okhotsk Sea. We applied novel organic geochemical proxies of sea ice (IP<SUB>25</SUB>), SSST ( TEX L 86 ) and open water marine productivity (a tri-unsaturated highly branched isoprenoid and biogenic opal) to marine sediment core MD01-2414 (53°11.77′N, 149°34.80′E, water depth 1123 m). To complement the proxy data, we also carried out transient Earth system model simulations and sensitivity tests to identify contributions of different climatic forcing factors. Our results show that the central Okhotsk Sea was ice-free during Marine Isotope Stage (MIS) 5e and the early-mid Holocene, but experienced variable sea ice cover during MIS 2–4, consistent with intervals of relatively high and low SSST, respectively. Our data also show that the sea ice extent was governed by precession-dominated insolation changes during intervals of atmospheric CO<SUB>2</SUB> concentrations ranging from 190 to 260 ppm. However, the proxy record and the model simulation data show that the central Okhotsk Sea was near ice-free regardless of insolation forcing throughout the penultimate interglacial, and during the Holocene, when atmospheric CO<SUB>2</SUB> was above ∼260 ppm. Past sea ice conditions in the central Okhotsk Sea were therefore strongly modulated by both orbital-driven insolation and CO<SUB>2</SUB>-induced radiative forcing during the past glacial/interglacial cycle.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The first orbital timescale proxy-model sea ice-sea surface temperature records from the northwestern subarctic Pacific Ocean. </LI> <LI> Strong precession forcing controlled and sea ice variations are modulated by greenhouse gas radiative forcing. </LI> <LI> Sea ice remained free in the central Okhotsk Sea during MIS 5e due to high greenhouse gas radiative forcing. </LI> </UL> </P>
ScienceON
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
