蓄血證과 蓄水證의 病理에 關한 文獻的 考察

崔昇勳,安圭錫,文濬典,朴鐘鉉 대한동의병리학회 1994 동의생리병리학회지 Vol.9 No.1

연구배경 : 축혈증과 축수증은 태양표증이 풀리지 않아 邪熱이 안으로 들어가 형성된 양대병증으로 이들의 부위 및 병리에 대한 설명이 명확치 못한 점이 많다. 이에 축혈증과 축수증의 본래 의미를 검토하고 그것의 병리에 대해서 부위, 증상, 개체별 차이 및 측수ㆍ축혈증의 실질에 대해서 연구하고자 함. 연구방법 : 축혈증과 축수증에 관련된 조문 및 유사증에 관한 조문들을 가려서 역대 주가들의 주를 참고로 연구하였다. 축수ㆍ축혈의 실질에 관해서는 처방을 중심으로 사용된 약재들의 현대적 약리작용을 통해 연구하였다. 결과 : 축혈증은 하초소복부의 혈액순환계통의 질환과 관련된 것으로 나타났으며, 축수증은 방광자체의 문제이기 보다는 기화분리로 인한 수액대사 장애와 관련된 병증으로 볼 수 있다. Through the philological study on syndrome of stagnated blood & syndrome of stagnated water, the results are obtained as following; 1. It is resonable to understand that the location of Syndrome of Stagnated Blood(蓄血證) is the lower abdomen and Syndrome of Stagnated Waste (蓄水證) is not exactly the disorder of Gall Bladder itself, but the disturbance of waterbolism derived from the disturbance of Qi (氣) transformation. 2. Syndrome of Stagnated Blood is that, being uncured Taiyang Channel Syndrom (太陽病), pathogen enters inside and pathogenic heat combines with blood at the lower abdomen; its main signs are spasmatic distention or muscular rigidity of the lower abdomen, mental derangement and normal urination. 3. Syndrome of Stagnated Water is that, being uncured Taiyang Channel Syndrom, pathogenic heat enters inside and combines with water and leads to disturbance of waterbolism; its main signs are thirsty, dysphoria, and difficulty in urination. 4. In the view of Western Medicine, Syndrome of Stagnated Blood is related with the disease of the blood circulation-especially in microcirculation- of the lower abdomen; Syndrome of Stagnated Water is similar to the disease which is related with the abnomal state of osmotic density derived from the unblance of electrolytes. 5. Lee Je-Ma regared the Syndrome of Stagnated Blood as SinSooYeolPyoYeolByung(腎受熱表熱病) of ShaoYin-Ren (少陰人), so explained it as the disease derived from the lower abdominal accumulation of Yang-Qi (陽氣) which coudn't have ascended; and regarded the Syndrome of Stagnated Water as PiSooHanPyoHanByung (脾受寒表寒病) of ShaoYang-Ren (少陽人), so explained it as the disease derived from the accumulation of internal heat because of discending disturbance of Yin-Qi (陰氣).

膈下逐瘀湯과 膈下逐瘀湯合四君子湯의 抗癌 및 免疫調節作用에 關한 實驗的 硏究

崔昇勳,安圭錫,文濬典,高光錫 대한동의병리학회 1994 동의생리병리학회지 Vol.9 No.1

연구배경 : 암은 사망의 주요 원인이 되는 질환으로 매년 증가하고 있는 추세이다. 이에 mouse에 암을 유발하여, 약물치료를 시행함으로써 높은 치료효과를 거두는 한약제재를 개발하여 암의 치료에 기여하고 아울러 근본적인 예방치료에 대한 새로운 방법을 제시하고자 함. 방법 : 생쥐에 Sacroma 180을 이식하여 복강암을 유발하고 격하축어탕 및 격하축어탕합사군자탕을 투여하여 생명연장률과 B cell 및 T cell, 혈청항체가, 임파구증식반응, IL-2 생산능 및 자연살해페소의 활성도를 측정하였다. 결과 : 격하축어탕과 격하축어탕합사군자탕은 면역조절작용을 통한 항암효과가 있을 것으로 생각되며, 활혈거어제인 격하축어탕과 보기제인 사군자탕을 합방했을때, 그 효과가 증가되었다. In order to investigate the effects of Gyeokhachukeotang and Gyeokhachukeotang plus Sagunjatang on anti-tumor and immunodulatory reaction to the ICR and C57BL/6 mice which have abdominal tumor after Sarcoma-180 cells were transplanted, the extracts of herbal medicines above mentioned were orally administered to the mice for 21 days to observe the extention of survival duration of the mice, quantitation of T cells and B cells, productivitiy of interleukin-2, lymphocytes transformation, hemagglutinin titer and hemolysin titer and activity of splenic natural killer cells. The results are summarized as follows; 1. In the effect of life extention, the Gyeokhachukeotang-medicated mice group inclined to show extended duration of life, which is of no great significant difference and the mice group medicated with mixture of Gyeokhachukeotang plus Sagunjatang appeared to survive longer than the Gyeokhachukeotang-medicated mice group, which is not meaningful. 2. Considering T cell and B cell content, the Gyeokhachukeotang-medicated mice group had a meaningful increase in B cell (P<0.05) content, and the mice group medicated with the mixture of Gyeokhachukeotang plus Sagunjatang remarkably showed a significant increase in both T cell and B cell (P<0.01). 3. Considering serum antibody titer tended to increase in case of the Gyeokhachukeotang-medicated mice group, which is of no significant difference, while decreasing in case of the mice group medicated with mixture of Gyeokhachukeotang plus Sagunjatang. 4. In lymphocyte transformation marked a significant increase the Gyeokhachukeotang-medicated mice group, marked a significant (P<0.01), and remarkably showed a significant increase the mice group medicated with the mixture of Gyeokhachukeotang plus Sagunjatang (P<0.001). 5. As for the productivity of interleukin-2 and the activity of NK cells, the both tested groups inclined to show an increase or a decrese, but there is no significance.

A Study on Feature Selection Method based on Random Forest for Cancer Diagnosis System

Gyoo Seok Choi(최규석),Jong jin Park(박종진),Ha-Nam Nguyen 한국정보기술학회 2008 한국정보기술학회논문지 Vol.6 No.3

One of the most important problems in bioinformatics is how to extract the useful information from a huge amount of data, and make a decision in diagnosis, prognosis, and medical treatment applications. Machine learning approaches such as Neural network, Decision tree, Support Vector Machines are well suited for domains characterized by the presence of large amount of data, noisy patterns, and absence of general theory. The main goal of our research is to propose an efficient feature selection method to achieve a cancer diagnosis system with high accuracies, and good adaptability to clinical dataset. We propose a new feature selection method based on Random Forest(RF) to be applicable to the learning algorithm for Cancer Diagnosis System. The experiments on clinical dataset such as colon cancer indicate that our proposed method obtain higher and more stable classification performance than the baseline methods. Our method also results in comparable and better classification performance than other classification methods.

Feature Selection Algorithm using Random Forest to Diagnose Cancer

Gyoo-Seok Choi,Jong-Jin Park,Ha-Nam Nguyen 한국인터넷방송통신학회 2009 International Journal of Internet, Broadcasting an Vol.1 No.1

진화 프로그램에 기초한 기종점간 최적경로탐색 알고리즘의 개발

崔圭錫(Gyoo-Seok Choi),禹廣芳(Kwang-Bang Woo) 대한전기학회 1997 전기학회논문지 Vol.46 No.2

지능형 주행 안내 시스템을 위한 유전 알고리즘에 근거한 최적 경로 탐색 알고리즘

최규석(Gyoo-Seok Choi),우광방(Kwang-Bang Woo) 제어로봇시스템학회 1997 제어·로봇·시스템학회 논문지 Vol.3 No.2

Risk Factors for TB in Patients With Early Gastric Cancer

Choi, Il Ju,Kim, Young-Woo,Lee, Hee Seok,Ryu, Keun Won,Yoon, Hong Man,Eom, Bang Wool,Kim, Chan Gyoo,Lee, Jong Yeul,Cho, Soo-Jeong,Nam, Byung-Ho American College of Chest Physicians 2015 Chest Vol. No.

<P>Gastrectomy is known as one of the risk factors for TB. However, there is no study about the association between TB development and gastrectomy performed in patients with early gastric cancer (EGC). This study evaluated conventional risk factors, including gastrectomy, associated with TB development in patients with EGC.</P>

Directed evolution of the 3-hydroxypropionic acid production pathway by engineering aldehyde dehydrogenase using a synthetic selection device

Seok, Joo Yeon,Yang, Jina,Choi, Sang Jin,Lim, Hyun Gyu,Choi, Un Jong,Kim, Kyung-Jin,Park, Sunghoon,Yoo, Tae Hyeon,Jung, Gyoo Yeol Elsevier 2018 Metabolic engineering Vol.47 No.-

<P><B>Abstract</B></P> <P>3-Hydroxypropionic acid (3-HP) is an important platform chemical, and biological production of 3-HP from glycerol as a carbon source using glycerol dehydratase (GDHt) and aldehyde dehydrogenase (ALDH) has been revealed to be effective because it involves a relatively simple metabolic pathway and exhibits higher yield and productivity than other biosynthetic pathways. Despite the successful attempts of 3-HP production from glycerol, the biological process suffers from problems arising from low activity and inactivation of the two enzymes. To apply the directed evolutionary approach to engineer the 3-HP production system, we constructed a synthetic selection device using a 3-HP-responsive transcription factor and developed a selection approach for screening 3-HP-producing microorganisms. The method was applied to an ALDH library, specifically aldehyde-binding site library of alpha-ketoglutaric semialdehyde dehydrogenase (KGSADH). Only two serial cultures resulted in enrichment of strains showing increased 3-HP production, and an isolated KGSADH variant enzyme exhibited a 2.79-fold higher catalytic efficiency toward its aldehyde substrate than the wild-type one. This approach will provide the simple and efficient tool to engineer the pathway enzymes in metabolic engineering.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A synthetic selection device was designed responding to 3-HP concentration. </LI> <LI> ALDH in the 3-HP pathway was engineered through a simple selection method. </LI> <LI> An ALDH variant exhibited a 2.79-fold improvement in the catalytic efficiency. </LI> <LI> <I>E. coli</I> with ALDH variant showed a 25% higher productivity than the parental strain. </LI> <LI> The developed strategy was highly efficient for engineering the pathway enzymes. </LI> </UL> </P>

Using Genetic-Fuzzy Methods TO Develop User-Preference Optimal Route Search Algorithm

최규석,박종진 한국데이타베이스학회 2000 Journal of information technology applications & m Vol.7 No.1

The Relationship between Status of Medical Knowledge of Medical Consumers and Satisfaction of Medical Service

Hyung-Seok Choi(최형석),Gyoo Hyung Kim(김규형) 한국방사선학회 2018 한국방사선학회 논문지 Vol.12 No.3

The supply of medical services using high-priced medical equipment is increasing due to the medicalization of medical science. The level of medical knowledge of medical consumers and the ability to select medical institutions are required to provide high quality medical services because of the popularization of medical information. As the attitudes of medical consumers toward medical institutions change, medical institutions also need to change their perception to improve customer satisfaction. The purpose of this study is to analyze the difference of medical service satisfaction according to the medical knowledge about the utility of PET / CT in order to change the consciousness structure of medical service. The results of this study showed that both medical satisfaction and environmental satisfaction were high in those who had medical knowledge about their own illness and the usefulness of PET / CT. Therefore, medical institutions will need a practical medical service countermeasures to provide medical information by noticing the changes in perception of the medical knowledge of medical consumers, rather than providing formal medical services. 의료의 과학화로 인해 고가의료장비를 이용한 의료서비스 공급이 증가하고 있다. 의학 정보의 대중화로 의료소비자들의 의학적 지식수준 및 의료기관 선택능력의 향상으로 높은 수준의 의료서비스가 요구되고 있다. 이처럼 의료소비자들이 의료기관을 대하는 태도가 바뀌면서 의료기관들 역시 고객 만족도 향상을 위한 인식의 변화가 필요하다. 이에 본 연구는 의료서비스의 의식구조 변화를 지향하기 위해 PET/CT의 효용성에 대한 의학적 지식 유무에 따라 의료서비스만족도 차이를 분석하였다. 연구 결과 의료소비자 자신의 질병과 PET/CT의 효용성에 대한 의학적 지식이 있는 사람이 진료만족과 환경만족 모두 높게 나타났다. 따라서, 의료기관에서는 형식적인 의료서비스 제공이 아닌 의료소비자의 의학적 지식에 대한 지각 변화를 파악하여 의학 정보를 제공하는 실질적인 의료서비스 대응책이 필요할 것이다.