http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration
Ryu, S.,McDonnell, K.,Choi, H.,Gao, D.,Hahn, M.,Joshi, N.,Park, S.M.,Catena, R.,Do, Y.,Brazin, J.,Vahdat, Linda T.,Silver, Randi B.,Mittal, V. Cell Press 2013 Cancer cell Vol.23 No.1
The progression of cancer to metastatic disease is a major cause of death. We identified miR-708 being transcriptionally repressed by polycomb repressor complex 2-induced H3K27 trimethylation in metastatic breast cancer. miR-708 targets the endoplasmic reticulum protein neuronatin to decrease intracellular calcium level, resulting in reduction of activation of ERK and FAK, decreased cell migration, and impaired metastases. Ectopic expression of neuronatin refractory to suppression by miR-708 rescued cell migration and metastasis defects. In patients with breast cancer, miR-708 expression was decreased in lymph node and distal metastases, suggesting a metastasis-suppressive role. Our findings uncover a mechanistic role for miR-708 in metastasis and provide a rationale for developing miR-708 as a therapeutic agent against metastatic breast cancer.
Joshi, Ratnadeep S.,Mandhane, Priyanka G.,Chate, Asha V.,Gill, Charansingh H. Korean Chemical Society 2011 대한화학회지 Vol.55 No.5
A new series of 1-(5-(2-tolyloxyquinoline-3-yl)-2-(pyridine-4-yl)-1,3,4-oxidiazol-3(2H)-yl)ethanones were synthesized from cyclisation of N'-((2-(p-tolyloxy)quinoline-3-yl)methylene) isonitonohydrazide in acetic unhydride at reflux condition for 3-4 hr. The structures of the new compounds were confirmed by elemental analyses as well as IR, 1H NMR and mass spectral data. All the synthesized compounds were screened for their antibacterial activities against various bacterial strains. Several of these compounds showed potential antibacterial activity.
Measurement of the branching fractions forB0→Ds*+π−andB0→Ds*−K+decays
Joshi, N. J.,Aziz, T.,Trabelsi, K.,Adachi, I.,Aihara, H.,Arinstein, K.,Aulchenko, V.,Aushev, T.,Bakich, A. M.,Balagura, V.,Barberio, E.,Bay, A.,Belous, K.,Bhardwaj, V.,Bischofberger, M.,Bondar, A.,Boz American Physical Society 2010 PHYSICAL REVIEW D - Vol.81 No.3
Asha V. Chate,Sanjay K. Dabhade,Pravin V. Badadhe,Ratnadeep S. Joshi,Charansingh H. Gill 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.11
An efficient synthesis of 1,5-Benzothiazepines via Michael addition of corresponding (E)-1-(2-hydroxyphenyl)-3-(4-(phenylthio)phenyl)prop-2-en-1-one is described under ultrasound irradiation. A series of novel 2-((E)-2,3-dihydro-2-(4-(phenylthio)phenyl)benzo[b][1,4]thiazepin-4-yl)phenol derivatives was confirmed on the basis of 1H NMR, Mass, IR spectral data and Elemental analysis. The synthesized compounds were evaluated for their antimicrobial activities. Most of the compounds were found to be comparable potent than the reference standard drugs. Utilization of ultrasound irradiation, simple reaction conditions, isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
Chate, Asha V.,Joshi, Ratnadeep S.,Badadhe, Pravin V.,Dabhade, Sanjay K.,Gill, Charansingh H. Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.11
An efficient synthesis of 1,5-Benzothiazepines via Michael addition of corresponding (E)-1-(2-hydroxyphenyl)-3-(4-(phenylthio)phenyl)prop-2-en-1-one is described under ultrasound irradiation. A series of novel 2-((E)-2,3-dihydro-2-(4-(phenylthio)phenyl)benzo[b][1,4]thiazepin-4-yl)phenol derivatives was confirmed on the basis of $^1H$ NMR, Mass, IR spectral data and Elemental analysis. The synthesized compounds were evaluated for their antimicrobial activities. Most of the compounds were found to be comparable potent than the reference standard drugs. Utilization of ultrasound irradiation, simple reaction conditions, isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
Joshi, Ratnadeep S.,Mandhane, Priyanka G.,Chate, Asha V.,Khan, Wajid,Gill, Charansingh H. Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.8
A convenient synthesis of substituted [1,2,4]-triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline 4(a-i) from substituted 2-chloroquinoline-3-carbaldehyde 1(a-i) and 4H-1,2,4-triazol-3-amine 2 by using $SiO_2/K_2CO_3$ under microwave irradiation. This method affords the [1,2,4]-Triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline 4(a-i) under the influence of microwave irradiation in solvent-free conditions within short span (12 - 20 min), & gaves excellent yields (89 - 95%). All the synthesized compounds were further screened for their antibacterial activities. Some of our compounds showed excellent antibacterial activities against control drugs.
MAGNETIC RECONNECTION DURING THE TWO-PHASE EVOLUTION OF A SOLAR ERUPTIVE FLARE
Joshi, Bhuwan,Veronig, Astrid,Cho, K.-S.,Bong, S.-C.,Somov, B. V.,Moon, Y.-J.,Lee, Jeongwoo,Manoharan, P. K.,Kim, Y.-H. IOP Publishing 2009 The Astrophysical journal Vol.706 No.2
<P>We present a detailed multi-wavelength analysis and interpretation of the evolution of an M7.6 flare that occurred near the southeast limb on 2003 October 24. Pre-flare images at TRACE 195 angstrom show that the bright and complex system of coronal loops already existed at the flaring site. The X-ray observations of the flare taken from the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) spacecraft reveal two phases of the flare evolution. The first phase is characterized by the altitude decrease of the X-ray looptop (LT) source for similar to 11 minutes. Such a long duration of the descending LT source motion is reported for the first time. The EUV loops, located below the X-ray LT source, also undergo contraction with similar speed (similar to 15 km s(-1)) in this interval. During the second phase the two distinct hard X-ray footpoint (FP) sources are observed which correlate well with UV and Ha flare ribbons. The X-ray LT source now exhibits upward motion as anticipated from the standard flare model. The RHESSI spectra during the first phase are soft and indicative of hot thermal emission from flaring loops with temperatures T > 25 MK at the early stage. On the other hand, the spectra at high energies (epsilon greater than or similar to 25 keV) follow hard power laws during the second phase (gamma = 2.6-2.8). We show that the observed motion of the LT and FP sources can be understood as a consequence of three-dimensional magnetic reconnection at a separator in the corona. During the first phase of the flare, the reconnection releases an excess of magnetic energy related to the magnetic tensions generated before a flare by the shear flows in the photosphere. The relaxation of the associated magnetic shear in the corona by the reconnection process explains the descending motion of the LT source. During the second phase, the ordinary reconnection process dominates describing the energy release in terms of the standard model of large eruptive flares with increasing FP separation and upward motion of the LT source.</P>
Pranav H. Nakhate,Chandrakanth R. Gadipelly,Nandkumar T. Joshi,Kumudini V. Marathe 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.69 No.-
Present study investigated the development and use of copper-doped zinc oxide as catalysts to facilitate degradation of real textile wastewater by ozonation. Effect of various operating parameters like catalyst dosage, pH, and ozone dosage was examined. The Cu-doped ZnO removes 89% of COD within 30 min of reaction whereas tertiary-butyl alcohol inhibited COD reduction at 10 mM concentration under the optimised conditions, indicating that catalytic ozonation follows hydroxyl (OH) radical method for COD reduction. MATLAB ODE45 function was used to draw kinetic plots where catalytic ozonation shows six times higher rate constant. Catalytic ozonation has been successfully implemented at pilot-scale.
Ratnadeep S. Joshi,Priyanka G. Mandhane,Asha V. Chate,Wajid Khan,Charansingh H. Gill 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.8
A convenient synthesis of substituted [1,2,4]-triazolo [1’,2’:1,2]pyrimido[6,5-b]-quinoline 4(a-i) from substituted 2-chloroquinoline-3-carbaldehyde 1(a-i) and 4H-1,2,4-triazol-3-amine 2 by using SiO2/K2CO3 under microwave irradiation. This method affords the [1,2,4]-Triazolo [1’,2’:1,2]pyrimido[6,5-b]-quinoline 4(a-i) under the influence of microwave irradiation in solvent-free conditions within short span (12 - 20 min), & gaves excellent yields (89 -95%). All the synthesized compounds were further screened for their antibacterial activities. Some of our compounds showed excellent antibacterial activities against control drugs.
Physiological and Morphological Aspects of Bipolaris sorokiniana Conidia Surviving on Wheat Straw
R.Chand,H.V.Singh,A.K.Joshi,E.Duveiller 한국식물병리학회 2002 Plant Pathology Journal Vol.18 No.6
Wheat samples showing typical spot blotch symptoms on stems and sheaths were collected from the field after physiological maturity, and were sealed in paper bags and stored in the laboratory at room temperature to study the survival of Bipolaris sorokiniana conidia on wheat straw. The materials were observed at monthly intervals to assess the conidia viability during storage. After 4 months, the frequency of individual conidia already present on wheat straw at the time of sampling was reduced and appeared to be progressively replaced by the formation of round structures consisting of conidia aggregates. After 5 months, distinct, individual conidia were no longer detected, and only ‘clumps of conidia’ were observed. These dark black aggregates or ‘clumps of conidia’ measured 157-170 mm in diameter and were grouped into boat-shaped olivacious conidia showing thick wall and measuring 50-82 ´ 20-30 mm. The germination was unipolar and below 0.5%, suggesting the occurrence of dormancy. In contrast, individual conidium produced on wheat during the growing season were 96-130 ´ 16-20 mm, slightly curved, hyaline to light pale, and euseptate with a bipolar germination reaching 98-100%. Bipolaris sorokiniana conidia produced on PDA were 55-82 ´ 20- 27 mm, tapered at both ends, dark brown to olivacious, distoseptate, showed up to 1% germination, and were predominantly unipolar. Results of the present study suggest that B. sorokiniana conidia belonged to two different physiological categories corresponding to the pathogen's infection phase and its survival, respectively. The infection phase is characterized by a high germination percentage as opposed to the survival phase harboring apparent dormancy.