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차라리 ( Ra Ri Cha ),백동훈 ( Dong Hoon Baek ),이경원 ( Gyeong Won Lee ),박선자 ( Seun Ja Park ),이종훈 ( Jong Hoon Lee ),박종하 ( Jong Ha Park ),김태오 ( Tae Oh Kim ),이상훈 ( Sang Heon Lee ),김형욱 ( Hyung Wook Kim ),김현진 ( Hy 대한소화기학회 2021 대한소화기학회지 Vol.78 No.6
Background/Aims: This multicenter study reviewed the clinical features and prognosis according to the primary site of involvement and the treatment modality in patients with B-cell primary intestinal lymphoma (PIL). Methods: Among 125 consecutive patients diagnosed with PIL, 100 patients were analyzed. Results: The median age was 59 years, and the male to female ratio was 1.86:1. Diffuse large B-cell lymphoma (66/100, 66.0%) was the most common histological subtype. The estimated 5-year survival rate (5-YSR) was 48.5%. The 5-YSR was similar regardless of the type of primary treatment (chemotherapy alone vs. surgery/chemotherapy, 50.7 vs. 45.3%, p=0.582). A comparison of the survival according to the primary site of involvement revealed a 5-YSR of 32.5% (p=0.027), 64.3% (reference), 46.5% (p=0.113), and 49.8% (p=0.024) for the small intestine, ileocecal region, large intestine, and multiple sites, respectively. Multivariate analysis, however, revealed a low hemoglobin level, advanced Ann Arbor stage, and aggressive histological type to be independent prognostic factors for shorter survival but not ileocecal region involvement. Conclusions: The Ann Arbor stage, hemoglobin level, and histological type were independent prognostic factors for survival, while the primary site of involvement and treatment modality did not affect the prognosis in patients with B-cell PIL. (Korean J Gastroenterol 2021;78:320-327)
도축장 출하 돼지에서의 milk-spots 출현율 및 돈회충 감염에 관한 역학적 조사
양하영 ( Ha Young Yang ),이정구 ( Jung Goo Lee ),윤가리 ( Ga Ri Yun ),라도경 ( Do Kyung Ra ),박은정 ( Eun Jeong Park ),이승환 ( Seung Hwan Lee ),김철완 ( Cheol Wan Kim ),김기호 ( Ki Ho Kim ),이성모 ( Sung Mo Lee ),황현순 ( Hyun So 한국가축위생학회 2008 韓國家畜衛生學會誌 Vol.31 No.2
Swine ascariasis is one of the major parasitic diseases to cause economic losses. This study was carried out to investigate the prevalence of Ascaris suum from slaughtered pigs and return the result to the farm (Feed-back). A total of 8,121 pigs (315 farms) were examined from January to November in 2007. The prevalence of farms detected with milk-spots was 42.9% (135 / 315 farms), and that of pigs with milk-spots was 7% (565 / 8,121 heads). Among 565 pigs with milk-spots, the pigs with grade 1 and grade 2 were 380 and 185, respectively. The percentage of pigs and farms detected with adult worm were 0.6% (45/8,121) and 7.3%(23/315) respectively. There was no statistical difference in affection rate among seasons. The rate was 5.0% in spring, 8.8% in summer, 8.2% in autumn and 6.3% in winter. There was no enough difference in pig infection rate based on piggery type. The prevalence of milk-spots in stolic type and in sawdust one were 15% and 18.5%, respectively.
식도 암육종 환자에서 이시적으로 발생한 식도 편평상피세포암
차라리 ( Ra Ri Cha ),정운태 ( Woon Tae Jung ),오혜원 ( Hye Won Oh ),김희진 ( Hee Jin Kim ),하창윤 ( Chang Yoon Ha ),김홍준 ( Hong Jun Kim ),김태효 ( Tae Hyo Kim ),고경혁 ( Gyung Hyuck Ko ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.6
Esophageal carcinosarcoma is a rare malignant esophageal neoplasm consisting of both carcinomatous and sarcomatous elements, with an incidence of 0.5%. There have been only a few case reports of carcinosarcoma and squamous cell carcinoma coexisting in the esophagus. However, all of these are cases of synchronous or metachronous development of carcinosarcoma after chemoradiotherapy in patients of esophageal squamous cell carcinoma. A 53-year-old man underwent esophagogastroduodenoscopy because of chest pain for several months. Endoscopic examination revealed a huge pedunculated esophageal polypoid mass. Endoscopic submucosal dissection (ESD) was performed and histopathologic examination confirmed spindle cell carcinoma (carcinosarcoma). He refused additional esophagectomy. After 21 months, third follow-up endoscopy showed poorly-demarcated flat, faint discolored lesions at different location from the previous ESD site and endoscopic biopsies confirmed squamous cell carcinoma. To the best of our knowledge, this is the first case of metachronous development of esophageal squamous cell carcinoma in a patient with esophageal carcinosarcoma. (Korean J Gastroenterol 2014;64:364-369)
상부위장관 상피하병변 환자에서 상피하종양과 위장관기질종양의 예측인자
차라리 ( Ra Ri Cha ),오혜원 ( Hye Won Oh ),유현선 ( Hyun Seon Yoo ),홍정우 ( Jeong Woo Hong ),이상수 ( Sang Soo Lee ),김홍준 ( Hong Jun Kim ),하창윤 ( Chang Yoon Ha ),김현진 ( Hyun Jin Kim ),김태효 ( Tae Hyo Kim ),이옥재 ( Ok Jae 대한소화기학회 2014 대한소화기학회지 Vol.64 No.4
목적: 위장관 상피하병변에서 종양성 병변을 비종양성 병변으로부터 감별하는 것은 환자의 적절한 치료에 매우 중요하다. 저자들은 상부위장관 상피하병변 환자에서 종양성 상피하병변을 감별할 수 있는 예측인자를 알아보고자 이 연구를 수행하였다. 대상 및 방법: 2008년 1월부터 2013년 6월까지 경상대학교병원에서 상부위장관 상피하병변에 대해 EUS를 시행한 527예의 의무기록을 후향적으로 검토하여, 내시경적 또는 수술적 절제를 통하여 조직학적 확진이 가능했던 환자 84예를 선정하고, 종양 및 비종양성 상피하병변으로 분류하여 특성을 비교 분석하였다. 결과: 조직학적으로 확인된 84예의 상피하병변 중 상피하종양이 64예(76.2%), 비종양성 상피하병변은 20예(23.8%)였다. 상피하종양은 GIST (42.9%)와 평활근종(19.0%)이 가장 많았다. 성별(p=0.195), 병변의 크기(p=0.266), 에코상(p=0.051)은 상피하종양군과 비종양성병변군 사이에 유의한 차이가 없었다. 비종양성 상피하병변군에 비하여 상피하종양군의 평균연령 (p=0.047), 호발연령대(p=0.047) 및 50세 이상 환자의 비율 (p=0.015)이 높았으며, 고유근층 기원(79.7%)이 많았다. (p=0.001). 상피하종양 중, GIST는 평활근종보다 환자의 평균연령이 높고(57.7세 vs. 47.0세, p=0.049), 50세 이상 (p=0.016), 종양의 위체부 위치(p<0.001), 고유근층 기원 (p=0.003)이 많았다. 다변량분석에서 환자의 연령(≥50세), 종양의 크기(≥30 mm), 고유근층기원이 점막하종양의 독립적인 예측인자였고, 평활근종과 GIST의 감별인자는 찾을 수 없었다. 결론: 상부위장관 상피하병변으로 50세 이상, 30 mm 이상, 고유근층 기원이 상피하종양의 독립적인 예측인자였으며, 평활근종과 감별할 수 있는 GIST의 예측인자는 없으므로 고유근층 기원의 위 상피하종양은 GIST의 가능성을 고려하여 적극적인 치료 및 철저한 추적관찰이 필요하다. Background/Aims: Differentiating subepithelial tumor (SET) from non-neoplastic gastrointestinal subepithelial lesion (SEL) and gastrointestinal stromal tumor (GIST) from leiomyoma are very important for proper management. This study was conducted to analyze factors that could predict the presence of SET and GIST in patients with upper gastrointestinal (UGI) SELs. Methods: A total of 527 patients were diagnosed with UGI SELs endosonographically at Gyeongsang National University Hospital from January 2008 to June 2013. Among these patients, histologic diagnosis was made in 84 patients. Data were collected by retrospectively reviewing the medical records. Variables that could differentiate neoplastic from non-neoplastic SELs and GIST from leiomyoma were analyzed. Results: Among 84 patients with SELs, 64 (76.2%) had SETs including GIST (42.9%) and leiomyoma (19.0%). The patients` mean age (p=0.047), peak age distribution (p=0.047), proportions of patient ≥50 years (p=0.015), and number of proper muscle-originated lesions (p=0.001) were higher in neoplastic than non-neoplastic group. There were no significant differences in gender (p=0.195), size (p=0.266) and echogenicity (p=0.051) of the lesions. Older age (57.7 vs. 47.0 years, p=0.049), age ≥50 years (p=0.016), location in gastric body (p<0.001), and proper muscle origin (p=0.003) were significantly related to the presence of GIST compared to leiomyoma. Multiple regression analysis showed that the patients` age ≥50 years, size ≥30 mm, and proper muscle-origin of lesion were independent predictors of SET; however, there were no predictive factors that could differentiate GIST from leiomyoma. Conclusions: In patients with SEL, the possibility of having SET should be considered for patients ≥50 years with UGI SELs ≥30 mm that arise from the proper muscle. Thorough monitoring and aggressive management is warranted for those with gastric muscular SET since factors predictive of GIST are lacking. (Korean J Gastroenterol 2014;64:189-197)
윤가리 ( Ga Ri Yun ),정은하 ( Eun Ha Jung ),라도경 ( Do Kyung Ra ),정철 ( Cheol Jeong ),이경민 ( Kyung Min Lee ),채현우 ( Hyun Woo Chae ),이정구 ( Jung Goo Lee ),이성모 ( Sung Mo Lee ) 한국동물위생학회 2014 韓國家畜衛生學會誌 Vol.37 No.4
Animals and disease frequency of the rescued dogs were investigated in Incheon Veterinary Medical Association Animal Shelter from January in 2012 to December in 2013. Three zoonoses (rabies, brucellosis, and dirofilariosis) and three infectious diseases (canine distemper, canine parvoviral enteritis, and canine influenza) were examined for stray dogs. Among 5,603 heads, 647 (11.5%) went back to their owner and 969 (17.3%) were adopted to new families. Prevalence of dirofilariosis, canine distemper and canine parvoviral enteritis were 2.2% (16/718), 6.0% (24/399) and 6.1% (24/396), respectively. Positive antibody rates against rabies, B. canis and canine influenza virus were 20.5% (41/200), 0.1% (1/718) and 2.0% (4/200), respectively. Protective antibody for canine distemper virus and canine parvovirus were shown in 47.0% (94/200). The data indicate that control measures including facility standards and disease control program are one of the important aspects of the shelter management because stray dogs are exposed to various infectious agents.
광주지역에서 즉석 제조ㆍ판매하는 식육가공품의 안전성 조사
고바라다 ( Ba-ra-da Koh ),서은주 ( Eun-ju Seo ),안아진 ( Ah-jin Ahn ),정보람 ( Bo-ram Jung ),하이든 ( Yi-deun Ha ),서두리 ( Doo-ri Seo ),임진택 ( Jin-taek Lim ),김용환 ( Yong-hwan Kim ),김은선 ( Eun-sun Kim ) 한국가축위생학회 2017 韓國家畜衛生學會誌 Vol.40 No.1
The main goal of this survey was to assess the current sanitation status and safety standards of meat processed products purchased at instant meat sales and processing operators. Analyses were carried out from April to September in 2016 in Gwangju area, Republic of Korea. A total number of 150 samples including seasoned meats, ground meat products, meat extract products, heated seasoned meats, sausages and hams from 35 butcher shops was collected. The number of inappropriate cases was revealed eleven cases (7.3%) in total viable count of bacteria (TVC), total coliform counts (TCC) and Listeria monocytogenes. The reported data indicate that more systemic and technical guidance is needed to monitor instant meat sales and processing operators in order to guarantee safety of meat processed products.
( Hye Won Oh ),( Ra Ri Cha ),( Sang Soo Lee ),( Chang Min Lee ),( Wan Soo Kim ),( Hyun Chin Cho ),( Jin Joo Kim ),( Jae Min Lee ),( Hong Jun Kim ),( Chang Yoon Ha ),( Hyun Jin Kim ),( Tae Hyo Kim ),( 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Genotype 3/4 hepatitis E virus (HEV) is an emerging infection in developed countries. This study investigated the etiology of acute viral hepatitis, and compared the clinical features of HEV infections with those of hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in Korea. Methods: This study included 116 consecutive patients who were diagnosed with acute viral hepatitis between January 2007 and January 2016. Acute viral infections were observed in 23 patients with HEV (19.8%), 49 patients with HAV (42.2%), 28 patients with HBV (24.1%), and 16 patients with HCV (13.8%). Results: The incidence of acute HEV infection was higher among older patients (median age: 49 years) and male patients (69.6%), and was associated with the consumption of undercooked or uncooked meat 43.5%). Most acute HEV infections were associated with pre-existing liver disease (e.g., alcoholic liver disease, chronic hepatitis B, biliary stones, and autoimmune hepatitis) and frequently presented with jaundice (56.5%). HEV-infected patients exhibited significantly lower median peak alanine aminotransferase levels (525 U/L), compared to HAV-infected patients (2,413 U/L, P < 0.001) and HBV-infected patients (1,356 U/L, P = 0.001). HEV-infected patients exhibited significantly higher median total bilirubin levels (6.8 mg/dL), compared to HCV-infected patients (1.2 mg/dL, P = 0.028). Two HEV-infected patients were diagnosed with Guillain-Barre syndrome, although no patients developed fulminant hepatitis. Conclusions: Our findings indicate that HEV is no longer a rare cause of acute viral hepatitis in Korea.
( Sang Soo Lee ),( Ra Ri Cha ),( Chang Min Lee ),( Wan Soo Kim ),( Hyun Chin Cho ),( Jin Joo Kim ),( Jae Min Lee ),( Hong Jun Kim ),( Chang Yoon Ha ),( Hyun Jin Kim ),( Tae Hyo Kim ),( Woon Tae Jung ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims:HepaticCvirus(HCV)genotype3infectionisthemostdifficultformofHCVtotreat,withamorerapidprogressiontofibrosisandcirrhosiscomparedwithothergenotypes.Theaimsofthisretrospectiveobservationalstudyweretoelucidatetheimpactofgenotype3infectiononhepatocellularcarcinoma(HCC)developmentandoverallmortalityinpatientswithHCV-relatedcirrhosis,comparedtoHCVgenotype1and2intheGyeongnamProvince,locatedonthesoutheastcoastofKorea.Methods:Atotal153patientswithHCV-relatedcirrhosiswereincludedbetweenJanuary2005andDecember2014.Amongthese,74hadgenotype1,55genotype2,and24patientshadgenotype3infection.Results:Theprevalenceofgenotype3inHCV-relatedcirrhosiswas16%.Individualsatriskforgenotype3infectionwereyoung,malegender,andpeoplewhoinjectdrugs.Duringmedianamedianfollow-up40.1months,38patientsdevelopedHCC,and23patientsdied.TheincidenceofHCCdevelopmentandoverallmortalitywassignificanthigherinpatientswithgenotype3comparedtopatientswithgenotype1and2inthelogranktest.Despitebeingyounger,HCVgenotype3wasaindependentriskfactorforHCCdevelopment(adjustedhazardratio[HR〕=2.55)andoverallmortality(adjustedHR=3.69)onmultivariateanlalysis.Afterexclusionofpatientswithachievedsustainedvirologicresponse,theincidenceofHCCdevelopmentandoverallmortalitywassignificanthigherinpatientswithgenotype3comparedtopatientswithnogenotype3.Conclusions:HCVgenotype3infectionisassociatedwithanincreasedriskofHCCandoverallmortalityinpatientswithcirrhosisafteradjustingwithconfoundingfactors.
홍성희 ( Seong Hee Hong ),라도경 ( Do Kyung Ra ),윤가리 ( Ga Ri Yun ),정윤정 ( Yun Joung Joung ),남지현 ( Ji Hyeon Nam ),정은하 ( Eun Ha Cheong ),이정구 ( Jung Goo Lee ),이성모 ( Sung Mo Lee ) 한국동물위생학회 2012 韓國家畜衛生學會誌 Vol.35 No.2
This study was performed to investigate the freshness and nutritive components of eggs from Incheon area. The eggs of 64 brands collected from 7 hypermarkets and 6 brands collected from farms were examined to test the Haugh unit (HU), egg yolk index and specific gravity. HU and specific gravity were higher in farm eggs than in hypermarket eggs (P<0.05), and there was no difference in the egg yolk index. Among hypermarket eggs, HU and egg yolk index were higher in the graded eggs than in non-graded eggs (P<0.05), and specific gravity was not different between them. HU and egg yolk index of the eggs collected in March were higher than those in August (P<0.05). To monitor the bacterial contamination, total coliforms, total bacterial counts (TBC) and Salmonella enteritidis were examined. Salmonella enteritidis and total coliforms were not detected from all eggs. TBC of farm eggs were less than 101 CFU/mL in all samples and TBC of hypermarket eggs were less than 101 CFU/mL in 187 samples, 101∼102 CFU/mL in 3 samples and 103∼104 CFU/mL in 2 samples, respectively. Antimicrobial residues were not detected from all eggs tested. The vitamin E contents in the vitamin E enriched eggs from 6 brands hypermarket were 1.98∼22.96 mg/yolk100 g (14.04±8.81 mg/yolk100g), and those of 5 brands among them were higher than the average of ordinary eggs. In one brand egg, vitamin E content was lower than the average of ordinary eggs. The vitamin E contents of ordinary eggs were 1.75∼16.36 mg/yolk100 g (average 5.57±2.76 mg/yolk100 g) and there were no price differences between vitamin E enriched eggs and ordinary eggs. In the contents of vitamin E, docosahexaenoic acid (DHA) and cholesterol, there were no significant differences according to the price. These results suggests that egg production, distribution, and management system should be improved for supplying fresh eggs to consumers at reasonable prices.