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Gregorio Bertani,Luca Patruno,Fernando Gandìa Aguera 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.34 No.6
Computational Wind Engineering has rapidly grown in the last decades and it is currently reaching a relatively mature state. The prediction of wind loading by means of numerical simulations has been proved effective in many research studies and applications to design practice are rapidly spreading. Despite such success, caution in the use of simulations for wind loading assessment is still advisable and, indeed, required. The computational burden and the know-how needed to run highfidelity simulations is often unavailable and the possibility to use simplified models extremely attractive. In this paper, the applicability of some well-known 2D unsteady RANS models, particularly the k-ω SST, in the aerodynamic characterization of extruded bodies with bluff sections is investigated. The main focus of this paper is on the drag coefficient prediction. The topic is not new, but, in the authors' opinion, worth a careful revisitation. In fact, despite their great technical relevance, a systematic study focussing on sections which manifest a fully detached flow configuration has been overlooked. It is here shown that the considered 2D RANS exhibit a pathological behaviour, failing to reproduce the transition between reattached and fully detached flow regime.
Gregorio Iraola,Martín Hernández,Lucía Calleros,Fernando Paolicchi,Silvia Silveyra,Alejandra Velilla,Luis Carretto,Eliana Rodríguez,Ruben Pérez 대한수의학회 2012 JOURNAL OF VETERINARY SCIENCE Vol.13 No.4
Campylobacter (C.) fetus (epsilonproteobacteria) is an important veterinary pathogen. This species is currently divided into C. fetus subspecies (subsp.) fetus (Cff) and C. fetus subsp. venerealis (Cfv). Cfv is the causative agent of bovine genital Campylobacteriosis, an infectious disease that leads to severe reproductive problems in cattle worldwide. Cff is a more general pathogen that causes reproductive problems mainly in sheep although cattle can also be affected. Here we describe a multiplex PCR method to detect C. fetus and differentiate between subspecies in a single step. The assay was standardized using cultured strains and successfully used to analyze the abomasal liquid of aborted bovine fetuses without any pre-enrichment step. Results of our assay were completely consistent with those of traditional bacteriological diagnostic methods. Furthermore, the multiplex PCR technique we developed may be easily adopted by any molecular diagnostic laboratory as a complementary tool for detecting C. fetus subspecies and obtaining epidemiological information about abortion events in cattle.
Advances in neoadjuvant therapy for resectable pancreatic cancer over the past two decades
Alvaro Gregorio Morales Taboad,Pablo Lozano Lominchar,Lorena Martin Roman,Pilar Garcia-Alfonso,Andres Jesus Munoz Martin,Jose Antonio Blanco Rodriguez,Jose Manuel Asencio Pascual 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.2
In the last two decades, pancreatic cancer has been undergoing important changes in its perioperative management due to the great interest in multidisciplinary management and preoperative multimodal therapy, which in numerous studies have shown promising clinical results. Although the standard of treatment for resectable pancreatic ductal adenocarcinoma (PDAC) today is surgery followed by adjuvant therapy, as it is a biologically aggressive disease, even with complete resection, it has high rates of local and distant relapse. Several retrospective and prospective phase I/II studies have opened the window for neoadjuvant therapy with chemotherapy (CT), chemoradiotherapy (CRT), or both, as an alternative treatment for resectable pancreatic cancer, with promising results. Neoadjuvant therapy could has some advantages, including early administration of systemic treatment, in vivo assessment of response to treatment, increase resectability rate in borderline patients, increase resection rate with negative margin and survival benefit. While it seems clear that even potentially resectable disease would benefit from preoperative multimodal therapy, the optimal neoadjuvant therapeutic strategy is still controversial and currently there are only recommendations for neoadjuvant treatment, in clinical guidelines such as the NCCN and ESMO, for borderline and/or locally advanced PDAC. This review provides an overview of recent studies available and how they relate to systemic treatment of resectable PDAC in the neoadjuvant setting.
Neoadjuvant therapy impact in early pancreatic cancer: “bioborderline” vs. “non-bioborderline”
Alvaro Gregorio Morales Taboad,Pablo Lozano Lominchar,Maria Fernandez Martinez,Pilar Garcia-Alfonso,Andres Munoz Martin,Jose Manuel Asencio 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.4
A size dependent evaluation of the cytotoxicity and uptake of nanographene oxide
Mendes, Rafael Gregorio,Koch, Britta,Bachmatiuk, Alicja,Ma, Xing,Sanchez, Samuel,Damm, Christine,Schmidt, Oliver G.,Gemming, Thomas,Eckert, Jü,rgen,Rü,mmeli, Mark H. The Royal Society of Chemistry 2015 Journal of Materials Chemistry B Vol.3 No.12
<P>Graphene oxide (GO) has attracted great interest due to its extraordinary potential for biomedical application. Although it is clear that the naturally occurring morphology of biological structures is crucial to their precise interactions and correct functioning, the geometrical aspects of nanoparticles are often ignored in the design of nanoparticles for biological applications. A few <I>in vitro</I> and <I>in vivo</I> studies have evaluated the cytotoxicity and biodistribution of GO, however very little is known about the influence of flake size and cytotoxicity. Herein, we aim at presenting an initial cytotoxicity evaluation of different nano-sized GO flakes for two different cell lines (HeLa (Kyoto) and macrophage (J7742)) when they are exposed to samples containing different sized nanographene oxide (NGO) flakes (mean diameter of 89 and 277 nm). The obtained data suggests that the larger NGO flakes reduce cell viability as compared to smaller flakes. In addition, the viability reduction correlates with the time and the concentration of the NGO nanoparticles to which the cells are exposed. Uptake studies were also conducted and the data suggests that both cell lines internalize the GO nanoparticles during the incubation periods studied.</P>
A New Formulated Stable Papin-pectin Aerosol Spray for Skin Wound Healing
Karla Monzerratt Gregorio Jáuregui,Juan Carlos Cano Cabrera,Elda Patricia Segura Ceniceros,Jose Luis Martínez Hernández,Anna Ilyina 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.4
A new spray-on topical wound debrider composition consisting of 0.1% w/v papain immobilized in 6% w/v pectin gel was formulated for skin wound healing. The stability of the enzyme activity of this new formulated spray was compared with the 0.1% w/v papain in water solution at the refrigerated temperature of 4 and 75°C. Two aerosol propellants, air and nitrogen, were evaluated for their efficacy. The new formulated spray was then evaluated for its thermal stability under air and N2 at 75°C. All enzyme activity of papain was measured with a spectrophotometer using casein as a substrate at 37°C and in 0.1 M phosphate buffer at pH 6, as well as trichloral acetic acid to separate the product of casein hydrolysis. All the evaluations showed the new aerosol spray formulation to be far better than the liquid formulation in storage stability and thermal stability at 75°C under atmospheric or higher pressures. The new formulation was tested in a rabbit experiment to evaluate the effectiveness of wound healing. As compared to untreated wound, the formulated spray clearly was superior, yielding a 20% more healing progress in the first 4 days alone.
Evangelos Voudoukis,Georgios Tribonias,Aikaterini Tavernaraki,Angeliki Theodoropoulou,Emmanouil Vardas,Konstantina Paraskeva,Gregorios Chlouverakis,Gregorios A. Paspatis 대한소화기내시경학회 2015 Clinical Endoscopy Vol.48 No.2
Background/Aims: Endoscopic mucosal resection (EMR) of large colorectal lesions is associated with increased procedural time. Theobjective of this study was to evaluate the effect of double-channel gastroscope (DCG) use on the procedural time of EMRs in the rectosigmoidarea. Methods: All EMRs for sessile or flat rectosigmoid lesions ≥2 cm performed between July 2011 and September 2012 were retrospectivelyanalyzed. Results: There were 55 lesions ≥2 cm in the rectosigmoid area in 55 patients, of which 26 were removed by EMR using a DCG (DCgroup) and 29 by using an ordinary colonoscope or gastroscope (OS group). The mean size of the removed polyps, morphology, adverseeffects, and other parameters were similar between the two groups. The mean procedural time was significantly lower in the DC groupthan in the OS group (24.4±18.3 minutes vs. 36.3±24.4 minutes, p=0.015). Moreover, in a subgroup of patients with polyps >40 mm, thestatistical difference in the mean procedural time between the DC and OS groups was even more pronounced (33±21 minutes vs. 58.7±20.6 minutes, p=0.004). Conclusions: Our data suggest that the use of a DCG in the resection of large nonpedunculated rectosigmoid lesions significantly reducesthe procedural time.