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Training Early Childhood Educators for the Future
Alice Sterling Honig 한국유아교육학회 1997 INTERNATIONAL JOURNAL OF EARLY CHILDHOOD EDUCATION Vol.2 No.1
This presentation focuses on future needs and ideas for training early childhood educators. Current emphases on cognitive preparation for success in schools and on developmentally appropriate practices with young children sometimes give short shrift to the importance of new ways of conceptualizing teacher education so that those who dedicate themselves to preparing young children for the next century will be more confidently prepared to do so. Nurturing teachers are wise in the ways of young children, thoroughly conversant with child development theories and knowledge, reflective and observant of the special nature and needs of each child. Creative trainers will help teachers of the future become skilled not only at classroom organization and management, but also adept at individualizing the curriculum, depending on each child‘s personal style, gifts, and interests, as well as flexible in working with families.
Holly E . BrophyHerb,Alice Sterling Honig 한국유아교육학회 1999 INTERNATIONAL JOURNAL OF EARLY CHILDHOOD EDUCATION Vol.4 No.1
Seventy-eight unmarried adolescent mothers, ages 14-19 years, completed an open-ended interview at 3 weeks postpartum to ascertain their perceptions of the nursing care they received during labor and delivery, and immediately after childbirth. Qualitative analyses of interview data revealed mothers‘ perceptions of components of satisfaction or dissatisfaction with care. These results emphasize the importance of the attentiveness and emotional support of nurses and other early education professionals in the process of providing care to adolescent mothers.
Intergenerational Comparisons of Fathering Practices and Attitudes: A Cross-cultural study
Kwang Hee Jung,Alice Sterling Honig 한국유아교육학회 2001 INTERNATIONAL JOURNAL OF EARLY CHILDHOOD EDUCATION Vol.7 No.-
Eighty grandfathers and fathers from United States and Korea were interviewed for this study. To identify similarities and differences between grandfathers and their grown sons‘ child rearing practices and attitudes, four dimensions of fathering behaviors were coded from the Sears Interview Schedule (Sears, Maccoby, & Levin, 1957): nurturance, aggression, parental rules, and discipline. American grandfather-father pairs and Korean grandfather-father pairs revealed similar results. In permissiveness regarding child aggression toward others and in strictness with parental rules, fathers reported behavior similar to their fathers. In father‘s nurturance, fathers from both countries showed more enlightened and affectionate behavior than their own fathers. In severity of discipline, American grandfathers reported more severe discipline than their sons did. The findings of this study are discussed in light of modeling theory, compensatory hypothesis, and cohort hypothesis.
조수진,Nikolaos Scarmeas,장태원,Karen Marder,Ming-Xin Tang,Lawrence S. Honig 대한의학회 2011 Journal of Korean medical science Vol.26 No.3
The coexistence of cerebral infarcts and Alzheimer’s disease (AD) is common, but the influence of symptomatic cerebral infarcts on cognition is uncertain in AD. We hypothesize that symptomatic cerebral infarcts may provide an additive cognitive factor contributing to dementia in the AD population. We studied 1,001 clinically probable or possible AD patients in the Alzheimer Disease Research Center (ADRC) database. Linear regression was used to evaluate for an association between symptomatic cerebral infarcts and memory,language, executive function, abstract reasoning, and visuospatial performance,separately. Models were adjusted for covariates including age, gender, education,ethnicity, hypertension, diabetes mellitus, heart disease, clinical dementia rating, the presence of silent cerebral infarcts, and multiplicity or location of infarcts. Clinical history of stroke was present in 107 patients, radiological infarcts in 308 patients, and 68 patients with both were considered to have symptomatic infarcts. Adjusting for all covariates, AD patients with symptomatic infarcts had more impairment of executive function (P < 0.05). The influence of cerebral infarcts is neither general nor diffuse, and the presence of clinical history may have a more important influence on executive performance in AD.
Chen, Y.,Sheng, R.,Kallberg, M.,Silkov, A.,Tun, Moe P.,Bhardwaj, N.,Kurilova, S.,Hall, Randy A.,Honig, B.,Lu, H.,Cho, W. Cell Press 2012 Molecular cell Vol.46 No.2
Emerging evidence indicates that membrane lipids regulate protein networking by directly interacting with protein-interaction domains (PIDs). As a pilot study to identify and functionally annodate lipid-binding PIDs on a genomic scale, we performed experimental and computational studies of PDZ domains. Characterization of 70 PDZ domains showed that ~40% had submicromolar membrane affinity. Using a computational model built from these data, we predicted the membrane-binding properties of 2,000 PDZ domains from 20 species. The accuracy of the prediction was experimentally validated for 26 PDZ domains. We also subdivided lipid-binding PDZ domains into three classes based on the interplay between membrane- and protein-binding sites. For different classes of PDZ domains, lipid binding regulates their protein interactions by different mechanisms. Functional studies of a PDZ domain protein, rhophilin 2, suggest that all classes of lipid-binding PDZ domains serve as genuine dual-specificity modules regulating protein interactions at the membrane under physiological conditions.
Kim, D.,Park, M.J.,Gwon, G.,Silkov, A.,Xu, Z.Y.,Yang, E.,Song, S.,Song, K.,Kim, Y.,Yoon, H.,Honig, B.,Cho, W.,Cho, Y.,Hwang, I. Cell Press 2014 DEVELOPMENTAL CELL Vol.30 No.5
In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targeting factor for chloroplast outer membrane (COM) proteins, evolved from the ankyrin repeat domain (ARD) of the host cell by stepwise extensions of its N-terminal domain and that two lipids, monogalactosyldiacylglycerol (MGDG) and phosphatidylglycerol (PG), of the endosymbiont were selected to function as the AKR2A receptor. Structural analysis, molecular modeling, and mutational analysis of the ARD identified two adjacent sites for coincidental and synergistic binding of MGDG and PG. Based on these findings, we propose that the targeting mechanism of COM proteins was established using components from both the endosymbiont and host cell through a modification of the protein-protein-interacting ARD into a lipid binding domain.