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Shin, Gu-Choul,Na, Byoung-Kuk,Lee, Joo-Yeon,Ahn, Jung-Bae,Park, Jong-Won,Lee, Jin-Soo,Kim, Jee-Hee,Kim, Woo-Joo,Kang, Chun The Korean Society for Microbiology 2003 Journal of Bacteriology and Virology Vol.33 No.4
Although Korean influenza virus isolates have been genetically associated with the vaccine strains of the corresponding year, influenza B viruses have prevailed almost every year in Korea during the past decades. We have 'analyzed the genetic characteristics and evolutionary patterns of the haemagglutinin (HA) 1 domains of influenza B viruses isolated during 1988-1999 using direct RT-PCR and sequencing. Phylogenetic analysis of influenza B viruses isolated in Korea indicated that antigenically and genetically distinguishable strains of the lineage II and lineage III variants had been cocirculated. Variants prevailed in early 1990s are represented in 1996/97 and 1998/99 and some different variants have been co circulated geographically and prevailed concurrently in Korea. All HA1s of Korean isolates have amino acid substitutions mainly in the region between position 124 and 310, which was previously proposed an immunodominant region. Insertion-deletion patterns of the HA gene revealed that Korean influenza B viruses were evolved from Lee40 with different manner between lineage II and III viruses. Lineage III viruses were also divided into two groups as conserved group and inserted group, in relation to Lee40. But lineage II viruses had evolved with directional pattern. Antigenic index proposed that influenza B isolates prevailed since 1996/97 seasons might had emerged from the antigenic variants of a Seo1697-like virus and that new variants might appear from the lineage II viruses resulting in persistent prevalence in Korea.
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Lee, Mi-Hwa,Kim, Ji-Young,Ju, Hyun-Yang,Lee, Ju-Young,Roh, Sang-Keun,Gu, Bon-Seong,Kim, Min-Ho,Han, Sang-Min,Kim, Hong-Sik,Choi, Won-Chul The Society of Korean Medicine 2003 대한한의학회지 Vol.24 No.4
So-Hap-Hyang-Won, a traditional oriental medicine used in the treatment of stroke patients, was examined for its ability to reverse the cell damage caused by lipid peroxidation products and oxidative stress in bovine aortic endothelial cells (BAEC). The effects of herbal medicine on cell proliferation and recovery of oxidative damaged situation were studied in BAEC, which was considered an appropriate in vitro model for stroke resulting from various vascular diseases prevalent in advanced age. In a clinical study of stroke patients, So-Hap-Hyang-Won appeared to improve considerably arm and leg movements as well as consciousness disturbance condition, compared with other traditional medicines used for stroke. When BAEC were treated with extracts of the lyophilized herbal medicines, only that of So-Hap-Hyang-Won stimulated cell proliferation and showed no toxicity even at high concentrations. In studies of BAEC treated with extracts of the lyophilized material of the 14 components of So-Hap-Hyang-Won, only the extract of Foeniculi Fructus stimulated cell growth at all concentrations tested. Moreover, when cells were treated with Foeniculi Fructus (10 and 100 mg/ml) extract after prior exposure to t-BHP ($l0\mu\textrm{M}$) or HNE ($0.2\mu\textrm{M}$), lipid peroxidation products which are known to be involved in aging and vascular diseases, or after the exposure to SIN-l ($500\mu\textrm{M}$), which generates nitric oxide (NO) and other reactive oxygen species, there was substantial recovery from the oxidative damage, presumably due to the radical-scavenging effect of Foeniculi Fructus extract. Foeniculi Fructus not only showed stimulatory effects on cell growth and cell damage repair in BAEC, but also appeared to show the most anti-aging activity among all the herbal components of So-Hap-Hyang-Won.
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Effects of chebulic acid on advanced glycation endproducts-induced collagen cross-links.
Lee, Ji-Young,Oh, Jun-Gu,Kim, Jin Sook,Lee, Kwang-Won Pharmaceutical Society of Japan 2014 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.37 No.7
<P>Advanced glycation end-products (AGEs) have been implicated in the development of diabetic complications. We report the antiglycating activity of chebulic acid (CA), isolated from Terminalia chebula on breaking the cross-links of proteins induced by AGEs and inhibiting the formation of AGEs. Aminoguanidine (AG) reduced 50% of glycated bovine serum albumin (BSA) with glycolaldehyde (glycol-BSA)-induced cross-links of collagen at a concentration of 67.8 2.5 mM, the level of CA required for exerting a similar antiglycating activity was 38.8 0.5 ?M. Also, the breaking activity on collagen cross-links induced by glycol-BSA was potent with CA (IC50=1.46 0.05 mM), exhibiting 50-fold stronger breaking activity than with ALT-711, a well-known cross-link breaker (IC50=72.2 2.4 mM). IC50 values of DPPH scavenging activity for CA and ascorbic acid (AA) were 39.2 4.9 and 19.0 1.2 ?g dry matter (DM) mL(-1), respectively, and ferric reducing and antioxidant power (FRAP) activities for CA and AA were 4.70 0.06 and 11.4 0.1 mmol/FeSO47H2O/g DM, respectively. The chelating activities of CA, AG and ALT711 on copper-catalyzed oxidation of AA were compared, and in increasing order, ALT-711 (IC50 of 1.92 0.20 mM)<CA (IC50 of 0.96 0.07 mM)<AG (0.47 0.05 mM). Thus, CA could be a breaker as well as an inhibitor of AGE cross-linking, the activity of which may be explained in large part by its chelating and antioxidant activities, suggesting that CA may constitute a promising antiglycating candidate in intervening AGE-mediated diabetic complications.</P>
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A nanoporous substrate-based low temperature solid oxide fuel cell using a thin film Ni anode
Lee, Sanghoon,Cho, Gu Young,Park, Taehyun,Lee, Yoon Ho,Yu, Wonjong,Lee, Yeageun,Chang, Ikwhang,Cha, Suk Won Elsevier 2018 THIN SOLID FILMS - Vol.666 No.-
<P><B>Abstract</B></P> <P>A thin film solid oxide fuel cell (TF-SOFC) with a Ni anode on a nanoporous anodic aluminum oxide substrate was demonstrated. In our experiments, Ni was used as an anode material, while a very small amount of Pt was used as a cathode material, which reduced the thickness of the thin film cathode to 65 nm. In addition, a plasma-enhanced atomic layer deposition method was used to prepare a yttria-stabilized zirconia electrolyte. The open circuit voltage and the peak power density of the as-fabricated fuel cells, both of which were measured at 500 °C, were 1.04 V and 150 mW/cm<SUP>2</SUP>, respectively.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Thin film solid oxide fuel cell(TF-SOFC) with Ni/YSZ/Pt was demonstrated. </LI> <LI> The peak power density of 150 mW/cm<SUP>2</SUP> was measured at 500 °C. </LI> <LI> Ni is significantly comparable to Pt for hydrogen oxidation reaction. </LI> </UL> </P>
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Design of Novel Overhang Structure for Separated Pole-Piece Type Ferrite Magnet Motor
Won-Ho Kim,Ik-Sang Jang,Chang-Sung Jin,Ju Lee,Sung-Gu Lee IEEE 2015 IEEE transactions on magnetics Vol.51 No.3
<P>A separated pole-piece type ferrite magnet motor (FMM) is a novel type of motor that can maximize reluctance torque and reduce leakage flux by separating the pole pieces and the web. However, when this type of motor has a short stack length and a large area of pole pieces, the leakage flux in the axial direction has significant influence on the motor's performance. A rotor overhang structure is one of the most crucial design parameters that compensate for the side effects of leakage flux. A conventional overhang structure increases magnetic torque but raises the level of induced voltage. This limits the operation speed range. To overcome such problems, this paper presents a novel multilevel overhang structure. Based on the unique structure of the separated pole-piece type FMM, the overhang length of the pole pieces was set to be shorter than the other parts of the rotor. It was observed that the operating speed range was widened, and more reluctance torque was generated, compared to motors with conventional overhang structures. The proposed overhang structure was optimized by 3-D finite element analysis, and the model was validated by comparing the actual experimental results with its predicted performance.</P>
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Lee, Sang-Hee,Gu, Gum-Gyoung,Han, Tae-Jin,Paik, Byung-Yoon,Chun, Sail,Min, Won-Ki 대한임상검사과학회 2011 대한임상검사과학회지(KJCLS) Vol.43 No.4
It is a very important diagnosis and evalution of Hepatocellular carcinoma (HCC) in Korea where hepatitis B-virus is endemic. Protein induced by vitamin K absence or antagonist II (PIVKA-II) appears to be a useful tumor marker. This study was purposed to investigate usefulness of PIVKA-II in the diagnosis and fallow-up after treatment of HCC. A total of 418 patients were included in 187 patients (44.7%) of HCC, 83 patients (19.9%) of liver cirrhosis, 74 patients (17.7%) of chronic hepatitis and 74 patients (17.7%) of other liver diseases with serum PIVKA-II levels by Hicatch PIVKA-II kit. PIVKA-II level were analysed for difference of groups and the comparison of treatment responses. The sensitivity and specificity of PIVKA-II in the diagnosis of HCC were 80.2%, 87.0% at the cut-off value of 40 mAU/mL. There were statistically significant difference between the HCC and other groups (p<0.001), before and after PIVKA-II levels after treatment in HCC (p<0.001). PIVKA-II can be used as a useful tumor marker for patients with HCC, especially early diagnosis in high risk groups, treatment response assesment and monitoring of recurrence.
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Won, Hee‐,Young,Lee, Jeong‐,Yeon,Shin, Dong‐,Hui,Park, Ji‐,Hye,Nam, Jeong‐,Seok,Kim, Hyoung‐,Chin,Kong, Gu Federation of American Society for Experimental Bi 2012 The FASEB Journal Vol.26 No.12
<P>Mel-18 has been proposed as a negative regulator of Bmi-1, a cancer stem cell (CSC) marker, but it is still unclear whether Mel-18 is involved in CSC regulation. Here, we examined the effect of Mel-18 on the stemness of human breast CSCs. In Mel-18 small hairpin RNA (shRNA)-transduced MCF-7 cells, side population (SP) cells and breast CSC surface marker (CD44(+)/CD24(-)/ESA(+))-expressing cells, which imply a CSC population, were enriched. Moreover, the self-renewal of CSCs was enhanced by Mel-18 knockdown, as measured by the ability for tumorsphere formation in vitro and tumor-initiating capacity in vivo. Similarly, Mel-18 overexpression inhibited the number and self-renewal activity of breast CSCs in SK-BR-3 cells. Furthermore, our data showed that Mel-18 blockade up-regulated the expression of the Wnt/TCF target Jagged-1, a Notch ligand, and consequently activated the Notch pathway. Pharmacologic inhibition of the Notch and Wnt pathways abrogated Mel-18 knockdown-mediated tumorsphere formation ability. Taken together, our findings suggest that Mel-18 is a novel negative regulator of breast CSCs that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt-mediated Notch signaling.</P>
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Polarographic Behavior of Cadmium-Tartrate Complexes in Weak Acid and Alkaline Media
Lee, Kyung-Ae,Choi, Q.-Won,Ha, Young-Gu,Choy, Jin-Ho,Kim, Ha-Suck Korean Chemical Society 1989 Bulletin of the Korean Chemical Society Vol.10 No.5
The electrochemical behavior of cadmium(Ⅱ) in tartrate solution has been studied over the pH range of 6 to 13.6 in order to explain the phenomena of the changes in limiting current depending on the pH. The polarographic limiting current showed a constant value up to pH of 7.8, after which it decreased sharply to show a minimum at pH between 11 and 12. The limiting current, then, increased again with increasing pH. The number of peaks in cyclic voltammogram was 1 to 3 depending on the pH of the solution. Two other voltammetric peaks could be observed when the main reduction peak diminished. The decrease of limiting current at 7.5<pH<9 was explained as the formation of complex $Cd(C_4H_3O_6)^-$. The increase of limiting current at strong alkaline solution, however, was due to the complex $Cd(Tart)_2(OH)_2^{4-}$.
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