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RISS 인기검색어
- 검색키워드
- 저자 : Gap Jin Cheon (검색결과 4 건)
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전진숙(Jin Sook Cheon),조원용(Won Yong Cho),전갑수(Gap Soo Jeon),송혜란(Hae Ran Song),오병훈(Byoung Hoon Oh) 대한노인정신의학회 2004 노인정신의학 Vol.8 No.2
Objectives:The hippocampal atrophy has been known to be an important biological marker for the early diagnosis of mild cognitive impairment (MCI). The aims of this study are to disclose the differerence in the interuncal distance (IUD) between MCI, dementia of the Alzheimer's type (DAT) and healthy aged controls, and to identify the affecting factors. Methods:In transaxial plane, the IUDs at the level of the suprasellar cistern on the T1-weighted images on the brain MRI were measured in patients with MCI (N=30), those with DAT (N=34), and healthy aged controls (N=20). Furthermore, demographic data about age, sex, educational level as well as cerebrovascular factors were obtained by structured interviews and medical records, and the severity of cognitive disorders were assessed using the Mini-Mental Status Examination (MMSE), the Clinical Dementia Rating (CDR) and the Global Deterioration Scale (GDS). Results:1) The mean (±S.D.) IUD of DAT group (26.52±3.37 mm) was significantly different from that of healthy aged controls (24.35±2.91 mm)(p=0.044). However, there were no significant differences between IUD of MCI group (25.60±2.66 mm) and that of DAT group (p=0.483) as well as that of healthy aged controls and that of MCI group (p=0.363). 2) Variables such as age, sex, educational level, cerebrovascular risk factors and severity of cognitive disorder were not related to the IUD. Conclusions:The measurement of IUD on the brain MRI did not seem to be a helpful biological marker for the early detection of MCI in clinical practice.
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경도인지장애에서 뇌자기공명영상검사상 백질병소에 관한 연구
전진숙(Jin Sook Cheon),전갑수(Gap Soo Jeon),조원용(Won Yong Cho),송혜란(Hae Ran Song),오병훈(Byoung Hoon Oh) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.1
Objectives : The aims of this study were to know the frequency of white matter lesions(WMLs) on brain magnetic resonance imaging(MRI) in patients with mild cognitive impairment(MCI), and to identify related factors. Methods : Among WMLs, periventricular hyperintensities(PVHs) and deep white matter hyperintensities(DWMHs) on brain MRI in patients with MCI(N=30), patients with dementia of the Alzheimer's type (DAT)(N=34) and normal aged controls(N=20) were analyzed. Furthermore, related variables including cardiovascular risk factors were discussed. Results : 1) The frequencies of the third degree PVHs in patients with MCI(16.6%) were significantly different from those of normal aged controls(5.0%), and from those of patients with DAT(38.2%)(p<0.05). However, frequencies of the third degree DWMHs in patients with MCI(23.3%) were not different from those of normal aged controls(10.0%), and from those of patients with DAT(35.3%). 2) The frequencies of various cardiovascular risk factors in patients with MCI, patients with DAT and normal aged controls were not significantly different. 3) The severity of PVLs seemed to be related to age(p<0.05), systolic blood pressure(p<0.05) and diastolic blood pressure(p<0.005). The severity of DWMHs were seemed to be related to sex(p<0.05), education(p<0.05), Global Deterioration Scale(p<0.05), systolic blood pressure(p<0.01) and diastolic blood pressure(p<0.05). Conclusion : The PVHs might be useful to discriminate patients with MCI from normal aged person. Active management of hypertension seemed to be crucial to prevent from development of WMLs.
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Forskolin Changes the Relationship between Cytosolic $Ca^{2+}$ and Contraction in Guinea Pig Ileum
Han, Koon-Hee,Cheon, Gap-Jin,Yeon, Dong-Soo,Kwon, Seong-Chun The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
This study was designed to clarify the mechanism of the inhibitory effect of forskolin on contraction, cytosolic $Ca^{2+}$ level $([Ca^{2+}]_i)$, and $Ca^{2+}$ sensitivity in guinea pig ileum. Forskolin (0.1 nM ${\sim}$ 10 ${\mu}M$) inhibited high $K^+$ (25 mM and 40 mM)- or histamine (3 ${\mu}M$)-evoked contractions in a concentration-dependent manner. Histamine-evoked contractions were more sensitive to forskolin than high $K^+$-evoked contractions. Spontaneous changes in $[Ca^{2+}]_i$ and contractions were inhibited by forskolin (1 ${\mu}M$) without changing the resting $[Ca^{2+}]_i$. Forskoln (10 ${\mu}M$ ) inhibited muscle tension more strongly than $[Ca^{2+}]_i$ stimulated by high $K^+$, and thus shifted the $[Ca^{2+}]_i$-tension relationship to the lower-right. In histamine-stimulated contractions, forskolin (1 ${\mu}M$) inhibited both $[Ca^{2+}]_i$ and muscle tension without changing the $[Ca^{2+}]_i$-tension relationship. In ${\alpha}$-toxin-permeabilized tissues, forskolin (10 ${\mu}M$) inhibited the 0.3 ${\mu}M$ $Ca^{2+}$-evoked contractions in the presence of 0.1 mM GTP, but showed no effect on the $Ca^{2+}$-tension relationship. We conclude that forskolin inhibits smooth muscle contractions by the following two mechanisms: a decrease in $Ca^{2+}$ sensitivity of contractile elements in high $K^+$-stimulated muscle and a decrease in $[Ca^{2+}]_i$ in histamine-stimulated muscle.
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Koon Hee Han,Gap Jin Cheon,Dong Soo Yeon,Seong Chun Kwon 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
This study was designed to clarify the mechanism of the inhibitory effect of forskolin on contraction, cytosolic Ca<sup>2+</sup> level ([Ca<sup>2+</sup>]<sub>i</sub>), and Ca<sup>2+</sup> sensitivity in guinea pig ileum. Forskolin (0.1 nM∼10ՌM) inhibited high K<sup>+</sup> (25 mM and 40 mM)- or histamine (3ՌM)-evoked contractions in a concentration- dependent manner. Histamine-evoked contractions were more sensitive to forskolin than high K<sup>+</sup>- evoked contractions. Spontaneous changes in [Ca<sup>2+</sup>]<sub>i</sub> and contractions were inhibited by forskolin (1ՌM) without changing the resting [Ca<sup>2+</sup>]<sub>i</sub>. Forskoln (10ՌM) inhibited muscle tension more strongly than [Ca<sup>2+</sup>]<sub>i</sub> stimulated by high K<sup>+</sup>, and thus shifted the [Ca<sup>2+</sup>]<sub>i</sub>-tension relationship to the lower-right. In histamine-stimulated contractions, forskolin (1ՌM) inhibited both [Ca<sup>2+</sup>]<sub>i</sub> and muscle tension without changing the [Ca<sup>2+</sup>]<sub>i</sub>-tension relationship. In Ձ-toxin-permeabilized tissues, forskolin (10ՌM) inhibited the 0.3ՌM Ca<sup>2+</sup>-evoked contractions in the presence of 0.1 mM GTP, but showed no effect on the Ca<sup>2+</sup>-tension relationship. We conclude that forskolin inhibits smooth muscle contractions by the following two mechanisms: a decrease in Ca<sup>2+</sup> sensitivity of contractile elements in high K<sup>+</sup>- stimulated muscle and a decrease in [Ca<sup>2+</sup>]<sub>i</sub> in histamine-stimulated muscle.
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